Drug & supplement interaction

Bitter Melon + Clopidogrel

Clopidogrel brand name: Plavix.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Bitter Melon and Clopidogrel in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Bitter Melon and Clopidogrel

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Clopidogrel and Bitter Melon in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bitter Melon safety at a glance

Bitter Melon overall Use caution Generally tolerated as food, but supplement amounts may lower blood sugar and cause stomach upset.
Pregnancy Avoid Traditionally avoided in pregnancy because seeds and high doses may cause uterine or other harmful effects.
Breastfeeding Use caution Not enough reliable safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Clopidogrel and Bitter Melon? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Clopidogrel

Interactions in our licensed database are recorded against drug classes, not just single drug names. Clopidogrel is filed under 7 classifications — including cytochrome p450 2c9 (cyp2c9) substrates, anticoagulant/antiplatelet drugs, cytochrome p450 1a2 (cyp1a2) substrates. Bitter Melon has documented interactions with 3 drug classes — the most serious being antidiabetes drugs (moderate), p-glycoprotein substrates (moderate) and pazopanib (votrient) (moderate) — and none of Clopidogrel’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Bitter Melon Does Interact With Other Medications

Bitter Melon has 282 moderate known drug interactions in our database — Clopidogrel isn’t one of them. If you take anything else, check it against the full list below.

Moderate 282 No known interaction 2,548 (incl. Clopidogrel)
Taking anything else?

Check Another of Your Medications Against Bitter Melon

Covers the 2,830 medications we’ve checked against Bitter Melon. Pick one to open its full report.

What to actually watch for

What Bitter Melon Itself Has Been Linked To

This is not an interaction — nothing below involves Clopidogrel. It is the side-effect record for Bitter Melon on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Bitter Melon, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Seizures Worth acting on Additional detail

    “Headaches, dizziness, and fatigue have been reported after the ingestion of bitter melon. In one clinical study, about 5% of patients taking bitter melon 2-4 grams daily reported dizziness. Two cases of seizures have occurred in children after administration of a bitter melon tea.”

    Bitter Melon · Natural Medicines adverse-effect record, reported in epilepsy.

    4 sources cited
    1. 15568. Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003;60:356-9. PubMed
    2. 92126. Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015;14:13. PubMed
    3. 100633. Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. J Med Food. 2018;21(7):672-7. doi: 10.108
    4. 112372. Kim B, Lee HS, Kim HJ, et al. Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study. Food Sci Biotechnol 2022;32(5):697-704. PubMed
  • Kidney problems Worth acting on Additional detail

    “In one case report, a 60-year-old female was diagnosed with acute interstitial nephritis after a gradual decline in renal function over 9 months. The patient later admitted to taking bitter melon extract 600 mg daily for 3 months followed by 1200 mg daily for 4 months for diabetes. Upon discontinuation of bitter melon and treatment with prednisolone, serum creatinine levels returned to baseline within 3 months.”

    Bitter Melon · Natural Medicines adverse-effect record, reported in diabetes.

    1 source cited
    1. 109582. Bae W, Kim S, Choi J, et al. Acute interstitial nephritis associated with ingesting a Momordica charantia extract: a case report. Medicine (Baltimore) 2021;100(27):e26606. PubMed
  • Heartburn / Bloating or gas / Stomach upset / Constipation / Diarrhea Additional detail

    “The most common adverse effects associated with bitter melon in clinical studies are gastrointestinal, such as heartburn, anorexia, nausea, vomiting, diarrhea, constipation, flatulence, and abdominal discomfort. In one study, these events occurred in about 3% to 16% of patients taking bitter melon.”

    Bitter Melon · Natural Medicines adverse-effect record, reported in anorexia.

    4 sources cited
    1. 92126. Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015;14:13. PubMed
    2. 100632. Peter EL, Kasali FM, Deyno S, et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. J Ethnopharmacol. 2019;231:311-24. doi: 10.1016/j.jep.2018.10.033. PubMed
    3. 100633. Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. J Med Food. 2018;21(7):672-7. doi: 10.108
    4. 106408. Kim SK, Jung J, Jung JH, et al. Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus. Complement Ther Med. 2020 Aug;52:102524. doi: 10.1016/j.ctim.2020.102524. PubMed
  • Reduced appetite Additional detail

    Recorded for Bitter Melon in the same Natural Medicines adverse-effect record shown under Heartburn / Bloating or gas / Stomach upset / Constipation / Diarrhea above.

  • Tiredness / Dizziness Additional detail

    Recorded for Bitter Melon in the same Natural Medicines adverse-effect record shown under Seizures above.

Showing the 10 most notable of 13 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Bitter Melon — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Clopidogrel’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Clopidogrel column appears here.

From our Q&A

Questions About Bitter Melon or Clopidogrel

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Bitter Melon or Clopidogrel, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Clopidogrel

This page covers Bitter Melon only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Clopidogrel page lists 309 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Grapefruit (major), Piracetam (major) and St. John's Wort (major).

By severity: 5 major · 258 moderate · 46 minor.

From our pharmacist’s overview on the Clopidogrel page

“Clopidogrel (Plavix) keeps platelets from sticking together after a stent, heart attack, or stroke, which makes this a list to take carefully. Of the 309 supplements and herbs on file, 202 carry blood-thinning or antiplatelet activity of their own and can stack bleeding risk on top of the drug's, while most of the rest change how the l…”

Reviewed by 2 · Jul 18, 2026

Open the Clopidogrel interaction page

One more smart check

Taking Bitter Melon as Part of a Dietary Supplement Product? Check It for Interactions

We hold 736 real supplement products containing Bitter Melon, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bitter Melon. Even though Bitter Melon itself has no known interaction with Clopidogrel, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bitter Melon and Clopidogrel Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bitter Melon
Top 25%

#233 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Clopidogrel
Top 1%

#14 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bitter Melon reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Bitter Melon and Clopidogrel records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bitter Melon

What is Bitter Melon?

Bitter Melon
  • Blood sugar support
  • Diabetes
  • Digestive complaints
  • Antioxidant source
  • Skin conditions

Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it may modestly lower blood sugar, the evidence is limited and inconsistent, so it should not replace proven diabetes treatment. Talk with your pharmacist or doctor before using it, especially if you take diabetes medicines or are pregnant.

Momordica charantia · Cucurbitaceae · Fruit, seeds, leaves, and juice · Fresh fruit, juice, capsules, dried powder, tea, extracts

An interaction check asks whether these two react with each other — it does not ask whether Bitter Melon is a good idea for someone in your situation. Here is what our Bitter Melon record says about it on its own.

Bitter Melon: dosing

There is no well-established standard dose for bitter melon. Studies have used different forms, including fresh fruit, juice, and extracts, which makes it hard to give a single reliable amount.If you choose to use a supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Bitter Melon monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bitter Melon monograph & all interactions
Medication

About Clopidogrel

What Is Clopidogrel Used For?

Brand name: Plavix

Clopidogrel tablets are used to reduce the risk of heart attack and stroke in people with acute coronary syndrome (ACS) — including unstable angina and non-ST-elevation or ST-elevation heart attacks — and in people with a history of recent heart attack, recent stroke, or established peripheral arterial disease. For ACS, it is typically given alongside aspirin.

It works by preventing platelets (blood cells that trigger clotting) from clumping together, which helps keep arteries open and lowers the chance of a dangerous clot forming.

Most-Reported Side Effects for Clopidogrel

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 10,950 reports
Myocardial infarction 10,227 reports
Fatigue 9,428 reports
Gastrointestinal haemorrhage 8,776 reports
Nausea 8,686 reports
See full Clopidogrel drug information
Keep checking

Other Drugs & Bitter Melon

Browse every other medication we’ve checked against Bitter Melon — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
282Moderate
0Minor
2,547No known interaction
282 Moderate 2,547 No interaction
Moderate

282 interactions

Showing 60 of 282 moderate interactions — see all 282 on the Bitter Melon page.

No interaction 2,547 drugs checked — show the list

We also checked Bitter Melon against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,547 medications checked with no known interaction — see the full Bitter Melon list.

See the full Bitter Melon interactions page
See every supplement checked against Clopidogrel, ranked by severity
Evidence & sources

Bitter Melon References

The 18 references that drive our Bitter Melon monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Leatherdale B, Panesar RK, Singh G, et al. Improvement in glucose tolerance due to Momordica charantia. Br Med J (Clin Res Ed) 1981;282:1823-4.
  2. Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 1986;17:277-82. PubMed
  3. Srivastava Y, Venkatakrishna-Bhatt H, Verma Y, et al. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother Res 1993;7:285-9.
  4. Baldwa VS, Bhandari CM, Pangaria A, Goyal RK. Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant sources. Ups J Med Sci 1977;82:39-41. PubMed
  5. Aslam M, Stockley IH. Interaction between curry ingredient (karela) and drug (chlorpropamide). Lancet 1979:1:607. PubMed
  6. Ahmad N, Hassan MR, Halder H, Bennoor KS. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients (abstract). Bangladesh Med Res Counc Bull 1999;25:11-3.
  7. Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003;60:356-9. PubMed
  8. Yin RV, Lee NC, Hirpara H, Phung OJ. T. The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: s systematic review and meta-analysis. Nutr Diabetes. 2014;4:e145.
  9. Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015;14:13. PubMed
  10. Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. PubMed
  11. Konishi T, Satsu H, Hatsugai Y, et al. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br J Pharmacol. 2004;143(3):379-87. PubMed
  12. Peter EL, Kasali FM, Deyno S, et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. J Ethnopharmacol. 2019;231:311-24. doi: 10.1016/j.jep.2018.10.033. PubMed
  13. Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. J Med Food. 2018;21(7):672-7. doi: 10.108
  14. Kim SK, Jung J, Jung JH, et al. Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus. Complement Ther Med. 2020 Aug;52:102524. doi: 10.1016/j.ctim.2020.102524. PubMed
  15. Unsal O, Sütcüoglu O, Yazici O. Dangerous interaction of bitter melon (Momordica charantia) with pazopanib: a case of acute pancreatitis. J Oncol Pharm Pract 2022;28(2):486-8.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bitter Melon and Clopidogrel Together: Common Questions

Is it safe to take Bitter Melon with Clopidogrel?
We do not list a known interaction between Bitter Melon and Clopidogrel. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Bitter Melon and Clopidogrel combination checked?
Interactions in our licensed database are recorded against drug classes. Clopidogrel is filed under 7 classifications, and Bitter Melon has documented interactions with 3 drug classes — none of Clopidogrel's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Bitter Melon interact with any other medications?
Yes. Bitter Melon has 282 documented drug interactions in our database — Clopidogrel is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Clopidogrel interact with any supplements?
Yes. Clopidogrel has documented interactions with 309 supplements in our database — Bitter Melon is not one of them. The Clopidogrel interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bitter Melon monograph Uses, safety profile, and every drug interaction in one place Clopidogrel drug information The full plain-English guide to this medication Clopidogrel supplement interactions Every supplement checked against Clopidogrel, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 18 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Clopidogrel and Bitter Melon?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.