Major interaction on record — check this product against your medications before combining. Based on 1 of 6 ingredients. Check your meds →
Dietary supplement

Dark Matter Blue Raspberry Ingredients & Drug Interactions

by MHP Maximum Human Performance

Dark Matter Blue Raspberry label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Dark Matter Blue Raspberry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Dark Matter Blue Raspberry is a dietary supplement by MHP Maximum Human Performance with 6 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,027 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Dietary Fiber. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Dark Matter Blue Raspberry by MHP Maximum Human Performance

Ask about any prescription or over-the-counter medication and we check it for interactions with Dark Matter Blue Raspberry by MHP Maximum Human Performance — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Dark Matter Blue Raspberry by MHP Maximum Human Performance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 17 active ingredients.
  • “Dark Matter Proprietary Blend” is a proprietary blend — the label gives one combined amount (60 g) without saying how much of each component you get.
  • “Waximax-C3G” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “HydroSize” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Dark Matter Blue Raspberry is a 16-ingredient amino acid and carbohydrate powder designed for athletic performance. Its active ingredients include essential amino acids—L-leucine, L-isoleucine, L-valine, L-methionine, L-phenylalanine, L-histidine, L-threonine, and L-lysine—along with glucose polymers (maltoplex-18) for rapid carbohydrate delivery, creatine (in the IntraPhase and MicroTein components) for muscle strength and performance, and proprietary blends (Dark Matter, Waximax-C3G, HydroSize, and others) whose exact amounts aren't disclosed.

The product also contains inactive ingredients—black rice extract, lecithin, citric acid, malic acid, natural and artificial flavors, silica, and food colorings (blue #1, red #40)—plus sweeteners (acesulfame potassium and sucralose). These excipients are added for taste, stability, and appearance.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: post-workout muscle growth and recovery.
  • We looked for evidence on: Athletic performance, Muscle strength, Muscle breakdown, Physical performance, Postoperative recovery, Muscle hypertrophy — and 2 related terms.
  • The strongest evidence on file: Glycerol is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Athletic performance, Muscle strength.
  • Also on file: Lysine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Muscle strength.

The evidence for this product's ingredients is mixed. Creatine (IntraPhase and MicroTein components) is possibly effective for muscle strength and athletic performance, and possibly effective for sarcopenia (age-related muscle loss).

Glycerol is possibly effective for athletic performance. L-phenylalanine is possibly effective for vitiligo (a pigmentation disorder), though evidence for ADHD is insufficient.

L-lysine is possibly effective for herpes labialis (cold sores). The other amino acids lack established effectiveness ratings in our data, or their evidence is insufficient to rate.

If you're taking this product to support athletic performance and muscle gains, the creatine and glycerol components have some evidence behind them, but we'd recommend discussing your specific goals with your doctor or a sports nutritionist.

The evidence, ingredient by ingredient Black Psyllium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Creatine (IntraPhase and MicroTein) is generally well tolerated in healthy adults but requires caution if you have kidney problems; most common side effects are dehydration, diarrhea, gastrointestinal upset, muscle cramps, and water retention. Glycerol, the amino acids L-methionine, L-phenylalanine, L-histidine, L-threonine, and L-lysine are generally well tolerated at typical doses, though they may cause stomach upset, headache, dizziness, nausea, or constipation in some people.

L-phenylalanine should be avoided by anyone with phenylketonuria (PKU), a genetic condition affecting how the body processes this amino acid. Creatine safety during pregnancy and breastfeeding has not been established, so it should be avoided in those situations; L-phenylalanine should also be avoided in pregnancy and while breastfeeding due to lack of safety data.

For the other ingredients, pregnancy and breastfeeding data are either not established or not well studied—discuss this product with your doctor before using it if you're pregnant or nursing.

Side effects, ingredient by ingredient Black Psyllium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 8 matched ingredients can interact with medications — Black Psyllium, Lysine, Phenylalanine, Threonine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 2,028 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you're on levodopa (Parkinson disease), monoamine oxidase inhibitors or MAOIs (older antidepressants and some blood pressure drugs), baclofen (muscle relaxant), NMDA antagonists (used for memory and neurological conditions), or 5-HT4 agonists. These are the medication types with documented interactions in this product's ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Dark Matter Blue Raspberry is an amino acid and carbohydrate supplement aimed at athletes and people training for muscle and strength gains, with some evidence supporting its creatine and glycerol content. It carries significant interaction risks with levodopa, MAOIs, baclofen, NMDA antagonists, and 5-HT4 agonists, so if you take any prescription medications—especially for Parkinson disease, depression, blood pressure, muscle spasticity, or neurological conditions—run this product through the checker below or talk to your pharmacist before you start.

If you're pregnant, nursing, or have kidney issues, discuss this with your doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 17 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Dark Matter Blue Raspberry, straight from the product label.

Brand MHP Maximum Human Performance
Barcode (UPC) 666222011462
Net contents 2.6 lb; 1200 g
Market status On market
Date entered into DSLD Feb 23, 2012
DSLD ID 5751
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Dark Matter Blue Raspberry by MHP Maximum Human Performance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
60.7 Gram(s)
Maximum serving Sizes:
60.7 Gram(s)
Servings per container
20
UPC/BARCODE
666222011462
IngredientAmount% DV
Calories240 {Calories}--
Total Carbohydrates48 g16%
Sugar10 g--
Calories from Fat0 g--
Total Fat0 g--
Dietary Fiber0 g--
Protein12 g20%
Saturated Fat0 g--
Trans Fat0 g--
Cholesterol0 g--
L-Leucine0 NP--
Waxy Maize0 NP--
Glycerol Monostearate0 NP--
L-Isoleucine0 NP--
L-Methionine0 NP--
L-Phenylalanine0 NP--
L-Valine0 NP--
L-Histidine0 NP--
L-Threonine0 NP--
L-Lysine0 NP--
Dark Matter Proprietary Blend60 g--
Waximax-C3G0 NP--
Maltoplex-18 Glucose Polymers0 NP--
C3G Anthocyanidins0 NP--
HydroSize0 NP--
IstaPeak0 NP--
IntraPhase0 NP--
MicroTein0 NP--
ProSynthagen0 NP--
Free Form Infusion0 NP--
Leucrose Peptide Infusion0 NP--

Other ingredients: Black Rice extract, Lecithin, Citric Acid, Malic Acid, Natural and Artificial flavors, Silica, Blue #1, Red #40, Acesulfame Potassium, Sucralose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

The Ultimate Post Workout Muscle Growth Accelerator* Fast Absorption Than Whey-Stimulates Protein Synthesis-Dramatically Spikes Insulin-Maximizes Creating Uptake and Glycogen Replenishment*

Blue Raspberry

Don’t waste another workout! If you want to start gaining serious size, chug down some DARK MATTER and introduce your muscles to a new frontier of muscle growth as you enter the ANABOLIC AXIS. The biggest opportunity to stimulate muscle growth is immediately after your workout. The faster you can get critical nutrients into your bloodstream and muscles, the better. DARK MATTER employs new technologies and compounds which allow for the fastest possible nutrient uptake and sparks a synergistic anabolic reaction in which insulin levels simultaneously peak with amino acid, creatine and glycogen transport at the Anabolic Axis to trigger extreme muscle growth and speed recovery.*

Every Workout Ends with DARK MATTER… Enter the Anabolic Axis for the Most Powerful Anabolic Reaction Ever Experienced!*

High Velocity Nano - Physics

High Velocity Nano-Physics: New Technology for Rapid Absorption & Bioavailability The final step in taking post-workout supplementation into a new anabolic dimension was the development of a new type of nano-technology, called High Velocity Nano-Physics. This technology is based on high velocity particle physics collision of nano-fusible compatible materials. High Velocity Nano-Physics allows for maximum speed, bio-effectiveness and micro-nutrient timing to open the Anabolic window fast and create a synergistic delivery of ProSynthagen, WaxiMax-C3G and HydroSize to simultaneously peak at the “Anabolic Axis.”*

Brand IP Statement(s)

HydroSIZE(TM): Multi-phase Creatine Transport & Cell Volumizing Matrix To complete the anabolic infusion, MHP’s research team developed HyrdoSIZE, which is a multi-source creatine/glycerol complex for the greatest muscle volumizing and bioenergetic creatine loading into muscle tissue. This complex provides an optimal amount of creatine in the form of Creatine Pyruvate and Creating Gluconate to quickly be transported in tandem with peak insulin levels, amino acids and glycogen at the Anabolic Axis. The inclusion of MicroTein, a microencapsulated sustained release creating provides a continuous supply of creatine for maximum creatine saturation and cell volumizing.*

ProSYNTHAGEN(TM): Increases Protein Synthesis Faster Than Whey ProSynthagen’s unique combination of essential free form amino acids greatly stimulates protein synthesis faster than whey protein isolate. ProSynthagen isn’t just fast, it’s powerful too-each serving stimulates protein synthesis equivalent to 40 grams of protein. Additionally, ProSynthagen’s amino acid matrix is fine-tuned with “Dual Portal Transport” for even faster and greater intestinal uptake by combining these powerful free form aminos with Leucrose(TM), an exclusive newly developed leucine-alanine dipeptide. Leucrose(TM) also increases anabolic activity by regulating protein synthesis and sparing critical Branched Chain Amino Acids. These unique characteristics give ProSynthagen a much higher Protein Synthesis Score than any other protein source, which will result in the greatest muscle building effects.*

The Ultimate Post Workout Muscle Growth Acclerator* Absorbs Faster Than Whey Isolate* 600% Increase in Protein Synthesis-Equal to 40 Grams of Protein* Dramatically Spikes Insulin with WaxiMAX-C3G(TM)* Multi-Phase HydroSIZE(TM) Creatine Transport* Replenishes Glycogen and Increases Cell Volume*

WaxiMAX(TM)-C3G: Dramatically Spikes Insulin and Replenishes Glycogen! WaxiMax-C3G is a tri-polymer carbohydrate matrix comprised of low viscosity, high molecular weight, osmotic waxy maize starch, Maltoplex-18 glucose polymer and dextrose. This matrix allows for fast gastric emptying, a quick, powerful insulin spike and maximum glycogen replenishment. WaxiMax-C3G’s tri-polymer matrix was developed to deliver the precise infusion to illicit the best insulin response to open the anabolic window faster and keep it open longer. Amazingly, this tri-polymer greatly increases insulin levels with only 10 grams of sugar-a huge benefit over most creatine products and post workout formulas. And to make things even better and more anabolic, DARK MATTER, contains a patented concentrated source of C3G (cyaniding-3-glucoside), which improves insulin sensitivity for increased nutrient transport, protein syntheis, creatine/nutrient uptake and glycogen replenishment.*

Precautions

Do not purchase if seal is broken.

Keep out of reach of children.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: DARK MATTER is your Ultimate Post Workout Muscle Growth Accelerator designed to be taken immediately after your workout before you consume any other shake or meal. All other substances will only slow down the precise nutrient infusion of the High Velocity nano-physic particles in Dark Matter, shorten your anabolic window and impede maximum muscle growth and recovery.* Add 2 scoops to 20oz of water in a glass or shaker bottle immediately after training. Stir or shake vigorously. Any other post-workout shake or meal may be taken 1 hour later.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Protect from heat, light and moisture.

Store at 15-30(0)C (59-86(0)F).

General

B833

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Dark Matter Blue Raspberry by MHP Maximum Human Performance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Dark Matter Blue Raspberry label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Dark Matter Blue Raspberry by MHP Maximum Human Performance

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size60.7 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

10 g per serving

Dietary Fiber

Interacts with
2,025 drugs
0 g per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Protein

12 g per serving

Dark Matter Proprietary Blend

60 g per serving
  • › Waximax-C3G
  • › HydroSize
  • › ProSynthagen

Other (inactive) ingredients: Black Rice extract, Lecithin, Citric Acid, Malic Acid, Natural and Artificial flavors, Silica, Blue #1, Red #40, Acesulfame Potassium, Sucralose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Dark Matter Blue Raspberry by MHP Maximum Human Performance Drug Interactions

Want to check YOUR meds against Dark Matter Blue Raspberry?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,027Drugs
8 Major 34 Moderate 1,985 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025

Individual Drug Interactions

The ingredients in Dark Matter Blue Raspberry interact with 2,027 drugs. Click any drug to see the details.

1 of the 6 ingredients in Dark Matter Blue Raspberry interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber

Each ingredient & the kinds of drugs it affects

For each ingredient in Dark Matter Blue Raspberry with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Dark Matter Blue Raspberry, from the product label.

MHP Maximum Human Performance

See all MHP Maximum Human Performance products
Name
Maximum Human Performance, Inc.
Street Address
21 Dwight Place
City
Fairfield
State
NJ
ZipCode
07004
Phone Number
1.888.783.8844
Web Address
www.getMHP.com
Pharmacist Counseling Corner

Dark Matter Blue Raspberry by MHP Maximum Human Performance: Common Questions

Does Dark Matter Blue Raspberry by MHP Maximum Human Performance interact with any medications?
Yes. Based on its ingredients, Dark Matter Blue Raspberry has a known interaction with 2,027 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Dark Matter Blue Raspberry contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Not safely based on the data we have. Creatine and L-phenylalanine should be avoided during pregnancy; L-phenylalanine should also be avoided while breastfeeding. For other ingredients, pregnancy and breastfeeding safety hasn't been well studied. Talk to your doctor or midwife before using this product in either situation.
What does creatine in this product do?
Creatine supports muscle strength and athletic performance, and may help with age-related muscle loss (sarcopenia). It works by helping your muscles produce energy during intense exercise. The most common side effect is water retention; some people also report muscle cramps or diarrhea.
Is this product safe if I have kidney problems?
No—creatine requires caution in people with kidney issues, and this product contains creatine in two components (IntraPhase and MicroTein). Talk to your doctor before using it if you have kidney disease or are at risk for it.
What are the amino acids in this for?
The amino acids—leucine, isoleucine, valine, methionine, phenylalanine, histidine, threonine, and lysine—are the building blocks your body uses to build and repair muscle tissue. Together with the creatine and carbohydrates, they're designed to support muscle recovery and performance during and after training.
Does this product have any fillers?
It contains several inactive ingredients added for taste, texture, and appearance—including black rice extract, lecithin, citric acid, malic acid, natural and artificial flavors, silica, and food colorings. These are standard in powdered supplements and don't add nutritional value.
Can I take this with my blood pressure medication?
It depends which one. If you're on an older antidepressant or blood pressure drug called an MAOI (monoamine oxidase inhibitor), this product's L-phenylalanine may interact and raise the risk of dangerously high blood pressure. Check your exact medication with your pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Dark Matter Blue Raspberry is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Dark Matter Blue Raspberry label
Go deeper

The Full Monographs Behind Dark Matter Blue Raspberry’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph →
Sources

Sources & How We Checked

Dark Matter Blue Raspberry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 161 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
  5. Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
  6. Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
  7. Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
  8. Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
  9. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
  10. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  11. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  12. Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
  13. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
  15. Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
  16. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  17. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  18. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

See these in context on the Black Psyllium monograph →

Glycerol 8 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Wagner DR. Hyperhydrating with glycerol: implications for athletic performance. J Am Diet Assoc 1999;99:207-12. PubMed
  3. Yu YL, Kumana CR, Lauder IJ, et al. Treatment of acute cortical infarct with intravenous glycerol. A double-blind, placebo-controlled randomized trial. Stroke 1993;24:1119-24. PubMed
  4. Frei A, Cottier C, Wunderlich P, Ludin E. Glycerol and dextran combined in the therapy of acute stroke. A placebo-controlled, double-blind trial with a planned interim analysis. Stroke 1987;18:373-9. PubMed
  5. Balaskas E, Szepietowski JC, Bessis D, Ioannides D, Ponticelli C, Ghienne C, Taberly A, Dupuy P. Randomized, double-blind study with glycerol and paraffin in uremic xerosis. Clin J Am Soc Nephrol. 2011 Apr;6(4):748-52. PubMed
  6. Blanchet-Bardon C, Tadini G, Machado Matos M, Delarue A. Association of glycerol and paraffin in the treatment of ichthyosis in children: an international, multicentric, randomized, controlled, double-blind study. J Eur Acad Dermatol Venereol. 2012 Aug;26 PubMed
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Histidine 3 references
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See these in context on the Creatine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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