Herb & supplement monograph

Alchemilla Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated June 2026

What is this page for?

First and foremost: how Alchemilla interacts with medications. The heart of this page is the interaction list — every drug Alchemilla is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Alchemilla is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Alchemilla Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Alchemilla drug interaction appears low for most people. None of the listed interactions are rated major or moderate, and all of them are graded minor.

Interactions deserving the most attention

Genuinely little in this profile stands out as a serious concern. The main flag involves topical drugs, where a small human study reported local mouth irritation after a product combining alchemilla extract with glycerol was applied inside the mouth. That reaction was mild and tied to skin or mucous membrane contact, not to taking alchemilla by mouth alongside other medicines. No interactions affecting closely monitored medicines, such as blood thinners or diabetes drugs, are supported by this data.

What the rest of the list means

A long list of interacting medications can look worrying, but here it does not mean the combinations are harmful. Nearly all of these pairings are minor and lightly documented, resting on limited or theoretical findings rather than proven problems in people. No side effects have been reported from taking alchemilla by mouth in the available evidence.

Check your medications against Alchemilla

Based on HelloPharmacist’s Alchemilla interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Alchemilla

198 medications have a known interaction with Alchemilla, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Alchemilla using our pharmacist-reviewed interaction data.

AI summaries are generated from our Alchemilla interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Alchemilla combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Alchemilla affects

Every type of medication (drug category) Alchemilla is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Alchemilla interacts with

Topical Drugs

While no side effects have been reported from orally using Alchemilla, a clinical study titled "Treatment of Aphthous Stomatitis with Topical Alchemilla vulgaris in Glycerine," published in Clinical Drug Investigation (https://pubmed.ncbi.nlm.nih.gov/17163290/), found that local mouth irritation occurred after applying a commercial product containing 3% alchemilla extract and glycerol (Aphtarine, Laboratoires Biosphere). Aphtarine was non-irritating in 68.2% of cases within 2-3 days, in 18.8% of cases within 4-7 days, and in 13.6% of cases with moderate irritation. Theoretically, combining Alchemilla with other potentially irritating topical products could increase the risk of local irritation and discomfort. The drug in this drug interaction monograph is available in a topical dosage form. There is no interaction expected from the oral dosage form of the drug.

Likelihood Possible Evidence D

Monograph

Alchemilla: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed June 2026 ·

The bottom line

Alchemilla (lady's mantle) is a European herb traditionally used for digestive complaints, women's health issues, and as an astringent for skin and wounds. Solid human research is very limited, so its benefits remain largely unproven, and it should be avoided in pregnancy and breastfeeding due to a lack of safety data.

Scientific name: Alchemilla vulgaris
Family: Rosaceae
Part used: Above-ground parts (leaves and flowering tops)
Common forms: Tea, tincture, dried herb, capsules, topical gels and creams

People commonly use it for

Menstrual and women's health complaints
Diarrhea and digestive upset
Wound healing (topical)
Skin moisturizing (topical)
Mild inflammation

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallUse caution

Generally considered low-risk in small amounts, but human safety data are limited.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail

BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Alchemilla, commonly called lady's mantle, is a low-growing perennial herb in the rose family. It grows wild across Europe and parts of Asia, often in meadows, grassy slopes, and woodland edges. Its rounded, fan-shaped leaves are a recognizable feature, and dew often collects in their center.

People have used the above-ground parts (leaves and flowering tops) in traditional European herbal medicine for hundreds of years. It has historically been linked to "women's complaints," which is part of how it earned the name lady's mantle. Today it is sold as a tea, tincture, dried herb, capsule, and in topical skin products.

How it works

Alchemilla is rich in tannins (such as ellagic and gallic acid derivatives) and flavonoids like quercetin and luteolin. Tannins have an astringent effect, meaning they can tighten and dry tissues. This is the likely reason it has traditionally been used for diarrhea and applied to minor wounds and irritated skin.

In laboratory studies, Alchemilla extracts have shown antioxidant activity, helping neutralize unstable molecules called free radicals. Some lab work also suggests it may influence enzymes involved in skin breakdown and may support skin cell movement during healing.

It is important to know these findings are mostly from test-tube and animal research. They do not prove the same effects happen in people who take or apply the herb.

Effectiveness

Does Alchemilla work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by Dr. Brian Staiger, PharmD.

Evidence overview · 2 uses evaluated

2 Insufficient evidence

How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.

2Likely EffectiveGood evidence, though not yet conclusive.

3Possibly EffectiveSome evidence suggests a benefit.

4Possibly IneffectiveSome evidence it may not help.

5Likely IneffectiveFairly strong evidence it doesn’t help.

6IneffectiveStrong evidence it doesn’t work.

7Insufficient Reliable Evidence to RateToo little research to say either way.

For Alchemilla, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 2 conditions — evidence insufficient to rate

Insufficient Reliable Evidence To Rate Canker sores

Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical alchemilla is beneficial for canker sores.

Insufficient Reliable Evidence To Rate Postoperative sore throat

Rating & evidence shown verbatim from Natural Medicines

It is unclear if alchemilla throat spray reduces sore throat after surgery.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Alchemilla has a long history of traditional use and is generally thought to be low-risk when used in small, food-like amounts such as tea. However, good-quality human safety studies are lacking, so its true safety profile is not well defined.

Because it contains a high amount of tannins, large or frequent doses could potentially upset the stomach or affect the liver in sensitive people. People with liver problems should be cautious. As with any herbal product, quality and purity can vary between brands.

Pregnancy and breastfeeding: There is not enough safety information, and Alchemilla has traditionally been associated with effects on the menstrual cycle and uterus. To be safe, avoid it during pregnancy and while breastfeeding. Always check with your pharmacist or doctor before starting any new supplement.

Side effects

Reported side effects are uncommon, partly because the herb has not been studied much in formal trials. The most likely issues come from its high tannin content, which may cause stomach upset, nausea, or constipation, especially at higher doses.

Topical use may rarely cause skin irritation or an allergic reaction. Stop using it and seek medical care if you notice a rash, swelling, or trouble breathing. There is a theoretical concern that very high tannin intake over time could stress the liver, so avoid excessive amounts.

Dosing

There is no well-established or standardized dose for Alchemilla, because it has not been studied enough in clinical trials. Traditional use often involves a tea made from the dried herb or a tincture, and topical products are applied to the skin.

The best approach is to follow the directions on the product label and not exceed the recommended amount. Because product strength varies, talk with a pharmacist or doctor before using it, especially if you take other medications or have a health condition.

Pregnancy & Breastfeeding

Alchemilla & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Alchemilla & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 1 sources that drive our Alchemilla monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.

Herbs at a Glance — NIH NCCIH Source

Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Brand directory

Brands that make products with Alchemilla

9 brands in our database make a supplement containing Alchemilla.

Cellusyn Laboratories 16 products Doakes Nutraceuticals 5 products Earth Mama Organics 43 products Hawaii Pharm 4,726 products Herbal Terra 3,138 products Hydroxycut 37 products NeoLife Nutritionals 221 products NutriPharm 42 products Sun God Medicinals 29 products

Product directory

Supplement products with Alchemilla

19 products in our database contain Alchemilla. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

Alchemilla: Common Questions

What is Alchemilla used for, and does it work?

People use Alchemilla for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.

Does Alchemilla interact with prescription medications?

Yes. We list 198 medications with a known interaction with Alchemilla. Use the checker above to see how Alchemilla interacts with a specific drug.

How are Alchemilla interactions rated?

Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.

Is it safe to take Alchemilla with my medications?

It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.

Where does this Alchemilla interaction information come from?

Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.

What is Alchemilla (lady's mantle) used for?

It is traditionally used for women's menstrual complaints, diarrhea and digestive upset, and as an astringent applied to the skin for minor wounds and irritation. Strong human evidence for these uses is lacking.

Is Alchemilla safe to take?

In small, tea-like amounts it is generally considered low-risk, but human safety data are limited. High doses may cause stomach upset due to its tannin content, so use it cautiously and check with a healthcare professional.

Can I use Alchemilla during pregnancy or breastfeeding?

No. There isn't enough safety information, and it has traditionally been linked to effects on the uterus and menstrual cycle, so it is best avoided during pregnancy and breastfeeding.

How is Alchemilla usually taken?

It is commonly taken as a tea, tincture, or capsule, and is also found in skin creams and gels. Because there is no standardized dose, follow the product label and ask your pharmacist for guidance.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Alchemilla

A rotating sample of real supplements in our database that list Alchemilla — open any to see its full ingredients and every drug interaction we check.

See all 19 products with Alchemilla →

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Alchemilla Drug Interactions, Uses, Effectiveness, Safety & More

Your Choice:

Alchemilla Drug Interactions: The Bottom Line

Drugs that interact with Alchemilla

Don’t want to scroll the list? Just ask.

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Likelihood — How Well It’s Documented

Where This Data Comes From

The kinds of drugs Alchemilla affects

Alchemilla: Uses, Safety & Side Effects

Overview

How it works

Does Alchemilla work?

Safety & precautions

Side effects

Dosing

Alchemilla & Pregnancy

Alchemilla & Breastfeeding

References & further reading

Brands that make products with Alchemilla

Supplement products with Alchemilla

Alchemilla: Common Questions

Related supplements & herbs

Products that contain Alchemilla

Have a question about Alchemilla?