Medication interaction hub

What Supplements Interact with Olanzapine?

Olanzapine brand name: Zyprexa. Every interaction below applies to the brands too.

160 Interactions 4 Major 118 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Olanzapine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Olanzapine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Olanzapine (Zyprexa) is an antipsychotic prescribed for schizophrenia and bipolar disorder, and adding supplements to it warrants genuine care. Four of the 160 ingredients on file rate major, and those four deserve your attention before anything else: lithium supplements raise the risk of serotonin syndrome, activated charcoal can trap the medication before it ever absorbs, and two rauwolfia herbs, Indian snakeroot among them, can intensify olanzapine's tranquilizing effects.

The other 118 moderate and 38 minor entries mostly work through the liver. Olanzapine is cleared by enzymes called CYP1A2 and CYP2D6, and dozens of ingredients can speed those enzymes up or slow them down, nudging the drug's level in either direction. A smaller group of 20 adds to serotonin, six can make seizures slightly more likely, and 17 can interfere with how any pill absorbs. If a supplement matters to you, ask your pharmacist how it fits with this medication rather than guessing.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 118 Minor 38 No known interaction 1,292

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Olanzapine: Top Interactions at a Glance

The Olanzapine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 160 interacting ingredients — plus 1,292 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Olanzapine Combinations Today

The Olanzapine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Melatonin + Olanzapinei

Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.

Read the full interaction Minor Likelihood Possible Rhodiola + Olanzapinei

Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.

Read the full interaction Minor Likelihood Possible Ginger + Olanzapinei

Theoretically, ginger might increase the levels of CYP1A2 substrates.

Read the full interaction Moderate Likelihood Possible Psilocybin + Olanzapinei

Theoretically, combining psilocybin with serotonergic drugs might cause additive serotonergic effects.

Read the full interaction Minor Likelihood Possible Ashwagandha + Olanzapinei

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.

Read the full interaction Moderate Likelihood Possible German Chamomile + Olanzapinei

Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.

Read the full interaction
The complete list

Every Supplement Checked Against Olanzapine

All 1,452 ingredients in our database, ranked by severity — 160 with a Olanzapine interaction on file and 1,292 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Olanzapine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Melatonin with Olanzapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.

Full Melatonin + Olanzapine answer

Can you take Rhodiola with Olanzapine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.

Full Rhodiola + Olanzapine answer

Can you take Ginger with Olanzapine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ginger might increase the levels of CYP1A2 substrates.

Full Ginger + Olanzapine answer

Can you take Psilocybin with Olanzapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining psilocybin with serotonergic drugs might cause additive serotonergic effects.

Full Psilocybin + Olanzapine answer

Can you take Ashwagandha with Olanzapine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.

Full Ashwagandha + Olanzapine answer

Can you take Methylene Blue with Olanzapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining serotonergic drugs with methylene blue can cause additive serotonergic effects, including serotonin syndrome.

Full Methylene Blue + Olanzapine answer

Can you take N,n-dmpea with Olanzapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that N,N-DMPEA strongly inhibits cytochrome P450 2D6 (CYP2D6).

Full N,n-dmpea + Olanzapine answer

Can you take Neem with Olanzapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP1A2 substrates.

Full Neem + Olanzapine answer

Can you take Nutmeg with Olanzapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, nutmeg might decrease levels of drugs metabolized by CYP1A2.

Full Nutmeg + Olanzapine answer

Can you take Oregon Grape with Olanzapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP2D6.

Full Oregon Grape + Olanzapine answer

Can you take Panax Ginseng with Olanzapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng might increase levels of drugs metabolized by CYP2D6.

Full Panax Ginseng + Olanzapine answer

Can you take Panax Notoginseng with Olanzapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Panax notoginseng might reduce the levels and clinical effects of CYP1A2 substrates.

Full Panax Notoginseng + Olanzapine answer

Can you take Parsley with Olanzapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, parsley might increase serum levels of CYP1A2 substrates.

Full Parsley + Olanzapine answer

Can you take Peony with Olanzapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.

Full Peony + Olanzapine answer

Can you take Phellodendron with Olanzapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2D6.

Full Phellodendron + Olanzapine answer

Can you take Phenethylamine (pea) with Olanzapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of serotonergic adverse effects.

Full Phenethylamine (pea) + Olanzapine answer

Can you take Pomegranate with Olanzapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Full Pomegranate + Olanzapine answer

Can you take Propolis with Olanzapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.

Full Propolis + Olanzapine answer

Can you take Quercetin with Olanzapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of CYP2D6 substrates.

Full Quercetin + Olanzapine answer

Can you take Rauwolscine with Olanzapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.

Full Rauwolscine + Olanzapine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Olanzapine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Olanzapine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Olanzapine sits in 9 interaction categories. Open any one to see what the group means:

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Olanzapine through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Olanzapine through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Olanzapine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Olanzapine through this category.

Antipsychotic Drugs 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Olanzapine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Olanzapine through this category.

Olanzapine (Zyprexa) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Olanzapine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Olanzapine through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Olanzapine through this category.

About Olanzapine

Olanzapine is an atypical antipsychotic used to treat schizophrenia and bipolar disorder.

Generic name: Olanzapine  ·  Brand name: Zyprexa.

See the full Olanzapine drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Olanzapine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Olanzapine.

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Pharmacist Counseling Corner

Olanzapine & Supplements: Common Questions

What supplements interact with Olanzapine?
In our interaction database, 160 supplement and herbal ingredients have an interaction with Olanzapine on file — 4 rated major, 118 moderate, and 38 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Indian Snakeroot, Lithium.
Which Olanzapine supplement interactions are the most serious?
Focus on the major group: Activated Charcoal, Indian Snakeroot, Lithium and Rauvolfia Vomitoria. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Olanzapine?
That depends entirely on which supplement. The honest answer for Olanzapine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Zyprexa have the same supplement interactions as Olanzapine?
Yes — Zyprexa all contain Olanzapine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Olanzapine and my other medications?
This page covers Olanzapine against supplements and herbal ingredients. Checking Olanzapine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Olanzapine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.