Drug & supplement interaction

Safed Musli + Zileuton

Zileuton brand names: Zyflo, Zyflo CR.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Safed Musli and Zileuton in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Zileuton states a food rule worth keeping to.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Safed Musli and Zileuton

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Zileuton and Safed Musli in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Safed Musli at all — not against Zileuton, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Safed Musli safety at a glance

Safed Musli overall Use caution Generally considered well tolerated in traditional use, but high-quality human safety data are limited.
Pregnancy Avoid Not enough safety information is available, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid it unless a doctor advises otherwise.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Zileuton and Safed Musli? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Zileuton’s Own FDA Label Lists

This is not an interaction — none of it involves Safed Musli. These are the most notable effects listed in the ADVERSE REACTIONS section of Zileuton’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on mentioned in 11.9% of FDA reports for Zileuton
  • Liver problems Worth acting on
  • An allergic reaction Worth acting on
  • Stomach upset
  • Stomach pain
  • Nausea mentioned in 6.3% of FDA reports for Zileuton
  • Diarrhea
  • A skin rash
  • Vomiting

From the ADVERSE REACTIONS section of the FDA label for Zileuton. Read the label on DailyMed › Where a percentage is shown, it is the share of 637 voluntary FDA FAERS reports for Zileuton that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Safed Musli’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Safed Musli side to compare — that is a limit of the record, not a statement that Safed Musli has no side effects.

How to take them

Some Zileuton Products Have a Food Rule — Safed Musli Should Not Break It

At least one FDA label for a product containing Zileuton says to take it with food. If you take Safed Musli on an empty stomach out of habit, keep them separate — and take Zileuton with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Zileuton products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

For ease of administration, ZYFLO may be taken with meals and at bedtime.

From the Dosage and Administration section of the FDA label we read for Zileuton — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Zileuton

This page covers Safed Musli only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Zileuton page lists 213 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 163 moderate · 44 minor.

Open the Zileuton interaction page

One more smart check

Taking Safed Musli as Part of a Dietary Supplement Product? Check It for Interactions

We hold 117 real supplement products containing Safed Musli, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Safed Musli. Even though Safed Musli itself has no known interaction with Zileuton, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Safed Musli and Zileuton Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Safed Musli
Top half

#487 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Zileuton
Steady interest

#1,665 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Safed Musli reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Safed Musli and Zileuton records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Safed Musli

What is Safed Musli?

  • Male sexual health and libido
  • General energy and vitality tonic
  • Physical strength and stamina
  • Postpartum and recovery support (traditional)
  • Aphrodisiac (Ayurvedic use)

Safed Musli is an Ayurvedic herb traditionally used as a tonic and aphrodisiac, especially for male sexual health and energy. Human evidence is limited and mostly preliminary, so its benefits are not well proven. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding due to a lack of safety data.

Chlorophytum borivilianum · Asparagaceae · Dried roots (tubers) · Powder (churna), capsules, tablets, and as an ingredient in herbal tonics

An interaction check asks whether these two react with each other — it does not ask whether Safed Musli is a good idea for someone in your situation. Here is what our Safed Musli record says about it on its own.

Safed Musli: dosing

There is no official, standardized dose for Safed Musli. Traditional preparations and commercial products vary widely in strength and form.The safest approach is to follow the directions on the product label and not exceed the recommended amount. Avoid guessing or taking large amounts in hopes of stronger effects.

From our Safed Musli monograph — the full record covers uses, side effects and every documented interaction.

Read the full Safed Musli monograph & all interactions
Medication

About Zileuton

What Is Zileuton Used For?

Brand names: Zyflo, Zyflo CR

Zileuton is used for the ongoing prevention and treatment of asthma in adults and adolescents aged 12 and older. It is a maintenance medicine — meaning it is taken regularly to keep asthma under control, not to stop an asthma attack once it has started.

Zyflo (the tablet form) and zileuton extended-release tablets are both approved for this same purpose. Neither form should be used to treat a sudden asthma attack. However, both can be continued during a flare-up of asthma while you also use your rescue inhaler.

See full Zileuton drug information
Keep checking

Other Drugs & Safed Musli

Browse every other medication we’ve checked against Safed Musli — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Safed Musli against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Safed Musli list.

See the full Safed Musli interactions page
See every supplement checked against Zileuton, ranked by severity
Evidence & sources

Safed Musli References

The 1 references that drive our Safed Musli monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Tripathi RK, Dethe PD, Bhojne SK, Raut AA, Rege NN. A prospective, randomized, placebo-controlled, double-blind comparative pilot study to evaluate the efficacy of Chlorophytum borivilianum on physical performance. Indian J Pharmacol 2019;51(3):150-6. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Safed Musli and Zileuton Together: Common Questions

Is it safe to take Safed Musli with Zileuton?
We do not list a known interaction between Safed Musli and Zileuton. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Safed Musli and Zileuton at the same time of day?
At least one FDA label for a product containing Zileuton says to take it with food. If you take Safed Musli on an empty stomach out of habit, keep them separate and take Zileuton with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Zileuton products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Zileuton interact with any supplements?
Yes. Zileuton has documented interactions with 213 supplements in our database — Safed Musli is not one of them. The Zileuton interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Safed Musli monograph Uses, safety profile, and every drug interaction in one place Zileuton drug information The full plain-English guide to this medication Zileuton supplement interactions Every supplement checked against Zileuton, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Zileuton and Safed Musli?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.