Is Krill Oil Safe To Take With Losartan?
In our latest question and answer, the pharmacist discusses whether there is any known interaction between krill oil and the blood pressure medication losartan.
Does krill oil interfere with Losartan? My husband usually takes 25 mg each morning. In general, his daily exercise brings his blood pressure down enough that he doesn’t need a second dose at night, per his doctor’s instructions. I’d love for him to be able to take krill oil if it doesn’t interfere with the Losartan in any way. I take krill oil daily myself and know it helps me! Many thanks for your help!
Aug 08, 2025- Krill oil is generally considered safe to take with losartan, as there are no known direct interactions between them. Krill oil contains omega-3 fatty acids that may slightly reduce blood clotting, so if your husband takes blood thinners or aspirin, discuss this with his doctor. It's a good idea to talk with your doctor before starting krill oil to ensure it works well with all of his medications.
Answer
Thanks so much for your question!
Krill oil is certainly a popular supplement, and I'm happy to hear you're checking into interactions before taking it (well, for your husband in this case)!
Krill oil is very popular because it contains beneficial omega-3 fatty acids, specifically EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), just like fish oil. In addition to these, it also provides other nutrients like triglycerides, vitamin A, vitamin E, and astaxanthin (an antioxidant).
People often take krill oil to support heart health, although it’s used for other purposes as well. The key benefits of krill oil are mostly tied to the anti-inflammatory and blood-thinning properties of omega-3 fatty acids.
Krill Oil Interactions
Our supplement interaction database doesn't show many serious concerns with krill oil overall, but there are a couple of theoretical interactions worth noting.
1. Anticoagulants / Antiplatelet Drugs:
Because krill oil contains omega-3s, it may slightly reduce blood clotting. When combined with blood thinners (like warfarin, clopidogrel, or aspirin), this could slightly increase the risk of bleeding, especially at high doses. That said, krill oil usually has lower omega-3 levels than fish oil, so the risk is likely lower.
2. Diabetes Medications:
Some early research suggests krill oil may help lower blood sugar. If you’re taking medication for diabetes, there’s a small theoretical risk of blood sugar dropping too low. However, in one small study (in the references below) of people with type 2 diabetes already on medication, krill oil didn’t significantly change blood sugar levels. So while it’s something to watch, it’s not a major concern.
These are not considered major interactions and are more theoretical than proven. We include them in our interaction checker for completeness.
Regarding losartan (Krill Oil - Losartan Potassium Interaction Details | HelloPharmacist), we don’t list any known interaction. Krill oil may have mild effects on blood pressure, but current studies suggest these effects are small. There’s no evidence of any direct interaction with losartan.
Final Words
Krill oil is generally considered safe to take alongside losartan. While there’s no data suggesting a specific interaction between the two, it’s always a good idea to talk to your doctor before starting any supplement. This way, they can help ensure everything you’re taking works well together and monitor for any unexpected side effects.
Thanks again for reaching out!
References & sources
- n-3 Fatty acids from fish and fish oil: panacea or nostrum? — PubMed
- Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia — PubMed
- Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial — PubMed
Glossary — Terms in This Answer
- Omega-3 fatty acids
- Essential healthy fats that help reduce inflammation and support heart and brain health.
- EPA (eicosapentaenoic acid)
- A type of omega-3 fatty acid found in fish and krill that supports heart and brain function.
- DHA (docosahexaenoic acid)
- A type of omega-3 fatty acid important for brain and eye health.
- Astaxanthin
- A powerful antioxidant compound that helps protect cells from damage.
- Anticoagulants
- Medications that thin the blood and prevent blood clots from forming.
- Antiplatelet drugs
- Medications that prevent blood cells called platelets from sticking together and forming clots.
- Warfarin
- A blood-thinning medication commonly used to prevent dangerous blood clots.
- Clopidogrel
- A blood-thinning medication that prevents platelets from clumping together to form clots.
Dr. Brian Staiger, PharmD
Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified
Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...
More answers from Brian →