Drug & supplement interaction

Collard + Zileuton

Zileuton brand names: Zyflo, Zyflo CR.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Collard and Zileuton in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Zileuton states a food rule worth keeping to.

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Interaction report

Collard and Zileuton

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Zileuton and Collard in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Collard safety at a glance

Collard overall Generally safe Collard is widely eaten as a food and is generally safe for most people.
Pregnancy Generally safe Normal food amounts are considered safe and nutritious during pregnancy.
Breastfeeding Generally safe Eating collard as a food is generally considered safe while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Zileuton and Collard? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Zileuton

Interactions in our licensed database are recorded against drug classes, not just single drug names. Zileuton is filed under 8 classifications — including cytochrome p450 1a2 (cyp1a2) inhibitors, cytochrome p450 2c9 (cyp2c9) substrates, cytochrome p450 3a4 (cyp3a4) inhibitors. Collard has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Zileuton’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Collard Does Interact With Other Medications

Collard has 86 moderate known drug interactions in our database — Zileuton isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Zileuton)
Taking anything else?

Check Another of Your Medications Against Collard

Covers the 2,830 medications we’ve checked against Collard. Pick one to open its full report.

What to actually watch for

What Zileuton’s Own FDA Label Lists

This is not an interaction — none of it involves Collard. These are the most notable effects listed in the ADVERSE REACTIONS section of Zileuton’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on mentioned in 11.9% of FDA reports for Zileuton
  • Liver problems Worth acting on
  • An allergic reaction Worth acting on
  • Stomach upset
  • Stomach pain
  • Nausea mentioned in 6.3% of FDA reports for Zileuton
  • Diarrhea
  • A skin rash
  • Vomiting

From the ADVERSE REACTIONS section of the FDA label for Zileuton. Read the label on DailyMed › Where a percentage is shown, it is the share of 637 voluntary FDA FAERS reports for Zileuton that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Collard’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Collard side to compare — that is a limit of the record, not a statement that Collard has no side effects.

How to take them

Some Zileuton Products Have a Food Rule — Collard Should Not Break It

At least one FDA label for a product containing Zileuton says to take it with food. If you take Collard on an empty stomach out of habit, keep them separate — and take Zileuton with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Zileuton products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

For ease of administration, ZYFLO may be taken with meals and at bedtime.

From the Dosage and Administration section of the FDA label we read for Zileuton — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Zileuton

This page covers Collard only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Zileuton page lists 213 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 163 moderate · 44 minor.

Open the Zileuton interaction page

One more smart check

Taking Collard as Part of a Dietary Supplement Product? Check It for Interactions

We hold 379 real supplement products containing Collard, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Collard. Even though Collard itself has no known interaction with Zileuton, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Collard and Zileuton Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Collard
Top half

#513 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Zileuton
Steady interest

#2,576 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Collard reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Collard and Zileuton records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Collard

What is Collard?

  • General nutrition and vitamin source
  • Bone health
  • Heart health support
  • Digestive fiber
  • Antioxidant intake

Collard is a leafy green vegetable in the cabbage family that is rich in vitamins, minerals, and fiber, and is best thought of as a nutritious food rather than a medicine. Eating it as part of a balanced diet is healthy for most people, but there is little high-quality research on collard as a concentrated supplement. If you take blood thinners or have kidney concerns, talk with your pharmacist or doctor because of its vitamin K and oxalate content.

Brassica oleracea var. viridis · Brassicaceae · Leaves · Fresh or cooked leaves, frozen greens; occasionally powders or capsules

An interaction check asks whether these two react with each other — it does not ask whether Collard is a good idea for someone in your situation. Here is what our Collard record says about it on its own.

Collard: dosing

There is no established medicinal dose for collard. As a food, it can be enjoyed in normal serving sizes as part of a varied diet, just like other vegetables.If you choose a collard powder or capsule, there is no standardized dose, so follow the directions on the product label.

From our Collard monograph — the full record covers uses, side effects and every documented interaction.

Read the full Collard monograph & all interactions
Medication

About Zileuton

What Is Zileuton Used For?

Brand names: Zyflo, Zyflo CR

Zileuton is used for the ongoing prevention and treatment of asthma in adults and adolescents aged 12 and older. It is a maintenance medicine — meaning it is taken regularly to keep asthma under control, not to stop an asthma attack once it has started.

Zyflo (the tablet form) and zileuton extended-release tablets are both approved for this same purpose. Neither form should be used to treat a sudden asthma attack. However, both can be continued during a flare-up of asthma while you also use your rescue inhaler.

See full Zileuton drug information
Keep checking

Other Drugs & Collard

Browse every other medication we’ve checked against Collard — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Collard page.

No interaction 2,743 drugs checked — show the list

We also checked Collard against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Collard list.

See the full Collard interactions page
See every supplement checked against Zileuton, ranked by severity
Evidence & sources

Collard References

The 4 references that drive our Collard monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Zhao H, Lin J, Grossman HB, et al. Dietary isothiocyanates, GSTM1, GSTT1, NAT2 polymorphisms and bladder cancer risk. Int J Cancer 2007;120:2208-13.
  2. Cohen, J. H., Kristal, A. R., and Stanford, J. L. Fruit and vegetable intakes and prostate cancer risk. J Natl.Cancer Inst. 1-5-2000;92(1):61-68. PubMed
  3. Gaudet MM, Britton JA, Kabat GC, et al. Fruits, vegetables, and micronutrients in relation to breast cancer modified by menopause and hormone receptor status. Cancer Epidemiol Biomarkers Prev 2004;13(9):1485-94. DOI
  4. Amssayef A, Eddouks M. Antihyperglycemic Effect of the Moroccan Collard Green (Brassica oleracea var. viridis) in Streptozotocin-Induced Diabetic Rats. Endocr Metab Immune Disord Drug Targets 2020. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Collard and Zileuton Together: Common Questions

Is it safe to take Collard with Zileuton?
We do not list a known interaction between Collard and Zileuton. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Collard and Zileuton at the same time of day?
At least one FDA label for a product containing Zileuton says to take it with food. If you take Collard on an empty stomach out of habit, keep them separate and take Zileuton with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Zileuton products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Collard and Zileuton combination checked?
Interactions in our licensed database are recorded against drug classes. Zileuton is filed under 8 classifications, and Collard has documented interactions with 1 drug class — none of Zileuton's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Collard interact with any other medications?
Yes. Collard has 86 documented drug interactions in our database — Zileuton is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Zileuton interact with any supplements?
Yes. Zileuton has documented interactions with 213 supplements in our database — Collard is not one of them. The Zileuton interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Collard monograph Uses, safety profile, and every drug interaction in one place Zileuton drug information The full plain-English guide to this medication Zileuton supplement interactions Every supplement checked against Zileuton, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Zileuton and Collard?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.