Apremilast

Generic name: Pronounced as (a pre' mi last)
Brand names
  • Otezla®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 02/15/2020

Apremilast is used to treat psoriatic arthritis (a condition that causes joint pain and swelling and scales on the skin). It is also used to treat moderate to severe plaque psoriasis (skin disease in which red, scaly patches form on some areas of the body) in people who may benefit from medications or phototherapy (a treatment that involves exposing the skin to ultraviolet light). Apremilast is used to treat ulcers in the mouth in people with Behcet's syndrome (a disorder that causes blood vessel swelling in the body). Apremilast is in a class of medications called phosphodiesterase inhibitors. It works by blocking the action of certain natural substances in the body that cause inflammation.

Apremilast comes as a tablet to take by mouth. It is usually taken twice a day. Take apremilast at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take apremilast exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them.

Your doctor will probably start you on a low dose of apremilast and gradually increase your dose once every day for the first 5 days of treatment.

Apremilast controls psoriatic arthritis or plaque psoriasis, or treats oral ulcers, but does not cure them. Continue to take apremilast even if you feel well. Do not stop taking apremilast without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking apremilast,

  • tell your doctor and pharmacist if you are allergic to apremilast, any other medications, or any of the ingredients in apremilast tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain medications for seizures such as carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenobarbital, phenytoin (Dilantin, Phenytek), or rifampin (Rifadin, Rimactane). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had depression, mood problems, thoughts about harming or killing yourself, or planning or trying to do so, or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking apremilast, call your doctor.

  • you should know that your mental health may change in unexpected ways and you may become depressed or suicidal (thinking about harming or killing yourself or planning or trying to do so) while you are taking apremilast. You and your doctor will decide whether the risks of taking this medication are greater than the risks of not taking the medication. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression, talking or thinking about wanting to hurt yourself or end your life, or any other unusual changes in behavior or mood. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

  • you should know that apremilast can cause weight loss. Your weight should be checked regularly by your doctor and you should also check your weight on a regular basis during treatment with apremilast. If you notice you are losing weight, call your doctor.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Apremilast may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • diarrhea

    • nausea

    • stomach pain

    • vomiting

    • headache

    • sore throat, cough, and fever

    • sneezing, runny nose, and nasal congestion

  • Apremilast may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The metabolism of Apremilast can be decreased when combined with Moxifloxacin.
Repaglinide Repaglinide The metabolism of Repaglinide can be increased when combined with Apremilast.
Montelukast Montelukast The metabolism of Montelukast can be increased when combined with Apremilast.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The metabolism of Apremilast can be increased when combined with Insulin glargine.
Leflunomide Leflunomide The risk or severity of adverse effects can be increased when Leflunomide is combined with Apremilast.
Delavirdine Delavirdine The metabolism of Delavirdine can be increased when combined with Apremilast.
Nevirapine Nevirapine The metabolism of Nevirapine can be increased when combined with Apremilast.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be increased when combined with Apremilast.
Dolasetron Dolasetron The metabolism of Dolasetron can be increased when combined with Apremilast.
Aminophylline Aminophylline The metabolism of Aminophylline can be increased when combined with Apremilast.
Anagrelide Anagrelide The metabolism of Anagrelide can be increased when combined with Apremilast.
Candesartan Candesartan The metabolism of Candesartan can be increased when combined with Apremilast.
Cilostazol Cilostazol The metabolism of Cilostazol can be increased when combined with Apremilast.
Clopidogrel Clopidogrel The metabolism of Clopidogrel can be increased when combined with Apremilast.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Erythromycin can be increased when combined with Apremilast.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The metabolism of Conjugated estrogens can be increased when combined with Apremilast.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be increased when combined with Apremilast.
Guanfacine Guanfacine Guanfacine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Magnesium Hydroxide Magnesium Hydroxide Apremilast may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Mycophenolate Mycophenolate The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Apremilast.
Olsalazine Olsalazine Olsalazine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Paregoric Paregoric The metabolism of Morphine can be increased when combined with Apremilast.
Penbutolol Penbutolol The metabolism of Acebutolol can be increased when combined with Apremilast.
Potassium Potassium Potassium cation may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Apremilast.
Ranitidine Ranitidine The metabolism of Ranitidine can be increased when combined with Apremilast.
Reserpine Reserpine Reserpine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Rizatriptan Rizatriptan Rizatriptan may decrease the excretion rate of Apremilast which could result in a higher serum level.
Sumatriptan Sumatriptan Sumatriptan may decrease the excretion rate of Apremilast which could result in a higher serum level.
Tacrolimus Tacrolimus Tacrolimus may increase the immunosuppressive activities of Apremilast.
Tizanidine Tizanidine The metabolism of Tizanidine can be increased when combined with Apremilast.
Triamcinolone Triamcinolone The metabolism of Triamcinolone can be increased when combined with Apremilast.
Zolmitriptan Zolmitriptan The metabolism of Zolmitriptan can be increased when combined with Apremilast.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Apremilast which could result in a higher serum level.
Famotidine Injection Famotidine Injection The metabolism of Apremilast can be decreased when combined with Famotidine.
Fluconazole Injection Fluconazole Injection Fluconazole may decrease the excretion rate of Apremilast which could result in a higher serum level.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Apremilast which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection The metabolism of Hydromorphone can be increased when combined with Apremilast.
Interferon Beta-1b Injection Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Apremilast.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Apremilast.
Levofloxacin Injection Levofloxacin Injection The metabolism of Apremilast can be decreased when combined with Levofloxacin.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be increased when combined with Apremilast.
Methylprednisolone Injection Methylprednisolone Injection The risk or severity of adverse effects can be increased when Methylprednisolone is combined with Apremilast.
Metoclopramide Injection Metoclopramide Injection The metabolism of Metoclopramide can be increased when combined with Apremilast.
Metronidazole Injection Metronidazole Injection The metabolism of Metronidazole can be increased when combined with Apremilast.
Morphine Injection Morphine Injection The metabolism of Morphine can be increased when combined with Apremilast.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Apremilast which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Apremilast may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The metabolism of Zidovudine can be increased when combined with Apremilast.
Altretamine Altretamine The metabolism of Amphetamine can be increased when combined with Apremilast.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cyclosporine Cyclosporine Apremilast may increase the immunosuppressive activities of Cyclosporine.
Ondansetron Ondansetron The metabolism of Ondansetron can be increased when combined with Apremilast.
Torsemide Torsemide The metabolism of Torasemide can be increased when combined with Apremilast.
Olanzapine Olanzapine The metabolism of Olanzapine can be increased when combined with Apremilast.
Alosetron Alosetron The metabolism of Alosetron can be increased when combined with Apremilast.
Dofetilide Dofetilide The metabolism of Dofetilide can be increased when combined with Apremilast.
Hydroxychloroquine Hydroxychloroquine The metabolism of Apremilast can be increased when combined with Hydroxychloroquine.
Meloxicam Meloxicam The metabolism of Meloxicam can be increased when combined with Apremilast.
Pantoprazole Pantoprazole The metabolism of Pantoprazole can be increased when combined with Apremilast.
Temozolomide Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Apremilast.
Zaleplon Zaleplon The metabolism of Zaleplon can be increased when combined with Apremilast.
Anakinra Anakinra The therapeutic efficacy of Apremilast can be decreased when used in combination with Anakinra.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Apremilast.
Trimipramine Trimipramine The metabolism of Trimipramine can be increased when combined with Apremilast.
Etanercept Injection Etanercept Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Etanercept.
Modafinil Modafinil The metabolism of Modafinil can be increased when combined with Apremilast.
Perindopril Perindopril Perindopril may decrease the excretion rate of Apremilast which could result in a higher serum level.
Tenofovir Tenofovir The metabolism of Tenofovir can be increased when combined with Apremilast.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Apremilast which could result in a higher serum level.
Sirolimus Sirolimus The metabolism of Sirolimus can be increased when combined with Apremilast.
Dutasteride Dutasteride The metabolism of Dutasteride can be increased when combined with Apremilast.
Epirubicin Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Apremilast.
Eplerenone Eplerenone The metabolism of Eplerenone can be increased when combined with Apremilast.
Escitalopram Escitalopram The metabolism of Escitalopram can be increased when combined with Apremilast.
Zonisamide Zonisamide The metabolism of Zonisamide can be increased when combined with Apremilast.
Adalimumab Injection Adalimumab Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be increased when combined with Apremilast.
Atomoxetine Atomoxetine The metabolism of Atomoxetine can be increased when combined with Apremilast.
Glatiramer Injection Glatiramer Injection The risk or severity of adverse effects can be increased when Glatiramer is combined with Apremilast.
Atazanavir Atazanavir The metabolism of Atazanavir can be increased when combined with Apremilast.
Almotriptan Almotriptan The metabolism of Almotriptan can be increased when combined with Apremilast.
Eletriptan Eletriptan The metabolism of Eletriptan can be increased when combined with Apremilast.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be increased when combined with Apremilast.
Vardenafil Vardenafil The metabolism of Vardenafil can be increased when combined with Apremilast.
Aprepitant Aprepitant The metabolism of Aprepitant can be increased when combined with Apremilast.
Emtricitabine Emtricitabine Emtricitabine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Interferon Beta-1a Subcutaneous Injection Interferon Beta-1a Subcutaneous Injection The metabolism of Apremilast can be decreased when combined with Interferon beta-1a.
Memantine Memantine Memantine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Tegaserod Tegaserod The metabolism of Tegaserod can be increased when combined with Apremilast.
Tadalafil Tadalafil The metabolism of Tadalafil can be increased when combined with Apremilast.
Frovatriptan Frovatriptan The metabolism of Frovatriptan can be increased when combined with Apremilast.
Gemifloxacin Gemifloxacin The metabolism of Apremilast can be decreased when combined with Gemifloxacin.
Progesterone Progesterone The metabolism of Progesterone can be increased when combined with Apremilast.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be increased when combined with Apremilast.
Infliximab Injection Infliximab Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Infliximab.
Protriptyline Protriptyline The metabolism of Protriptyline can be increased when combined with Apremilast.
Duloxetine Duloxetine The metabolism of Duloxetine can be increased when combined with Apremilast.
Norethindrone Norethindrone The metabolism of Norethisterone can be increased when combined with Apremilast.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Apremilast which could result in a higher serum level.
Bosentan Bosentan The metabolism of Bosentan can be increased when combined with Apremilast.
Cefditoren Cefditoren Cefdinir may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cinacalcet Cinacalcet The metabolism of Cinacalcet can be increased when combined with Apremilast.
Natalizumab Injection Natalizumab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Natalizumab.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Erlotinib can be increased when combined with Apremilast.
Eszopiclone Eszopiclone The metabolism of Eszopiclone can be increased when combined with Apremilast.
Ganciclovir Ganciclovir Ganciclovir may decrease the excretion rate of Apremilast which could result in a higher serum level.
Ribavirin Ribavirin Ribavirin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Solifenacin Solifenacin The metabolism of Solifenacin can be increased when combined with Apremilast.
Valganciclovir Valganciclovir Valganciclovir may decrease the excretion rate of Apremilast which could result in a higher serum level.
Voriconazole Voriconazole The metabolism of Voriconazole can be increased when combined with Apremilast.
Adefovir Adefovir Adefovir may decrease the excretion rate of Apremilast which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine The metabolism of Amphetamine can be increased when combined with Apremilast.
Entecavir Entecavir The metabolism of Entecavir can be increased when combined with Apremilast.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Apremilast.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Apremilast can be increased when it is combined with Peginterferon alfa-2b.
Ramelteon Ramelteon The metabolism of Ramelteon can be increased when combined with Apremilast.
Darifenacin Darifenacin The metabolism of Darifenacin can be increased when combined with Apremilast.
Fentanyl Fentanyl The metabolism of Fentanyl can be increased when combined with Apremilast.
Pregabalin Pregabalin Pregabalin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Deferasirox Deferasirox The serum concentration of Apremilast can be increased when it is combined with Deferasirox.
Phenylephrine Phenylephrine The metabolism of Apremilast can be increased when combined with Phenylephrine.
Tipranavir Tipranavir The metabolism of Tipranavir can be increased when combined with Apremilast.
Felbamate Felbamate The metabolism of Felbamate can be increased when combined with Apremilast.
Ranolazine Ranolazine The metabolism of Apremilast can be increased when combined with Ranolazine.
Abatacept Injection Abatacept Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Abatacept.
Rasagiline Rasagiline The metabolism of Rasagiline can be increased when combined with Apremilast.
Imatinib Imatinib The metabolism of Imatinib can be increased when combined with Apremilast.
Sitagliptin Sitagliptin The metabolism of Sitagliptin can be increased when combined with Apremilast.
Varenicline Varenicline Varenicline may decrease the excretion rate of Apremilast which could result in a higher serum level.
Bevacizumab Injection Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Apremilast.
Gefitinib Gefitinib The metabolism of Gefitinib can be increased when combined with Apremilast.
Albuterol Albuterol Salbutamol may decrease the excretion rate of Apremilast which could result in a higher serum level.
Paliperidone Paliperidone The metabolism of Paliperidone can be increased when combined with Apremilast.
Bortezomib Bortezomib The metabolism of Bortezomib can be increased when combined with Apremilast.
Clofarabine Injection Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Apremilast.
Hepatitis B Vaccine Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Apremilast.
Influenza Vaccine, Inactivated or Recombinant Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Apremilast.
Influenza Vaccine, Live Intranasal Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Apremilast.
Live Shingles (Zoster) Vaccine (ZVL) Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Apremilast.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The metabolism of Apremilast can be increased when combined with Insulin glulisine.
Lubiprostone Lubiprostone Lubiprostone may decrease the excretion rate of Apremilast which could result in a higher serum level.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Apremilast.
Primaquine Primaquine The metabolism of Primaquine can be increased when combined with Apremilast.
Rituximab Injection Rituximab Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Rituximab.
Pemetrexed Injection Pemetrexed Injection The metabolism of Pemetrexed can be increased when combined with Apremilast.
Lisdexamfetamine Lisdexamfetamine The metabolism of Lisdexamfetamine can be increased when combined with Apremilast.
Vorinostat Vorinostat The risk or severity of adverse effects can be increased when Vorinostat is combined with Apremilast.
Sorafenib Sorafenib The metabolism of Sorafenib can be increased when combined with Apremilast.
Sunitinib Sunitinib The metabolism of Sunitinib can be increased when combined with Apremilast.
Dronabinol Dronabinol The metabolism of Dronabinol can be increased when combined with Apremilast.
Lapatinib Lapatinib The metabolism of Lapatinib can be increased when combined with Apremilast.
Levocetirizine Levocetirizine Apremilast may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Pegaptanib may decrease the excretion rate of Apremilast which could result in a higher serum level.
Dasatinib Dasatinib The metabolism of Dasatinib can be increased when combined with Apremilast.
Mexiletine Mexiletine The metabolism of Mexiletine can be increased when combined with Apremilast.
Armodafinil Armodafinil The metabolism of Apremilast can be increased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection The risk or severity of adverse effects can be increased when Azacitidine is combined with Apremilast.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be increased when combined with Apremilast.
Nelarabine Injection Nelarabine Injection The risk or severity of adverse effects can be increased when Nelarabine is combined with Apremilast.
Lenalidomide Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Apremilast.
Nilotinib Nilotinib The metabolism of Apremilast can be increased when combined with Nilotinib.
Bexarotene Bexarotene The metabolism of Bexarotene can be increased when combined with Apremilast.
Budesonide Budesonide The risk or severity of adverse effects can be increased when Budesonide is combined with Apremilast.
Chloramphenicol Injection Chloramphenicol Injection The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Apremilast.
Decitabine Injection Decitabine Injection The risk or severity of adverse effects can be increased when Decitabine is combined with Apremilast.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Doripenem Injection Doripenem Injection Apremilast may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine Etravirine The metabolism of Etravirine can be increased when combined with Apremilast.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Apremilast.
Mitoxantrone Injection Mitoxantrone Injection The risk or severity of adverse effects can be increased when Mitoxantrone is combined with Apremilast.
Desvenlafaxine Desvenlafaxine Apremilast may decrease the excretion rate of Desvenlafaxine which could result in a higher serum level.
Cevimeline Cevimeline The metabolism of Apremilast can be increased when combined with Cevimeline.
Nebivolol Nebivolol The metabolism of Nebivolol can be increased when combined with Apremilast.
Tretinoin Tretinoin The metabolism of Tretinoin can be increased when combined with Apremilast.
Bendamustine Injection Bendamustine Injection The metabolism of Bendamustine can be increased when combined with Apremilast.
Pilocarpine Pilocarpine The metabolism of Apremilast can be decreased when combined with Pilocarpine.
Flecainide Flecainide The metabolism of Flecainide can be increased when combined with Apremilast.
Certolizumab Injection Certolizumab Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Apremilast can be increased when combined with Ixabepilone.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be increased when combined with Apremilast.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Estramustine Estramustine The risk or severity of adverse effects can be increased when Estramustine is combined with Apremilast.
Praziquantel Praziquantel The metabolism of Praziquantel can be increased when combined with Apremilast.
Methylnaltrexone Injection Methylnaltrexone Injection Apremilast may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Apremilast.
Rufinamide Rufinamide The metabolism of Rufinamide can be increased when combined with Apremilast.
Midazolam Midazolam The metabolism of Midazolam can be increased when combined with Apremilast.
Dexrazoxane Injection Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Apremilast.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be increased when combined with Apremilast.
Ibritumomab Injection Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Apremilast.
Milnacipran Milnacipran Milnacipran may decrease the excretion rate of Apremilast which could result in a higher serum level.
Dexlansoprazole Dexlansoprazole The metabolism of Dexlansoprazole can be increased when combined with Apremilast.
Plerixafor Injection Plerixafor Injection Apremilast may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine Fesoterodine The metabolism of Fesoterodine can be increased when combined with Apremilast.
Betaxolol Betaxolol The metabolism of Betaxolol can be increased when combined with Apremilast.
Iloperidone Iloperidone The metabolism of Iloperidone can be increased when combined with Apremilast.
Prasugrel Prasugrel The metabolism of Prasugrel can be increased when combined with Apremilast.
Lacosamide Lacosamide The metabolism of Lacosamide can be increased when combined with Apremilast.
Everolimus Everolimus The metabolism of Everolimus can be increased when combined with Apremilast.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Apremilast can be increased when combined with Tolvaptan.
Dronedarone Dronedarone The metabolism of Dronedarone can be increased when combined with Apremilast.
Pralatrexate Injection Pralatrexate Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Pralatrexate.
Palonosetron Injection Palonosetron Injection The metabolism of Apremilast can be increased when combined with Palonosetron.
Saxagliptin Saxagliptin The metabolism of Saxagliptin can be increased when combined with Apremilast.
Telavancin Injection Telavancin Injection Apremilast may decrease the excretion rate of Telavancin which could result in a higher serum level.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be increased when combined with Apremilast.
Tapentadol Tapentadol The metabolism of Tapentadol can be increased when combined with Apremilast.
Topotecan Topotecan The risk or severity of adverse effects can be increased when Topotecan is combined with Apremilast.
Golimumab Injection Golimumab Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be increased when combined with Apremilast.
Asenapine Asenapine The metabolism of Asenapine can be increased when combined with Apremilast.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be increased when combined with Apremilast.
Albendazole Albendazole The metabolism of Albendazole can be increased when combined with Apremilast.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Apremilast.
Oxymorphone Oxymorphone The metabolism of Oxymorphone can be increased when combined with Apremilast.
Denosumab Injection Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Apremilast.
Tocilizumab Injection Tocilizumab Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Tocilizumab.
Dalfampridine Dalfampridine Apremilast may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Fingolimod Fingolimod Apremilast may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection Eribulin Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Eribulin.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be increased when combined with Apremilast.
Ustekinumab Injection Ustekinumab Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Ustekinumab.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Apremilast which could result in a higher serum level.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be increased when combined with Apremilast.
Vilazodone Vilazodone The metabolism of Vilazodone can be increased when combined with Apremilast.
Ipilimumab Injection Ipilimumab Injection Apremilast may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection The risk or severity of adverse effects can be increased when Aldesleukin is combined with Apremilast.
Sipuleucel-T Injection Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Apremilast.
Terbutaline Injection Terbutaline Injection Terbutaline may decrease the excretion rate of Apremilast which could result in a higher serum level.
Belimumab Injection Belimumab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Belimumab.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be increased when combined with Apremilast.
Roflumilast Roflumilast Apremilast may increase the immunosuppressive activities of Roflumilast.
Linagliptin Linagliptin The metabolism of Linagliptin can be increased when combined with Apremilast.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be increased when combined with Apremilast.
Abiraterone Abiraterone The serum concentration of Abiraterone can be increased when it is combined with Apremilast.
Rivaroxaban Rivaroxaban The metabolism of Rivaroxaban can be increased when combined with Apremilast.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be increased when combined with Apremilast.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Apremilast.
Vandetanib Vandetanib The metabolism of Vandetanib can be increased when combined with Apremilast.
Clobazam Clobazam The metabolism of Clobazam can be increased when combined with Apremilast.
Vemurafenib Vemurafenib The serum concentration of Apremilast can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Vismodegib can be increased when combined with Apremilast.
Belatacept Injection Belatacept Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Belatacept.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be increased when combined with Apremilast.
Basiliximab Injection Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Apremilast.
Deferiprone Deferiprone Apremilast may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be increased when combined with Apremilast.
Crizotinib Crizotinib The metabolism of Crizotinib can be increased when combined with Apremilast.
Melphalan Injection Melphalan Injection The risk or severity of adverse effects can be increased when Melphalan is combined with Apremilast.
Cabergoline Cabergoline The metabolism of Cabergoline can be increased when combined with Apremilast.
Naloxone Injection Naloxone Injection Naloxone may decrease the excretion rate of Apremilast which could result in a higher serum level.
Ambrisentan Ambrisentan The metabolism of Ambrisentan can be increased when combined with Apremilast.
Eculizumab Injection Eculizumab Injection The risk or severity of adverse effects can be increased when Eculizumab is combined with Apremilast.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Apremilast which could result in a higher serum level.
Carfilzomib Injection Carfilzomib Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Carfilzomib.
Enzalutamide Enzalutamide The metabolism of Enzalutamide can be increased when combined with Apremilast.
Mirabegron Mirabegron The metabolism of Mirabegron can be increased when combined with Apremilast.
Regorafenib Regorafenib The metabolism of Regorafenib can be increased when combined with Apremilast.
Bosutinib Bosutinib The metabolism of Bosutinib can be increased when combined with Apremilast.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of adverse effects can be increased when Corticotropin is combined with Apremilast.
Teriflunomide Teriflunomide The serum concentration of Apremilast can be decreased when it is combined with Teriflunomide.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be increased when combined with Apremilast.
Teduglutide Injection Teduglutide Injection Apremilast may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Tofacitinib Tofacitinib The therapeutic efficacy of Apremilast can be decreased when used in combination with Tofacitinib.
Alogliptin Alogliptin The metabolism of Alogliptin can be increased when combined with Apremilast.
Dimethyl Fumarate Dimethyl Fumarate The risk or severity of adverse effects can be increased when Apremilast is combined with Dimethyl fumarate.
Ponatinib Ponatinib The metabolism of Ponatinib can be increased when combined with Apremilast.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be increased when combined with Apremilast.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be increased when combined with Apremilast.
Apixaban Apixaban The metabolism of Apixaban can be increased when combined with Apremilast.
Canagliflozin Canagliflozin Canagliflozin may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The metabolism of Dabrafenib can be increased when combined with Apremilast.
Ospemifene Ospemifene The metabolism of Ospemifene can be increased when combined with Apremilast.
Trametinib Trametinib Apremilast may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Apremilast.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Apremilast which could result in a higher serum level.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be increased when combined with Apremilast.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Apremilast.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be increased when combined with Apremilast.
Lomitapide Lomitapide The metabolism of Lomitapide can be increased when combined with Apremilast.
Ketorolac Injection Ketorolac Injection The metabolism of Apremilast can be increased when combined with Ketorolac.
Obinutuzumab Injection Obinutuzumab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Obinutuzumab.
Simeprevir Simeprevir The metabolism of Apremilast can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir Apremilast may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be increased when combined with Apremilast.
Droxidopa Droxidopa Apremilast may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib The metabolism of Ceritinib can be increased when combined with Apremilast.
Siltuximab Injection Siltuximab Injection The metabolism of Siltuximab can be increased when combined with Apremilast.
Vedolizumab Injection Vedolizumab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Vedolizumab.
Belinostat Injection Belinostat Injection The risk or severity of adverse effects can be increased when Belinostat is combined with Apremilast.
Idelalisib Idelalisib The metabolism of Idelalisib can be increased when combined with Apremilast.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be increased when combined with Apremilast.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be increased when combined with Apremilast.
Hydrocodone Hydrocodone The metabolism of Hydrocodone can be increased when combined with Apremilast.
Suvorexant Suvorexant The metabolism of Suvorexant can be increased when combined with Apremilast.
Edoxaban Edoxaban Apremilast may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Peginterferon beta-1a.
Olaparib Olaparib The metabolism of Olaparib can be increased when combined with Apremilast.
Blinatumomab Injection Blinatumomab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Blinatumomab.
Methamphetamine Methamphetamine The metabolism of Metamfetamine can be increased when combined with Apremilast.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be increased when combined with Apremilast.
Riociguat Riociguat Apremilast may increase the hypotensive activities of Riociguat.
Pirfenidone Pirfenidone The metabolism of Pirfenidone can be increased when combined with Apremilast.
Nintedanib Nintedanib The metabolism of Nintedanib can be increased when combined with Apremilast.
Secukinumab Injection Secukinumab Injection The metabolism of Secukinumab can be increased when combined with Apremilast.
Risperidone Injection Risperidone Injection The metabolism of Risperidone can be increased when combined with Apremilast.
Palbociclib Palbociclib The metabolism of Palbociclib can be increased when combined with Apremilast.
Insulin Human Inhalation Insulin Human Inhalation The metabolism of Apremilast can be increased when combined with Insulin human.
Lenvatinib Lenvatinib The metabolism of Lenvatinib can be decreased when combined with Apremilast.
Panobinostat Panobinostat The metabolism of Panobinostat can be increased when combined with Apremilast.
Dinutuximab Injection Dinutuximab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Dinutuximab.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Apremilast.
Amiloride Amiloride Amiloride may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan Macitentan Apremilast may decrease the excretion rate of Macitentan which could result in a higher serum level.
Sonidegib Sonidegib The metabolism of Sonidegib can be increased when combined with Apremilast.
Prednisolone Prednisolone The risk or severity of adverse effects can be increased when Prednisolone is combined with Apremilast.
Daclatasvir Daclatasvir The metabolism of Daclatasvir can be increased when combined with Apremilast.
Brexpiprazole Brexpiprazole The metabolism of Brexpiprazole can be increased when combined with Apremilast.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be increased when combined with Apremilast.
Cariprazine Cariprazine The metabolism of Cariprazine can be increased when combined with Apremilast.
Penicillin G Procaine Injection Penicillin G Procaine Injection Apremilast may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The metabolism of Apremilast can be increased when combined with Insulin degludec.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be increased when combined with Apremilast.
Mepolizumab Injection Mepolizumab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Mepolizumab.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Apremilast.
Osimertinib Osimertinib The serum concentration of Osimertinib can be decreased when it is combined with Apremilast.
Alectinib Alectinib The metabolism of Alectinib can be increased when combined with Apremilast.
Ixazomib Ixazomib The metabolism of Ixazomib can be increased when combined with Apremilast.
Lesinurad Lesinurad The metabolism of Lesinurad can be increased when combined with Apremilast.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Apremilast which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The metabolism of Apremilast can be increased when combined with Dexamethasone.
Ixekizumab Injection Ixekizumab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Ixekizumab.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be increased when combined with Apremilast.
Venetoclax Venetoclax The metabolism of Venetoclax can be increased when combined with Apremilast.
Cobicistat Cobicistat The metabolism of Cobicistat can be increased when combined with Apremilast.
Selexipag Selexipag The metabolism of Selexipag can be increased when combined with Apremilast.
Obeticholic Acid Obeticholic Acid The metabolism of Apremilast can be decreased when combined with Obeticholic acid.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be increased when combined with Apremilast.
Furosemide Injection Furosemide Injection Furosemide may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib Rucaparib The metabolism of Rucaparib can be increased when combined with Apremilast.
Lixisenatide Injection Lixisenatide Injection Apremilast may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ribociclib Ribociclib The metabolism of Ribociclib can be increased when combined with Apremilast.
Brodalumab Injection Brodalumab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Brodalumab.
Brigatinib Brigatinib The metabolism of Brigatinib can be increased when combined with Apremilast.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be increased when combined with Apremilast.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be increased when combined with Apremilast.
Valbenazine Valbenazine The metabolism of Valbenazine can be increased when combined with Apremilast.
Deflazacort Deflazacort The risk or severity of adverse effects can be increased when Apremilast is combined with Deflazacort.
Safinamide Safinamide The metabolism of Safinamide can be decreased when combined with Apremilast.
Ocrelizumab Injection Ocrelizumab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Ocrelizumab.
Naldemedine Naldemedine Apremilast may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Sarilumab Injection Sarilumab Injection The therapeutic efficacy of Apremilast can be decreased when used in combination with Sarilumab.
Midostaurin Midostaurin The metabolism of Midostaurin can be increased when combined with Apremilast.
Neratinib Neratinib The metabolism of Neratinib can be increased when combined with Apremilast.
Guselkumab Injection Guselkumab Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Guselkumab.
Enasidenib Enasidenib The metabolism of Enasidenib can be increased when combined with Apremilast.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Apremilast.
Benznidazole Benznidazole Apremilast may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be increased when combined with Apremilast.
Delafloxacin Delafloxacin Apremilast may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be increased when combined with Apremilast.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Apremilast.
Gemtuzumab Ozogamicin Injection Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Apremilast.
Letermovir Letermovir The metabolism of Letermovir can be increased when combined with Apremilast.
Tetrabenazine Tetrabenazine The metabolism of Tetrabenazine can be increased when combined with Apremilast.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be increased when combined with Apremilast.
Apalutamide Apalutamide The metabolism of Apalutamide can be increased when combined with Apremilast.
Penicillamine Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Apremilast.
Baricitinib Baricitinib The metabolism of Baricitinib can be increased when combined with Apremilast.
Lofexidine Lofexidine The metabolism of Lofexidine can be increased when combined with Apremilast.
Plazomicin Injection Plazomicin Injection Apremilast may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat Eliglustat The metabolism of Eliglustat can be increased when combined with Apremilast.
Encorafenib Encorafenib The metabolism of Encorafenib can be increased when combined with Apremilast.
Binimetinib Binimetinib The metabolism of Binimetinib can be increased when combined with Apremilast.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be increased when combined with Apremilast.
Elagolix Elagolix The metabolism of Elagolix can be increased when combined with Apremilast.
Doravirine Doravirine The metabolism of Doravirine can be increased when combined with Apremilast.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be increased when combined with Apremilast.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be increased when combined with Apremilast.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be increased when combined with Apremilast.
Duvelisib Duvelisib The metabolism of Duvelisib can be increased when combined with Apremilast.
Stiripentol Stiripentol The metabolism of Stiripentol can be increased when combined with Apremilast.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be increased when combined with Apremilast.
Glasdegib Glasdegib The metabolism of Glasdegib can be increased when combined with Apremilast.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be increased when combined with Apremilast.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Apremilast.
Rifamycin Rifamycin The metabolism of Apremilast can be decreased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Prucalopride can be increased when combined with Apremilast.
Ravulizumab-cwvz Injection Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Ravulizumab.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Emapalumab can be increased when combined with Apremilast.
Siponimod Siponimod The metabolism of Siponimod can be increased when combined with Apremilast.
Acyclovir Ophthalmic Acyclovir Ophthalmic The metabolism of Acyclovir can be increased when combined with Apremilast.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be increased when combined with Apremilast.
Esomeprazole Injection Esomeprazole Injection The metabolism of Esomeprazole can be increased when combined with Apremilast.
Risankizumab-rzaa Injection Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Apremilast is combined with Risankizumab.
Alpelisib Alpelisib The metabolism of Alpelisib can be increased when combined with Apremilast.
Cladribine Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Apremilast.
Solriamfetol Solriamfetol Apremilast may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be increased when combined with Apremilast.
Entrectinib Entrectinib The metabolism of Entrectinib can be increased when combined with Apremilast.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be increased when combined with Apremilast.
Istradefylline Istradefylline The metabolism of Istradefylline can be increased when combined with Apremilast.
Pitolisant Pitolisant The serum concentration of Apremilast can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The metabolism of Fedratinib can be increased when combined with Apremilast.
Lefamulin Lefamulin The metabolism of Lefamulin can be increased when combined with Apremilast.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be increased when combined with Apremilast.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be increased when combined with Apremilast.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Apremilast.
Voxelotor Voxelotor The metabolism of Voxelotor can be increased when combined with Apremilast.
Avapritinib Avapritinib The metabolism of Avapritinib can be increased when combined with Apremilast.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be increased when combined with Apremilast.
Cenobamate Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Apremilast.
Ozanimod Ozanimod The risk or severity of adverse effects can be increased when Apremilast is combined with Ozanimod.
Selumetinib Selumetinib The metabolism of Selumetinib can be increased when combined with Apremilast.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Apremilast.
Capmatinib Capmatinib The metabolism of Apremilast can be decreased when combined with Capmatinib.
Lemborexant Lemborexant The metabolism of Lemborexant can be increased when combined with Apremilast.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Apremilast can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Apremilast.
Viloxazine Viloxazine Apremilast may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Theophylline Theophylline The metabolism of Theophylline can be increased when combined with Apremilast.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Apremilast which could result in a higher serum level.
Indomethacin Indomethacin The metabolism of Indomethacin can be increased when combined with Apremilast.
Mefenamic Acid Mefenamic Acid The metabolism of Mefenamic acid can be increased when combined with Apremilast.
Naproxen Naproxen The metabolism of Naproxen can be increased when combined with Apremilast.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Apremilast which could result in a higher serum level.
Trazodone Trazodone The metabolism of Trazodone can be increased when combined with Apremilast.
Isotretinoin Isotretinoin Isotretinoin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Apremilast which could result in a higher serum level.
Hydroxyurea Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Apremilast.
Floxuridine Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Apremilast.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be increased when combined with Apremilast.
Metaxalone Metaxalone Metaxalone may decrease the excretion rate of Apremilast which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection The metabolism of Apremilast can be increased when combined with Methotrexate.
Primidone Primidone The metabolism of Primidone can be increased when combined with Apremilast.
Methsuximide Methsuximide The metabolism of Methsuximide can be increased when combined with Apremilast.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Apremilast.
Diazepam Diazepam The metabolism of Diazepam can be increased when combined with Apremilast.
Oxazepam Oxazepam Oxazepam may decrease the excretion rate of Apremilast which could result in a higher serum level.
Flurazepam Flurazepam The metabolism of Flurazepam can be increased when combined with Apremilast.
Clorazepate Clorazepate Clorazepic acid may decrease the excretion rate of Apremilast which could result in a higher serum level.
Lorazepam Lorazepam The metabolism of Lorazepam can be increased when combined with Apremilast.
Carmustine Carmustine The metabolism of Carmustine can be increased when combined with Apremilast.
Amantadine Amantadine Amantadine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Codeine Codeine The metabolism of Apremilast can be increased when combined with Codeine.
Tranylcypromine Tranylcypromine The metabolism of Apremilast can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine Phenelzine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Apremilast.
Tetracycline Tetracycline Tetracycline may decrease the excretion rate of Apremilast which could result in a higher serum level.
Thioguanine Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Apremilast.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be increased when combined with Apremilast.
Thioridazine Thioridazine The metabolism of Thioridazine can be increased when combined with Apremilast.
Trifluoperazine Trifluoperazine The metabolism of Trifluoperazine can be increased when combined with Apremilast.
Bleomycin Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Apremilast.
Dapsone Dapsone The metabolism of Dapsone can be increased when combined with Apremilast.
Sulfadiazine Sulfadiazine The metabolism of Sulfadiazine can be increased when combined with Apremilast.
Oxycodone Oxycodone The metabolism of Oxycodone can be increased when combined with Apremilast.
Methadone Methadone The metabolism of Methadone can be increased when combined with Apremilast.
Oxybutynin Oxybutynin The metabolism of Oxybutynin can be increased when combined with Apremilast.
Benztropine Benztropine The metabolism of Benzatropine can be increased when combined with Apremilast.
Maprotiline Maprotiline The metabolism of Maprotiline can be increased when combined with Apremilast.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be increased when combined with Apremilast.
Orphenadrine Orphenadrine The metabolism of Orphenadrine can be decreased when combined with Apremilast.
Perphenazine Perphenazine The metabolism of Perphenazine can be increased when combined with Apremilast.
Azathioprine Azathioprine The metabolism of Azathioprine can be increased when combined with Apremilast.
Phentermine Phentermine The metabolism of Phentermine can be increased when combined with Apremilast.
Methylphenidate Methylphenidate Methylphenidate may decrease the excretion rate of Apremilast which could result in a higher serum level.
Amoxapine Amoxapine The metabolism of Amoxapine can be increased when combined with Apremilast.
Sulfasalazine Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Apremilast.
Hydrocortisone Hydrocortisone The metabolism of Hydrocortisone can be increased when combined with Apremilast.
Lomustine Lomustine The risk or severity of adverse effects can be increased when Lomustine is combined with Apremilast.
Doxorubicin Doxorubicin The metabolism of Apremilast can be increased when combined with Doxorubicin.
Cytarabine Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Apremilast.
Mechlorethamine Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Apremilast.
Dactinomycin Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Apremilast.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Carbamazepine Carbamazepine The metabolism of Apremilast can be increased when combined with Carbamazepine.
Methyldopa Methyldopa Methyldopa may decrease the excretion rate of Apremilast which could result in a higher serum level.
Clonidine Clonidine The metabolism of Apremilast can be increased when combined with Clonidine.
Hydralazine Hydralazine Hydralazine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cimetidine Cimetidine Cimetidine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Warfarin Warfarin The metabolism of Warfarin can be increased when combined with Apremilast.
Clonazepam Clonazepam Clonazepam may decrease the excretion rate of Apremilast which could result in a higher serum level.
Loperamide Loperamide The metabolism of Loperamide can be increased when combined with Apremilast.
Promethazine Promethazine The metabolism of Promethazine can be increased when combined with Apremilast.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Apremilast which could result in a higher serum level.
Daunorubicin Daunorubicin The risk or severity of adverse effects can be increased when Daunorubicin is combined with Apremilast.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Apremilast can be increased when combined with Griseofulvin.
Digoxin Digoxin Apremilast may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine The metabolism of Chloroquine can be increased when combined with Apremilast.
Quinine Quinine The metabolism of Quinine can be increased when combined with Apremilast.
Ethosuximide Ethosuximide The metabolism of Ethosuximide can be increased when combined with Apremilast.
Triamterene Triamterene The metabolism of Triamterene can be increased when combined with Apremilast.
Chlorothiazide Chlorothiazide Chlorothiazide may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Metolazone may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Apremilast.
Secobarbital Secobarbital The metabolism of Apremilast can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Apremilast can be increased when combined with Desipramine.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be increased when combined with Apremilast.
Imipramine Imipramine The metabolism of Apremilast can be increased when combined with Imipramine.
Probenecid Probenecid Probenecid may decrease the excretion rate of Apremilast which could result in a higher serum level.
Quinidine Quinidine The metabolism of Apremilast can be increased when combined with Quinidine.
Procainamide Procainamide The metabolism of Procainamide can be increased when combined with Apremilast.
Isoniazid Isoniazid The metabolism of Apremilast can be decreased when combined with Isoniazid.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Apremilast which could result in a higher serum level.
Rifampin Rifampin The metabolism of Apremilast can be increased when combined with Rifampicin.
Disopyramide Disopyramide The metabolism of Disopyramide can be increased when combined with Apremilast.
Valproic Acid Valproic Acid The metabolism of Apremilast can be increased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be increased when combined with Apremilast.
Mitomycin Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Apremilast.
Butabarbital Butabarbital Butabarbital may decrease the excretion rate of Apremilast which could result in a higher serum level.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Methimazole Methimazole The risk or severity of adverse effects can be increased when Methimazole is combined with Apremilast.
Propylthiouracil Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Apremilast.
Chlorpropamide Chlorpropamide The metabolism of Chlorpropamide can be increased when combined with Apremilast.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be increased when combined with Apremilast.
Tolazamide Tolazamide The metabolism of Tolazamide can be increased when combined with Apremilast.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be increased when combined with Apremilast.
Cyclobenzaprine Cyclobenzaprine The metabolism of Apremilast can be increased when combined with Cyclobenzaprine.
Baclofen Baclofen Baclofen may decrease the excretion rate of Apremilast which could result in a higher serum level.
Chlorpheniramine Chlorpheniramine The metabolism of Chlorpheniramine can be increased when combined with Apremilast.
Brompheniramine Brompheniramine The metabolism of Brompheniramine can be increased when combined with Apremilast.
Meclizine Meclizine The metabolism of Meclizine can be increased when combined with Apremilast.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Apremilast which could result in a higher serum level.
Methyclothiazide Methyclothiazide Methyclothiazide may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Apremilast which could result in a higher serum level.
Chlorzoxazone Chlorzoxazone The metabolism of Chlorzoxazone can be increased when combined with Apremilast.
Carisoprodol Carisoprodol The metabolism of Carisoprodol can be increased when combined with Apremilast.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Apremilast which could result in a higher serum level.
Disulfiram Disulfiram The metabolism of Disulfiram can be increased when combined with Apremilast.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Propranolol can be increased when combined with Apremilast.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be increased when combined with Apremilast.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Apremilast which could result in a higher serum level.
Mercaptopurine Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Apremilast.
Phytonadione Phytonadione Phylloquinone may decrease the excretion rate of Apremilast which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Nadolol Nadolol The metabolism of Nadolol can be increased when combined with Apremilast.
Allopurinol Allopurinol Allopurinol may decrease the excretion rate of Apremilast which could result in a higher serum level.
Flavoxate Flavoxate Flavoxate may decrease the excretion rate of Apremilast which could result in a higher serum level.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be increased when combined with Apremilast.
Colchicine Colchicine The risk or severity of adverse effects can be increased when Colchicine is combined with Apremilast.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cephalexin Cephalexin The metabolism of Cephalexin can be increased when combined with Apremilast.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Dacarbazine Dacarbazine The metabolism of Dacarbazine can be increased when combined with Apremilast.
Acetazolamide Acetazolamide Acetazolamide may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Apremilast which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Bacillus Calmette-Guerin (BCG) Vaccine Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Apremilast.
Pyrantel Pyrantel Apremilast may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Thiotepa Injection Thiotepa Injection The metabolism of Apremilast can be increased when combined with Thiotepa.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be increased when combined with Apremilast.
Vinblastine Vinblastine The metabolism of Apremilast can be increased when combined with Vinblastine.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Apremilast which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Apremilast which could result in a higher serum level.
Metoprolol Metoprolol The metabolism of Metoprolol can be increased when combined with Apremilast.
Hydroxyzine Hydroxyzine The metabolism of Hydroxyzine can be increased when combined with Apremilast.
Thiothixene Thiothixene The metabolism of Thiothixene can be increased when combined with Apremilast.
Aspirin Aspirin The metabolism of Acetylsalicylic acid can be increased when combined with Apremilast.
Salsalate Salsalate Salsalate may decrease the excretion rate of Apremilast which could result in a higher serum level.
Chlorambucil Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Apremilast.
Alprazolam Alprazolam The metabolism of Apremilast can be increased when combined with Alprazolam.
Temazepam Temazepam Temazepam may decrease the excretion rate of Apremilast which could result in a higher serum level.
Triazolam Triazolam The metabolism of Triazolam can be increased when combined with Apremilast.
Dicyclomine Dicyclomine Dicyclomine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Propantheline Propantheline Propantheline may decrease the excretion rate of Apremilast which could result in a higher serum level.
Trimethoprim Trimethoprim The metabolism of Trimethoprim can be increased when combined with Apremilast.
Diltiazem Diltiazem The metabolism of Diltiazem can be increased when combined with Apremilast.
Nifedipine Nifedipine The metabolism of Nifedipine can be increased when combined with Apremilast.
Timolol Timolol The metabolism of Timolol can be increased when combined with Apremilast.
Verapamil Verapamil The metabolism of Verapamil can be increased when combined with Apremilast.
Atenolol Atenolol The metabolism of Atenolol can be increased when combined with Apremilast.
Pindolol Pindolol The metabolism of Pindolol can be increased when combined with Apremilast.
Cisplatin Injection Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Apremilast.
Diflunisal Diflunisal Diflunisal may decrease the excretion rate of Apremilast which could result in a higher serum level.
Piroxicam Piroxicam The metabolism of Piroxicam can be increased when combined with Apremilast.
Bumetanide Bumetanide Bumetanide may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Streptozocin Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Apremilast.
Etoposide Etoposide The metabolism of Etoposide can be increased when combined with Apremilast.
Glyburide Glyburide The metabolism of Glyburide can be increased when combined with Apremilast.
Glipizide Glipizide The metabolism of Glipizide can be increased when combined with Apremilast.
Indapamide Indapamide Indapamide may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Amoxicillin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Nafcillin Injection Nafcillin Injection The metabolism of Apremilast can be increased when combined with Nafcillin.
Oxacillin Injection Oxacillin Injection Oxacillin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Pentoxifylline Pentoxifylline The metabolism of Pentoxifylline can be increased when combined with Apremilast.
Pentamidine Injection Pentamidine Injection The metabolism of Pentamidine can be increased when combined with Apremilast.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Apremilast which could result in a higher serum level.
Labetalol Labetalol The metabolism of Apremilast can be increased when combined with Labetalol.
Auranofin Auranofin Auranofin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may decrease the excretion rate of Apremilast which could result in a higher serum level.
Gemfibrozil Gemfibrozil The metabolism of Gemfibrozil can be decreased when combined with Apremilast.
Guanabenz Guanabenz The metabolism of Guanabenz can be increased when combined with Apremilast.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Apremilast which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Apremilast which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Apremilast which could result in a higher serum level.
Pimozide Pimozide The metabolism of Pimozide can be increased when combined with Apremilast.
Flurbiprofen Flurbiprofen The metabolism of Flurbiprofen can be increased when combined with Apremilast.
Amiodarone Amiodarone The metabolism of Amiodarone can be increased when combined with Apremilast.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Apremilast which could result in a higher serum level.
Buspirone Buspirone The metabolism of Buspirone can be increased when combined with Apremilast.
Lovastatin Lovastatin The metabolism of Lovastatin can be increased when combined with Apremilast.
Ciprofloxacin Ciprofloxacin The metabolism of Apremilast can be decreased when combined with Ciprofloxacin.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Diclofenac Diclofenac The metabolism of Diclofenac can be increased when combined with Apremilast.
Fluoxetine Fluoxetine The metabolism of Fluoxetine can be increased when combined with Apremilast.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Apremilast.
Clozapine Clozapine The metabolism of Apremilast can be increased when combined with Clozapine.
Estazolam Estazolam Estazolam may decrease the excretion rate of Apremilast which could result in a higher serum level.
Idarubicin Idarubicin The metabolism of Idarubicin can be increased when combined with Apremilast.
Ofloxacin Ofloxacin The metabolism of Apremilast can be decreased when combined with Ofloxacin.
Didanosine Didanosine Didanosine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Fludarabine Injection Fludarabine Injection The risk or severity of adverse effects can be increased when Fludarabine is combined with Apremilast.
Pentostatin Injection Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Apremilast.
Clarithromycin Clarithromycin The metabolism of Clarithromycin can be increased when combined with Apremilast.
Etodolac Etodolac The metabolism of Etodolac can be increased when combined with Apremilast.
Felodipine Felodipine The metabolism of Felodipine can be increased when combined with Apremilast.
Fosinopril Fosinopril Fosinopril may decrease the excretion rate of Apremilast which could result in a higher serum level.
Nabumetone Nabumetone The metabolism of Nabumetone can be increased when combined with Apremilast.
Simvastatin Simvastatin The metabolism of Simvastatin can be increased when combined with Apremilast.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be increased when combined with Apremilast.
Lisinopril Lisinopril Lisinopril may decrease the excretion rate of Apremilast which could result in a higher serum level.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Sotalol Sotalol The metabolism of Sotalol can be increased when combined with Apremilast.
Bisoprolol Bisoprolol Bisoprolol may decrease the excretion rate of Apremilast which could result in a higher serum level.
Zolpidem Zolpidem The metabolism of Apremilast can be increased when combined with Zolpidem.
Doxazosin Doxazosin The metabolism of Doxazosin can be increased when combined with Apremilast.
Isradipine Isradipine Isradipine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Omeprazole Omeprazole The metabolism of Omeprazole can be increased when combined with Apremilast.
Cisapride Cisapride The metabolism of Apremilast can be increased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be increased when combined with Apremilast.
Venlafaxine Venlafaxine The metabolism of Venlafaxine can be increased when combined with Apremilast.
Famciclovir Famciclovir The metabolism of Famciclovir can be increased when combined with Apremilast.
Fluvoxamine Fluvoxamine The metabolism of Fluvoxamine can be increased when combined with Apremilast.
Nefazodone Nefazodone The metabolism of Apremilast can be increased when combined with Nefazodone.
Lamotrigine Lamotrigine Lamotrigine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Losartan Losartan The metabolism of Losartan can be increased when combined with Apremilast.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Apremilast which could result in a higher serum level.
Tramadol Tramadol The metabolism of Tramadol can be increased when combined with Apremilast.
Vinorelbine Injection Vinorelbine Injection The metabolism of Apremilast can be increased when combined with Vinorelbine.
Carboplatin Injection Carboplatin Injection The risk or severity of adverse effects can be increased when Carboplatin is combined with Apremilast.
Lansoprazole Lansoprazole The metabolism of Lansoprazole can be increased when combined with Apremilast.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Apremilast.
Pegaspargase Injection Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Apremilast.
Nicardipine Nicardipine The metabolism of Nicardipine can be increased when combined with Apremilast.
Bupropion Bupropion The metabolism of Bupropion can be increased when combined with Apremilast.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be increased when combined with Apremilast.
Saquinavir Saquinavir The metabolism of Saquinavir can be increased when combined with Apremilast.
Metformin Metformin Metformin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Nisoldipine Nisoldipine The metabolism of Nisoldipine can be increased when combined with Apremilast.
Lamivudine Lamivudine Lamivudine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Riluzole Riluzole The metabolism of Riluzole can be increased when combined with Apremilast.
Acarbose Acarbose Acarbose may decrease the excretion rate of Apremilast which could result in a higher serum level.
Glimepiride Glimepiride The metabolism of Glimepiride can be increased when combined with Apremilast.
Anastrozole Anastrozole The metabolism of Anastrozole can be increased when combined with Apremilast.
Gemcitabine Injection Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Apremilast.
Indinavir Indinavir The metabolism of Indinavir can be increased when combined with Apremilast.
Ritonavir Ritonavir The serum concentration of Apremilast can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Apremilast.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Apremilast which could result in a higher serum level.
Meropenem Injection Meropenem Injection Meropenem may decrease the excretion rate of Apremilast which could result in a higher serum level.
Clomipramine Clomipramine The metabolism of Apremilast can be increased when combined with Clomipramine.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be increased when combined with Apremilast.
Fosfomycin Fosfomycin Fosfomycin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Mirtazapine Mirtazapine The metabolism of Mirtazapine can be increased when combined with Apremilast.
Topiramate Topiramate Topiramate may decrease the excretion rate of Apremilast which could result in a higher serum level.
Zileuton Zileuton The metabolism of Zileuton can be increased when combined with Apremilast.
Valsartan Valsartan The metabolism of Valsartan can be increased when combined with Apremilast.
Insulin Lispro Injection Insulin Lispro Injection The metabolism of Apremilast can be increased when combined with Insulin lispro.
Pramipexole Pramipexole Pramipexole may decrease the excretion rate of Apremilast which could result in a higher serum level.
Donepezil Donepezil The metabolism of Donepezil can be increased when combined with Apremilast.
Azithromycin Azithromycin The metabolism of Azithromycin can be increased when combined with Apremilast.
Carvedilol Carvedilol The metabolism of Carvedilol can be increased when combined with Apremilast.
Nilutamide Nilutamide Nilutamide may decrease the excretion rate of Apremilast which could result in a higher serum level.
Flutamide Flutamide The metabolism of Flutamide can be increased when combined with Apremilast.
Selegiline Selegiline The metabolism of Selegiline can be increased when combined with Apremilast.
Bicalutamide Bicalutamide The metabolism of Bicalutamide can be increased when combined with Apremilast.
Sertraline Sertraline The metabolism of Sertraline can be increased when combined with Apremilast.
Propafenone Propafenone The metabolism of Propafenone can be increased when combined with Apremilast.
Letrozole Letrozole The metabolism of Letrozole can be increased when combined with Apremilast.
Irbesartan Irbesartan The metabolism of Irbesartan can be increased when combined with Apremilast.
Tamsulosin Tamsulosin The metabolism of Apremilast can be increased when combined with Tamsulosin.
Ropinirole Ropinirole The metabolism of Ropinirole can be increased when combined with Apremilast.
Finasteride Finasteride The metabolism of Finasteride can be increased when combined with Apremilast.
Quetiapine Quetiapine The metabolism of Quetiapine can be increased when combined with Apremilast.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Apremilast which could result in a higher serum level.
Cetirizine Cetirizine Cetirizine may decrease the excretion rate of Apremilast which could result in a higher serum level.
Paroxetine Paroxetine The metabolism of Paroxetine can be increased when combined with Apremilast.
Tolcapone Tolcapone Tolcapone may decrease the excretion rate of Apremilast which could result in a higher serum level.
Citalopram Citalopram The metabolism of Citalopram can be increased when combined with Apremilast.
Capecitabine Capecitabine The metabolism of Apremilast can be increased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Efavirenz can be increased when combined with Apremilast.
Abacavir Abacavir Abacavir may decrease the excretion rate of Apremilast which could result in a higher serum level.
Sildenafil Sildenafil The metabolism of Sildenafil can be increased when combined with Apremilast.
Pioglitazone Pioglitazone The metabolism of Pioglitazone can be increased when combined with Apremilast.
Trastuzumab Injection Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Apremilast.
Celecoxib Celecoxib The metabolism of Celecoxib can be increased when combined with Apremilast.
Rosiglitazone Rosiglitazone The metabolism of Rosiglitazone can be increased when combined with Apremilast.
Tolterodine Tolterodine The metabolism of Tolterodine can be increased when combined with Apremilast.
Thalidomide Thalidomide The metabolism of Thalidomide can be increased when combined with Apremilast.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Apremilast which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Apremilast which could result in a higher serum level.
Nateglinide Nateglinide The metabolism of Nateglinide can be increased when combined with Apremilast.
Galantamine Galantamine The metabolism of Apremilast can be increased when combined with Galantamine.
Rabeprazole Rabeprazole The metabolism of Rabeprazole can be increased when combined with Apremilast.
Terbinafine Terbinafine The metabolism of Terbinafine can be increased when combined with Apremilast.

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