Herb & supplement monograph

Ground Ivy Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Ground Ivy

0 medications have a known interaction with Ground Ivy, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Ground Ivy. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Ground Ivy combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Ground Ivy: Uses, Safety & Side Effects

The bottom line

Ground ivy is a creeping plant in the mint family that has a long history of folk use for coughs, digestive problems, and urinary complaints. Modern human studies are lacking, so its benefits are unproven. Because of safety concerns, it should be avoided during pregnancy and breastfeeding and used cautiously by everyone else.

Ground Ivy
Scientific name
Glechoma hederacea
Family
Lamiaceae
Part used
Above-ground parts (leaves, flowers, and stems)
Common forms
Tea, tincture, dried herb, capsules, and occasionally fresh herb
People commonly use it for
  • Coughs and upper respiratory complaints
  • Digestive upset
  • Kidney and bladder complaints
  • Mild inflammation or arthritis
  • Menstrual irregularities

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Limited safety data exist, and high doses or essential oil may be harmful.

PregnancyLikely Unsafe

When used orally because of abortifacient activity; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Ground ivy (Glechoma hederacea) is a low, creeping plant in the mint family. It is sometimes called creeping Charlie, alehoof, gill-over-the-ground, or catsfoot. It has rounded, scalloped leaves and small purple-blue flowers, and it spreads quickly across lawns and shady areas, where many gardeners consider it a weed.

The plant grows widely in Europe, Asia, and North America. Historically it was added to beer before hops became common, which is one reason for the name "alehoof." In folk medicine, the leaves and flowering tops have been dried and brewed into teas or made into tinctures.

People have traditionally used ground ivy for coughs and chest complaints, digestive troubles, kidney and bladder problems, and as a general tonic. Today it is found in some herbal teas and supplement blends.

How it works

Ground ivy contains a mix of plant compounds, including flavonoids, rosmarinic acid, tannins, terpenes, and a small amount of volatile (essential) oil. These compounds are common in mint-family plants.

In laboratory and animal studies, some of these substances show antioxidant, anti-inflammatory, and mild antimicrobial activity. The tannins may have an astringent effect, which is one proposed reason for its traditional use in digestive and throat complaints.

It is important to know that these mechanisms are based mostly on test-tube and animal research. We do not have good evidence that ground ivy produces meaningful effects in the human body at the amounts found in teas or supplements.

Effectiveness

Does Ground Ivy work?

Evidence overview · 1 use evaluated
1 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Ground Ivy, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Sunburn
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical ground ivy is beneficial for sunburn.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

There is not enough modern research to call ground ivy clearly safe. It has been used as a food and beverage flavoring in the past, which suggests small amounts may be tolerated, but concentrated extracts and the essential oil are more concerning.

The essential oil contains compounds (such as pulegone-related terpenes found in some mint plants) that can be toxic in larger amounts and may stress the liver or kidneys. For this reason, concentrated forms should be avoided.

Pregnancy: Avoid. Ground ivy has been used traditionally to bring on menstruation, which raises concern about pregnancy. Breastfeeding: Avoid, because there is not enough safety information. People with kidney disease, liver disease, or seizure disorders, and young children, should also avoid it unless a doctor advises otherwise.

Always talk with a pharmacist or doctor before trying ground ivy, especially if you have a health condition or take medications.

Side effects

Because ground ivy has not been well studied, its full side effect profile is unknown. Mild stomach upset is possible, especially with strong teas or tinctures.

In animals, particularly horses, eating large amounts of ground ivy has caused poisoning. While people generally consume much smaller amounts, this shows that large or concentrated doses can be harmful.

Allergic reactions are possible, especially in people sensitive to plants in the mint family. Stop using it and seek care if you notice a rash, swelling, trouble breathing, or other signs of a reaction.

Ground Ivy: Reported Adverse Effects

Documented safety reports on Ground Ivy from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally and topically, ground ivy seems to be well tolerated. However, a thorough evaluation of safety outcomes has not been conducted.

Topically: Itching and stinging.

Reports by condition
Pruritus Dermatologic

Skin stinging and itching has been reported in patients applying a ground ivy extract 1% lotion twice daily. This occurred during the first two weeks of treatment, but disappeared upon further treatment.

  1. Ha JH, Kang WH, Lee JO, et al. Clinical evaluation of the depigmenting effect of Glechoma Hederacea extract by topical treatment for 8 weeks on UV-induced pigmentation in Asian skin. Eur J Dermatol. 2011;21(2):218-22.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no well-established or standardized dose for ground ivy. Traditional use most often involved a tea made from the dried leaves and flowering tops, or a tincture.

Because product strength varies widely and reliable dosing studies are lacking, the safest approach is to follow the directions on a specific product's label and to start low. Avoid the essential oil and highly concentrated extracts.

Before using ground ivy, check with a pharmacist or doctor — especially if you are pregnant, breastfeeding, have a health condition, or take other medicines.

Pregnancy & Breastfeeding

Ground Ivy & Pregnancy

Likely Unsafe

When used orally because of abortifacient activity; avoid using.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

Ground Ivy & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 references that drive our Ground Ivy monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Ha JH, Kang WH, Lee JO, et al. Clinical evaluation of the depigmenting effect of Glechoma Hederacea extract by topical treatment for 8 weeks on UV-induced pigmentation in Asian skin. Eur J Dermatol. 2011;21(2):218-22. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Ground Ivy

4 brands in our database make a supplement containing Ground Ivy.

Pharmacist Counseling Corner

Ground Ivy: Common Questions

What is Ground Ivy used for, and does it work?
People use Ground Ivy for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Ground Ivy interact with prescription medications?
We do not currently list any known drug interactions for Ground Ivy. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Ground Ivy interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Ground Ivy with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Ground Ivy interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Ground Ivy used for?
Traditionally it has been used as a tea for coughs and colds, digestive upset, and kidney or bladder complaints. These uses come from folk tradition and are not proven by good human studies.
Is Ground Ivy safe to take?
Small amounts in tea may be tolerated, but it has not been well studied and concentrated forms or the essential oil may be harmful. Use caution and check with a pharmacist or doctor first.
Can I use Ground Ivy if I'm pregnant or breastfeeding?
No. It has traditionally been used to affect menstruation and there is not enough safety information, so it should be avoided during pregnancy and breastfeeding.
Is Ground Ivy the same as the climbing ivy on walls?
No. Ground Ivy is a low, creeping plant in the mint family (Glechoma hederacea) and is different from English ivy (Hedera helix), which climbs walls and is more toxic.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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