FDA-filed SPL labeling · retrieved through openFDA

Olanzapine

Olanzapine is an atypical antipsychotic used to treat schizophrenia, bipolar I disorder, and acute agitation associated with schizophrenia and bipolar I mania.

Brand names ZyprexaZYPREXA ZydisZYPREXA RelprevvOlanzapine IntramuscularZYPREXA Intramuscular
Drug class ⓘ Atypical Antipsychotic
Rx Forms 4 Routes Oral · Intramuscular
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 97 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveNov 18, 2025
Clinical labels in scope ⓘ97
AvailabilityRx
Earliest approval/marketing year ⓘ1996
FDA-listed product records ⓘ643
Boxed warningYes
How we combine label and product data →
✓No current FDA shortage listed · checked Sep 23, 2026 🚨Recall on record
Other forms & routes:
Injection
⭐ Olanzapine at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Olanzapine is an effective antipsychotic for schizophrenia and bipolar I disorder, but it requires close monitoring for weight gain, blood sugar changes, and cholesterol. It must not be used in elderly patients with dementia-related psychosis due to a serious risk of death. Take it exactly as prescribed, keep all lab appointments, and tell your doctor right away about any unusual symptoms.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Important safety warning: Olanzapine should NOT be used to treat psychosis related to dementia in elderly patients. Older adults with dementia who take antipsychotic drugs like olanzapine have a significantly higher risk of death compared to those taking a placebo. Most of these deaths were due to heart-related causes (such as heart failure or sudden death) or infections like pneumonia. Elderly patients with dementia treated with olanzapine also had more strokes and mini-strokes (transient ischemic attacks). Olanzapine is not approved for this use. If you have a loved one with dementia who is being considered for this medication, talk to their doctor about the risks.

Read the full warning on DailyMed →

📖 Olanzapine: Patient Information Guide

A plain-language walkthrough of Olanzapine — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Olanzapine is an atypical antipsychotic approved for several psychiatric conditions across multiple forms and products.

  • Treats schizophrenia in adults and adolescents ages 13–17 (oral tablets and orally disintegrating tablets)
  • Treats acute manic or mixed episodes of bipolar I disorder and provides maintenance treatment of bipolar I disorder in adults and adolescents ages 13–17 (oral forms)
  • Used alongside valproate or lithium to treat manic or mixed episodes of bipolar I disorder in adults (oral forms)
  • Olanzapine tablets and orally disintegrating tablets, in combination with fluoxetine, treat depressive episodes associated with bipolar I disorder and treatment-resistant depression in adults
  • Olanzapine intramuscular injection (short-acting) treats acute agitation associated with schizophrenia and bipolar I mania in adults
  • Zyprexa Relprevv (long-acting intramuscular injection) is indicated for the treatment of schizophrenia in adults and is available only through a restricted program
⚙️How it works▾

Olanzapine's precise mechanism is not fully known, but it's thought to work by blocking dopamine and serotonin type 2 (5HT2) receptors in the brain. These are chemical messenger systems that, when dysregulated, can drive symptoms like hallucinations, delusions, and manic episodes. By dampening overactive signals in these pathways, olanzapine helps to reduce psychotic and manic symptoms. It also binds to histamine, adrenergic, and muscarinic receptors — effects that contribute to side effects like drowsiness, weight gain, and dry mouth.

💊How it's taken▾

Oral forms (tablets and orally disintegrating tablets) are generally taken once daily, with or without food — food does not change how much olanzapine reaches the bloodstream. It typically takes about a week of daily dosing to reach steady, stable levels in the body. The intramuscular injection is given by a healthcare professional in a clinical setting; it is not taken at home. Always follow your prescriber's specific instructions — starting doses are lower for adolescents than for adults, and some patients may need dose adjustments based on their age, smoking status, or other medications.

  • Oral route: once daily, any time, with or without food
  • Injection (short-acting): given by a healthcare provider for acute agitation; up to three doses may be given several hours apart if needed
  • Zyprexa Relprevv (long-acting injection): given on a scheduled interval by a healthcare provider in a registered setting only
🤒Side effects — in detail▾

The most frequently reported side effects with olanzapine include:

  • Drowsiness or sedation
  • Weight gain
  • Dizziness, including when standing up
  • Dry mouth
  • Constipation
  • Increased appetite
  • Tremor
  • Low blood pressure when standing (postural hypotension)

More serious reactions to watch for include signs of high blood sugar (extreme thirst, frequent urination, unusual weakness), uncontrolled muscle movements (tardive dyskinesia), high fever with muscle rigidity (neuroleptic malignant syndrome), or a severe rash with fever and organ symptoms (DRESS). Contact your doctor promptly if any of these occur.

⚠️Warnings & precautions▾

The most critical warning: olanzapine is not approved for treating dementia-related psychosis in elderly patients and significantly increases their risk of death and stroke. This risk applies to all antipsychotics in this class.

  • Metabolic changes: olanzapine raises blood sugar (sometimes severely, including diabetic ketoacidosis), increases triglycerides and cholesterol, and causes weight gain — all requiring regular monitoring
  • Tardive dyskinesia: long-term use can cause involuntary, repetitive muscle movements that may be permanent — report any unusual movements to your doctor
  • Neuroleptic malignant syndrome (NMS): a rare, potentially fatal reaction causing high fever, rigid muscles, confusion, and unstable blood pressure — requires immediate medical attention
  • DRESS: a rare but serious drug reaction with rash, fever, swollen lymph nodes, and possible organ damage — stop the drug and seek care if suspected
  • Low blood pressure when standing (orthostatic hypotension): can cause dizziness and fainting, especially early in treatment
  • Cognitive and motor impairment: olanzapine can affect thinking and coordination — use caution when driving
  • Suicide risk: schizophrenia and bipolar disorder carry inherent suicide risk — close monitoring is needed
🔀What it interacts with▾

Several drugs and substances can interact with olanzapine — either changing its levels in your body or adding to its effects:

  • Alcohol: increases the risk of dizziness and low blood pressure; avoid combining
  • Diazepam (Valium) and benzodiazepines: worsen low blood pressure when standing
  • Carbamazepine: speeds up olanzapine's removal from the body, potentially making it less effective
  • Fluvoxamine: slows olanzapine clearance significantly, raising olanzapine blood levels
  • Fluoxetine: causes a small increase in olanzapine levels; dose adjustment is not usually needed but check with your prescriber
  • Antihypertensive (blood pressure) medications: olanzapine can enhance their blood-pressure-lowering effect
  • Levodopa and dopamine agonists: olanzapine may reduce the effectiveness of these Parkinson's medications
  • Anticholinergic drugs: combining with olanzapine raises the risk of serious gut side effects from slowed intestinal movement
  • Omeprazole and rifampin: may increase olanzapine clearance

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Tell your doctor if you have or have ever had diabetes or high blood sugar — olanzapine can worsen glucose control
  • Tell your doctor if you have high cholesterol or triglycerides — olanzapine can worsen lipid levels
  • Tell your doctor if you have heart disease, a history of stroke or mini-stroke, or conditions that affect blood pressure
  • Tell your doctor if you have a history of seizures
  • Tell your doctor if you have urinary retention, enlarged prostate, constipation, or paralytic ileus (intestinal blockage)
  • Tell your doctor about all medications you take, especially benzodiazepines, antihypertensives, anticholinergic drugs, or carbamazepine
  • Pregnancy: third-trimester exposure may cause muscle stiffness or withdrawal symptoms in newborns — weigh risks and benefits with your doctor; a pregnancy registry is available at 1-866-961-2388
  • Breastfeeding: olanzapine passes into breast milk; infants should be monitored for sedation, poor feeding, irritability, and abnormal muscle movements
  • Adolescents (13–17): approved for schizophrenia and bipolar I disorder, but they experience more weight gain, sedation, and metabolic effects than adults — prescribers may consider other medications first
  • Older adults: NOT approved for dementia-related psychosis; increased risk of death and stroke in this population
🚑If you take too much▾

Taking too much olanzapine can cause agitation, slurred speech, rapid heartbeat, reduced consciousness, and in serious cases, respiratory depression, seizures, or cardiac events — fatalities have been reported. There is no specific antidote. If you suspect an overdose, call Poison Control at 1-800-222-1222 or go to an emergency room immediately.

📡Pharmacodynamics — effects in the body▾

Olanzapine binds strongly to multiple receptors in the brain and body, including serotonin (5HT2A/2C, 5HT6), dopamine (D1–D4), histamine (H1), and adrenergic alpha-1 receptors. It also has moderate binding at muscarinic receptors. These receptor interactions explain both its therapeutic effects (reducing psychosis and mania) and many of its side effects — including sedation from histamine blockade, dry mouth and constipation from muscarinic blockade, and low blood pressure from adrenergic blockade.

🔬Pharmacokinetics — how your body processes it▾

When taken by mouth, olanzapine is well absorbed and reaches peak levels in about 6 hours; food does not affect this. About 40% is metabolized before reaching the bloodstream. It has a long half-life — averaging around 30 hours — which is why it can be taken just once a day, reaching stable blood levels after about one week of daily dosing. The drug is extensively metabolized by the liver (mainly through CYP1A2 enzymes) and excreted primarily in the urine, with only a small amount leaving the body unchanged. When given as an intramuscular injection, peak levels are reached much faster — within 15 to 45 minutes — and the initial blood concentration is considerably higher than with the same oral dose, though the overall exposure over time is similar.

📦How to store it▾

Store ZYPREXA tablets, ZYPREXA ZYDIS, and ZYPREXA IntraMuscular vials (before reconstitution) at controlled room temperature, 20° to 25°C (68° to 77°F) . stored at controlled room temperature, 20° to 25°C (68° to 77°F) for up to 1 hour if necessary. do not freeze.

📄 Written from Olanzapine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

160

Supplements & herbs that interact with Olanzapine

160 supplements and herbal products have documented interactions with Olanzapine in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 4
  • Moderate · 118
  • Minor · 38
ACTIVATED CHARCOAL Major INDIAN SNAKEROOT Major LITHIUM Major RAUVOLFIA VOMITORIA Major 1,3-DMAA Moderate 5-HTP Moderate ACACIA RIGIDULA Moderate ACETYL-L-CARNITINE Moderate +152 more
Every supplement checked against Olanzapine — ranked by severity The full interaction hub: 4 major · 118 moderate · 38 minor · every one linked to its full report. Check Olanzapine against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Olanzapine — the kind of thing our pharmacy team would talk through with you at the counter.

What exactly is olanzapine supposed to do for me? ▾
Olanzapine helps bring certain brain chemicals — mainly dopamine and serotonin — back into balance. Depending on what it's prescribed for, it can reduce symptoms of psychosis like hallucinations or delusions in schizophrenia, help stabilize mood during manic or mixed episodes of bipolar I disorder, or calm severe agitation quickly when given as an injection. Some people also take it alongside another medication, fluoxetine, to treat depressive episodes in bipolar I disorder or treatment-resistant depression.
Will olanzapine make me gain weight or affect my blood sugar? ▾
Honestly, yes — weight gain and changes in blood sugar and cholesterol are real and well-documented with olanzapine. Some people gain a significant amount of weight. Blood sugar can rise, and in rare cases, serious problems like diabetic ketoacidosis have occurred. Your doctor will likely check your blood sugar and blood fats before you start and periodically while you're on it. It's worth talking to your prescriber about monitoring your weight and eating habits, too.
Can I drink alcohol while taking olanzapine? ▾
It's best to avoid alcohol while you're on olanzapine. Alcohol can add to olanzapine's sedating effects and also worsens the drop in blood pressure you can get when you stand up — which can make you feel dizzy or faint. It's not worth the risk, especially early in treatment when your body is still adjusting to the medication.
I feel really dizzy when I stand up — is that normal, and what should I do? ▾
Yes, that dizzy feeling when standing up is a known side effect called orthostatic hypotension — basically a temporary drop in blood pressure when you change position. It's more common when you first start olanzapine or when your dose is being adjusted. Try standing up slowly, hold onto something if you need to, and give yourself a moment before walking. Let your doctor know if it's happening a lot or if you feel like you might faint — they may want to adjust your dose or timing.
Are there any movement problems I should watch out for? ▾
There are two main ones to know about. Tardive dyskinesia is the term for repetitive, uncontrolled movements — often affecting the face, tongue, or limbs — that can develop with long-term antipsychotic use and may be permanent. Report any unusual movements to your doctor right away. There's also a rarer but more urgent condition called neuroleptic malignant syndrome, which causes high fever, severe muscle stiffness, confusion, and unstable heart rate or blood pressure — that's a medical emergency. Call for help immediately if those symptoms appear.
Is it safe to take olanzapine during pregnancy or while breastfeeding? ▾
This is an important conversation to have with your doctor. Babies born to people who took olanzapine in the third trimester can sometimes have muscle stiffness, tremors, or withdrawal symptoms after birth — though many recover within days. The available evidence hasn't confirmed a clear increase in major birth defects, but there are risks on both sides: untreated schizophrenia or bipolar disorder also carries real risks during pregnancy. If you're breastfeeding, olanzapine does pass into breast milk, so your baby should be monitored for drowsiness and abnormal movements. A pregnancy registry exists if you want to report or track outcomes — your healthcare provider can give you that information.
Is Olanzapine available over the counter? ▾
Olanzapine is dispensed by prescription according to its FDA labeling, so it isn't sold over the counter. Your prescriber and pharmacist will determine if it's appropriate for you.
When was Olanzapine first available? ▾
Olanzapine has been available in the United States since at least 1996, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Olanzapine? ▾
Olanzapine is supplied by 83 manufacturers listed in the FDA NDC Directory, including Remedyrepack Inc., Bryant Ranch Prepack, Aurobindo Pharma Limited.

💬 Answers drafted from Olanzapine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

📊Olanzapine supplement interactions160 checked — ranked by severity 🌿Drug & Supplement CheckerOlanzapine vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Olanzapine NDCs & costs 🅰️Browse Drugs A–ZLook up any medication

💊 How Olanzapine comes

Olanzapine is available in 4 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Tablet

By mouth
Brands Zyprexa
How this form is used
What it may be used for
  • Treats schizophrenia in adults and adolescents ages 13–17
  • Treats manic or mixed episodes of bipolar I disorder in adults and adolescents ages 13–17
  • Used alongside lithium or valproate for bipolar I manic or mixed episodes in adults
  • Used in combination with fluoxetine for depressive episodes associated with bipolar I disorder and treatment-resistant depression in adults
Important instructions
  • Taken by mouth once daily, with or without food
  • Food does not affect how the body absorbs the tablet
  • Follow your prescriber's instructions for dose and timing
  • Zyprexa tablets: tolerability with oral olanzapine should be established before switching to certain long-acting injectable formulations
Available strengths 6 strengths
2.5 mg 5 mg 7.5 mg 10 mg 15 mg 20 mg
415 FDA-listed product records ⓘ

Orally disintegrating tablet

By mouth
Brands Zyprexa
How this form is used
What it may be used for
  • Treats schizophrenia in adults and adolescents ages 13–17
  • Treats manic or mixed episodes of bipolar I disorder in adults and adolescents ages 13–17
  • Used alongside lithium or valproate for bipolar I manic or mixed episodes in adults
  • Used in combination with fluoxetine for depressive episodes associated with bipolar I disorder and treatment-resistant depression in adults
Important instructions
  • Dissolves on the tongue without water — do not chew or swallow whole before it dissolves
  • Taken once daily, with or without food
  • Zyprexa Zydis (orally disintegrating tablet) delivers the same amount of drug to the body as the standard Zyprexa tablet
Available strengths 4 strengths
5 mg 10 mg 15 mg 20 mg
162 FDA-listed product records ⓘ

Injection

By injection · Into a muscle
Brands Zyprexa
How this form is used
What it may be used for
  • Olanzapine for injection (short-acting): treats acute agitation associated with schizophrenia and bipolar I mania in adults
  • Zyprexa Relprevv (long-acting injection): treats schizophrenia in adults and is available only through a restricted distribution program
Important instructions
  • Given by a healthcare professional as a deep intramuscular injection — not self-administered at home
  • Zyprexa Relprevv is for deep intramuscular gluteal injection only and must never be given intravenously or under the skin
  • Zyprexa Relprevv requires patients, prescribers, pharmacies, and healthcare settings to be enrolled in the Zyprexa Relprevv REMS program
  • Zyprexa Relprevv and Zyprexa IntraMuscular (short-acting) are different formulations with different dosing schedules and must not be confused with each other
Available strengths 5 strengths
10 mg 10 mg/2 mL 210 mg/1.4 mL 300 mg/2 mL 405 mg/2.7 mL
31 FDA-listed product records ⓘ

Oral suspension

By mouth
Available strengths 1 strength
1 mg/mg
2 FDA-listed product records ⓘ

📊 Olanzapine across the U.S. market

How Olanzapine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

4
Dose forms ⓘ
83
Manufacturers
6
Brand names
643
FDA-listed product records ⓘ
1996
First marketed ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (21) · Kit (12) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Remedyrepack Inc.12%
Bryant Ranch Prepack7%
Aurobindo Pharma Limited6%
Golden State Medical Supply, Inc.5%
Eli Lilly and Company5%
Apotex Corp.5%
Other makers59%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Olanzapine is used

A general measure of how commonly Olanzapine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Olanzapine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

2,565,436
Medicaid prescriptions filled (Q1–Q4 2025)
$37.6M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Olanzapine prescribed? Of the 1,596 medications we measure, Olanzapine ranks #91 by Medicaid prescriptions — more than 94% of them.

Where Olanzapine ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #91 of 1,596
#86 Mirtazapine 2,693,128 Rx #87 Sodium Chloride 2,643,128 Rx #88 Methylprednisolone 2,620,269 Rx #89 Ketoconazole 2,593,228 Rx #90 Ketoconazole Topical 2,579,373 Rx #91 Olanzapine 2,565,436 Rx #92 Naproxen 2,556,513 Rx #93 Methylprednisolone Inj... 2,550,742 Rx #94 Spironolactone 2,528,169 Rx #95 Oseltamivir 2,322,109 Rx #96 Insulin Lispro Injecti... 2,318,237 Rx

Utilization by Olanzapine product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 10 mg oral tablet is the most-dispensed Olanzapine product — about 26% of these Medicaid prescriptions.

olanzapine 10 MG Oral Tablet Most dispensed

667,844 Medicaid prescriptions (Q1–Q4 2025) 26% of Olanzapine prescriptions shown $9M gross reimbursement (before rebates) ≈ $13 per prescription (gross)

Summed across the 18 of 117 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 314154

olanzapine 5 MG Oral Tablet

625,447 Medicaid prescriptions (Q1–Q4 2025) 24% of Olanzapine prescriptions shown $7.3M gross reimbursement (before rebates) ≈ $12 per prescription (gross)

Summed across the 19 of 136 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 312078

olanzapine 20 MG Oral Tablet

435,258 Medicaid prescriptions (Q1–Q4 2025) 17% of Olanzapine prescriptions shown $7.3M gross reimbursement (before rebates) ≈ $17 per prescription (gross)

Summed across the 18 of 94 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 283639

olanzapine 15 MG Oral Tablet

308,760 Medicaid prescriptions (Q1–Q4 2025) 12% of Olanzapine prescriptions shown $4.5M gross reimbursement (before rebates) ≈ $14 per prescription (gross)

Summed across the 18 of 89 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 312077

olanzapine 2.5 MG Oral Tablet

224,421 Medicaid prescriptions (Q1–Q4 2025) 9% of Olanzapine prescriptions shown $2.5M gross reimbursement (before rebates) ≈ $11 per prescription (gross)

Summed across the 16 of 116 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 200034

olanzapine 7.5 MG Oral Tablet

105,233 Medicaid prescriptions (Q1–Q4 2025) 4% of Olanzapine prescriptions shown $1.2M gross reimbursement (before rebates) ≈ $12 per prescription (gross)

Summed across the 12 of 99 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 312079

olanzapine 5 MG Disintegrating Oral Tablet

77,554 Medicaid prescriptions (Q1–Q4 2025) 3% of Olanzapine prescriptions shown $1.6M gross reimbursement (before rebates) ≈ $21 per prescription (gross)

Summed across the 9 of 45 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 314155

olanzapine 10 MG Disintegrating Oral Tablet

57,405 Medicaid prescriptions (Q1–Q4 2025) 2% of Olanzapine prescriptions shown $1.5M gross reimbursement (before rebates) ≈ $26 per prescription (gross)

Summed across the 8 of 41 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 312076

olanzapine 20 MG Disintegrating Oral Tablet

29,674 Medicaid prescriptions (Q1–Q4 2025) 1% of Olanzapine prescriptions shown $1.1M gross reimbursement (before rebates) ≈ $36 per prescription (gross)

Summed across the 7 of 40 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 351108

olanzapine 15 MG Disintegrating Oral Tablet

21,458 Medicaid prescriptions (Q1–Q4 2025) <1% of Olanzapine prescriptions shown $713,197 gross reimbursement (before rebates) ≈ $33 per prescription (gross)

Summed across the 7 of 39 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 351107

olanzapine 10 MG Injection

11,946 Medicaid prescriptions (Q1–Q4 2025) <1% of Olanzapine prescriptions shown $474,995 gross reimbursement (before rebates) ≈ $40 per prescription (gross)

Summed across the 9 of 16 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 485968

olanzapine 405 MG Injection

394 Medicaid prescriptions (Q1–Q4 2025) <1% of Olanzapine prescriptions shown $462,970 gross reimbursement (before rebates) ≈ $1,175 per prescription (gross)

Summed across the 2 of 3 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1718925

olanzapine 300 MG Injection

42 Medicaid prescriptions (Q3–Q4 2025) <1% of Olanzapine prescriptions shown $56,264 gross reimbursement (before rebates) ≈ $1,340 per prescription (gross)

Summed across the 1 of 3 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1718930

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Olanzapine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 144 of 838 listed Olanzapine NDCs with Medicaid activity.

🔍 Compare Olanzapine products

A representative set of FDA-listed product records for Olanzapine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 200 of 643 products — FDA National Drug Code Directory. See every product, package size and price: browse all 643 Olanzapine NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Olanzapine RxCUI 61381 3 dose forms · 14 strengths
  1. Dose form (SCDF) Disintegrating Oral Tablet RxCUI 374627 In current FDA listings
    Clinical drug / strength (SCD) 5 MG RxCUI 314155 10 MG RxCUI 312076 15 MG RxCUI 351107 20 MG RxCUI 351108
  2. Dose form (SCDF) Injection RxCUI 1718924 In current FDA listings
    Clinical drug / strength (SCD) 10 MG RxCUI 485968 210 MG RxCUI 1718934 300 MG RxCUI 1718930 405 MG RxCUI 1718925
  3. Dose form (SCDF) Oral Tablet RxCUI 373142 In current FDA listings
    Clinical drug / strength (SCD) 2.5 MG RxCUI 200034 5 MG RxCUI 312078 7.5 MG RxCUI 312079 10 MG RxCUI 314154 15 MG RxCUI 312077 20 MG RxCUI 283639

Look up RxCUI 61381 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Zyprexa ZYPREXA Zydis ZYPREXA Relprevv Olanzapine Intramuscular ZYPREXA Intramuscular

🏭 Manufacturers & labelers

Remedyrepack Inc. 66 Bryant Ranch Prepack 38 Aurobindo Pharma Limited 32 Golden State Medical Supply, Inc. 30 Eli Lilly and Company 30 Apotex Corp. 30 H2-Pharma LLC 28 Macleods Pharmaceuticals Limited 20 Torrent Pharmaceuticals Limited 18 Major Pharmaceuticals 14 NorthStar RxLLC 13 Coupler LLC 13 Cadila Pharmaceuticals Limited 13 Strides Pharma Science Limited 12 Modavar Pharmaceuticals LLC 12 Zydus Lifesciences Limited 12 Ascend Laboratories, LLC 12 Dr.Reddy's Laboratories Limited 12 HEC Pharm USA Inc. 10 American Health Packaging 10 Preferred Pharmaceuticals Inc. 9 Dr. Reddy's Laboratories Inc. 9 Dr. Reddy's Laboratories Ltd. 9 Cardinal Health 107, LLC 8

…and 16 more on the FDA NDC directory.

RxNorm drug class

Olanzapine belongs to the Atypical Antipsychotic class.

Pharmacologic class Atypical Antipsychotic
Drug family (ATC) Diazepines, oxazepines, thiazepines and oxepines

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Nov 18, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Olanzapine.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Olanzapine after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
97
NDC products indexed
643
Distinct labelers/manufacturers represented
83
Linked representative label ⓘ
Eli Lilly and Company
Linked label effective
Nov 18, 2025
Composite sections available
26
Linked SPL Set ID
d5051fbc-846b-4946-82df-341fb1216341
Linked SPL Document ID
9073f34c-307c-4a3a-8273-580ef5742229
Open the linked representative label on DailyMed ↗

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 97 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Eli Lilly and Company is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.