Medication interaction hub

What Supplements Interact with Zileuton?

Zileuton brand names: Zyflo, Zyflo CR. Every interaction below applies to the brands too.

213 Interactions 6 Major 163 Moderate 44 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Zileuton? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Zileuton against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

213 supplements and herbal ingredients have interactions with Zileuton on file in the HelloPharmacist interaction database — 6 rated major, 163 moderate, and 44 minor. The most serious involve Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and St. John's Wort.

Our assessment: with 6 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Zileuton.

Major 6 Moderate 163 Minor 44 No known interaction 1,239

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Zileuton: Top Interactions at a Glance

The Zileuton supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 213 interacting ingredients — plus 1,239 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Zileuton Combinations Today

The Zileuton + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Black Seed + Zileutoni

Theoretically, black seed might increase levels of drugs metabolized by CYP2C9.

Read the full interaction Moderate Likelihood Possible Black Pepper + Zileutoni

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Turmeric + Zileutoni

Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.

Read the full interaction Moderate Likelihood Possible Zizyphus + Zileutoni

Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.

Read the full interaction Moderate Likelihood Possible Corydalis Yanhusuo + Zileutoni

Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP2C9.

Read the full interaction Moderate Likelihood Possible Uva Ursi + Zileutoni

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Zileuton

All 1,452 ingredients in our database, ranked by severity — 213 with a Zileuton interaction on file and 1,239 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Zileuton?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Seed with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black seed might increase levels of drugs metabolized by CYP2C9.

Full Black Seed + Zileuton answer

Can you take Black Pepper with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Zileuton answer

Can you take Turmeric with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Turmeric + Zileuton answer

Can you take Zizyphus with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.

Full Zizyphus + Zileuton answer

Can you take Corydalis Yanhusuo with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP2C9.

Full Corydalis Yanhusuo + Zileuton answer

Can you take European Mandrake with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Zileuton answer

Can you take Evodia with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evodia might reduce the levels and clinical effects of CYP1A2 substrates through induction of CYP1A2.

Full Evodia + Zileuton answer

Can you take Glucomannan with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Zileuton answer

Can you take Guggul with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, guggul might reduce the effects of CYP3A4 substrates.

Full Guggul + Zileuton answer

Can you take Melatonin with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.

Full Melatonin + Zileuton answer

Can you take Schisandra with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Schisandra + Zileuton answer

Can you take Tree Turmeric with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.

Full Tree Turmeric + Zileuton answer

Can you take Acacia Rigidula with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP3A4 su...

Full Acacia Rigidula + Zileuton answer

Can you take Adrafinil with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, adrafinil might reduce the levels and clinical effects of CYP1A2 substrates.

Full Adrafinil + Zileuton answer

Can you take African Wild Potato with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that African wild potato extract inhibits cytochrome P450 1A2 (CYP1A2).

Full African Wild Potato + Zileuton answer

Can you take American Elder with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking American elder might increase levels of CYP3A4 substrates.

Full American Elder + Zileuton answer

Can you take Ashitaba with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.

Full Ashitaba + Zileuton answer

Can you take Ashwagandha with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.

Full Ashwagandha + Zileuton answer

Can you take Astaxanthin with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.

Full Astaxanthin + Zileuton answer

Can you take Ayahuasca with Zileuton?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase plasma concentrations of CYP3A4 substrates.

Full Ayahuasca + Zileuton answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Zileuton is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Zileuton, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Zileuton sits in 8 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Zileuton through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Zileuton through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Zileuton through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Zileuton through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Zileuton through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Zileuton through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Zileuton through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Zileuton through this category.

About Zileuton

Zileuton is a leukotriene synthesis inhibitor used for the long-term prevention and treatment of asthma in adults and children 12 and older.

Generic name: Zileuton  ·  Brand names: Zyflo, Zyflo CR.

See the full Zileuton drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Zileuton

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Zileuton.

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Pharmacist Counseling Corner

Zileuton & Supplements: Common Questions

What supplements interact with Zileuton?
In our interaction database, 213 supplement and herbal ingredients have an interaction with Zileuton on file — 6 rated major, 163 moderate, and 44 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Zileuton supplement interactions are the most serious?
The 6 major-rated combinations — led by Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Zileuton?
That depends entirely on which supplement. The honest answer for Zileuton is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Zyflo have the same supplement interactions as Zileuton?
Yes — Zyflo, Zyflo CR all contain Zileuton, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Zileuton and my other medications?
This page covers Zileuton against supplements and herbal ingredients. Checking Zileuton against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Zileuton drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.