Dragon's Blood Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Dragon's Blood interacts with medications. The heart of this page is the interaction list — every drug Dragon's Blood is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Dragon's Blood is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Dragon's Blood against your medication
Add one medicationDrugs that interact with Dragon's Blood
0 medications have a known interaction with Dragon's Blood, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Dragon's Blood. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Dragon's Blood combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Dragon's Blood: Uses, Safety & Side Effects
Dragon's Blood is a red plant resin used in traditional medicine for wound healing, skin problems, and digestive complaints. Some early research on certain types (especially Croton lechleri "Sangre de Drago") is promising for the gut and skin, but high-quality human evidence is limited. Talk with your pharmacist or doctor before using it, especially while pregnant or breastfeeding.

- Part used
- Red resin (sap) from the bark, stem, or fruit, depending on the source plant
- Common forms
- Resin powder, capsules, tinctures, topical liquids, creams, and skincare products
- Wound healing and skin care
- Digestive upset and diarrhea
- Minor cuts and insect bites
- Sore throat and mouth sores
- Anti-inflammatory skincare
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Topical use is generally considered low-risk for most people, but human safety data are limited and product sources vary.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Dragon's Blood is the name for a deep red resin or sap that comes from several different plants. The name is shared by more than one source, which can be confusing. One common source is a palm tree called Daemonorops draco from Southeast Asia. Another well-known source is a South American tree often called Croton lechleri, whose red sap is known as Sangre de Drago ("blood of the dragon").
Because the bright red color looks like blood, the resin has been valued for centuries. It has been used in traditional medicine, as a dye or varnish, and in incense and rituals. Today it shows up in folk remedies, dietary supplements, and skincare products.
People most often use Dragon's Blood on the skin for wounds and irritation, or take it by mouth for digestive complaints. The type sold matters, since different plants have different chemistry.
Uses & effectiveness
Dragon's Blood is traditionally used as an astringent (something that tightens tissue), for wound healing, and for stomach and bowel problems such as diarrhea. People also apply it to cuts, scrapes, insect bites, and minor skin irritation, and use it for sore throats and mouth sores.
The honest summary is that good human evidence is limited. The strongest research has looked at Sangre de Drago (from Croton lechleri). A purified compound from that sap has been studied for certain types of diarrhea, and some laboratory and small studies suggest the resin may help skin and gut tissue. Even so, the quality and amount of human research is not enough to consider most uses proven.
For the palm-derived Daemonorops type of Dragon's Blood, there is even less reliable human research. Much of what is known comes from laboratory or animal studies, which do not always apply to people. If you are considering Dragon's Blood for a health problem, treat it as unproven and check with a healthcare professional.
How it works
Dragon's Blood resin contains a mix of natural compounds, including proanthocyanidins (a type of plant tannin), and pigments such as dracorubin and related red coloring molecules. Depending on the plant source, it may also contain alkaloids like taspine and various other phenolic compounds.
Researchers think the tannins give it astringent properties, meaning they can tighten and protect tissue and may help form a protective layer over wounds. Some compounds appear to have antioxidant, anti-inflammatory, and antimicrobial activity in the lab. Certain components have also been studied for effects on fluid movement in the gut, which is one proposed reason for use in diarrhea.
It is important to know that most of these mechanisms come from test-tube and animal research. Showing an effect in a lab dish does not prove the same benefit when a person uses the product.
Safety & precautions
For most adults, applying Dragon's Blood to the skin for a short time appears to be relatively low-risk, but solid human safety data are limited. Quality and purity can vary a lot between products, and some products may be mislabeled or come from a different plant than expected.
Be cautious if you have allergies to plants or resins, sensitive skin, or a chronic medical condition. Do a small patch test before using a topical product over a large area. Avoid putting it into deep or serious wounds without medical advice.
Pregnancy and breastfeeding: there is not enough reliable safety information, so it is best to avoid Dragon's Blood during pregnancy and while breastfeeding. Do not give Dragon's Blood to infants or children unless directed by a pediatric clinician. When in doubt, ask your pharmacist or doctor before using it.
Side effects
Reported side effects are not well documented because high-quality studies are limited. When used on the skin, the most likely problems are local irritation, redness, itching, or an allergic skin reaction, especially in people sensitive to plant resins.
When taken by mouth, it may cause stomach upset or other digestive symptoms in some people. Because tannins can be strong, large amounts taken internally could be harsh on the stomach.
Stop using it and seek medical care if you notice signs of an allergic reaction, such as a spreading rash, swelling, or trouble breathing. As with any supplement, contamination or mislabeling is a concern, so choose products from reputable companies.
Dosing
There is no established standard dose for Dragon's Blood. The right amount depends on the specific plant source, the product type (resin, tincture, capsule, or cream), and how it is being used.
If you choose to use a Dragon's Blood product, follow the directions on the label and do not exceed the suggested amount. For skin products, apply a small amount and watch for irritation first.
Because dosing is not well defined and products differ, it is smart to check with a pharmacist or doctor before starting, especially if you take medications or have a health condition.
Dragon's Blood & Pregnancy
Dragon's Blood & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 2 sources that drive our Dragon's Blood monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.
Keep readingThis information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Brands that make products with Dragon's Blood
8 brands in our database make a supplement containing Dragon's Blood.
Supplement products with Dragon's Blood
27 products in our database contain Dragon's Blood. Open any to see its full ingredient list and every drug interaction we check.
Dragon's Blood: Common Questions
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Is all Dragon's Blood the same?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Dragon's Blood
A rotating sample of real supplements in our database that list Dragon's Blood — open any to see its full ingredients and every drug interaction we check.
- Dragon's Blood Powder by TerraVita Premium Collection
- Dragon's Blood 450 mg 4:1 Extract by TerraVita Premium Collection
- Dragon Blood Alcohol Free by Hawaii Pharm
- Memory Plus by Remedys Nutrition
- Dragon Blood by Hawaii Pharm
- Dragon Blood by Hawaii Pharm
- Resinall K by Health Concerns
- Dragon's Blood Powder by TerraVita Premium Collection
- Aroma Resins by Hawaii Pharm
- Dragon Blood Non-Alcohol by Hawaii Pharm
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