Olanzapine

101 interactions 8 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Olanzapine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Olanzapine Abametapir Explained Increased exposure of CYP1A2 substrates Details Olanzapine Omeprazole Gastrobim Explained Reduced OLANZapine exposure and reduced efficacy of OLANZapine Details Olanzapine Amitriptyline Elavil Explained Increased risk of severe gastrointestinal adverse reactions and an increased risk of QT interval prolongation Details Olanzapine Sertraline Explained An increased risk of QT interval prolongation Details Olanzapine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation, an increased risk of CNS and respiratory depression and an increased risk of paraly... Details Olanzapine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Olanzapine Trospium / Xanomeline Cobenfy Explained Increased risk of severe gastrointestinal adverse reactions Details Olanzapine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Olanzapine Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Olanzapine Aripiprazole Injection Abilify An increased risk of QT interval prolongation and an increased risk of CNS depression Details Olanzapine Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Olanzapine Asciminib Scemblix Reduced OLANZapine exposure and reduced efficacy of OLANZapine Details Olanzapine Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation and an increased risk of CNS depression Details Olanzapine Azithromycin AzaSite An increased risk of QT interval prolongation Details Olanzapine Cabergoline Dostinex® Reduced efficacy of dopamine agonist Details Olanzapine Aclidinium Oral Inhalation Tudorza Increased risk of severe gastrointestinal adverse reactions Details Olanzapine Alfuzosin UroXatral An increased risk of QT interval prolongation Details Olanzapine Anagrelide Agrylin Increased risk of QT interval prolongation Details Olanzapine Atropine Ophthalmic Atropine Care 1% Increased risk of severe gastrointestinal adverse reactions Details Olanzapine Bedaquiline Sirturo An increased risk of QT interval prolongation Details Olanzapine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Olanzapine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Olanzapine Capmatinib Tabrecta Increased CYP1A2 substrate exposure and an increased risk of adverse reactions Details Olanzapine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Olanzapine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Olanzapine Chloroquine Aralen® Increased risk of QT-interval prolongation Details Olanzapine Cyclopentolate Ophthalmic Akpentolate® Increased risk of severe gastrointestinal adverse reactions Details Olanzapine Dasatinib Phyrago An increased risk of QT interval prolongation Details Olanzapine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Olanzapine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Olanzapine Diazepam Nasal Spray Valtoco An increased risk of CNS depression, orthostatic hypotension, potentiation of excessive sedation and cardiorespiratory depression Details Olanzapine Diazepam Rectal Diastat An increased risk of CNS depression, orthostatic hypotension, potentiation of excessive sedation and cardiorespiratory depression Details Olanzapine Diphenhydramine Injection Banophen Increased risk of severe gastrointestinal adverse reactions and an increased risk of CNS depression Details Olanzapine Diphenhydramine Topical Afterbite with Antihistamine Increased risk of severe gastrointestinal adverse reactions and an increased risk of CNS depression Details Olanzapine Disopyramide Norpace An increased risk of QT interval prolongation Details Olanzapine Dofetilide Tikosyn An increased risk of QT interval prolongation Details Olanzapine Dolasetron Anzemet An increased risk of QT interval prolongation Details

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