Dragon's Blood + Zileuton
Zileuton brand names: Zyflo, Zyflo CR.
We found no known interaction between Dragon's Blood and Zileuton in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Zileuton states a food rule worth keeping to.
Dragon's Blood and Zileuton
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Zileuton and Dragon's Blood in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Dragon's Blood at all — not against Zileuton, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Dragon's Blood safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Zileuton Products Have a Food Rule — Dragon's Blood Should Not Break It
At least one FDA label for a product containing Zileuton says to take it with food. If you take Dragon's Blood on an empty stomach out of habit, keep them separate — and take Zileuton with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Zileuton products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
For ease of administration, ZYFLO may be taken with meals and at bedtime.
From the Dosage and Administration section of the FDA label we read for Zileuton — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Zileuton
This page covers Dragon's Blood only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Zileuton page lists 213 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).
By severity: 6 major · 163 moderate · 44 minor.
Taking Dragon's Blood as Part of a Dietary Supplement Product? Check It for Interactions
We hold 21 real supplement products containing Dragon's Blood, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Dragon's Blood. Even though Dragon's Blood itself has no known interaction with Zileuton, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Dragon's Blood and Zileuton Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,222 of 1,452 supplements looked up here in the last 7 days
#1,978 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Dragon's Blood is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Dragon's Blood reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Dragon's Blood and Zileuton records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Dragon's Blood
What is Dragon's Blood?
- Wound healing and skin care
- Digestive upset and diarrhea
- Minor cuts and insect bites
- Sore throat and mouth sores
- Anti-inflammatory skincare
Dragon's Blood is a red plant resin used in traditional medicine for wound healing, skin problems, and digestive complaints. Some early research on certain types (especially Croton lechleri "Sangre de Drago") is promising for the gut and skin, but high-quality human evidence is limited. Talk with your pharmacist or doctor before using it, especially while pregnant or breastfeeding.
Red resin (sap) from the bark, stem, or fruit, depending on the source plant · Resin powder, capsules, tinctures, topical liquids, creams, and skincare products
An interaction check asks whether these two react with each other — it does not ask whether Dragon's Blood is a good idea for someone in your situation. Here is what our Dragon's Blood record says about it on its own.
Dragon's Blood: dosing
There is no established standard dose for Dragon's Blood. The right amount depends on the specific plant source, the product type (resin, tincture, capsule, or cream), and how it is being used.If you choose to use a Dragon's Blood product, follow the directions on the label and do not exceed the suggested amount.
From our Dragon's Blood monograph — the full record covers uses, side effects and every documented interaction.
About Zileuton
What Is Zileuton Used For?
Brand names: Zyflo, Zyflo CR
Zileuton is used for the ongoing prevention and treatment of asthma in adults and adolescents aged 12 and older. It is a maintenance medicine — meaning it is taken regularly to keep asthma under control, not to stop an asthma attack once it has started.
Zyflo (the tablet form) and zileuton extended-release tablets are both approved for this same purpose. Neither form should be used to treat a sudden asthma attack. However, both can be continued during a flare-up of asthma while you also use your rescue inhaler.
Other Drugs & Dragon's Blood
Browse every other medication we’ve checked against Dragon's Blood — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Dragon's Blood against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Losartan Potassium ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Amitriptyline ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Dragon's Blood list.
Dragon's Blood References
The 2 sources that drive our Dragon's Blood monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Dragon's Blood is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Dragon's Blood and Zileuton Together: Common Questions
Is it safe to take Dragon's Blood with Zileuton?
Should I take Dragon's Blood and Zileuton at the same time of day?
Does Zileuton interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.