Drug & supplement interaction

Nadh + Zileuton

Zileuton brand names: Zyflo, Zyflo CR.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Nadh and Zileuton in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Zileuton states a food rule worth keeping to.

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Interaction report

Nadh and Zileuton

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Zileuton and Nadh in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Nadh at all — not against Zileuton, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Nadh safety at a glance

Nadh overall Use caution Generally well tolerated short-term, but long-term safety and quality data are limited.
Pregnancy Avoid Not enough safety information; best to avoid during pregnancy.
Breastfeeding Avoid Not enough safety information; best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Zileuton and Nadh? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Zileuton’s Own FDA Label Lists

This is not an interaction — none of it involves Nadh. These are the most notable effects listed in the ADVERSE REACTIONS section of Zileuton’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on mentioned in 11.9% of FDA reports for Zileuton
  • Liver problems Worth acting on
  • An allergic reaction Worth acting on
  • Stomach upset
  • Stomach pain
  • Nausea mentioned in 6.3% of FDA reports for Zileuton
  • Diarrhea
  • A skin rash
  • Vomiting

From the ADVERSE REACTIONS section of the FDA label for Zileuton. Read the label on DailyMed › Where a percentage is shown, it is the share of 637 voluntary FDA FAERS reports for Zileuton that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Nadh’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Nadh side to compare — that is a limit of the record, not a statement that Nadh has no side effects.

How to take them

Some Zileuton Products Have a Food Rule — Nadh Should Not Break It

At least one FDA label for a product containing Zileuton says to take it with food. If you take Nadh on an empty stomach out of habit, keep them separate — and take Zileuton with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Zileuton products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

For ease of administration, ZYFLO may be taken with meals and at bedtime.

From the Dosage and Administration section of the FDA label we read for Zileuton — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Zileuton

This page covers Nadh only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Zileuton page lists 213 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 163 moderate · 44 minor.

Open the Zileuton interaction page

One more smart check

Taking Nadh as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3 real supplement products containing Nadh, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Nadh. Even though Nadh itself has no known interaction with Zileuton, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Nadh and Zileuton Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Nadh
Steady interest

#976 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Zileuton
Steady interest

#2,387 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Nadh is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Nadh reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Nadh and Zileuton records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Nadh

What is Nadh?

  • Chronic fatigue syndrome
  • Low energy and tiredness
  • Athletic performance
  • Mental clarity and focus
  • Parkinson's disease (investigational)
  • Jet lag

NADH is the active, electron-carrying form of niacin (vitamin B3) that your body uses to make energy in cells. Some people take it as a supplement for fatigue, mental sharpness, and athletic performance, but solid human evidence is limited and mostly preliminary. It appears generally well tolerated in the short term, but talk with your pharmacist or doctor before trying it.

Not applicable (a coenzyme form of vitamin B3/niacin) · Tablets, capsules, sublingual lozenges, sometimes intravenous (clinical settings)

An interaction check asks whether these two react with each other — it does not ask whether Nadh is a good idea for someone in your situation. Here is what our Nadh record says about it on its own.

Nadh: dosing

There is no official, standardized dose of NADH. Doses used in studies have varied, and product strengths differ from brand to brand. Sublingual (under-the-tongue) forms are marketed as being better absorbed, though strong proof for this is limited.The safest approach is to follow the directions on the product label and not exceed the recommended amount. Taking it earlier in the day may help avoid sleep problems.

From our Nadh monograph — the full record covers uses, side effects and every documented interaction.

Read the full Nadh monograph & all interactions
Medication

About Zileuton

What Is Zileuton Used For?

Brand names: Zyflo, Zyflo CR

Zileuton is used for the ongoing prevention and treatment of asthma in adults and adolescents aged 12 and older. It is a maintenance medicine — meaning it is taken regularly to keep asthma under control, not to stop an asthma attack once it has started.

Zyflo (the tablet form) and zileuton extended-release tablets are both approved for this same purpose. Neither form should be used to treat a sudden asthma attack. However, both can be continued during a flare-up of asthma while you also use your rescue inhaler.

See full Zileuton drug information
Keep checking

Other Drugs & Nadh

Browse every other medication we’ve checked against Nadh — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Nadh against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Nadh list.

See the full Nadh interactions page
See every supplement checked against Zileuton, ranked by severity
Evidence & sources

Nadh References

The 1 sources that drive our Nadh monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Nadh is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Niacin - Health Professional Fact Sheet — NIH Office of Dietary Supplements Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Nadh and Zileuton Together: Common Questions

Is it safe to take Nadh with Zileuton?
We do not list a known interaction between Nadh and Zileuton. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Nadh and Zileuton at the same time of day?
At least one FDA label for a product containing Zileuton says to take it with food. If you take Nadh on an empty stomach out of habit, keep them separate and take Zileuton with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Zileuton products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Zileuton interact with any supplements?
Yes. Zileuton has documented interactions with 213 supplements in our database — Nadh is not one of them. The Zileuton interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Nadh monograph Uses, safety profile, and every drug interaction in one place Zileuton drug information The full plain-English guide to this medication Zileuton supplement interactions Every supplement checked against Zileuton, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Zileuton and Nadh?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.