Medication interaction hub

What Supplements Interact with Estradiol?

Estradiol brand names: Estrace, Gynodiol, Vagifem, Estring, Vivelle, and others. Every interaction below applies to the brands too.

213 Interactions 3 Major 172 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Estradiol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Estradiol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Estradiol (Estrace, Vivelle, Vagifem, and other brands) is estrogen therapy, and its interaction list deserves careful reading, especially the three entries rated major. Grapefruit can push estradiol levels higher, St. John's wort speeds its breakdown enough to undercut the therapy, and activated charcoal binds the hormone in the gut so less reaches your bloodstream. Each one changes how much estrogen you actually get.

Most of the remaining 172 moderate and 38 minor entries fall into recognizable patterns. Roughly 60 ingredients, fo-ti among them, carry estrogen-like activity of their own that can compete with or pile onto your prescribed dose. A large caffeine cluster (coffee, tea, guarana) matters because estradiol slows caffeine clearance, so a normal cup can hit harder and linger longer. Fiber-heavy products like glucomannan can blunt absorption of the pill forms, so space them well apart from your dose.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 172 Minor 38 No known interaction 1,239

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Estradiol: Top Interactions at a Glance

The Estradiol supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 213 interacting ingredients — plus 1,239 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Estradiol Combinations Today

The Estradiol + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Black Pepper + Estradioli

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Hemp + Estradioli

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Read the full interaction Moderate Likelihood Possible Saw Palmetto + Estradioli

Saw palmetto might reduce the effectiveness of estrogens.

Read the full interaction Moderate Likelihood Possible Black Cohosh + Estradioli

Theoretically, black cohosh may alter the effects of estrogen therapy.

Read the full interaction Moderate Likelihood Probable Red Clover + Estradioli

Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.

Read the full interaction Moderate Likelihood Possible Wild Yam + Estradioli

Theoretically, wild yam might increase or decrease the effects of estrogen.

Read the full interaction
The complete list

Every Supplement Checked Against Estradiol

All 1,452 ingredients in our database, ranked by severity — 213 with a Estradiol interaction on file and 1,239 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Estradiol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Pepper with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Estradiol answer

Can you take Hemp with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Full Hemp + Estradiol answer

Can you take Saw Palmetto with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Saw palmetto might reduce the effectiveness of estrogens.

Full Saw Palmetto + Estradiol answer

Can you take Black Cohosh with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black cohosh may alter the effects of estrogen therapy.

Full Black Cohosh + Estradiol answer

Can you take Red Clover with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.

Full Red Clover + Estradiol answer

Can you take Schisandra with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Schisandra + Estradiol answer

Can you take Tree Turmeric with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.

Full Tree Turmeric + Estradiol answer

Can you take Vitamin C with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Vitamin C might increase blood levels of estrogens.

Full Vitamin C + Estradiol answer

Can you take Vitex Agnus-castus with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitex agnus-castus could interfere with the activity of estrogens.

Full Vitex Agnus-castus + Estradiol answer

Can you take Wild Carrot with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, excessive use of the above ground parts of wild carrot might interfere with hormonal therapy due to estrogenic effects of wil...

Full Wild Carrot + Estradiol answer

Can you take Yerba Mate with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of the caffeine in yerba mate.

Full Yerba Mate + Estradiol answer

Can you take Acacia Rigidula with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP3A4 su...

Full Acacia Rigidula + Estradiol answer

Can you take Adrafinil with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, adrafinil might reduce the levels and clinical effects of CYP1A2 substrates.

Full Adrafinil + Estradiol answer

Can you take African Wild Potato with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that African wild potato extract inhibits cytochrome P450 1A2 (CYP1A2).

Full African Wild Potato + Estradiol answer

Can you take Aletris with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Aletris might have estrogenic effects.

Full Aletris + Estradiol answer

Can you take Alfalfa with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, alfalfa might interfere with hormone therapy.

Full Alfalfa + Estradiol answer

Can you take American Elder with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking American elder might increase levels of CYP3A4 substrates.

Full American Elder + Estradiol answer

Can you take Androstenediol with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Androstenediol is a precursor to estrogen and can increase levels of estradiol and estrone.

Full Androstenediol + Estradiol answer

Can you take Androstenedione with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, androstenedione might increase the effects and adverse effects of estrogens.

Full Androstenedione + Estradiol answer

Can you take Anise with Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, anise might interfere with estrogen-based hormone replacement therapy.

Full Anise + Estradiol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Estradiol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Estradiol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Estradiol sits in 10 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Estradiol through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Estradiol through this category.

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach Estradiol through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Estradiol through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Estradiol through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Estradiol through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Estradiol through this category.

Ethinyl Estradiol 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Estradiol through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Estradiol through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Estradiol through this category.

Related: does Estradiol deplete any nutrients?

Estradiol has 60 reported nutrient associations in the research literature — see the Estradiol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Estradiol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Estradiol.

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Pharmacist Counseling Corner

Estradiol & Supplements: Common Questions

What supplements interact with Estradiol?
Our database currently documents 213 ingredients with a known Estradiol interaction (3 major, 172 moderate, 38 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 213. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Estradiol supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Estradiol?
Plenty of supplements coexist fine with Estradiol; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Estrace have the same supplement interactions as Estradiol?
Yes — Estrace, Gynodiol, Vagifem, Estring, Vivelle and other brands all contain Estradiol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Estradiol deplete any vitamins or nutrients?
It might — Estradiol has 60 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Estradiol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Estradiol and my other medications?
This page covers Estradiol against supplements and herbal ingredients. Checking Estradiol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.