Ground Ivy Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Ground Ivy interacts with medications. The heart of this page is the interaction list — every drug Ground Ivy is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Ground Ivy is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Ground Ivy against your medication
Add one medicationDrugs that interact with Ground Ivy
0 medications have a known interaction with Ground Ivy, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Ground Ivy. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Ground Ivy combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Ground Ivy: Uses, Safety & Side Effects
Ground ivy is a creeping plant in the mint family that has a long history of folk use for coughs, digestive problems, and urinary complaints. Modern human studies are lacking, so its benefits are unproven. Because of safety concerns, it should be avoided during pregnancy and breastfeeding and used cautiously by everyone else.

- Scientific name
- Glechoma hederacea
- Family
- Lamiaceae
- Part used
- Above-ground parts (leaves, flowers, and stems)
- Common forms
- Tea, tincture, dried herb, capsules, and occasionally fresh herb
- Coughs and upper respiratory complaints
- Digestive upset
- Kidney and bladder complaints
- Mild inflammation or arthritis
- Menstrual irregularities
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Limited safety data exist, and high doses or essential oil may be harmful.
When used orally because of abortifacient activity; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Ground ivy (Glechoma hederacea) is a low, creeping plant in the mint family. It is sometimes called creeping Charlie, alehoof, gill-over-the-ground, or catsfoot. It has rounded, scalloped leaves and small purple-blue flowers, and it spreads quickly across lawns and shady areas, where many gardeners consider it a weed.
The plant grows widely in Europe, Asia, and North America. Historically it was added to beer before hops became common, which is one reason for the name "alehoof." In folk medicine, the leaves and flowering tops have been dried and brewed into teas or made into tinctures.
People have traditionally used ground ivy for coughs and chest complaints, digestive troubles, kidney and bladder problems, and as a general tonic. Today it is found in some herbal teas and supplement blends.
How it works
Ground ivy contains a mix of plant compounds, including flavonoids, rosmarinic acid, tannins, terpenes, and a small amount of volatile (essential) oil. These compounds are common in mint-family plants.
In laboratory and animal studies, some of these substances show antioxidant, anti-inflammatory, and mild antimicrobial activity. The tannins may have an astringent effect, which is one proposed reason for its traditional use in digestive and throat complaints.
It is important to know that these mechanisms are based mostly on test-tube and animal research. We do not have good evidence that ground ivy produces meaningful effects in the human body at the amounts found in teas or supplements.
Does Ground Ivy work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Ground Ivy, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Sunburn
It is unclear if topical ground ivy is beneficial for sunburn.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
There is not enough modern research to call ground ivy clearly safe. It has been used as a food and beverage flavoring in the past, which suggests small amounts may be tolerated, but concentrated extracts and the essential oil are more concerning.
The essential oil contains compounds (such as pulegone-related terpenes found in some mint plants) that can be toxic in larger amounts and may stress the liver or kidneys. For this reason, concentrated forms should be avoided.
Pregnancy: Avoid. Ground ivy has been used traditionally to bring on menstruation, which raises concern about pregnancy. Breastfeeding: Avoid, because there is not enough safety information. People with kidney disease, liver disease, or seizure disorders, and young children, should also avoid it unless a doctor advises otherwise.
Always talk with a pharmacist or doctor before trying ground ivy, especially if you have a health condition or take medications.
Side effects
Because ground ivy has not been well studied, its full side effect profile is unknown. Mild stomach upset is possible, especially with strong teas or tinctures.
In animals, particularly horses, eating large amounts of ground ivy has caused poisoning. While people generally consume much smaller amounts, this shows that large or concentrated doses can be harmful.
Allergic reactions are possible, especially in people sensitive to plants in the mint family. Stop using it and seek care if you notice a rash, swelling, trouble breathing, or other signs of a reaction.
Ground Ivy: Reported Adverse Effects
Documented safety reports on Ground Ivy from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally and topically, ground ivy seems to be well tolerated. However, a thorough evaluation of safety outcomes has not been conducted.
Topically: Itching and stinging.
Pruritus Dermatologic
Skin stinging and itching has been reported in patients applying a ground ivy extract 1% lotion twice daily. This occurred during the first two weeks of treatment, but disappeared upon further treatment.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no well-established or standardized dose for ground ivy. Traditional use most often involved a tea made from the dried leaves and flowering tops, or a tincture.
Because product strength varies widely and reliable dosing studies are lacking, the safest approach is to follow the directions on a specific product's label and to start low. Avoid the essential oil and highly concentrated extracts.
Before using ground ivy, check with a pharmacist or doctor — especially if you are pregnant, breastfeeding, have a health condition, or take other medicines.
Ground Ivy & Pregnancy
Ground Ivy & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 2 references that drive our Ground Ivy monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Ha JH, Kang WH, Lee JO, et al. Clinical evaluation of the depigmenting effect of Glechoma Hederacea extract by topical treatment for 8 weeks on UV-induced pigmentation in Asian skin. Eur J Dermatol. 2011;21(2):218-22. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Ground Ivy
4 brands in our database make a supplement containing Ground Ivy.
Supplement products with Ground Ivy
11 products in our database contain Ground Ivy. Open any to see its full ingredient list and every drug interaction we check.
Ground Ivy: Common Questions
What is Ground Ivy used for, and does it work?
Does Ground Ivy interact with prescription medications?
How are Ground Ivy interactions rated?
Is it safe to take Ground Ivy with my medications?
Where does this Ground Ivy interaction information come from?
What is Ground Ivy used for?
Is Ground Ivy safe to take?
Can I use Ground Ivy if I'm pregnant or breastfeeding?
Is Ground Ivy the same as the climbing ivy on walls?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Ground Ivy
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