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Olanzapine

Olanzapine is an atypical antipsychotic used to treat schizophrenia and bipolar I disorder (manic, mixed and, with fluoxetine, depressive episodes), and to calm acute agitation linked to those conditions when given by injection.

Brand names ZyprexaZYPREXA ZydisZYPREXA RelprevvOlanzapine IntramuscularZYPREXA Intramuscular
Drug class Atypical Antipsychotic
Rx Forms 4
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 98 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 6, 2026 🚨Recall on record
Other forms & routes:
Injection
Olanzapine at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Olanzapine is an atypical antipsychotic for schizophrenia and bipolar I disorder, thought to work by blocking dopamine and serotonin signals; on the market since about 1996 and available generically, it is regarded as one of the more effective options, though often not the first tried. Drowsiness and a bigger appetite are what most people notice, and weight gain is common. The thing to watch is weight, blood sugar and cholesterol, checked with fasting labs and weigh-ins before and during treatment; its boxed warning is a higher risk of death in older adults with dementia-related psychosis, a use it is not approved for. Never stop or change it without your prescriber.

Clinical pearls

  • Food does not affect absorption, and many people take it in the evening because it tends to cause drowsiness.
  • Fluvoxamine can raise olanzapine levels, while carbamazepine, omeprazole and rifampin can lower them, so mention any of these to prescribers.
  • Alcohol and blood pressure medicines can deepen its dizziness on standing, so get up slowly, especially in the first weeks.
  • Report extreme thirst, frequent urination or unusual hunger, which can signal blood sugar climbing, even without diabetes.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Olanzapine is not approved for dementia-related psychosis, and older adults with dementia who take antipsychotics have a higher risk of death. In trials, deaths were about 4.5% with these drugs versus about 2.6% with placebo. Most deaths were from heart problems (such as heart failure or sudden death) or infections (such as pneumonia). Strokes and mini-strokes were also more common. If you care for someone with dementia who takes olanzapine, talk to their prescriber.

Read the full warning on DailyMed →
How you get itPrescription only
Comes asTablet, Orally disintegrating tablet, Injection +1
Earliest FDA record1996
Companies listing it with the FDA44
FDA label last updatedNov 18, 2025
FDA’s strongest warning (boxed)Yes, read the warning

Patient information guide A plain-language walkthrough of Olanzapine, written from its FDA label.

What Olanzapine is used for

▾

Olanzapine is approved for several uses, depending on the product.

  • Oral olanzapine (tablets and orally disintegrating tablets): schizophrenia in adults and teens ages 13 to 17.
  • Oral olanzapine: manic or mixed episodes of bipolar I disorder, and maintenance treatment, in adults and teens.
  • Oral olanzapine: added to lithium or valproate for manic or mixed episodes in adults.
  • Olanzapine for injection (intramuscular): acute agitation with schizophrenia or bipolar I mania in adults.
  • Zyprexa Relprevv (long-acting intramuscular): schizophrenia.
  • Oral olanzapine with fluoxetine: depressive episodes of bipolar I disorder.

How Olanzapine works

▾

The exact way olanzapine works is unclear. Its benefit in schizophrenia may come from blocking dopamine and serotonin type 2 receptors in the brain. It also binds to histamine, adrenergic and muscarinic receptors, which may help explain side effects such as sleepiness, dizziness and dry mouth.

Olanzapine dosage

▾

Oral olanzapine is generally taken once a day, with or without food. The injection forms are given by a healthcare professional. Your prescriber chooses the starting dose, which is often lower for teens, frail patients or those sensitive to the drug.

  • Olanzapine for injection: given into a muscle, with up to three doses allowed a few hours apart if needed.
  • Zyprexa Relprevv: deep buttock injection on a schedule of every few weeks, after tolerability with oral olanzapine is established.

Follow your prescriber’s and label directions.

Dosing details from the FDA-approved label

From the Olanzapine prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Schizophrenia in adults (oral)
    • Start at 5-10 mg once daily
    • Target dose of 10 mg/day within several days
    • Dosage adjustments generally at intervals of not less than 1 week; increments/decrements of 5 mg QD recommended; lower starting dose in debilitated or pharmacodynamically sensitive patients or those predisposed to hypotensive reactions
  • Schizophrenia in adolescents (oral)
    • Start at 2.5-5 mg once daily
    • Target 10 mg/day
  • Bipolar I Disorder (manic or mixed episodes) in adults (oral)
    • Start at 10 or 15 mg once daily
  • Bipolar I Disorder (manic or mixed episodes) in adolescents (oral)
    • Start at 2.5-5 mg once daily
    • Target 10 mg/day
  • Bipolar I Disorder (manic or mixed episodes) with lithium or valproate in adults (oral)
    • Start at 10 mg once daily
  • Agitation associated with Schizophrenia and Bipolar I Mania in adults (IM)
    • 10 mg (5 mg or 7.5 mg when clinically warranted)
    • Maximum: max. 3 doses 2-4 hrs apart
    • Assess for orthostatic hypotension prior to subsequent dosing
  • Depressive Episodes associated with Bipolar I Disorder in adults (oral, in combination with fluoxetine)
    • Start at 5 mg of oral olanzapine and 20 mg of fluoxetine once daily
    • Maximum: Safety of co-administration of doses above 18 mg olanzapine with 75 mg fluoxetine has not been evaluated in adults
  • Depressive Episodes associated with Bipolar I Disorder in children and adolescents (oral, in combination with fluoxetine)
    • Start at 2.5 mg of oral olanzapine and 20 mg of fluoxetine once daily
    • Maximum: Safety of co-administration of doses above 12 mg olanzapine with 50 mg fluoxetine has not been evaluated in children and adolescents ages 10 to 17
  • Treatment Resistant Depression in adults (oral, in combination with fluoxetine)
    • Start at 5 mg of oral olanzapine and 20 mg of fluoxetine once daily
    • Maximum: Safety of co-administration of doses above 18 mg olanzapine with 75 mg fluoxetine has not been evaluated in adults
  • Zyprexa Relprevv (long-acting injection), patients debilitated, predisposed to hypotensive reactions, or with factors causing slower metabolism (e.g., nonsmoking females ≥65 years) or pharmacodynamic sensitivity
    • Recommended starting dose 150 mg/4 wks
    • Maximum: Doses above 405 mg every 4 weeks or 300 mg every 2 weeks have not been evaluated in clinical trials
    • Dose escalation with caution when indicated
Read the label’s full dosing text

2 DOSAGE AND ADMINISTRATION Schizophrenia in adults (2.1) Oral: Start at 5 to 10 mg once daily; Target: 10 mg/day within several days Schizophrenia in adolescents ( 2.1 ) Oral: Start at 2.5 to 5 mg once daily; Target: 10 mg/day Bipolar I Disorder (manic or mixed episodes) in adults (2.2) Oral: Start at 10 or 15 mg once daily Bipolar I Disorder (manic or mixed episodes) in adolescents (2.2) Oral: Start at 2.5 to 5 mg once daily; Target: 10 mg/day Bipolar I Disorder (manic or mixed episodes) with lithium or valproate in adults (2.2) Oral: Start at 10 mg once daily Depressive Episodes associated with Bipolar I Disorder in adults (2.5) Oral in combination with fluoxetine: Start at 5 mg of oral olanzapine and 20 mg of fluoxetine once daily Depressive Episodes associated with Bipolar I Disorder in children and adolescents (2.5) Oral in combination with fluoxetine: Start at 2.5 mg of oral olanzapine and 20 mg of fluoxetine once daily Treatment Resistant Depression in adults ( 2.6) Oral in combination with fluoxetine: Start at 5 mg of oral olanzapine and 20 mg of fluoxetine once daily Lower starting dose recommended in debilitated or pharmacodynamically sensitive patients or patients with predisposition to hypotensive reactions, or with potential for slowed metabolism. ( 2.1 ) Olanzapine may be given without regard to meals. ( 2.1 ) Olanzapine and Fluoxetine in Combination: Dosage adjustments, if indicated, should be made with the individual components according to efficacy and tolerability. ( 2.5, 2.6 ) Olanzapine monotherapy is not indicated for the treatment of depressive episodes associated with bipolar I disorder or treatment resistant depression. ( 2.5, 2.6 ) Safety of co-administration of doses above 18 mg olanzapine with 75 mg fluoxetine has not been evaluated in adults. ( 2.5, 2.6 ) Safety of co-administration of doses above 12 mg olanzapine with 50 mg fluoxetine has not been evaluated in children and adolescents ages 10 to 17. (2.5) 2.1 Schizophrenia Adults Dose Selection — Oral olanzapine should be administered on a once-a-day schedule without regard to meals, generally beginning with 5 to 10 mg initially, with a target dose of 10 mg/day within several days.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Olanzapine side effects

▾

Common side effects in trials included:

Common side effects

  • Sleepiness or drowsiness
  • Dizziness
  • Dry mouth
  • Constipation
  • Weight gain and increased appetite
  • Weakness or tiredness
  • Tremor or restlessness (akathisia)
  • Low blood pressure when standing

When to get medical help

  • Get help right away for fever, stiff muscles, confusion, fast or irregular heartbeat or heavy sweating (possible neuroleptic malignant syndrome).
  • Call your doctor for a rash with fever, swollen glands or signs of organ problems (possible DRESS, a serious drug reaction).
  • Call your doctor for extreme thirst, frequent urination, increased hunger or weakness (possible high blood sugar).
  • Tell your doctor about uncontrolled muscle movements (tardive dyskinesia).
  • Seek help if you faint or feel very dizzy, especially when starting treatment.
  • Report signs of infection, since olanzapine can lower white blood cell counts.
  • Report seizures.
  • Tell your doctor right away about thoughts of suicide or self-harm.

Olanzapine warnings and precautions

▾
  • Dementia-related psychosis: higher risk of death and stroke in older adults.
  • Metabolic changes: high blood sugar, abnormal cholesterol and triglycerides, and weight gain.
  • Neuroleptic malignant syndrome and DRESS: rare but serious reactions.
  • Tardive dyskinesia: movements you cannot control.
  • Low blood pressure when standing, mostly early in treatment.
  • Low white blood cell counts, seizures, and impaired thinking or movement.
  • Suicide risk is part of these illnesses, so close monitoring matters.

Olanzapine interactions

▾

Several drugs and substances can change how olanzapine works or add to its effects.

  • Alcohol and diazepam: can worsen dizziness and low blood pressure.
  • Carbamazepine, omeprazole, rifampin: may lower olanzapine levels by speeding clearance.
  • Fluvoxamine: raises olanzapine levels.
  • Blood pressure medicines: effect may be stronger.
  • Levodopa and dopamine agonists: olanzapine may reduce their effect.
  • Anticholinergic drugs: higher risk of serious gut slowing.
  • Lithium and valproate: no dose changes needed for olanzapine’s effect on them.

Interactions listed in the FDA-approved label

From the Olanzapine prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Diazepam: Co-administration potentiated the orthostatic hypotension observed with olanzapine; olanzapine did not influence diazepam pharmacokinetics.
  • Alcohol: Potentiated the orthostatic hypotension observed with olanzapine; ethanol did not affect olanzapine pharmacokinetics. Caution when taken with centrally acting drugs and alcohol
  • Carbamazepine: Carbamazepine therapy (200 mg bid) causes an approximately 50% increase in the clearance of olanzapine. Higher carbamazepine doses may cause an even greater increase in clearance
  • Fluvoxamine: Decreases olanzapine clearance; mean Cmax increase 54% in female nonsmokers and 77% in male smokers; mean AUC increase 52% and 108%, respectively. Lower doses of olanzapine should be considered
  • Fluoxetine: Causes a small (mean 16%) increase in olanzapine maximum concentration and small (mean 16%) decrease in clearance. Dose modification not routinely recommended; refer to Symbyax package insert when used in combination
  • Cimetidine and antacids (aluminum- and magnesium-containing): Did not affect the oral bioavailability of olanzapine.
  • Omeprazole and rifampin: May cause an increase in olanzapine clearance.
  • Activated charcoal: Reduced Cmax and AUC of oral olanzapine by about 60%. Charcoal may be a useful treatment for olanzapine overdose
  • Anticholinergic drugs: Can increase the risk for severe gastrointestinal adverse reactions related to hypomotility. Use olanzapine with caution
  • Antihypertensive agents: Olanzapine may enhance the effects of certain antihypertensive agents.
Read the label’s full interactions text

7 DRUG INTERACTIONS The risks of using olanzapine in combination with other drugs have not been extensively evaluated in systematic studies. Diazepam: May potentiate orthostatic hypotension. ( 7.1 , 7.2 ) Alcohol: May potentiate orthostatic hypotension. ( 7.1 ) Carbamazepine: Increased clearance of olanzapine. ( 7.1 ) Fluvoxamine: May increase olanzapine levels. ( 7.1 ) Olanzapine and Fluoxetine in Combination: Also refer to the Drug Interactions section of the package insert for Symbyax. ( 7.1 ) CNS Acting Drugs: Caution should be used when taken in combination with other centrally acting drugs and alcohol. ( 7.2 ) Antihypertensive Agents: Enhanced antihypertensive effect. ( 7.2 ) Levodopa and Dopamine Agonists: May antagonize levodopa/dopamine agonists. ( 7.2 ) Other Concomitant Drug Therapy: When using olanzapine in combination with lithium or valproate, refer to the Drug Interactions sections of the package insert for those products. ( 7.2 ) 7.1 Potential for Other Drugs to Affect Olanzapine Diazepam — The co-administration of diazepam with olanzapine potentiated the orthostatic hypotension observed with olanzapine [ see Drug Interactions (7.2) ] . Cimetidine and Antacids — Single doses of cimetidine (800 mg) or aluminum- and magnesium-containing antacids did not affect the oral bioavailability of olanzapine. Inducers of CYP1A2 — Carbamazepine therapy (200 mg bid) causes an approximately 50% increase in the clearance of olanzapine. This increase is likely due to the fact that carbamazepine is a potent inducer of CYP1A2 activity. Higher daily doses of carbamazepine may cause an even greater increase in olanzapine clearance. Alcohol — Ethanol (45 mg/70 kg single dose) did not have an effect on olanzapine pharmacokinetics. The co-administration of alcohol (i.e., ethanol) with olanzapine potentiated the orthostatic hypotension observed with olanzapine [see Drug Interactions (7.2)].

Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿160 supplements and herbs with documented Olanzapine interactions, ranked by severity Check Olanzapine against a supplement or herb →

Before taking Olanzapine

▾
  • Not approved for dementia-related psychosis.
  • No listed contraindications for olanzapine alone.
  • Pregnancy: third-trimester use can cause movement or withdrawal symptoms in newborns.
  • Breastfeeding: olanzapine passes into milk.
  • Not established for children under 13.
  • Teens: greater weight gain and cholesterol changes.
  • Older adults: a lower starting dose may be considered.
  • Diabetes, seizures, low white blood cell counts, heart or blood vessel disease: caution.

Olanzapine overdose

▾

Overdose can cause drowsiness, slurred speech, agitation, fast heartbeat, abnormal movements and reduced consciousness, up to coma. Serious cases may involve breathing problems, seizures or heart rhythm changes. There is no specific antidote, so call Poison Control at 1-800-222-1222 or seek emergency care.

What Olanzapine does in the body

▾

Olanzapine binds strongly to serotonin (5HT2A/2C, 5HT6), dopamine (D1 to D4), histamine H1 and adrenergic alpha-1 receptors. It has moderate binding to serotonin 5HT3 and muscarinic receptors, and low binding to GABA-A, benzodiazepine and beta-adrenergic receptors.

How your body processes Olanzapine

▾

Oral olanzapine is well absorbed, peaking in about 6 hours, and food doesn’t affect absorption. Its half-life averages about 30 hours, so steady levels build over about a week of daily dosing. It is heavily metabolized by the liver and excreted in urine and feces. Injected into a muscle, it peaks within 15 to 45 minutes.

How to store Olanzapine

▾

Store ZYPREXA tablets, ZYPREXA ZYDIS, and ZYPREXA IntraMuscular vials (before reconstitution) at controlled room temperature, 20° to 25°C (68° to 77°F) . stored at controlled room temperature, 20° to 25°C (68° to 77°F) for up to 1 hour if necessary. do not freeze.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

160

Supplements & herbs that interact with Olanzapine

160 supplements and herbal products have documented interactions with Olanzapine in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 4
  • Moderate · 118
  • Minor · 38
ACTIVATED CHARCOAL Major INDIAN SNAKEROOT Major LITHIUM Major RAUVOLFIA VOMITORIA Major 1,3-DMAA Moderate 5-HTP Moderate ACACIA RIGIDULA Moderate ACETYL-L-CARNITINE Moderate +152 more
Every supplement checked against Olanzapine — ranked by severity The full interaction hub: 4 major · 118 moderate · 38 minor · every one linked to its full report. Check Olanzapine against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

Olanzapine: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Olanzapine — the kind of thing our pharmacy team would talk through with you at the counter.

What is olanzapine for?

▾
It treats schizophrenia and manic or mixed episodes of bipolar I disorder, and can be added to lithium or valproate. An injection form is used for sudden agitation with those conditions, and with fluoxetine it treats bipolar I depressive episodes.

How should I take it?

▾
Oral olanzapine is usually taken once a day, with or without food. Take it as your prescriber directs and don’t stop on your own. Injections are given by a healthcare professional.

What side effects should I expect?

▾
Sleepiness, dizziness, dry mouth, constipation, increased appetite and weight gain are common. Stand up slowly, especially at first. Your prescriber will check blood sugar, cholesterol and weight.

When should I call my doctor?

▾
Call right away for fever with stiff muscles or confusion, a severe rash, fainting, seizures, uncontrolled movements, extreme thirst or urination, or thoughts of self-harm.

Can I drink alcohol or take other medicines with it?

▾
Alcohol and diazepam can make dizziness and low blood pressure worse. Carbamazepine, fluvoxamine and some others change olanzapine levels. Tell me about everything you take, including blood pressure pills.

Is it safe in pregnancy?

▾
Babies exposed late in pregnancy can have shaking, feeding trouble or withdrawal symptoms. Studies haven’t shown a clear rise in birth defects, but untreated illness has risks too. Talk with your prescriber before changing anything.

Is Olanzapine available over the counter?

▾
No. Olanzapine is a prescription medicine: every Olanzapine product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Olanzapine first available?

▾
The earliest FDA record we hold for Olanzapine is from 1996: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Olanzapine was first used.

Who makes Olanzapine?

▾
44 companies currently list Olanzapine products in the FDA's NDC Directory, including Remedyrepack Inc., Coupler LLC, H2-Pharma LLC. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Olanzapine on HelloPharmacist

📊Olanzapine supplement interactions160 checked — ranked by severity 🌿Drug & Supplement CheckerOlanzapine vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Olanzapine NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Olanzapine Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Olanzapine forms and strengths (how it comes)

Olanzapine is available in 4 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Olanzapine inactive ingredients by manufacturer.

Tablet

By mouth
Brands Zyprexa
How this form is used
What it may be used for
  • Olanzapine tablets are used for schizophrenia and for manic or mixed episodes of bipolar I disorder, including maintenance.
  • Olanzapine tablets can be used with lithium or valproate for manic or mixed episodes in adults.
Important instructions
  • Olanzapine tablets are generally taken by mouth once daily, with or without food.
Available strengths 6 strengths
2.5 mg 5 mg 7.5 mg 10 mg 15 mg 20 mg
319 FDA-listed product records ⓘ

Orally disintegrating tablet

By mouth
Brands Zyprexa
How this form is used
What it may be used for
  • Olanzapine orally disintegrating tablets are used for schizophrenia and for manic or mixed episodes of bipolar I disorder.
Important instructions
  • Zyprexa Zydis tablets and Zyprexa tablets are bioequivalent (absorbed to a similar extent), and olanzapine is generally taken by mouth once daily.
Available strengths 4 strengths
5 mg 10 mg 15 mg 20 mg
134 FDA-listed product records ⓘ

Injection

By injection · Into a muscle
Brands Zyprexa
How this form is used
What it may be used for
  • Olanzapine for injection is used for acute agitation linked to schizophrenia and bipolar I mania in adults.
  • Zyprexa Relprevv is a long-acting injection used for schizophrenia.
Important instructions
  • Olanzapine for injection is given into a muscle, with blood pressure checked before further doses.
  • Zyprexa Relprevv is for deep gluteal (buttock) muscle injection only, not into a vein or under the skin.
  • Zyprexa Relprevv is available only through a restricted program (REMS) and is not dispensed directly to patients.
Available strengths 5 strengths
10 mg 10 mg/2 mL 210 mg/1.4 mL 300 mg/2 mL 405 mg/2.7 mL
28 FDA-listed product records ⓘ

Oral suspension

By mouth
Available strengths 1 strength
1 mg/mg
2 FDA-listed product records ⓘ

Olanzapine on the U.S. market: products, makers and brands

How Olanzapine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

44 companies list 222 Olanzapine product records with the FDA, mostly as tablet, orally disintegrating tablet, injection; the earliest marketing or approval year on record is 1996. Brand names on the directory include Zyprexa, ZYPREXA Zydis, ZYPREXA Relprevv and 2 more; the rest are generics.

4
Dose forms ⓘ
44
Labelers (makers, repackagers, distributors)
6
Brand names
222
FDA-listed product records ⓘ
1996
Earliest FDA record ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (22) · Kit (6) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Remedyrepack Inc.7%
Coupler LLC6%
H2-Pharma LLC6%
Bryant Ranch Prepack5%
Apotex Corp.5%
Aurobindo Pharma Limited5%
Other makers67%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Olanzapine is used (Medicaid data)

A general measure of how commonly Olanzapine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Olanzapine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

2,565,436
Medicaid prescriptions filled (Q1–Q4 2025)
$37.6M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Olanzapine prescribed? Of the 1,601 medications we measure, Olanzapine ranks #91 by Medicaid prescriptions — more than 94% of them.

Where Olanzapine ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #91 of 1,601
#86 Mirtazapine 2,693,128 Rx #87 Sodium Chloride 2,643,128 Rx #88 Methylprednisolone 2,620,269 Rx #89 Ketoconazole 2,593,228 Rx #90 Ketoconazole Topical 2,579,373 Rx #91 Olanzapine 2,565,436 Rx #92 Naproxen 2,556,513 Rx #93 Methylprednisolone Inj... 2,550,742 Rx #94 Spironolactone 2,528,169 Rx #95 Oseltamivir 2,322,109 Rx #96 Insulin Lispro Injecti... 2,318,237 Rx

Utilization by Olanzapine product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 10 mg oral tablet is the most-dispensed Olanzapine product — about 26% of these Medicaid prescriptions.

olanzapine 10 MG Oral Tablet Most dispensed

667,844 Medicaid prescriptions (Q1–Q4 2025) 26% of Olanzapine prescriptions shown $9M gross reimbursement (before rebates) ≈ $13 per prescription (gross)

Summed across the 18 of 117 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 314154

olanzapine 5 MG Oral Tablet

625,447 Medicaid prescriptions (Q1–Q4 2025) 24% of Olanzapine prescriptions shown $7.3M gross reimbursement (before rebates) ≈ $12 per prescription (gross)

Summed across the 19 of 136 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 312078

olanzapine 20 MG Oral Tablet

435,258 Medicaid prescriptions (Q1–Q4 2025) 17% of Olanzapine prescriptions shown $7.3M gross reimbursement (before rebates) ≈ $17 per prescription (gross)

Summed across the 18 of 94 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 283639

olanzapine 15 MG Oral Tablet

308,760 Medicaid prescriptions (Q1–Q4 2025) 12% of Olanzapine prescriptions shown $4.5M gross reimbursement (before rebates) ≈ $14 per prescription (gross)

Summed across the 18 of 89 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 312077

olanzapine 2.5 MG Oral Tablet

224,421 Medicaid prescriptions (Q1–Q4 2025) 9% of Olanzapine prescriptions shown $2.5M gross reimbursement (before rebates) ≈ $11 per prescription (gross)

Summed across the 16 of 116 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 200034

olanzapine 7.5 MG Oral Tablet

105,233 Medicaid prescriptions (Q1–Q4 2025) 4% of Olanzapine prescriptions shown $1.2M gross reimbursement (before rebates) ≈ $12 per prescription (gross)

Summed across the 12 of 99 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 312079

olanzapine 5 MG Disintegrating Oral Tablet

77,554 Medicaid prescriptions (Q1–Q4 2025) 3% of Olanzapine prescriptions shown $1.6M gross reimbursement (before rebates) ≈ $21 per prescription (gross)

Summed across the 9 of 45 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 314155

olanzapine 10 MG Disintegrating Oral Tablet

57,405 Medicaid prescriptions (Q1–Q4 2025) 2% of Olanzapine prescriptions shown $1.5M gross reimbursement (before rebates) ≈ $26 per prescription (gross)

Summed across the 8 of 41 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 312076

olanzapine 20 MG Disintegrating Oral Tablet

29,674 Medicaid prescriptions (Q1–Q4 2025) 1% of Olanzapine prescriptions shown $1.1M gross reimbursement (before rebates) ≈ $36 per prescription (gross)

Summed across the 7 of 40 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 351108

olanzapine 15 MG Disintegrating Oral Tablet

21,458 Medicaid prescriptions (Q1–Q4 2025) <1% of Olanzapine prescriptions shown $713,197 gross reimbursement (before rebates) ≈ $33 per prescription (gross)

Summed across the 7 of 39 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 351107

olanzapine 10 MG Injection

11,946 Medicaid prescriptions (Q1–Q4 2025) <1% of Olanzapine prescriptions shown $474,995 gross reimbursement (before rebates) ≈ $40 per prescription (gross)

Summed across the 9 of 16 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 485968

olanzapine 405 MG Injection

394 Medicaid prescriptions (Q1–Q4 2025) <1% of Olanzapine prescriptions shown $462,970 gross reimbursement (before rebates) ≈ $1,175 per prescription (gross)

Summed across the 2 of 3 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1718925

olanzapine 300 MG Injection

42 Medicaid prescriptions (Q3–Q4 2025) <1% of Olanzapine prescriptions shown $56,264 gross reimbursement (before rebates) ≈ $1,340 per prescription (gross)

Summed across the 1 of 3 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1718930

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Olanzapine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 144 of 838 listed Olanzapine NDCs with Medicaid activity.

Compare Olanzapine products

A representative set of FDA-listed product records for Olanzapine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 200 of 222 products — FDA National Drug Code Directory. See every product, package size and price: browse all 222 Olanzapine NDCs →

Olanzapine side effects reported to the FDA (FAERS)

After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Olanzapine — a signal of what to watch for, not proof the drug caused it.

The effects most often named in FDA reports that mention Olanzapine are weight increased, diabetes mellitus, drug interaction; about 85% of the reports were classed as serious. These are voluntary reports, so they show what people report, not how often it happens.

109,183
Reports mentioning it
85%
Reported as serious
12
Distinct effects shown
Most reported effects
Weight Increased
6,930
Diabetes Mellitus
5,413
Drug Interaction
4,209
Toxicity To Various Agents
4,209
Nausea
4,139
Somnolence
4,131
Fatigue
3,686
Anxiety
3,515
Overdose
3,481
Vomiting
3,370
Age groups
Adult · 8,691Elderly · 2,698Adolescent · 577Neonate · 318Child · 287Infant · 80

Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Olanzapine in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.

Olanzapine FDA approval history

How Olanzapine went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.

Olanzapine was first approved by the FDA in 1996 (Brand: ZYPREXA · Cheplapharm); the first generic version was approved in 2011. It remains available in U.S. pharmacies today.

1996
Brand approved
Brand: ZYPREXA · Cheplapharm
2011
First generic approved
Lower-cost ANDA competition begins
2026
Available today
Active in U.S. pharmacies

Source: Drugs@FDA.

Olanzapine recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list 2 Olanzapine recalls since July 2021. One of them is still ongoing and is listed first. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.

Ongoing Class II Nov 25, 2024 · Macleods Pharmaceuticals Ltd
Failed Impurities/Degradation Specifications
  • Olanzapine Tablets, USP 2.5 mg, 30-count bottle, Rx Only, Manufactured for: Macleods Pharma USA, Inc. Princeton, NJ 08540, Manufactured for: Macleods Pharma USA Inc. Princeton, NJ,08540: Manufactured… Lots: Lot# BOB12318A Exp 07/31/2027 FDA record D-0154-2025 →
Class II Feb 16, 2022 · Terminated · Macleods Pharma Usa Inc
cGmp Deviations
  • Olanzapine Tablets, USP 10 mg, 30-count bottles, Rx only, Manufactured for: Macleods Pharma USA , Inc. Plainsboro, NJ 08536, Manufactured by: Macleods Pharmaceuticals Ltd., Baddi, HImachal Pradesh, I… Lots: Lot #: BOB42029A, BOB4202B, Exp. Date 09/2022 FDA record D-0639-2022 →

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Olanzapine RxCUI 61381 3 dose forms · 14 strengths
  1. Dose form (SCDF) Disintegrating Oral Tablet RxCUI 374627 In current FDA listings
    Clinical drug / strength (SCD) 5 MG RxCUI 314155 10 MG RxCUI 312076 15 MG RxCUI 351107 20 MG RxCUI 351108
  2. Dose form (SCDF) Injection RxCUI 1718924 In current FDA listings
    Clinical drug / strength (SCD) 10 MG RxCUI 485968 210 MG RxCUI 1718934 300 MG RxCUI 1718930 405 MG RxCUI 1718925
  3. Dose form (SCDF) Oral Tablet RxCUI 373142 In current FDA listings
    Clinical drug / strength (SCD) 2.5 MG RxCUI 200034 5 MG RxCUI 312078 7.5 MG RxCUI 312079 10 MG RxCUI 314154 15 MG RxCUI 312077 20 MG RxCUI 283639

Look up RxCUI 61381 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Olanzapine costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Tablet, Film Coated · Oral 7.5 mg $0.094 per tablet NDC details & price history
Tablet, Orally Disintegrating · Oral 5 mg $0.304 per tablet NDC details & price history
Tablet, Orally Disintegrating · Oral 10 mg $0.366 per tablet NDC details & price history
Tablet, Orally Disintegrating · Oral 15 mg $0.639 per tablet NDC details & price history
Tablet, Orally Disintegrating · Oral 20 mg $0.722 per tablet NDC details & price history
Tablet · Oral 10 mg $0.115 per tablet NDC details & price history
Tablet · Oral 2.5 mg $0.085 per tablet NDC details & price history
Tablet · Oral 20 mg $0.190 per tablet NDC details & price history
Tablet · Oral 15 mg $0.138 per tablet NDC details & price history
Tablet · Oral 5 mg $0.093 per tablet NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Olanzapine brand names

Olanzapine is sold under 5 brand names in the FDA directory — Zyprexa, ZYPREXA Zydis, ZYPREXA Relprevv, Olanzapine Intramuscular and others. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Zyprexa ZYPREXA Zydis ZYPREXA Relprevv Olanzapine Intramuscular ZYPREXA Intramuscular

Who makes Olanzapine: manufacturers and labelers

44 companies list Olanzapine products with the FDA. By number of product records, the largest are Remedyrepack Inc., Coupler LLC, H2-Pharma LLC. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Remedyrepack Inc. 15 Coupler LLC 14 H2-Pharma LLC 14 Bryant Ranch Prepack 11 Apotex Corp. 10 Aurobindo Pharma Limited 10 Golden State Medical Supply, Inc. 10 HEC Pharm USA Inc. 10 Macleods Pharmaceuticals Limited 10 Torrent Pharmaceuticals Limited 10 NorthStar RxLLC 7 Proficient Rx LP 7 Qilu Pharmaceutical Co., Ltd. 7 Ascend Laboratories, LLC 6 Cadila Pharmaceuticals Limited 6 Modavar Pharmaceuticals LLC 6 American Health Packaging 5 NCS HealthCare of KY, LLC dba Vangard Labs 5 Bionpharma Inc. 4 Dr.Reddy's Laboratories Limited 4 Jubilant Cadista Pharmacuticals Inc. 4 Lannett Company, Inc. 4 Major Pharmaceuticals 4 Strides Pharma Science Limited 4

…and 20 more on the FDA NDC directory.

Olanzapine drug class (RxNorm)

Olanzapine belongs to the Atypical Antipsychotic class.

Pharmacologic class Atypical Antipsychotic
Drug family (ATC) Diazepines, oxazepines, thiazepines and oxepines

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Olanzapine page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Nov 18, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Olanzapine.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Olanzapine after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
98
Finished products in the current FDA directory
222
Companies listing them (makers, repackagers, distributors)
44
FDA labeler codes behind them ⓘ
48
Linked representative label ⓘ
Eli Lilly and Company
Linked label effective
Nov 18, 2025
Composite sections available
26
Linked SPL Set ID
d5051fbc-846b-4946-82df-341fb1216341
Linked SPL Document ID
9073f34c-307c-4a3a-8273-580ef5742229
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Eli Lilly and Company is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →