Medication interaction hub

What Supplements Interact with Etonogestrel?

Etonogestrel brand name: Implanon. Every interaction below applies to the brands too.

175 Interactions 2 Major 135 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Etonogestrel? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Etonogestrel against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

St. John's wort is the supplement to understand first if you use etonogestrel (Implanon), because it revs up the liver enzyme that clears the hormone and can leave you with less pregnancy protection than you think you have. It is one of two major-rated entries among the 175 ingredients on file, and this list earns real attention. Grapefruit is the other major one, working the opposite direction by slowing that same enzyme so hormone levels climb.

Most of the remaining 135 moderate and 38 minor entries cluster around the same liver enzymes. A surprisingly big group involves caffeine, since hormonal contraceptives slow caffeine clearance by 40 to 65 percent, so coffee and tea can hit harder and linger longer than you expect. A smaller set, alfalfa among them, contains plant compounds with estrogen-like activity that could work against the contraceptive effect, which is exactly the effect you cannot afford to lose.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 135 Minor 38 No known interaction 1,277

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Etonogestrel: Top Interactions at a Glance

The Etonogestrel supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 175 interacting ingredients — plus 1,277 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Etonogestrel Combinations Today

The Etonogestrel + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Copper + Etonogestreli

Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.

Read the full interaction Minor Likelihood Possible Selenium + Etonogestreli

Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.

Read the full interaction Moderate Likelihood Possible Activated Charcoal + Etonogestreli

Activated charcoal may reduce the clinical effects of oral contraceptives.

Read the full interaction Moderate Likelihood Possible Cauliflower + Etonogestreli

Preliminary clinical evidence suggests that eating cruciferous vegetables, including broccoli, cauliflower, daikon radish sprouts, and cabbage, can increase cyt...

Read the full interaction Moderate Likelihood Possible Ashitaba + Etonogestreli

In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.

Read the full interaction Moderate Likelihood Probable Melatonin + Etonogestreli

Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.

Read the full interaction
The complete list

Every Supplement Checked Against Etonogestrel

All 1,452 ingredients in our database, ranked by severity — 175 with a Etonogestrel interaction on file and 1,277 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Etonogestrel?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Copper with Etonogestrel?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.

Full Copper + Etonogestrel answer

Can you take Selenium with Etonogestrel?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.

Full Selenium + Etonogestrel answer

Can you take Activated Charcoal with Etonogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Activated charcoal may reduce the clinical effects of oral contraceptives.

Full Activated Charcoal + Etonogestrel answer

Can you take Cauliflower with Etonogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary clinical evidence suggests that eating cruciferous vegetables, including broccoli, cauliflower, daikon radish sprouts, and cabba...

Full Cauliflower + Etonogestrel answer

Can you take Ashitaba with Etonogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.

Full Ashitaba + Etonogestrel answer

Can you take Cola Nut with Etonogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP1A2 inhibitors might increase the levels and adverse effects of the caffeine in cola nut.

Full Cola Nut + Etonogestrel answer

Can you take Coleus with Etonogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.

Full Coleus + Etonogestrel answer

Can you take Corydalis Yanhusuo with Etonogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP3A4.

Full Corydalis Yanhusuo + Etonogestrel answer

Can you take Cranberry with Etonogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Full Cranberry + Etonogestrel answer

Can you take Cubebs with Etonogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Several compounds isolated from cubebs can inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Cubebs + Etonogestrel answer

Can you take Dandelion with Etonogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.

Full Dandelion + Etonogestrel answer

Can you take Danshen with Etonogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP1A2.

Full Danshen + Etonogestrel answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Etonogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of THC.

Full Delta-9-tetrahydrocannabinol (thc) + Etonogestrel answer

Can you take Devil's Claw with Etonogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Full Devil's Claw + Etonogestrel answer

Can you take Dhea with Etonogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + Etonogestrel answer

Can you take Dimethylsulfoxide (dmso) with Etonogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Topical DMSO might increase the effects and adverse effects of topical drugs.

Full Dimethylsulfoxide (dmso) + Etonogestrel answer

Can you take Diosmin with Etonogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.

Full Diosmin + Etonogestrel answer

Can you take Echinacea with Etonogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.

Full Echinacea + Etonogestrel answer

Can you take Eleuthero with Etonogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Full Eleuthero + Etonogestrel answer

Can you take Ephedra with Etonogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ephedra might decrease levels of drugs metabolized by CYP1A2.

Full Ephedra + Etonogestrel answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Etonogestrel is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Etonogestrel, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Etonogestrel sits in 7 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Etonogestrel through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Etonogestrel through this category.

Contraceptive Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Etonogestrel through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Etonogestrel through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Etonogestrel through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Etonogestrel through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Etonogestrel through this category.

Related: does Etonogestrel deplete any nutrients?

Etonogestrel has 2 reported nutrient associations in the research literature — see the Etonogestrel nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Etonogestrel

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Etonogestrel.

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Pharmacist Counseling Corner

Etonogestrel & Supplements: Common Questions

What supplements interact with Etonogestrel?
Our database currently documents 175 ingredients with a known Etonogestrel interaction (2 major, 135 moderate, 38 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 175. The highest-ranked right now: Grapefruit, St. John's Wort, Black Tea.
Which Etonogestrel supplement interactions are the most serious?
The 2 major-rated combinations — led by Grapefruit and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Etonogestrel?
Plenty of supplements coexist fine with Etonogestrel; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Implanon have the same supplement interactions as Etonogestrel?
Yes — Implanon all contain Etonogestrel, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Etonogestrel deplete any vitamins or nutrients?
It might — Etonogestrel has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Etonogestrel nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Etonogestrel and my other medications?
This page covers Etonogestrel against supplements and herbal ingredients. Checking Etonogestrel against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.