Drug & supplement interaction

Alchemilla + Apremilast

Apremilast brand name: Otezla.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Alchemilla and Apremilast in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Alchemilla and Apremilast

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Apremilast and Alchemilla in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Alchemilla safety at a glance

Alchemilla overall Use caution Generally considered low-risk in small amounts, but human safety data are limited.
Pregnancy Avoid Not enough safety information; best avoided during pregnancy.
Breastfeeding Avoid Not enough safety information; best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Apremilast and Alchemilla? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Apremilast

Interactions in our licensed database are recorded against drug classes, not just single drug names. Apremilast is filed under 2 classifications — cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Alchemilla has documented interactions with 1 drug class — the most serious being topical drugs (minor) — and none of Apremilast’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Alchemilla Does Interact With Other Medications

Alchemilla has 198 minor known drug interactions in our database — Apremilast isn’t one of them. If you take anything else, check it against the full list below.

Minor 198 No known interaction 2,632 (incl. Apremilast)
Taking anything else?

Check Another of Your Medications Against Alchemilla

Covers the 2,830 medications we’ve checked against Alchemilla. Pick one to open its full report.

What to actually watch for

What Apremilast’s Own FDA Label Lists

This is not an interaction — none of it involves Alchemilla. These are the most notable effects listed in the ADVERSE REACTIONS section of Apremilast’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

  • Low mood Worth acting on
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on
  • Heartburn
  • Migraine
  • Mouth irritation or sores
  • Joint pain mentioned in 5.6% of FDA reports for Apremilast
  • Stomach upset mentioned in 5.7% of FDA reports for Apremilast
  • Diarrhea mentioned in 16.9% of FDA reports for Apremilast
  • Back pain

Showing the 10 most notable of 19 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Apremilast. Read the label on DailyMed › Where a percentage is shown, it is the share of 145,481 voluntary FDA FAERS reports for Apremilast that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Alchemilla’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Alchemilla side to compare — that is a limit of the record, not a statement that Alchemilla has no side effects.

Everything else you take

See Every Supplement That Interacts With Apremilast

This page covers Alchemilla only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Apremilast page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Apremilast page

“St. John's wort is the first thing I would rule out for anyone taking apremilast (Otezla) for psoriasis, psoriatic arthritis, or Behçet's mouth sores.”

Reviewed by 2 · Jul 18, 2026

Open the Apremilast interaction page

One more smart check

Taking Alchemilla as Part of a Dietary Supplement Product? Check It for Interactions

We hold 19 real supplement products containing Alchemilla, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Alchemilla. Even though Alchemilla itself has no known interaction with Apremilast, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Alchemilla and Apremilast Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Alchemilla
Steady interest

#960 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Apremilast
Steady interest

#1,548 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Alchemilla is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Alchemilla reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Alchemilla and Apremilast records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Alchemilla

What is Alchemilla?

Alchemilla
  • Menstrual and women's health complaints
  • Diarrhea and digestive upset
  • Wound healing (topical)
  • Skin moisturizing (topical)
  • Mild inflammation

Alchemilla (lady's mantle) is a European herb traditionally used for digestive complaints, women's health issues, and as an astringent for skin and wounds. Solid human research is very limited, so its benefits remain largely unproven, and it should be avoided in pregnancy and breastfeeding due to a lack of safety data.

Alchemilla vulgaris · Rosaceae · Above-ground parts (leaves and flowering tops) · Tea, tincture, dried herb, capsules, topical gels and creams

An interaction check asks whether these two react with each other — it does not ask whether Alchemilla is a good idea for someone in your situation. Here is what our Alchemilla record says about it on its own.

Alchemilla: dosing

There is no well-established or standardized dose for Alchemilla, because it has not been studied enough in clinical trials. Traditional use often involves a tea made from the dried herb or a tincture, and topical products are applied to the skin.The best approach is to follow the directions on the product label and not exceed the recommended amount.

From our Alchemilla monograph — the full record covers uses, side effects and every documented interaction.

Read the full Alchemilla monograph & all interactions
Medication

About Apremilast

What Is Apremilast Used For?

Brand name: Otezla

Otezla (apremilast) is used to treat active psoriatic arthritis and plaque psoriasis in adults and in children 6 years of age and older who weigh at least 20 kg. For plaque psoriasis, it is prescribed when phototherapy or systemic treatment is appropriate. Otezla is also approved to treat oral ulcers associated with Behçet's Disease in adults.

Dosing for children depends on body weight. Otezla is approved for pediatric patients weighing at least 20 kg. Otezla is not approved for children with Behçet's Disease.

Most-Reported Side Effects for Apremilast

From FAERS, the FDA’s public side-effect reporting system (145,481 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 24,624 reports
Nausea 22,177 reports
Psoriasis 20,585 reports
Headache 17,913 reports
Abdominal discomfort 8,234 reports
See full Apremilast drug information
Keep checking

Other Drugs & Alchemilla

Browse every other medication we’ve checked against Alchemilla — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
198Minor
2,631No known interaction
198 Minor 2,631 No interaction
Minor

198 interactions

Showing 60 of 198 minor interactions — see all 198 on the Alchemilla page.

No interaction 2,631 drugs checked — show the list

We also checked Alchemilla against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,631 medications checked with no known interaction — see the full Alchemilla list.

See the full Alchemilla interactions page
See every supplement checked against Apremilast, ranked by severity
Evidence & sources

Alchemilla References

The 1 sources that drive our Alchemilla monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Alchemilla is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs at a Glance — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Alchemilla and Apremilast Together: Common Questions

Is it safe to take Alchemilla with Apremilast?
We do not list a known interaction between Alchemilla and Apremilast. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Alchemilla and Apremilast combination checked?
Interactions in our licensed database are recorded against drug classes. Apremilast is filed under 2 classifications, and Alchemilla has documented interactions with 1 drug class — none of Apremilast's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Alchemilla interact with any other medications?
Yes. Alchemilla has 198 documented drug interactions in our database — Apremilast is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Apremilast interact with any supplements?
Yes. Apremilast has documented interactions with 138 supplements in our database — Alchemilla is not one of them. The Apremilast interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Alchemilla monograph Uses, safety profile, and every drug interaction in one place Apremilast drug information The full plain-English guide to this medication Apremilast supplement interactions Every supplement checked against Apremilast, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Apremilast and Alchemilla?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.