Herb & supplement monograph

Clown's Mustard Plant Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Clown's Mustard Plant

0 medications have a known interaction with Clown's Mustard Plant, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Clown's Mustard Plant. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Clown's Mustard Plant combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Clown's Mustard Plant: Uses, Safety & Side Effects

The bottom line

Clown's Mustard Plant (Iberis amara) is a small flowering herb best known as one ingredient in a popular European multi-herb digestive formula used for indigestion and IBS. Most of the supportive evidence comes from studies of that combination product, not the herb by itself, so it is hard to know how well Clown's Mustard alone works. If you want to try it, talk with your pharmacist or doctor first, especially if you are pregnant, breastfeeding, or have ongoing stomach problems.

Scientific name
Iberis amara
Family
Brassicaceae
Part used
Whole flowering plant (often used fresh or dried), including seeds
Common forms
Liquid herbal extract (a key ingredient in multi-herb combination products), tincture
People commonly use it for
  • Indigestion (dyspepsia)
  • Bloating and stomach fullness
  • Irritable bowel syndrome (IBS) symptoms
  • Heartburn and stomach discomfort
  • Gas and cramping

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally well tolerated as part of standardized combination products, but stand-alone safety data are limited.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Clown's Mustard Plant is a small flowering herb in the mustard (cabbage) family. Its scientific name is Iberis amara, and it is sometimes called bitter candytuft. It grows in parts of Europe and produces clusters of small white or pale flowers.

This herb is most famous as one of several plant ingredients in a well-known European liquid herbal formula used for digestive complaints. In that product, Clown's Mustard is combined with other herbs such as peppermint, chamomile, licorice, and others. It is much less common to find Clown's Mustard sold on its own.

People most often take it (usually as part of the combination product) for stomach upset, bloating, and symptoms of irritable bowel syndrome.

How it works

Researchers believe Clown's Mustard Plant may affect how the muscles in the digestive tract move. In laboratory studies, it has shown a tonic (tightening) effect on gut muscle, while other herbs in the common combination product seem to relax the gut. The idea is that combining herbs with opposite actions may help normalize digestion.

The plant contains natural compounds such as glucosinolates (typical of the mustard family) and flavonoids that may have mild anti-inflammatory or antioxidant effects in lab settings.

These proposed mechanisms come mostly from laboratory and animal research. How well they apply to people is not fully proven.

Effectiveness

Does Clown's Mustard Plant work?

Evidence overview · 1 use evaluated
1 Possibly effective
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Dyspepsia
Rating & evidence shown verbatim from Natural Medicines

A specific combination product containing clown's mustard plant (Iberogast, Medical Futures, Inc) seems to improve symptoms of dyspepsia. The combination includes clown's mustard plant plus peppermint leaf, German chamomile, caraway, licorice, milk thistle, celandine, angelica, and lemon balm. A meta-analysis of studies using this combination product suggests that taking 1 mL orally three times daily over a period of 4 weeks significantly reduces severity of acid reflux, epigastric pain, cramping, nausea, and vomiting compared to placebo.

Sources Ref 7049 Ref 12724 Ref 13089

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

As part of standardized combination products, Clown's Mustard Plant appears to be reasonably well tolerated in studies. However, safety data for the herb taken alone are limited, so caution is wise.

People with liver problems should be careful. The combination product that contains this herb has, in rare cases, been linked to reports of liver injury, though it is unclear which ingredient (if any) was responsible. Stop use and seek medical care if you notice yellowing of the skin or eyes, dark urine, severe stomach pain, or unusual tiredness.

People with allergies to plants in the mustard or cabbage family should be cautious. Pregnant and breastfeeding people should avoid this herb because there is not enough information to know it is safe. Always check with your pharmacist or doctor before starting any new supplement, especially if you have an ongoing health condition.

Side effects

When used in the common combination products, reported side effects are usually mild and may include stomach upset, nausea, or allergic-type skin reactions.

Rare but more serious concerns include allergic reactions and, very uncommonly, liver problems reported with the multi-herb formula. Seek medical attention right away if you have signs of a serious allergic reaction (such as rash, swelling, or trouble breathing) or symptoms of liver trouble.

Clown's Mustard Plant: Reported Adverse Effects

Documented safety reports on Clown's Mustard Plant from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, clown's mustard plant can cause nausea and diarrhea in some patients. Some patients might be hypersensitive to clown's mustard plant. There is one case of a facial rash following oral use.

  1. Steimer P. Iberogast therapy in gastroenterology. Der Krankenhaus Arzt 1983;56:1005-8.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no well-established stand-alone dose for Clown's Mustard Plant. In practice, it is almost always taken as part of a standardized liquid combination product, where the dose is set by the manufacturer.

If you use a product containing this herb, follow the directions on the label and do not exceed the recommended amount. Because formulas and concentrations vary, ask your pharmacist to help you understand the correct dose and whether the product is right for you.

Pregnancy & Breastfeeding

Clown's Mustard Plant & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Clown's Mustard Plant & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 4 references that drive our Clown's Mustard Plant monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Holtmann G, Madisch A, Juergen H, et al. A double-blind, randomized, placebo-controlled trial on the effects of an herbal preparation in patients with functional dyspepsia [Abstract]. Ann Mtg Digestive Disease Week 1999 May.
  2. Steimer P. Iberogast therapy in gastroenterology. Der Krankenhaus Arzt 1983;56:1005-8.
  3. Madisch A, Holtmann G, Mayr G, et al. Treatment of functional dyspepsia with a herbal preparation. A double-blind, randomized, placebo-controlled, multicenter trial. Digestion 2004;69:45-52. PubMed
  4. Melzer J, Rosch W, Reichling J, et al. Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast). Aliment Pharmacol Ther 2004;20:1279-87. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Clown's Mustard Plant

1 brand in our database make a supplement containing Clown's Mustard Plant.

Product directory

Supplement products with Clown's Mustard Plant

3 products in our database contain Clown's Mustard Plant. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

Clown's Mustard Plant: Common Questions

What is Clown's Mustard Plant used for, and does it work?
People use Clown's Mustard Plant for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Clown's Mustard Plant for Dyspepsia. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Clown's Mustard Plant interact with prescription medications?
We do not currently list any known drug interactions for Clown's Mustard Plant. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Clown's Mustard Plant interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Clown's Mustard Plant with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Clown's Mustard Plant interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Clown's Mustard Plant used for?
It is most often used for digestive problems such as indigestion, bloating, and symptoms of irritable bowel syndrome, usually as one ingredient in a multi-herb combination product.
Does Clown's Mustard Plant actually work?
The combination product that contains it has shown some benefit for indigestion in studies, but there is little evidence for the herb taken by itself, so its individual effect is unclear.
Is Clown's Mustard Plant safe to take?
It is generally well tolerated as part of standardized products, but stand-alone safety data are limited and rare liver concerns have been reported with the combination formula, so check with your pharmacist or doctor first.
Can I take it while pregnant or breastfeeding?
No. There is not enough safety information, so it is best to avoid Clown's Mustard Plant during pregnancy and breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Products that contain Clown's Mustard Plant

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