Apremilast drug information

Why is this medication prescribed?
How should this medicine be used?
Other uses for this medicine
What special precautions should I follow?
What special dietary instructions should I follow?
What should I do if I forget a dose?
What side effects can this medication cause?
What should I know about STORAGE and DISPOSAL of this medication?
What should I do in case of OVERDOSE?
What OTHER INFORMATION should I know?
Drug interactions

Why is this medication prescribed?

Apremilast is used to treat psoriatic arthritis (a condition that causes joint pain and swelling and scales on the skin). It is also used to treat moderate to severe plaque psoriasis (skin disease in which red, scaly patches form on some areas of the body) in people who may benefit from medications or phototherapy (a treatment that involves exposing the skin to ultraviolet light). Apremilast is used to treat ulcers in the mouth in people with Behcet's syndrome (a disorder that causes blood vessel swelling in the body). Apremilast is in a class of medications called phosphodiesterase inhibitors. It works by blocking the action of certain natural substances in the body that cause inflammation.

How should this medicine be used?

Apremilast comes as a tablet to take by mouth. It is usually taken twice a day. Take apremilast at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take apremilast exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them.

Your doctor will probably start you on a low dose of apremilast and gradually increase your dose once every day for the first 5 days of treatment.

Apremilast controls psoriatic arthritis or plaque psoriasis, or treats oral ulcers, but does not cure them. Continue to take apremilast even if you feel well. Do not stop taking apremilast without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking apremilast,

tell your doctor and pharmacist if you are allergic to apremilast, any other medications, or any of the ingredients in apremilast tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain medications for seizures such as carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenobarbital, phenytoin (Dilantin, Phenytek), or rifampin (Rifadin, Rimactane). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor if you have or have ever had depression, mood problems, thoughts about harming or killing yourself, or planning or trying to do so, or kidney disease.

tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking apremilast, call your doctor.

you should know that your mental health may change in unexpected ways and you may become depressed or suicidal (thinking about harming or killing yourself or planning or trying to do so) while you are taking apremilast. You and your doctor will decide whether the risks of taking this medication are greater than the risks of not taking the medication. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression, talking or thinking about wanting to hurt yourself or end your life, or any other unusual changes in behavior or mood. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

you should know that apremilast can cause weight loss. Your weight should be checked regularly by your doctor and you should also check your weight on a regular basis during treatment with apremilast. If you notice you are losing weight, call your doctor.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Apremilast may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- diarrhea
- nausea
- stomach pain
- vomiting
- headache
- sore throat, cough, and fever
- sneezing, runny nose, and nasal congestion

Apremilast may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What OTHER INFORMATION should I know?

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug interactions

Drug	Interaction
Moxifloxacin	Moxifloxacin The metabolism of Apremilast can be decreased when combined with Moxifloxacin.
Repaglinide	Repaglinide The metabolism of Repaglinide can be increased when combined with Apremilast.
Montelukast	Montelukast The metabolism of Montelukast can be increased when combined with Apremilast.
Insulin Glargine (rDNA origin) Injection	Insulin Glargine (rDNA origin) Injection The metabolism of Apremilast can be increased when combined with Insulin glargine.
Leflunomide	Leflunomide The risk or severity of adverse effects can be increased when Leflunomide is combined with Apremilast.
Delavirdine	Delavirdine The metabolism of Delavirdine can be increased when combined with Apremilast.
Nevirapine	Nevirapine The metabolism of Nevirapine can be increased when combined with Apremilast.
Atorvastatin	Atorvastatin The metabolism of Atorvastatin can be increased when combined with Apremilast.
Dolasetron	Dolasetron The metabolism of Dolasetron can be increased when combined with Apremilast.
Aminophylline	Aminophylline The metabolism of Aminophylline can be increased when combined with Apremilast.
Anagrelide	Anagrelide The metabolism of Anagrelide can be increased when combined with Apremilast.
Candesartan	Candesartan The metabolism of Candesartan can be increased when combined with Apremilast.
Cilostazol	Cilostazol The metabolism of Cilostazol can be increased when combined with Apremilast.
Clopidogrel	Clopidogrel The metabolism of Clopidogrel can be increased when combined with Apremilast.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The metabolism of Erythromycin can be increased when combined with Apremilast.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) The metabolism of Conjugated estrogens can be increased when combined with Apremilast.
Fenofibrate	Fenofibrate The metabolism of Fenofibrate can be increased when combined with Apremilast.
Guanfacine	Guanfacine Guanfacine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Magnesium Hydroxide	Magnesium Hydroxide Apremilast may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Mycophenolate	Mycophenolate The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Apremilast.
Olsalazine	Olsalazine Olsalazine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Paregoric	Paregoric The metabolism of Morphine can be increased when combined with Apremilast.
Penbutolol	Penbutolol The metabolism of Acebutolol can be increased when combined with Apremilast.
Potassium	Potassium Potassium cation may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone	Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Apremilast.
Ranitidine	Ranitidine The metabolism of Ranitidine can be increased when combined with Apremilast.
Reserpine	Reserpine Reserpine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Rizatriptan	Rizatriptan Rizatriptan may decrease the excretion rate of Apremilast which could result in a higher serum level.
Sumatriptan	Sumatriptan Sumatriptan may decrease the excretion rate of Apremilast which could result in a higher serum level.
Tacrolimus	Tacrolimus Tacrolimus may increase the immunosuppressive activities of Apremilast.
Tizanidine	Tizanidine The metabolism of Tizanidine can be increased when combined with Apremilast.
Triamcinolone	Triamcinolone The metabolism of Triamcinolone can be increased when combined with Apremilast.
Zolmitriptan	Zolmitriptan The metabolism of Zolmitriptan can be increased when combined with Apremilast.
Ampicillin Injection	Ampicillin Injection Ampicillin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Doxycycline Injection	Doxycycline Injection Doxycycline may decrease the excretion rate of Apremilast which could result in a higher serum level.
Famotidine Injection	Famotidine Injection The metabolism of Apremilast can be decreased when combined with Famotidine.
Fluconazole Injection	Fluconazole Injection Fluconazole may decrease the excretion rate of Apremilast which could result in a higher serum level.
Foscarnet Injection	Foscarnet Injection Foscarnet may decrease the excretion rate of Apremilast which could result in a higher serum level.
Hydromorphone Injection	Hydromorphone Injection The metabolism of Hydromorphone can be increased when combined with Apremilast.
Interferon Beta-1b Injection	Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Apremilast.
Interferon Gamma-1b Injection	Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Apremilast.
Levofloxacin Injection	Levofloxacin Injection The metabolism of Apremilast can be decreased when combined with Levofloxacin.
Meperidine Injection	Meperidine Injection The metabolism of Meperidine can be increased when combined with Apremilast.
Methylprednisolone Injection	Methylprednisolone Injection The risk or severity of adverse effects can be increased when Methylprednisolone is combined with Apremilast.
Metoclopramide Injection	Metoclopramide Injection The metabolism of Metoclopramide can be increased when combined with Apremilast.
Metronidazole Injection	Metronidazole Injection The metabolism of Metronidazole can be increased when combined with Apremilast.
Morphine Injection	Morphine Injection The metabolism of Morphine can be increased when combined with Apremilast.
Pamidronate Injection	Pamidronate Injection Pamidronic acid may decrease the excretion rate of Apremilast which could result in a higher serum level.
Vancomycin Injection	Vancomycin Injection Apremilast may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection	Zidovudine Injection The metabolism of Zidovudine can be increased when combined with Apremilast.
Altretamine	Altretamine The metabolism of Amphetamine can be increased when combined with Apremilast.
Cefuroxime	Cefuroxime Cefuroxime may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cyclosporine	Cyclosporine Apremilast may increase the immunosuppressive activities of Cyclosporine.
Ondansetron	Ondansetron The metabolism of Ondansetron can be increased when combined with Apremilast.
Torsemide	Torsemide The metabolism of Torasemide can be increased when combined with Apremilast.
Olanzapine	Olanzapine The metabolism of Olanzapine can be increased when combined with Apremilast.
Alosetron	Alosetron The metabolism of Alosetron can be increased when combined with Apremilast.
Dofetilide	Dofetilide The metabolism of Dofetilide can be increased when combined with Apremilast.
Hydroxychloroquine	Hydroxychloroquine The metabolism of Apremilast can be increased when combined with Hydroxychloroquine.
Meloxicam	Meloxicam The metabolism of Meloxicam can be increased when combined with Apremilast.
Pantoprazole	Pantoprazole The metabolism of Pantoprazole can be increased when combined with Apremilast.
Temozolomide	Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Apremilast.
Zaleplon	Zaleplon The metabolism of Zaleplon can be increased when combined with Apremilast.
Anakinra	Anakinra The therapeutic efficacy of Apremilast can be decreased when used in combination with Anakinra.
Linezolid	Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Apremilast.
Trimipramine	Trimipramine The metabolism of Trimipramine can be increased when combined with Apremilast.
Etanercept Injection	Etanercept Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Etanercept.
Modafinil	Modafinil The metabolism of Modafinil can be increased when combined with Apremilast.
Perindopril	Perindopril Perindopril may decrease the excretion rate of Apremilast which could result in a higher serum level.
Tenofovir	Tenofovir The metabolism of Tenofovir can be increased when combined with Apremilast.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Apremilast which could result in a higher serum level.
Sirolimus	Sirolimus The metabolism of Sirolimus can be increased when combined with Apremilast.
Dutasteride	Dutasteride The metabolism of Dutasteride can be increased when combined with Apremilast.
Epirubicin	Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Apremilast.
Eplerenone	Eplerenone The metabolism of Eplerenone can be increased when combined with Apremilast.
Escitalopram	Escitalopram The metabolism of Escitalopram can be increased when combined with Apremilast.
Zonisamide	Zonisamide The metabolism of Zonisamide can be increased when combined with Apremilast.
Adalimumab Injection	Adalimumab Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Adalimumab.
Aripiprazole	Aripiprazole The metabolism of Aripiprazole can be increased when combined with Apremilast.
Atomoxetine	Atomoxetine The metabolism of Atomoxetine can be increased when combined with Apremilast.
Glatiramer Injection	Glatiramer Injection The risk or severity of adverse effects can be increased when Glatiramer is combined with Apremilast.
Atazanavir	Atazanavir The metabolism of Atazanavir can be increased when combined with Apremilast.
Almotriptan	Almotriptan The metabolism of Almotriptan can be increased when combined with Apremilast.
Eletriptan	Eletriptan The metabolism of Eletriptan can be increased when combined with Apremilast.
Rosuvastatin	Rosuvastatin The metabolism of Rosuvastatin can be increased when combined with Apremilast.
Vardenafil	Vardenafil The metabolism of Vardenafil can be increased when combined with Apremilast.
Aprepitant	Aprepitant The metabolism of Aprepitant can be increased when combined with Apremilast.
Emtricitabine	Emtricitabine Emtricitabine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Interferon Beta-1a Subcutaneous Injection	Interferon Beta-1a Subcutaneous Injection The metabolism of Apremilast can be decreased when combined with Interferon beta-1a.
Memantine	Memantine Memantine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Tegaserod	Tegaserod The metabolism of Tegaserod can be increased when combined with Apremilast.
Tadalafil	Tadalafil The metabolism of Tadalafil can be increased when combined with Apremilast.
Frovatriptan	Frovatriptan The metabolism of Frovatriptan can be increased when combined with Apremilast.
Gemifloxacin	Gemifloxacin The metabolism of Apremilast can be decreased when combined with Gemifloxacin.
Progesterone	Progesterone The metabolism of Progesterone can be increased when combined with Apremilast.
Apomorphine Injection	Apomorphine Injection The metabolism of Apomorphine can be increased when combined with Apremilast.
Infliximab Injection	Infliximab Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Infliximab.
Protriptyline	Protriptyline The metabolism of Protriptyline can be increased when combined with Apremilast.
Duloxetine	Duloxetine The metabolism of Duloxetine can be increased when combined with Apremilast.
Norethindrone	Norethindrone The metabolism of Norethisterone can be increased when combined with Apremilast.
Tinidazole	Tinidazole Tinidazole may decrease the excretion rate of Apremilast which could result in a higher serum level.
Bosentan	Bosentan The metabolism of Bosentan can be increased when combined with Apremilast.
Cefditoren	Cefditoren Cefdinir may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cinacalcet	Cinacalcet The metabolism of Cinacalcet can be increased when combined with Apremilast.
Natalizumab Injection	Natalizumab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Natalizumab.
Cyanocobalamin Injection	Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Erlotinib	Erlotinib The metabolism of Erlotinib can be increased when combined with Apremilast.
Eszopiclone	Eszopiclone The metabolism of Eszopiclone can be increased when combined with Apremilast.
Ganciclovir	Ganciclovir Ganciclovir may decrease the excretion rate of Apremilast which could result in a higher serum level.
Ribavirin	Ribavirin Ribavirin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Solifenacin	Solifenacin The metabolism of Solifenacin can be increased when combined with Apremilast.
Valganciclovir	Valganciclovir Valganciclovir may decrease the excretion rate of Apremilast which could result in a higher serum level.
Voriconazole	Voriconazole The metabolism of Voriconazole can be increased when combined with Apremilast.
Adefovir	Adefovir Adefovir may decrease the excretion rate of Apremilast which could result in a higher serum level.
Dextroamphetamine	Dextroamphetamine The metabolism of Amphetamine can be increased when combined with Apremilast.
Entecavir	Entecavir The metabolism of Entecavir can be increased when combined with Apremilast.
Peginterferon Alfa-2a Injection	Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Apremilast.
Peginterferon Alfa-2b (PEG-Intron)	Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Apremilast can be increased when it is combined with Peginterferon alfa-2b.
Ramelteon	Ramelteon The metabolism of Ramelteon can be increased when combined with Apremilast.
Darifenacin	Darifenacin The metabolism of Darifenacin can be increased when combined with Apremilast.
Fentanyl	Fentanyl The metabolism of Fentanyl can be increased when combined with Apremilast.
Pregabalin	Pregabalin Pregabalin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Deferasirox	Deferasirox The serum concentration of Apremilast can be increased when it is combined with Deferasirox.
Phenylephrine	Phenylephrine The metabolism of Apremilast can be increased when combined with Phenylephrine.
Tipranavir	Tipranavir The metabolism of Tipranavir can be increased when combined with Apremilast.
Felbamate	Felbamate The metabolism of Felbamate can be increased when combined with Apremilast.
Ranolazine	Ranolazine The metabolism of Apremilast can be increased when combined with Ranolazine.
Abatacept Injection	Abatacept Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Abatacept.
Rasagiline	Rasagiline The metabolism of Rasagiline can be increased when combined with Apremilast.
Imatinib	Imatinib The metabolism of Imatinib can be increased when combined with Apremilast.
Sitagliptin	Sitagliptin The metabolism of Sitagliptin can be increased when combined with Apremilast.
Varenicline	Varenicline Varenicline may decrease the excretion rate of Apremilast which could result in a higher serum level.
Bevacizumab Injection	Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Apremilast.
Gefitinib	Gefitinib The metabolism of Gefitinib can be increased when combined with Apremilast.
Albuterol	Albuterol Salbutamol may decrease the excretion rate of Apremilast which could result in a higher serum level.
Paliperidone	Paliperidone The metabolism of Paliperidone can be increased when combined with Apremilast.
Bortezomib	Bortezomib The metabolism of Bortezomib can be increased when combined with Apremilast.
Clofarabine Injection	Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Apremilast.
Hepatitis B Vaccine	Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Apremilast.
Influenza Vaccine, Inactivated or Recombinant	Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Apremilast.
Influenza Vaccine, Live Intranasal	Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Apremilast.
Live Shingles (Zoster) Vaccine (ZVL)	Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Apremilast.
Insulin Glulisine (rDNA origin) Injection	Insulin Glulisine (rDNA origin) Injection The metabolism of Apremilast can be increased when combined with Insulin glulisine.
Lubiprostone	Lubiprostone Lubiprostone may decrease the excretion rate of Apremilast which could result in a higher serum level.
Oxaliplatin Injection	Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Apremilast.
Primaquine	Primaquine The metabolism of Primaquine can be increased when combined with Apremilast.
Rituximab Injection	Rituximab Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Rituximab.
Pemetrexed Injection	Pemetrexed Injection The metabolism of Pemetrexed can be increased when combined with Apremilast.
Lisdexamfetamine	Lisdexamfetamine The metabolism of Lisdexamfetamine can be increased when combined with Apremilast.
Vorinostat	Vorinostat The risk or severity of adverse effects can be increased when Vorinostat is combined with Apremilast.
Sorafenib	Sorafenib The metabolism of Sorafenib can be increased when combined with Apremilast.
Sunitinib	Sunitinib The metabolism of Sunitinib can be increased when combined with Apremilast.
Dronabinol	Dronabinol The metabolism of Dronabinol can be increased when combined with Apremilast.
Lapatinib	Lapatinib The metabolism of Lapatinib can be increased when combined with Apremilast.
Levocetirizine	Levocetirizine Apremilast may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection	Pegaptanib Injection Pegaptanib may decrease the excretion rate of Apremilast which could result in a higher serum level.
Dasatinib	Dasatinib The metabolism of Dasatinib can be increased when combined with Apremilast.
Mexiletine	Mexiletine The metabolism of Mexiletine can be increased when combined with Apremilast.
Armodafinil	Armodafinil The metabolism of Apremilast can be increased when combined with Armodafinil.
Azacitidine Injection	Azacitidine Injection The risk or severity of adverse effects can be increased when Azacitidine is combined with Apremilast.
Temsirolimus	Temsirolimus The metabolism of Temsirolimus can be increased when combined with Apremilast.
Nelarabine Injection	Nelarabine Injection The risk or severity of adverse effects can be increased when Nelarabine is combined with Apremilast.
Lenalidomide	Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Apremilast.
Nilotinib	Nilotinib The metabolism of Apremilast can be increased when combined with Nilotinib.
Bexarotene	Bexarotene The metabolism of Bexarotene can be increased when combined with Apremilast.
Budesonide	Budesonide The risk or severity of adverse effects can be increased when Budesonide is combined with Apremilast.
Chloramphenicol Injection	Chloramphenicol Injection The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Apremilast.
Decitabine Injection	Decitabine Injection The risk or severity of adverse effects can be increased when Decitabine is combined with Apremilast.
Desmopressin	Desmopressin Desmopressin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Doripenem Injection	Doripenem Injection Apremilast may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine	Etravirine The metabolism of Etravirine can be increased when combined with Apremilast.
Arsenic Trioxide Injection	Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Apremilast.
Mitoxantrone Injection	Mitoxantrone Injection The risk or severity of adverse effects can be increased when Mitoxantrone is combined with Apremilast.
Desvenlafaxine	Desvenlafaxine Apremilast may decrease the excretion rate of Desvenlafaxine which could result in a higher serum level.
Cevimeline	Cevimeline The metabolism of Apremilast can be increased when combined with Cevimeline.
Nebivolol	Nebivolol The metabolism of Nebivolol can be increased when combined with Apremilast.
Tretinoin	Tretinoin The metabolism of Tretinoin can be increased when combined with Apremilast.
Bendamustine Injection	Bendamustine Injection The metabolism of Bendamustine can be increased when combined with Apremilast.
Pilocarpine	Pilocarpine The metabolism of Apremilast can be decreased when combined with Pilocarpine.
Flecainide	Flecainide The metabolism of Flecainide can be increased when combined with Apremilast.
Certolizumab Injection	Certolizumab Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Certolizumab pegol.
Ixabepilone Injection	Ixabepilone Injection The metabolism of Apremilast can be increased when combined with Ixabepilone.
Irinotecan Injection	Irinotecan Injection The metabolism of Irinotecan can be increased when combined with Apremilast.
Daptomycin Injection	Daptomycin Injection Daptomycin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Estramustine	Estramustine The risk or severity of adverse effects can be increased when Estramustine is combined with Apremilast.
Praziquantel	Praziquantel The metabolism of Praziquantel can be increased when combined with Apremilast.
Methylnaltrexone Injection	Methylnaltrexone Injection Apremilast may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia)	Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Apremilast.
Rufinamide	Rufinamide The metabolism of Rufinamide can be increased when combined with Apremilast.
Midazolam	Midazolam The metabolism of Midazolam can be increased when combined with Apremilast.
Dexrazoxane Injection	Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Apremilast.
Eltrombopag	Eltrombopag The metabolism of Eltrombopag can be increased when combined with Apremilast.
Ibritumomab Injection	Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Apremilast.
Milnacipran	Milnacipran Milnacipran may decrease the excretion rate of Apremilast which could result in a higher serum level.
Dexlansoprazole	Dexlansoprazole The metabolism of Dexlansoprazole can be increased when combined with Apremilast.
Plerixafor Injection	Plerixafor Injection Apremilast may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine	Fesoterodine The metabolism of Fesoterodine can be increased when combined with Apremilast.
Betaxolol	Betaxolol The metabolism of Betaxolol can be increased when combined with Apremilast.
Iloperidone	Iloperidone The metabolism of Iloperidone can be increased when combined with Apremilast.
Prasugrel	Prasugrel The metabolism of Prasugrel can be increased when combined with Apremilast.
Lacosamide	Lacosamide The metabolism of Lacosamide can be increased when combined with Apremilast.
Everolimus	Everolimus The metabolism of Everolimus can be increased when combined with Apremilast.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) The metabolism of Apremilast can be increased when combined with Tolvaptan.
Dronedarone	Dronedarone The metabolism of Dronedarone can be increased when combined with Apremilast.
Pralatrexate Injection	Pralatrexate Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Pralatrexate.
Palonosetron Injection	Palonosetron Injection The metabolism of Apremilast can be increased when combined with Palonosetron.
Saxagliptin	Saxagliptin The metabolism of Saxagliptin can be increased when combined with Apremilast.
Telavancin Injection	Telavancin Injection Apremilast may decrease the excretion rate of Telavancin which could result in a higher serum level.
Romidepsin Injection	Romidepsin Injection The metabolism of Romidepsin can be increased when combined with Apremilast.
Tapentadol	Tapentadol The metabolism of Tapentadol can be increased when combined with Apremilast.
Topotecan	Topotecan The risk or severity of adverse effects can be increased when Topotecan is combined with Apremilast.
Golimumab Injection	Golimumab Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Golimumab.
Pazopanib	Pazopanib The metabolism of Pazopanib can be increased when combined with Apremilast.
Asenapine	Asenapine The metabolism of Asenapine can be increased when combined with Apremilast.
Pitavastatin	Pitavastatin The metabolism of Pitavastatin can be increased when combined with Apremilast.
Albendazole	Albendazole The metabolism of Albendazole can be increased when combined with Apremilast.
Levonorgestrel	Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Apremilast.
Oxymorphone	Oxymorphone The metabolism of Oxymorphone can be increased when combined with Apremilast.
Denosumab Injection	Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Apremilast.
Tocilizumab Injection	Tocilizumab Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Tocilizumab.
Dalfampridine	Dalfampridine Apremilast may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Fingolimod	Fingolimod Apremilast may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection	Eribulin Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Eribulin.
Cabazitaxel Injection	Cabazitaxel Injection The metabolism of Cabazitaxel can be increased when combined with Apremilast.
Ustekinumab Injection	Ustekinumab Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Ustekinumab.
Ceftaroline Injection	Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Apremilast which could result in a higher serum level.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Acetaminophen can be increased when combined with Apremilast.
Vilazodone	Vilazodone The metabolism of Vilazodone can be increased when combined with Apremilast.
Ipilimumab Injection	Ipilimumab Injection Apremilast may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection	Denileukin Diftitox Injection The risk or severity of adverse effects can be increased when Aldesleukin is combined with Apremilast.
Sipuleucel-T Injection	Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Apremilast.
Terbutaline Injection	Terbutaline Injection Terbutaline may decrease the excretion rate of Apremilast which could result in a higher serum level.
Belimumab Injection	Belimumab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Belimumab.
Busulfan Injection	Busulfan Injection The metabolism of Busulfan can be increased when combined with Apremilast.
Roflumilast	Roflumilast Apremilast may increase the immunosuppressive activities of Roflumilast.
Linagliptin	Linagliptin The metabolism of Linagliptin can be increased when combined with Apremilast.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Cyclophosphamide can be increased when combined with Apremilast.
Abiraterone	Abiraterone The serum concentration of Abiraterone can be increased when it is combined with Apremilast.
Rivaroxaban	Rivaroxaban The metabolism of Rivaroxaban can be increased when combined with Apremilast.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be increased when combined with Apremilast.
Ruxolitinib	Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Apremilast.
Vandetanib	Vandetanib The metabolism of Vandetanib can be increased when combined with Apremilast.
Clobazam	Clobazam The metabolism of Clobazam can be increased when combined with Apremilast.
Vemurafenib	Vemurafenib The serum concentration of Apremilast can be increased when it is combined with Vemurafenib.
Vismodegib	Vismodegib The metabolism of Vismodegib can be increased when combined with Apremilast.
Belatacept Injection	Belatacept Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Belatacept.
Ivacaftor	Ivacaftor The metabolism of Ivacaftor can be increased when combined with Apremilast.
Basiliximab Injection	Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Apremilast.
Deferiprone	Deferiprone Apremilast may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib	Axitinib The metabolism of Axitinib can be increased when combined with Apremilast.
Crizotinib	Crizotinib The metabolism of Crizotinib can be increased when combined with Apremilast.
Melphalan Injection	Melphalan Injection The risk or severity of adverse effects can be increased when Melphalan is combined with Apremilast.
Cabergoline	Cabergoline The metabolism of Cabergoline can be increased when combined with Apremilast.
Naloxone Injection	Naloxone Injection Naloxone may decrease the excretion rate of Apremilast which could result in a higher serum level.
Ambrisentan	Ambrisentan The metabolism of Ambrisentan can be increased when combined with Apremilast.
Eculizumab Injection	Eculizumab Injection The risk or severity of adverse effects can be increased when Eculizumab is combined with Apremilast.
Fondaparinux Injection	Fondaparinux Injection Fondaparinux may decrease the excretion rate of Apremilast which could result in a higher serum level.
Carfilzomib Injection	Carfilzomib Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Carfilzomib.
Enzalutamide	Enzalutamide The metabolism of Enzalutamide can be increased when combined with Apremilast.
Mirabegron	Mirabegron The metabolism of Mirabegron can be increased when combined with Apremilast.
Regorafenib	Regorafenib The metabolism of Regorafenib can be increased when combined with Apremilast.
Bosutinib	Bosutinib The metabolism of Bosutinib can be increased when combined with Apremilast.
Corticotropin, Repository Injection	Corticotropin, Repository Injection The risk or severity of adverse effects can be increased when Corticotropin is combined with Apremilast.
Teriflunomide	Teriflunomide The serum concentration of Apremilast can be decreased when it is combined with Teriflunomide.
Cabozantinib (thyroid cancer)	Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be increased when combined with Apremilast.
Teduglutide Injection	Teduglutide Injection Apremilast may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Tofacitinib	Tofacitinib The therapeutic efficacy of Apremilast can be decreased when used in combination with Tofacitinib.
Alogliptin	Alogliptin The metabolism of Alogliptin can be increased when combined with Apremilast.
Dimethyl Fumarate	Dimethyl Fumarate The risk or severity of adverse effects can be increased when Apremilast is combined with Dimethyl fumarate.
Ponatinib	Ponatinib The metabolism of Ponatinib can be increased when combined with Apremilast.
Pomalidomide	Pomalidomide The metabolism of Pomalidomide can be increased when combined with Apremilast.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be increased when combined with Apremilast.
Apixaban	Apixaban The metabolism of Apixaban can be increased when combined with Apremilast.
Canagliflozin	Canagliflozin Canagliflozin may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide	Methazolamide Methazolamide may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib	Dabrafenib The metabolism of Dabrafenib can be increased when combined with Apremilast.
Ospemifene	Ospemifene The metabolism of Ospemifene can be increased when combined with Apremilast.
Trametinib	Trametinib Apremilast may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran	Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Apremilast.
Ertapenem Injection	Ertapenem Injection Ertapenem may decrease the excretion rate of Apremilast which could result in a higher serum level.
Vortioxetine	Vortioxetine The metabolism of Vortioxetine can be increased when combined with Apremilast.
Perampanel	Perampanel The metabolism of Perampanel can be increased when combined with Apremilast.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be increased when combined with Apremilast.
Lomitapide	Lomitapide The metabolism of Lomitapide can be increased when combined with Apremilast.
Ketorolac Injection	Ketorolac Injection The metabolism of Apremilast can be increased when combined with Ketorolac.
Obinutuzumab Injection	Obinutuzumab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Obinutuzumab.
Simeprevir	Simeprevir The metabolism of Apremilast can be decreased when combined with Simeprevir.
Sofosbuvir	Sofosbuvir Apremilast may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin	Dapagliflozin The metabolism of Dapagliflozin can be increased when combined with Apremilast.
Droxidopa	Droxidopa Apremilast may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib	Ceritinib The metabolism of Ceritinib can be increased when combined with Apremilast.
Siltuximab Injection	Siltuximab Injection The metabolism of Siltuximab can be increased when combined with Apremilast.
Vedolizumab Injection	Vedolizumab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Vedolizumab.
Belinostat Injection	Belinostat Injection The risk or severity of adverse effects can be increased when Belinostat is combined with Apremilast.
Idelalisib	Idelalisib The metabolism of Idelalisib can be increased when combined with Apremilast.
Testosterone Injection	Testosterone Injection The metabolism of Testosterone can be increased when combined with Apremilast.
Vorapaxar	Vorapaxar The metabolism of Vorapaxar can be increased when combined with Apremilast.
Hydrocodone	Hydrocodone The metabolism of Hydrocodone can be increased when combined with Apremilast.
Suvorexant	Suvorexant The metabolism of Suvorexant can be increased when combined with Apremilast.
Edoxaban	Edoxaban Apremilast may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Peginterferon Beta-1a Injection	Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Peginterferon beta-1a.
Olaparib	Olaparib The metabolism of Olaparib can be increased when combined with Apremilast.
Blinatumomab Injection	Blinatumomab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Blinatumomab.
Methamphetamine	Methamphetamine The metabolism of Metamfetamine can be increased when combined with Apremilast.
Tasimelteon	Tasimelteon The metabolism of Tasimelteon can be increased when combined with Apremilast.
Riociguat	Riociguat Apremilast may increase the hypotensive activities of Riociguat.
Pirfenidone	Pirfenidone The metabolism of Pirfenidone can be increased when combined with Apremilast.
Nintedanib	Nintedanib The metabolism of Nintedanib can be increased when combined with Apremilast.
Secukinumab Injection	Secukinumab Injection The metabolism of Secukinumab can be increased when combined with Apremilast.
Risperidone Injection	Risperidone Injection The metabolism of Risperidone can be increased when combined with Apremilast.
Palbociclib	Palbociclib The metabolism of Palbociclib can be increased when combined with Apremilast.
Insulin Human Inhalation	Insulin Human Inhalation The metabolism of Apremilast can be increased when combined with Insulin human.
Lenvatinib	Lenvatinib The metabolism of Lenvatinib can be decreased when combined with Apremilast.
Panobinostat	Panobinostat The metabolism of Panobinostat can be increased when combined with Apremilast.
Dinutuximab Injection	Dinutuximab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Dinutuximab.
Haloperidol Injection	Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Apremilast.
Amiloride	Amiloride Amiloride may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan	Macitentan Apremilast may decrease the excretion rate of Macitentan which could result in a higher serum level.
Sonidegib	Sonidegib The metabolism of Sonidegib can be increased when combined with Apremilast.
Prednisolone	Prednisolone The risk or severity of adverse effects can be increased when Prednisolone is combined with Apremilast.
Daclatasvir	Daclatasvir The metabolism of Daclatasvir can be increased when combined with Apremilast.
Brexpiprazole	Brexpiprazole The metabolism of Brexpiprazole can be increased when combined with Apremilast.
Ziprasidone Injection	Ziprasidone Injection The metabolism of Ziprasidone can be increased when combined with Apremilast.
Cariprazine	Cariprazine The metabolism of Cariprazine can be increased when combined with Apremilast.
Penicillin G Procaine Injection	Penicillin G Procaine Injection Apremilast may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Insulin Degludec (rDNA Origin) Injection	Insulin Degludec (rDNA Origin) Injection The metabolism of Apremilast can be increased when combined with Insulin degludec.
Cobimetinib	Cobimetinib The metabolism of Cobimetinib can be increased when combined with Apremilast.
Mepolizumab Injection	Mepolizumab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Mepolizumab.
Trabectedin Injection	Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Apremilast.
Osimertinib	Osimertinib The serum concentration of Osimertinib can be decreased when it is combined with Apremilast.
Alectinib	Alectinib The metabolism of Alectinib can be increased when combined with Apremilast.
Ixazomib	Ixazomib The metabolism of Ixazomib can be increased when combined with Apremilast.
Lesinurad	Lesinurad The metabolism of Lesinurad can be increased when combined with Apremilast.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Apremilast which could result in a higher serum level.
Dexamethasone Injection	Dexamethasone Injection The metabolism of Apremilast can be increased when combined with Dexamethasone.
Ixekizumab Injection	Ixekizumab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Ixekizumab.
Brivaracetam Injection	Brivaracetam Injection The metabolism of Brivaracetam can be increased when combined with Apremilast.
Venetoclax	Venetoclax The metabolism of Venetoclax can be increased when combined with Apremilast.
Cobicistat	Cobicistat The metabolism of Cobicistat can be increased when combined with Apremilast.
Selexipag	Selexipag The metabolism of Selexipag can be increased when combined with Apremilast.
Obeticholic Acid	Obeticholic Acid The metabolism of Apremilast can be decreased when combined with Obeticholic acid.
Diphenhydramine Injection	Diphenhydramine Injection The metabolism of Diphenhydramine can be increased when combined with Apremilast.
Furosemide Injection	Furosemide Injection Furosemide may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib	Rucaparib The metabolism of Rucaparib can be increased when combined with Apremilast.
Lixisenatide Injection	Lixisenatide Injection Apremilast may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ribociclib	Ribociclib The metabolism of Ribociclib can be increased when combined with Apremilast.
Brodalumab Injection	Brodalumab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Brodalumab.
Brigatinib	Brigatinib The metabolism of Brigatinib can be increased when combined with Apremilast.
Doxepin (Insomnia)	Doxepin (Insomnia) The metabolism of Doxepin can be increased when combined with Apremilast.
Deutetrabenazine	Deutetrabenazine The metabolism of Deutetrabenazine can be increased when combined with Apremilast.
Valbenazine	Valbenazine The metabolism of Valbenazine can be increased when combined with Apremilast.
Deflazacort	Deflazacort The risk or severity of adverse effects can be increased when Apremilast is combined with Deflazacort.
Safinamide	Safinamide The metabolism of Safinamide can be decreased when combined with Apremilast.
Ocrelizumab Injection	Ocrelizumab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Ocrelizumab.
Naldemedine	Naldemedine Apremilast may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Sarilumab Injection	Sarilumab Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Sarilumab.
Midostaurin	Midostaurin The metabolism of Midostaurin can be increased when combined with Apremilast.
Neratinib	Neratinib The metabolism of Neratinib can be increased when combined with Apremilast.
Guselkumab Injection	Guselkumab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Guselkumab.
Enasidenib	Enasidenib The metabolism of Enasidenib can be increased when combined with Apremilast.
Aprepitant/Fosaprepitant Injection	Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Apremilast.
Benznidazole	Benznidazole Apremilast may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection	Copanlisib Injection The metabolism of Copanlisib can be increased when combined with Apremilast.
Delafloxacin	Delafloxacin Apremilast may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib	Abemaciclib The metabolism of Abemaciclib can be increased when combined with Apremilast.
Acalabrutinib	Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Apremilast.
Gemtuzumab Ozogamicin Injection	Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Apremilast.
Letermovir	Letermovir The metabolism of Letermovir can be increased when combined with Apremilast.
Tetrabenazine	Tetrabenazine The metabolism of Tetrabenazine can be increased when combined with Apremilast.
Ertugliflozin	Ertugliflozin Ertugliflozin may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection	Buprenorphine Injection The metabolism of Buprenorphine can be increased when combined with Apremilast.
Apalutamide	Apalutamide The metabolism of Apalutamide can be increased when combined with Apremilast.
Penicillamine	Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Apremilast.
Baricitinib	Baricitinib The metabolism of Baricitinib can be increased when combined with Apremilast.
Lofexidine	Lofexidine The metabolism of Lofexidine can be increased when combined with Apremilast.
Plazomicin Injection	Plazomicin Injection Apremilast may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat	Eliglustat The metabolism of Eliglustat can be increased when combined with Apremilast.
Encorafenib	Encorafenib The metabolism of Encorafenib can be increased when combined with Apremilast.
Binimetinib	Binimetinib The metabolism of Binimetinib can be increased when combined with Apremilast.
Ivosidenib	Ivosidenib The metabolism of Ivosidenib can be increased when combined with Apremilast.
Elagolix	Elagolix The metabolism of Elagolix can be increased when combined with Apremilast.
Doravirine	Doravirine The metabolism of Doravirine can be increased when combined with Apremilast.
Tafenoquine	Tafenoquine The metabolism of Tafenoquine can be increased when combined with Apremilast.
Cannabidiol	Cannabidiol The metabolism of Cannabidiol can be increased when combined with Apremilast.
Dacomitinib	Dacomitinib The metabolism of Dacomitinib can be increased when combined with Apremilast.
Duvelisib	Duvelisib The metabolism of Duvelisib can be increased when combined with Apremilast.
Stiripentol	Stiripentol The metabolism of Stiripentol can be increased when combined with Apremilast.
Gilteritinib	Gilteritinib The metabolism of Gilteritinib can be increased when combined with Apremilast.
Glasdegib	Glasdegib The metabolism of Glasdegib can be increased when combined with Apremilast.
Lorlatinib	Lorlatinib The metabolism of Lorlatinib can be increased when combined with Apremilast.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Apremilast.
Rifamycin	Rifamycin The metabolism of Apremilast can be decreased when combined with Rifamycin.
Prucalopride	Prucalopride The metabolism of Prucalopride can be increased when combined with Apremilast.
Ravulizumab-cwvz Injection	Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Ravulizumab.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Emapalumab can be increased when combined with Apremilast.
Siponimod	Siponimod The metabolism of Siponimod can be increased when combined with Apremilast.
Acyclovir Ophthalmic	Acyclovir Ophthalmic The metabolism of Acyclovir can be increased when combined with Apremilast.
Erdafitinib	Erdafitinib The metabolism of Erdafitinib can be increased when combined with Apremilast.
Esomeprazole Injection	Esomeprazole Injection The metabolism of Esomeprazole can be increased when combined with Apremilast.
Risankizumab-rzaa Injection	Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Risankizumab.
Alpelisib	Alpelisib The metabolism of Alpelisib can be increased when combined with Apremilast.
Cladribine	Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Apremilast.
Solriamfetol	Solriamfetol Apremilast may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Triclabendazole	Triclabendazole The metabolism of Triclabendazole can be increased when combined with Apremilast.
Entrectinib	Entrectinib The metabolism of Entrectinib can be increased when combined with Apremilast.
Pexidartinib	Pexidartinib The metabolism of Pexidartinib can be increased when combined with Apremilast.
Istradefylline	Istradefylline The metabolism of Istradefylline can be increased when combined with Apremilast.
Pitolisant	Pitolisant The serum concentration of Apremilast can be decreased when it is combined with Pitolisant.
Fedratinib	Fedratinib The metabolism of Fedratinib can be increased when combined with Apremilast.
Lefamulin	Lefamulin The metabolism of Lefamulin can be increased when combined with Apremilast.
Phenytoin Injection	Phenytoin Injection The metabolism of Phenytoin can be increased when combined with Apremilast.
Fosphenytoin Injection	Fosphenytoin Injection The metabolism of Fosphenytoin can be increased when combined with Apremilast.
Zanubrutinib	Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Apremilast.
Voxelotor	Voxelotor The metabolism of Voxelotor can be increased when combined with Apremilast.
Avapritinib	Avapritinib The metabolism of Avapritinib can be increased when combined with Apremilast.
Tazemetostat	Tazemetostat The metabolism of Tazemetostat can be increased when combined with Apremilast.
Cenobamate	Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Apremilast.
Ozanimod	Ozanimod The risk or severity of adverse effects can be increased when Apremilast is combined with Ozanimod.
Selumetinib	Selumetinib The metabolism of Selumetinib can be increased when combined with Apremilast.
Tucatinib	Tucatinib The metabolism of Tucatinib can be decreased when combined with Apremilast.
Capmatinib	Capmatinib The metabolism of Apremilast can be decreased when combined with Capmatinib.
Lemborexant	Lemborexant The metabolism of Lemborexant can be increased when combined with Apremilast.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Apremilast can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Apremilast.
Viloxazine	Viloxazine Apremilast may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection	Tobramycin Injection Tobramycin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Theophylline	Theophylline The metabolism of Theophylline can be increased when combined with Apremilast.
Fenoprofen	Fenoprofen Fenoprofen may decrease the excretion rate of Apremilast which could result in a higher serum level.
Indomethacin	Indomethacin The metabolism of Indomethacin can be increased when combined with Apremilast.
Mefenamic Acid	Mefenamic Acid The metabolism of Mefenamic acid can be increased when combined with Apremilast.
Naproxen	Naproxen The metabolism of Naproxen can be increased when combined with Apremilast.
Tolmetin	Tolmetin Tolmetin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Sulindac	Sulindac Sulindac may decrease the excretion rate of Apremilast which could result in a higher serum level.
Trazodone	Trazodone The metabolism of Trazodone can be increased when combined with Apremilast.
Isotretinoin	Isotretinoin Isotretinoin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Sucralfate	Sucralfate Sucralfate may decrease the excretion rate of Apremilast which could result in a higher serum level.
Hydroxyurea	Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Apremilast.
Floxuridine	Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Apremilast.
Phenobarbital	Phenobarbital The metabolism of Phenobarbital can be increased when combined with Apremilast.
Metaxalone	Metaxalone Metaxalone may decrease the excretion rate of Apremilast which could result in a higher serum level.
Methotrexate Injection	Methotrexate Injection The metabolism of Apremilast can be increased when combined with Methotrexate.
Primidone	Primidone The metabolism of Primidone can be increased when combined with Apremilast.
Methsuximide	Methsuximide The metabolism of Methsuximide can be increased when combined with Apremilast.
Chlorpromazine	Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Apremilast.
Diazepam	Diazepam The metabolism of Diazepam can be increased when combined with Apremilast.
Oxazepam	Oxazepam Oxazepam may decrease the excretion rate of Apremilast which could result in a higher serum level.
Flurazepam	Flurazepam The metabolism of Flurazepam can be increased when combined with Apremilast.
Clorazepate	Clorazepate Clorazepic acid may decrease the excretion rate of Apremilast which could result in a higher serum level.
Lorazepam	Lorazepam The metabolism of Lorazepam can be increased when combined with Apremilast.
Carmustine	Carmustine The metabolism of Carmustine can be increased when combined with Apremilast.
Amantadine	Amantadine Amantadine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Codeine	Codeine The metabolism of Apremilast can be increased when combined with Codeine.
Tranylcypromine	Tranylcypromine The metabolism of Apremilast can be decreased when combined with Tranylcypromine.
Phenelzine	Phenelzine Phenelzine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Procarbazine	Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Apremilast.
Tetracycline	Tetracycline Tetracycline may decrease the excretion rate of Apremilast which could result in a higher serum level.
Thioguanine	Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Apremilast.
Prochlorperazine	Prochlorperazine The metabolism of Prochlorperazine can be increased when combined with Apremilast.
Thioridazine	Thioridazine The metabolism of Thioridazine can be increased when combined with Apremilast.
Trifluoperazine	Trifluoperazine The metabolism of Trifluoperazine can be increased when combined with Apremilast.
Bleomycin	Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Apremilast.
Dapsone	Dapsone The metabolism of Dapsone can be increased when combined with Apremilast.
Sulfadiazine	Sulfadiazine The metabolism of Sulfadiazine can be increased when combined with Apremilast.
Oxycodone	Oxycodone The metabolism of Oxycodone can be increased when combined with Apremilast.
Methadone	Methadone The metabolism of Methadone can be increased when combined with Apremilast.
Oxybutynin	Oxybutynin The metabolism of Oxybutynin can be increased when combined with Apremilast.
Benztropine	Benztropine The metabolism of Benzatropine can be increased when combined with Apremilast.
Maprotiline	Maprotiline The metabolism of Maprotiline can be increased when combined with Apremilast.
Ibuprofen	Ibuprofen The metabolism of Ibuprofen can be increased when combined with Apremilast.
Orphenadrine	Orphenadrine The metabolism of Orphenadrine can be decreased when combined with Apremilast.
Perphenazine	Perphenazine The metabolism of Perphenazine can be increased when combined with Apremilast.
Azathioprine	Azathioprine The metabolism of Azathioprine can be increased when combined with Apremilast.
Phentermine	Phentermine The metabolism of Phentermine can be increased when combined with Apremilast.
Methylphenidate	Methylphenidate Methylphenidate may decrease the excretion rate of Apremilast which could result in a higher serum level.
Amoxapine	Amoxapine The metabolism of Amoxapine can be increased when combined with Apremilast.
Sulfasalazine	Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Apremilast.
Hydrocortisone	Hydrocortisone The metabolism of Hydrocortisone can be increased when combined with Apremilast.
Lomustine	Lomustine The risk or severity of adverse effects can be increased when Lomustine is combined with Apremilast.
Doxorubicin	Doxorubicin The metabolism of Apremilast can be increased when combined with Doxorubicin.
Cytarabine	Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Apremilast.
Mechlorethamine	Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Apremilast.
Dactinomycin	Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Apremilast.
Phenazopyridine	Phenazopyridine Phenazopyridine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Carbamazepine	Carbamazepine The metabolism of Apremilast can be increased when combined with Carbamazepine.
Methyldopa	Methyldopa Methyldopa may decrease the excretion rate of Apremilast which could result in a higher serum level.
Clonidine	Clonidine The metabolism of Apremilast can be increased when combined with Clonidine.
Hydralazine	Hydralazine Hydralazine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cimetidine	Cimetidine Cimetidine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Gentamicin Injection	Gentamicin Injection Gentamicin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Warfarin	Warfarin The metabolism of Warfarin can be increased when combined with Apremilast.
Clonazepam	Clonazepam Clonazepam may decrease the excretion rate of Apremilast which could result in a higher serum level.
Loperamide	Loperamide The metabolism of Loperamide can be increased when combined with Apremilast.
Promethazine	Promethazine The metabolism of Promethazine can be increased when combined with Apremilast.
Meclofenamate	Meclofenamate Meclofenamic acid may decrease the excretion rate of Apremilast which could result in a higher serum level.
Daunorubicin	Daunorubicin The risk or severity of adverse effects can be increased when Daunorubicin is combined with Apremilast.
Nitrofurantoin	Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Griseofulvin	Griseofulvin The metabolism of Apremilast can be increased when combined with Griseofulvin.
Digoxin	Digoxin Apremilast may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine	Chloroquine The metabolism of Chloroquine can be increased when combined with Apremilast.
Quinine	Quinine The metabolism of Quinine can be increased when combined with Apremilast.
Ethosuximide	Ethosuximide The metabolism of Ethosuximide can be increased when combined with Apremilast.
Triamterene	Triamterene The metabolism of Triamterene can be increased when combined with Apremilast.
Chlorothiazide	Chlorothiazide Chlorothiazide may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone	Chlorthalidone Chlorthalidone may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone	Metolazone Metolazone may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide	Isosorbide Isosorbide may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Clindamycin Injection	Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Apremilast.
Secobarbital	Secobarbital The metabolism of Apremilast can be increased when combined with Secobarbital.
Desipramine	Desipramine The metabolism of Apremilast can be increased when combined with Desipramine.
Amitriptyline	Amitriptyline The metabolism of Amitriptyline can be increased when combined with Apremilast.
Imipramine	Imipramine The metabolism of Apremilast can be increased when combined with Imipramine.
Probenecid	Probenecid Probenecid may decrease the excretion rate of Apremilast which could result in a higher serum level.
Quinidine	Quinidine The metabolism of Apremilast can be increased when combined with Quinidine.
Procainamide	Procainamide The metabolism of Procainamide can be increased when combined with Apremilast.
Isoniazid	Isoniazid The metabolism of Apremilast can be decreased when combined with Isoniazid.
Pyrazinamide	Pyrazinamide Pyrazinamide may decrease the excretion rate of Apremilast which could result in a higher serum level.
Rifampin	Rifampin The metabolism of Apremilast can be increased when combined with Rifampicin.
Disopyramide	Disopyramide The metabolism of Disopyramide can be increased when combined with Apremilast.
Valproic Acid	Valproic Acid The metabolism of Apremilast can be increased when combined with Valproic acid.
Tamoxifen	Tamoxifen The metabolism of Tamoxifen can be increased when combined with Apremilast.
Mitomycin	Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Apremilast.
Butabarbital	Butabarbital Butabarbital may decrease the excretion rate of Apremilast which could result in a higher serum level.
Liothyronine	Liothyronine Liothyronine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Methimazole	Methimazole The risk or severity of adverse effects can be increased when Methimazole is combined with Apremilast.
Propylthiouracil	Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Apremilast.
Chlorpropamide	Chlorpropamide The metabolism of Chlorpropamide can be increased when combined with Apremilast.
Tolbutamide	Tolbutamide The metabolism of Tolbutamide can be increased when combined with Apremilast.
Tolazamide	Tolazamide The metabolism of Tolazamide can be increased when combined with Apremilast.
Dextromethorphan	Dextromethorphan The metabolism of Dextromethorphan can be increased when combined with Apremilast.
Cyclobenzaprine	Cyclobenzaprine The metabolism of Apremilast can be increased when combined with Cyclobenzaprine.
Baclofen	Baclofen Baclofen may decrease the excretion rate of Apremilast which could result in a higher serum level.
Chlorpheniramine	Chlorpheniramine The metabolism of Chlorpheniramine can be increased when combined with Apremilast.
Brompheniramine	Brompheniramine The metabolism of Brompheniramine can be increased when combined with Apremilast.
Meclizine	Meclizine The metabolism of Meclizine can be increased when combined with Apremilast.
Ethambutol	Ethambutol Ethambutol may decrease the excretion rate of Apremilast which could result in a higher serum level.
Methyclothiazide	Methyclothiazide Methyclothiazide may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide	Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Apremilast which could result in a higher serum level.
Chlorzoxazone	Chlorzoxazone The metabolism of Chlorzoxazone can be increased when combined with Apremilast.
Carisoprodol	Carisoprodol The metabolism of Carisoprodol can be increased when combined with Apremilast.
Pyridoxine	Pyridoxine Pyridoxine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Folic Acid	Folic Acid Folic acid may decrease the excretion rate of Apremilast which could result in a higher serum level.
Disulfiram	Disulfiram The metabolism of Disulfiram can be increased when combined with Apremilast.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The metabolism of Propranolol can be increased when combined with Apremilast.
Nortriptyline	Nortriptyline The metabolism of Nortriptyline can be increased when combined with Apremilast.
Spironolactone	Spironolactone Spironolactone may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection	Amphotericin B Injection Amphotericin B may decrease the excretion rate of Apremilast which could result in a higher serum level.
Mercaptopurine	Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Apremilast.
Phytonadione	Phytonadione Phylloquinone may decrease the excretion rate of Apremilast which could result in a higher serum level.
Amikacin Injection	Amikacin Injection Amikacin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Nadolol	Nadolol The metabolism of Nadolol can be increased when combined with Apremilast.
Allopurinol	Allopurinol Allopurinol may decrease the excretion rate of Apremilast which could result in a higher serum level.
Flavoxate	Flavoxate Flavoxate may decrease the excretion rate of Apremilast which could result in a higher serum level.
Fluorouracil Injection	Fluorouracil Injection The metabolism of Fluorouracil can be increased when combined with Apremilast.
Colchicine	Colchicine The risk or severity of adverse effects can be increased when Colchicine is combined with Apremilast.
Cefaclor	Cefaclor Cefaclor may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cefadroxil	Cefadroxil Cefadroxil may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cefazolin Injection	Cefazolin Injection Cefazolin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cephalexin	Cephalexin The metabolism of Cephalexin can be increased when combined with Apremilast.
Cefoxitin Injection	Cefoxitin Injection Cefoxitin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Dacarbazine	Dacarbazine The metabolism of Dacarbazine can be increased when combined with Apremilast.
Acetazolamide	Acetazolamide Acetazolamide may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Cefotaxime Injection	Cefotaxime Injection Cefotaxime may decrease the excretion rate of Apremilast which could result in a higher serum level.
Calcitonin Salmon Injection	Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Bacillus Calmette-Guerin (BCG) Vaccine	Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Apremilast.
Pyrantel	Pyrantel Apremilast may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Thiotepa Injection	Thiotepa Injection The metabolism of Apremilast can be increased when combined with Thiotepa.
Vincristine Injection	Vincristine Injection The metabolism of Vincristine can be increased when combined with Apremilast.
Vinblastine	Vinblastine The metabolism of Apremilast can be increased when combined with Vinblastine.
Ethacrynic Acid	Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Apremilast which could result in a higher serum level.
Colistimethate Injection	Colistimethate Injection Colistimethate may decrease the excretion rate of Apremilast which could result in a higher serum level.
Metoprolol	Metoprolol The metabolism of Metoprolol can be increased when combined with Apremilast.
Hydroxyzine	Hydroxyzine The metabolism of Hydroxyzine can be increased when combined with Apremilast.
Thiothixene	Thiothixene The metabolism of Thiothixene can be increased when combined with Apremilast.
Aspirin	Aspirin The metabolism of Acetylsalicylic acid can be increased when combined with Apremilast.
Salsalate	Salsalate Salsalate may decrease the excretion rate of Apremilast which could result in a higher serum level.
Chlorambucil	Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Apremilast.
Alprazolam	Alprazolam The metabolism of Apremilast can be increased when combined with Alprazolam.
Temazepam	Temazepam Temazepam may decrease the excretion rate of Apremilast which could result in a higher serum level.
Triazolam	Triazolam The metabolism of Triazolam can be increased when combined with Apremilast.
Dicyclomine	Dicyclomine Dicyclomine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Propantheline	Propantheline Propantheline may decrease the excretion rate of Apremilast which could result in a higher serum level.
Trimethoprim	Trimethoprim The metabolism of Trimethoprim can be increased when combined with Apremilast.
Diltiazem	Diltiazem The metabolism of Diltiazem can be increased when combined with Apremilast.
Nifedipine	Nifedipine The metabolism of Nifedipine can be increased when combined with Apremilast.
Timolol	Timolol The metabolism of Timolol can be increased when combined with Apremilast.
Verapamil	Verapamil The metabolism of Verapamil can be increased when combined with Apremilast.
Atenolol	Atenolol The metabolism of Atenolol can be increased when combined with Apremilast.
Pindolol	Pindolol The metabolism of Pindolol can be increased when combined with Apremilast.
Cisplatin Injection	Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Apremilast.
Diflunisal	Diflunisal Diflunisal may decrease the excretion rate of Apremilast which could result in a higher serum level.
Piroxicam	Piroxicam The metabolism of Piroxicam can be increased when combined with Apremilast.
Bumetanide	Bumetanide Bumetanide may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Streptozocin	Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Apremilast.
Etoposide	Etoposide The metabolism of Etoposide can be increased when combined with Apremilast.
Glyburide	Glyburide The metabolism of Glyburide can be increased when combined with Apremilast.
Glipizide	Glipizide The metabolism of Glipizide can be increased when combined with Apremilast.
Indapamide	Indapamide Indapamide may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin	Amoxicillin Amoxicillin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Nafcillin Injection	Nafcillin Injection The metabolism of Apremilast can be increased when combined with Nafcillin.
Oxacillin Injection	Oxacillin Injection Oxacillin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Pentoxifylline	Pentoxifylline The metabolism of Pentoxifylline can be increased when combined with Apremilast.
Pentamidine Injection	Pentamidine Injection The metabolism of Pentamidine can be increased when combined with Apremilast.
Ceftriaxone Injection	Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Apremilast which could result in a higher serum level.
Labetalol	Labetalol The metabolism of Apremilast can be increased when combined with Labetalol.
Auranofin	Auranofin Auranofin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Leuprolide Injection	Leuprolide Injection Leuprolide may decrease the excretion rate of Apremilast which could result in a higher serum level.
Gemfibrozil	Gemfibrozil The metabolism of Gemfibrozil can be decreased when combined with Apremilast.
Guanabenz	Guanabenz The metabolism of Guanabenz can be increased when combined with Apremilast.
Dipivefrin Ophthalmic	Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Apremilast which could result in a higher serum level.
Ceftazidime Injection	Ceftazidime Injection Ceftazidime may decrease the excretion rate of Apremilast which could result in a higher serum level.
Ketoprofen	Ketoprofen Ketoprofen may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cefotetan Injection	Cefotetan Injection Cefotetan may decrease the excretion rate of Apremilast which could result in a higher serum level.
Pimozide	Pimozide The metabolism of Pimozide can be increased when combined with Apremilast.
Flurbiprofen	Flurbiprofen The metabolism of Flurbiprofen can be increased when combined with Apremilast.
Amiodarone	Amiodarone The metabolism of Amiodarone can be increased when combined with Apremilast.
Aztreonam Injection	Aztreonam Injection Aztreonam may decrease the excretion rate of Apremilast which could result in a higher serum level.
Buspirone	Buspirone The metabolism of Buspirone can be increased when combined with Apremilast.
Lovastatin	Lovastatin The metabolism of Lovastatin can be increased when combined with Apremilast.
Ciprofloxacin	Ciprofloxacin The metabolism of Apremilast can be decreased when combined with Ciprofloxacin.
Mesalamine	Mesalamine Mesalazine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Diclofenac	Diclofenac The metabolism of Diclofenac can be increased when combined with Apremilast.
Fluoxetine	Fluoxetine The metabolism of Fluoxetine can be increased when combined with Apremilast.
Interferon Alfa-2b Injection	Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Apremilast.
Clozapine	Clozapine The metabolism of Apremilast can be increased when combined with Clozapine.
Estazolam	Estazolam Estazolam may decrease the excretion rate of Apremilast which could result in a higher serum level.
Idarubicin	Idarubicin The metabolism of Idarubicin can be increased when combined with Apremilast.
Ofloxacin	Ofloxacin The metabolism of Apremilast can be decreased when combined with Ofloxacin.
Didanosine	Didanosine Didanosine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Fludarabine Injection	Fludarabine Injection The risk or severity of adverse effects can be increased when Fludarabine is combined with Apremilast.
Pentostatin Injection	Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Apremilast.
Clarithromycin	Clarithromycin The metabolism of Clarithromycin can be increased when combined with Apremilast.
Etodolac	Etodolac The metabolism of Etodolac can be increased when combined with Apremilast.
Felodipine	Felodipine The metabolism of Felodipine can be increased when combined with Apremilast.
Fosinopril	Fosinopril Fosinopril may decrease the excretion rate of Apremilast which could result in a higher serum level.
Nabumetone	Nabumetone The metabolism of Nabumetone can be increased when combined with Apremilast.
Simvastatin	Simvastatin The metabolism of Simvastatin can be increased when combined with Apremilast.
Teniposide Injection	Teniposide Injection The metabolism of Teniposide can be increased when combined with Apremilast.
Lisinopril	Lisinopril Lisinopril may decrease the excretion rate of Apremilast which could result in a higher serum level.
Oxaprozin	Oxaprozin Oxaprozin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Sotalol	Sotalol The metabolism of Sotalol can be increased when combined with Apremilast.
Bisoprolol	Bisoprolol Bisoprolol may decrease the excretion rate of Apremilast which could result in a higher serum level.
Zolpidem	Zolpidem The metabolism of Apremilast can be increased when combined with Zolpidem.
Doxazosin	Doxazosin The metabolism of Doxazosin can be increased when combined with Apremilast.
Isradipine	Isradipine Isradipine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Omeprazole	Omeprazole The metabolism of Omeprazole can be increased when combined with Apremilast.
Cisapride	Cisapride The metabolism of Apremilast can be increased when combined with Cisapride.
Fluvastatin	Fluvastatin The metabolism of Fluvastatin can be increased when combined with Apremilast.
Venlafaxine	Venlafaxine The metabolism of Venlafaxine can be increased when combined with Apremilast.
Famciclovir	Famciclovir The metabolism of Famciclovir can be increased when combined with Apremilast.
Fluvoxamine	Fluvoxamine The metabolism of Fluvoxamine can be increased when combined with Apremilast.
Nefazodone	Nefazodone The metabolism of Apremilast can be increased when combined with Nefazodone.
Lamotrigine	Lamotrigine Lamotrigine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Losartan	Losartan The metabolism of Losartan can be increased when combined with Apremilast.
Valacyclovir	Valacyclovir Valaciclovir may decrease the excretion rate of Apremilast which could result in a higher serum level.
Tramadol	Tramadol The metabolism of Tramadol can be increased when combined with Apremilast.
Vinorelbine Injection	Vinorelbine Injection The metabolism of Apremilast can be increased when combined with Vinorelbine.
Carboplatin Injection	Carboplatin Injection The risk or severity of adverse effects can be increased when Carboplatin is combined with Apremilast.
Lansoprazole	Lansoprazole The metabolism of Lansoprazole can be increased when combined with Apremilast.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Apremilast.
Pegaspargase Injection	Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Apremilast.
Nicardipine	Nicardipine The metabolism of Nicardipine can be increased when combined with Apremilast.
Bupropion	Bupropion The metabolism of Bupropion can be increased when combined with Apremilast.
Ticlopidine	Ticlopidine The metabolism of Ticlopidine can be increased when combined with Apremilast.
Saquinavir	Saquinavir The metabolism of Saquinavir can be increased when combined with Apremilast.
Metformin	Metformin Metformin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Nisoldipine	Nisoldipine The metabolism of Nisoldipine can be increased when combined with Apremilast.
Lamivudine	Lamivudine Lamivudine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Riluzole	Riluzole The metabolism of Riluzole can be increased when combined with Apremilast.
Acarbose	Acarbose Acarbose may decrease the excretion rate of Apremilast which could result in a higher serum level.
Glimepiride	Glimepiride The metabolism of Glimepiride can be increased when combined with Apremilast.
Anastrozole	Anastrozole The metabolism of Anastrozole can be increased when combined with Apremilast.
Gemcitabine Injection	Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Apremilast.
Indinavir	Indinavir The metabolism of Indinavir can be increased when combined with Apremilast.
Ritonavir	Ritonavir The serum concentration of Apremilast can be increased when it is combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Apremilast.
Cidofovir Injection	Cidofovir Injection Cidofovir may decrease the excretion rate of Apremilast which could result in a higher serum level.
Meropenem Injection	Meropenem Injection Meropenem may decrease the excretion rate of Apremilast which could result in a higher serum level.
Clomipramine	Clomipramine The metabolism of Apremilast can be increased when combined with Clomipramine.
Zafirlukast	Zafirlukast The metabolism of Zafirlukast can be increased when combined with Apremilast.
Fosfomycin	Fosfomycin Fosfomycin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Mirtazapine	Mirtazapine The metabolism of Mirtazapine can be increased when combined with Apremilast.
Topiramate	Topiramate Topiramate may decrease the excretion rate of Apremilast which could result in a higher serum level.
Zileuton	Zileuton The metabolism of Zileuton can be increased when combined with Apremilast.
Valsartan	Valsartan The metabolism of Valsartan can be increased when combined with Apremilast.
Insulin Lispro Injection	Insulin Lispro Injection The metabolism of Apremilast can be increased when combined with Insulin lispro.
Pramipexole	Pramipexole Pramipexole may decrease the excretion rate of Apremilast which could result in a higher serum level.
Donepezil	Donepezil The metabolism of Donepezil can be increased when combined with Apremilast.
Azithromycin	Azithromycin The metabolism of Azithromycin can be increased when combined with Apremilast.
Carvedilol	Carvedilol The metabolism of Carvedilol can be increased when combined with Apremilast.
Nilutamide	Nilutamide Nilutamide may decrease the excretion rate of Apremilast which could result in a higher serum level.
Flutamide	Flutamide The metabolism of Flutamide can be increased when combined with Apremilast.
Selegiline	Selegiline The metabolism of Selegiline can be increased when combined with Apremilast.
Bicalutamide	Bicalutamide The metabolism of Bicalutamide can be increased when combined with Apremilast.
Sertraline	Sertraline The metabolism of Sertraline can be increased when combined with Apremilast.
Propafenone	Propafenone The metabolism of Propafenone can be increased when combined with Apremilast.
Letrozole	Letrozole The metabolism of Letrozole can be increased when combined with Apremilast.
Irbesartan	Irbesartan The metabolism of Irbesartan can be increased when combined with Apremilast.
Tamsulosin	Tamsulosin The metabolism of Apremilast can be increased when combined with Tamsulosin.
Ropinirole	Ropinirole The metabolism of Ropinirole can be increased when combined with Apremilast.
Finasteride	Finasteride The metabolism of Finasteride can be increased when combined with Apremilast.
Quetiapine	Quetiapine The metabolism of Quetiapine can be increased when combined with Apremilast.
Cefepime Injection	Cefepime Injection Cefepime may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cefprozil	Cefprozil Cefprozil may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cefpodoxime	Cefpodoxime Cefpodoxime may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cetirizine	Cetirizine Cetirizine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Paroxetine	Paroxetine The metabolism of Paroxetine can be increased when combined with Apremilast.
Tolcapone	Tolcapone Tolcapone may decrease the excretion rate of Apremilast which could result in a higher serum level.
Citalopram	Citalopram The metabolism of Citalopram can be increased when combined with Apremilast.
Capecitabine	Capecitabine The metabolism of Apremilast can be increased when combined with Capecitabine.
Efavirenz	Efavirenz The metabolism of Efavirenz can be increased when combined with Apremilast.
Abacavir	Abacavir Abacavir may decrease the excretion rate of Apremilast which could result in a higher serum level.
Sildenafil	Sildenafil The metabolism of Sildenafil can be increased when combined with Apremilast.
Pioglitazone	Pioglitazone The metabolism of Pioglitazone can be increased when combined with Apremilast.
Trastuzumab Injection	Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Apremilast.
Celecoxib	Celecoxib The metabolism of Celecoxib can be increased when combined with Apremilast.
Rosiglitazone	Rosiglitazone The metabolism of Rosiglitazone can be increased when combined with Apremilast.
Tolterodine	Tolterodine The metabolism of Tolterodine can be increased when combined with Apremilast.
Thalidomide	Thalidomide The metabolism of Thalidomide can be increased when combined with Apremilast.
Oseltamivir	Oseltamivir Oseltamivir may decrease the excretion rate of Apremilast which could result in a higher serum level.
Balsalazide	Balsalazide Balsalazide may decrease the excretion rate of Apremilast which could result in a higher serum level.
Nateglinide	Nateglinide The metabolism of Nateglinide can be increased when combined with Apremilast.
Galantamine	Galantamine The metabolism of Apremilast can be increased when combined with Galantamine.
Rabeprazole	Rabeprazole The metabolism of Rabeprazole can be increased when combined with Apremilast.
Terbinafine	Terbinafine The metabolism of Terbinafine can be increased when combined with Apremilast.

Apremilast

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