Herb & supplement monograph

Black Rice Drug Interactions, Uses, Effectiveness, Safety & More

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Reviewed by licensed pharmacists Sourced from Natural Medicines
Interaction report

Drugs that interact with Black Rice

0 medications have a known interaction with Black Rice, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Black Rice. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Black Rice combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Black Rice: Uses, Safety & Side Effects

The bottom line

Black rice is a nutritious whole-grain food that is rich in fiber, plant protein, and antioxidant pigments called anthocyanins. Eaten as part of a balanced diet it is a healthy choice, but strong human evidence that black rice or its extracts treat or prevent specific diseases is still limited. Talk with your pharmacist or doctor before using concentrated black rice supplements.

Black Rice
Scientific name
Oryza sativa
Family
Poaceae
Part used
Whole grain (bran and endosperm)
Common forms
Whole grain, cooked rice, flour, rice bran, extracts, and supplement capsules
People commonly use it for
  • Heart health support
  • Antioxidant intake
  • Digestive and gut health
  • Blood sugar and weight management
  • General nutrition

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallLikely safe

As a food, black rice is generally safe for most people when eaten in normal amounts.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid amounts greater than those commonly found in foods.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid amounts greater than those commonly found in foods.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Black rice is a variety of rice (Oryza sativa) that has a deep purple-black color, a nutty flavor, and a slightly chewy texture. It is sometimes called "forbidden rice" because, according to tradition, it was once reserved for royalty in parts of Asia. Today it is widely available in grocery and health-food stores.

Its dark color comes from natural plant pigments called anthocyanins, the same kind of antioxidants found in blueberries and blackberries. Compared with white rice, black rice keeps its bran layer, so it tends to have more fiber, protein, and antioxidants.

People mostly use black rice as a whole-grain food in savory and sweet dishes. It is also sold as flour and, less commonly, as bran or extract supplements marketed for their antioxidant content.

How it works

The most studied compounds in black rice are anthocyanins, the purple-black pigments in its bran. In laboratory research, these act as antioxidants, meaning they may help reduce damage from unstable molecules called free radicals.

Black rice also contains fiber, which supports digestion and helps you feel full, and plant protein and minerals. The fiber may slow the rise in blood sugar after meals compared with refined white rice.

It is important to know that much of this evidence comes from test-tube and animal studies. How well these effects carry over to people eating normal portions of black rice is not fully proven.

Effectiveness

Does Black Rice work?

Evidence overview · 7 uses evaluated
7 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Black Rice, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 7 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Age-related cognitive decline
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black rice extract is beneficial for improving memory in older adults.

Insufficient Reliable Evidence To Rate Allergic rhinitis (hay fever)
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral black rice for allergic rhinitis, there is insufficient reliable information about the clinical effects of black rice for this condition.

Insufficient Reliable Evidence To Rate Atopic dermatitis (eczema)
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral black rice for eczema, there is insufficient reliable information about the clinical effects of black rice for this condition.

Insufficient Reliable Evidence To Rate Coronary Heart Disease (CHD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black rice pigment is beneficial for improving metabolic parameters in adults with CHD.

Insufficient Reliable Evidence To Rate Hyperlipidemia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black rice is beneficial in patients with hyperlipidemia.

Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black rice extract is beneficial for weight loss in postmenopausal adults.

Insufficient Reliable Evidence To Rate Physical performance
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black rice improves physical performance in older adults.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

As a food, black rice is generally safe for most people and can be prepared and eaten like other rice. It is naturally gluten-free, which can make it useful for people avoiding gluten.

Like all rice, black rice can absorb arsenic from soil and water. To lower exposure, you can rinse rice well before cooking, cook it in extra water, and eat a variety of grains rather than rice at every meal.

People with diabetes or who count carbohydrates should remember that black rice is still a starchy food and should be counted in meal planning. If you are considering concentrated black rice extracts or supplements, talk with your pharmacist or doctor first, since these are not well studied.

Pregnancy and breastfeeding: Black rice is fine to eat as a normal food during pregnancy and breastfeeding. However, concentrated supplements and extracts have not been tested for safety in these groups, so it is best to avoid them unless your healthcare provider approves.

Side effects

Black rice eaten as a food rarely causes problems. Because it is high in fiber, eating large amounts—especially if you are not used to it—may cause gas, bloating, or changes in bowel habits.

Allergic reactions to rice are uncommon but possible. Stop using it and seek care if you notice rash, itching, swelling, or trouble breathing.

Little is known about the side effects of concentrated black rice extracts, so use such products cautiously and only as directed.

Dosing

There is no established medicinal dose for black rice. As a food, a typical serving is a cooked portion similar to other rice, included as part of a balanced diet.

For supplements or extracts, follow the directions on the product label, since amounts vary by product and have not been standardized. Because these products are not well studied, check with your pharmacist or doctor before starting one, especially if you have a health condition or take other medicines.

Pregnancy & Breastfeeding

Black Rice & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid amounts greater than those commonly found in foods.

Black Rice & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid amounts greater than those commonly found in foods.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 sources that drive our Black Rice monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.

  1. Arsenic in Rice and Rice Products — U.S. Food and Drug Administration (FDA) Source
  2. Dietary Fiber — MedlinePlus (NIH) Source
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Product directory

Supplement products with Black Rice

37 products in our database contain Black Rice. Open any to see its full ingredient list and every drug interaction we check.

AntiOxidant Synergy by SuperSmart Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Beauty by FitLine Powder 6.88 Ounce(s) · 195 Gram(s) View ingredients & interactions Black Rice 500 mg by Everyday Health Capsule 60 Capsule(s) View ingredients & interactions Black Rice Extract by BioAnue Capsule 90 Capsule(s) · 380 mg View ingredients & interactions Black Rice Extract by BulkSupplements.com Powder 500 Gram(s) · 17.6 Ounce(s) View ingredients & interactions Black Rice Extract by BulkSupplements.com Powder 250 Gram(s) · 8.8 Ounce(s) View ingredients & interactions Black Rice Extract by BulkSupplements.com Powder 3.5 Ounce(s) · 100 Gram(s) View ingredients & interactions Black Rice Extract by BulkSupplements.com Powder 50 Gram(s) · 1.76 Ounce(s) View ingredients & interactions Black Rice Extract by BulkSupplements.com Powder 500 Gram(s) · 17.6 Oz(s) View ingredients & interactions Black Rice Extract by BioAnue Capsule 10 Capsule(s) · 380 mg View ingredients & interactions Black Rice Extract by BulkSupplements.com Powder 1 kg · 35.3 oz View ingredients & interactions Black Rice Extract by BulkSupplements.com Powder 50 Gram(s) · 1.76 Oz(s) View ingredients & interactions Black Rice Extract by BulkSupplements.com Powder 3.5 Ounce(s) · 100 Gram(s) View ingredients & interactions Black Rice Extract by BulkSupplements.com Powder 1 Kilogram(s) · 35.3 Ounce(s) View ingredients & interactions Black Rice Extract by BulkSupplements.com Powder 250 Gram(s) · 8.8 Oz(s) View ingredients & interactions Dark Matter Blue Raspberry by MHP Maximum Human Performance Powder 2.6 lb · 1200 g View ingredients & interactions Dark Matter Fruit Punch by MHP Maximum Human Performance Powder 2.6 lb · 1200 g View ingredients & interactions Essential Wellbeing Complex by Highbrow Hippie Capsule 120 Capsule(s) View ingredients & interactions Formula 503X 460 mg by TumoRx Capsule 1200 Capsule(s) View ingredients & interactions Formula 503X 460 mg by TumoRx Capsule 400 Capsule(s) View ingredients & interactions Formula 503X 460 mg by TumoRx Capsule 10 Capsule(s) View ingredients & interactions Global Greens by MRM Powder 3.5 Oz(s) · 100 Gram(s) View ingredients & interactions Global Greens by MRM Powder 8 Oz(s) · 225 Gram(s) View ingredients & interactions Immune + by Plexus Capsule 60 Capsule(s) View ingredients & interactions
Pharmacist Counseling Corner

Black Rice: Common Questions

What is Black Rice used for, and does it work?
People use Black Rice for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Black Rice interact with prescription medications?
We do not currently list any known drug interactions for Black Rice. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Black Rice interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Black Rice with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Black Rice interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Black Rice used for?
People mostly eat Black Rice as a nutritious whole grain and choose it for its fiber and antioxidant pigments. It is popularly linked to heart, digestive, and blood sugar health, but it is best thought of as a healthy food rather than a proven treatment.
Is Black Rice healthier than white rice?
Black Rice keeps its bran layer, so it usually has more fiber, protein, and antioxidants than white rice. This generally makes it a more nutritious choice, though both can be part of a healthy diet.
Is Black Rice safe during pregnancy?
Eaten as a normal food, Black Rice is fine during pregnancy. Concentrated Black Rice supplements or extracts have not been well studied in pregnancy, so it is safer to avoid them unless your doctor says otherwise.
Can Black Rice cause any side effects?
It is well tolerated for most people, but its high fiber content may cause gas or bloating if you eat a lot at once. Like all rice, it can contain trace arsenic, so rinsing it and eating a variety of grains is a good idea.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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