Clown's Mustard Plant Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Clown's Mustard Plant interacts with medications. The heart of this page is the interaction list — every drug Clown's Mustard Plant is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Clown's Mustard Plant is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
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0 medications have a known interaction with Clown's Mustard Plant, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Clown's Mustard Plant. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Clown's Mustard Plant combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Clown's Mustard Plant: Uses, Safety & Side Effects
Clown's Mustard Plant (Iberis amara) is a small flowering herb best known as one ingredient in a popular European multi-herb digestive formula used for indigestion and IBS. Most of the supportive evidence comes from studies of that combination product, not the herb by itself, so it is hard to know how well Clown's Mustard alone works. If you want to try it, talk with your pharmacist or doctor first, especially if you are pregnant, breastfeeding, or have ongoing stomach problems.
- Scientific name
- Iberis amara
- Family
- Brassicaceae
- Part used
- Whole flowering plant (often used fresh or dried), including seeds
- Common forms
- Liquid herbal extract (a key ingredient in multi-herb combination products), tincture
- Indigestion (dyspepsia)
- Bloating and stomach fullness
- Irritable bowel syndrome (IBS) symptoms
- Heartburn and stomach discomfort
- Gas and cramping
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally well tolerated as part of standardized combination products, but stand-alone safety data are limited.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Clown's Mustard Plant is a small flowering herb in the mustard (cabbage) family. Its scientific name is Iberis amara, and it is sometimes called bitter candytuft. It grows in parts of Europe and produces clusters of small white or pale flowers.
This herb is most famous as one of several plant ingredients in a well-known European liquid herbal formula used for digestive complaints. In that product, Clown's Mustard is combined with other herbs such as peppermint, chamomile, licorice, and others. It is much less common to find Clown's Mustard sold on its own.
People most often take it (usually as part of the combination product) for stomach upset, bloating, and symptoms of irritable bowel syndrome.
How it works
Researchers believe Clown's Mustard Plant may affect how the muscles in the digestive tract move. In laboratory studies, it has shown a tonic (tightening) effect on gut muscle, while other herbs in the common combination product seem to relax the gut. The idea is that combining herbs with opposite actions may help normalize digestion.
The plant contains natural compounds such as glucosinolates (typical of the mustard family) and flavonoids that may have mild anti-inflammatory or antioxidant effects in lab settings.
These proposed mechanisms come mostly from laboratory and animal research. How well they apply to people is not fully proven.
Does Clown's Mustard Plant work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
Possibly Effective Dyspepsia
A specific combination product containing clown's mustard plant (Iberogast, Medical Futures, Inc) seems to improve symptoms of dyspepsia. The combination includes clown's mustard plant plus peppermint leaf, German chamomile, caraway, licorice, milk thistle, celandine, angelica, and lemon balm. A meta-analysis of studies using this combination product suggests that taking 1 mL orally three times daily over a period of 4 weeks significantly reduces severity of acid reflux, epigastric pain, cramping, nausea, and vomiting compared to placebo.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
As part of standardized combination products, Clown's Mustard Plant appears to be reasonably well tolerated in studies. However, safety data for the herb taken alone are limited, so caution is wise.
People with liver problems should be careful. The combination product that contains this herb has, in rare cases, been linked to reports of liver injury, though it is unclear which ingredient (if any) was responsible. Stop use and seek medical care if you notice yellowing of the skin or eyes, dark urine, severe stomach pain, or unusual tiredness.
People with allergies to plants in the mustard or cabbage family should be cautious. Pregnant and breastfeeding people should avoid this herb because there is not enough information to know it is safe. Always check with your pharmacist or doctor before starting any new supplement, especially if you have an ongoing health condition.
Side effects
When used in the common combination products, reported side effects are usually mild and may include stomach upset, nausea, or allergic-type skin reactions.
Rare but more serious concerns include allergic reactions and, very uncommonly, liver problems reported with the multi-herb formula. Seek medical attention right away if you have signs of a serious allergic reaction (such as rash, swelling, or trouble breathing) or symptoms of liver trouble.
Clown's Mustard Plant: Reported Adverse Effects
Documented safety reports on Clown's Mustard Plant from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, clown's mustard plant can cause nausea and diarrhea in some patients. Some patients might be hypersensitive to clown's mustard plant. There is one case of a facial rash following oral use.
- Steimer P. Iberogast therapy in gastroenterology. Der Krankenhaus Arzt 1983;56:1005-8.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no well-established stand-alone dose for Clown's Mustard Plant. In practice, it is almost always taken as part of a standardized liquid combination product, where the dose is set by the manufacturer.
If you use a product containing this herb, follow the directions on the label and do not exceed the recommended amount. Because formulas and concentrations vary, ask your pharmacist to help you understand the correct dose and whether the product is right for you.
Clown's Mustard Plant & Pregnancy
Clown's Mustard Plant & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 4 references that drive our Clown's Mustard Plant monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Holtmann G, Madisch A, Juergen H, et al. A double-blind, randomized, placebo-controlled trial on the effects of an herbal preparation in patients with functional dyspepsia [Abstract]. Ann Mtg Digestive Disease Week 1999 May.
- Steimer P. Iberogast therapy in gastroenterology. Der Krankenhaus Arzt 1983;56:1005-8.
- Madisch A, Holtmann G, Mayr G, et al. Treatment of functional dyspepsia with a herbal preparation. A double-blind, randomized, placebo-controlled, multicenter trial. Digestion 2004;69:45-52. PubMed
- Melzer J, Rosch W, Reichling J, et al. Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast). Aliment Pharmacol Ther 2004;20:1279-87. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Clown's Mustard Plant
1 brand in our database make a supplement containing Clown's Mustard Plant.
Supplement products with Clown's Mustard Plant
3 products in our database contain Clown's Mustard Plant. Open any to see its full ingredient list and every drug interaction we check.
Clown's Mustard Plant: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Clown's Mustard Plant
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