Safinamide

Generic name: Pronounced as (sa fin' a mide)
Brand names
  • Xadago®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 06/15/2017

Safinamide is used along with the combination of levodopa and carbidopa (Duopa, Rytary, Sinemet, others) to treat ''off'' episodes (times of difficulty moving, walking, and speaking that may happen as medication wears off or at random) in people with Parkinson's disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance). Safinamide is in a group of medications called monoamine oxidase type B (MAO-B) inhibitors. It works by increasing the amount of dopamine (a natural substance that is needed to control movement) in the brain.

Safinamide comes as a tablet to take by mouth. It is usually taken with or without food once daily. Take safinamide at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take safinamide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of safinamide and may increase your dose once after at least 2 weeks of treatment.

Do not stop taking safinamide without talking to your doctor. Your doctor will probably decrease your dose before stopping. If you suddenly stop taking safinamide, you may experience withdrawal symptoms such as a fever; muscle stiffness; confusion; or changes in consciousness. Tell your doctor if you experience any of these symptoms when your dose of safinamide is decreased.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking safinamide,

  • tell your doctor and pharmacist if you are allergic to safinamide (mouth or tongue swelling, shortness of breath), any other medications, or any of the ingredients in safinamide tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor if you are taking any of the following: amphetamines (stimulants, 'uppers') such as amphetamine (Adderall, Adzenys, Dyanavel XR, in Adderall), dextroamphetamine (Dexedrine, in Adderall), and methamphetamine (Desoxyn); certain antidepressants such as amitriptyline (Elavil), amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), mirtazapine (Remeron) and trazodone; buspirone; cyclobenzaprine (Amrix); methylphenidate (Aptensio, Metadate, Ritalin, others); opioids such as meperidine (Demerol), methadone (Dolophine, Methadose), propoxyphene (no longer available in U.S.; Darvon), or tramadol (Conzip, Ultram, in Ultracet); selective serotonin and norepinephrine reuptake inhibitors (SSNRIs) such as duloxetine (Cymbalta) and venlafaxine (Effexor); and St. John's wort; Also tell your doctor if you are taking an MAO inhibitor such as isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate).or have stopped taking them within the past two weeks. Your doctor will probably tell you that you should not take safinamide along with any of these medications. If you stop taking safinamide, you should wait at least 14 days before you start to take any of these medications. Also, do not take dextromethorphan (in Robitussin DM; found in many nonprescription cough and cold products) along with safinamide.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antipsychotics such as clozapine (Clozaril, Fazaclo, Versacloz) and olanzapine (Zyprexa); benzodiazepines such as alprazolam (Xanax), diazepam (Diastat, Valium), lorazepam (Ativan), temazepam (Restoril), and triazolam (Halcion); medications for colds and allergies (decongestants) including those placed in the eye or nose; imatinib (Gleevec); irinotecan (Camptosar, Onivyde); isoniazid (Laniazid, in Rifamate, in Rifater); lapatinib (Tykerb); methotrexate (Otrexup, Rasuvo); metoclopramide (Reglan); mitoxantrone; rosuvastatin (Crestor); selective serotonin reuptake inhibitors such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax, others), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); sulfasalazine (Azulfidine); and topotecan (Hycamtin). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have liver disease. Your doctor will probably tell you not to take safinamide.

  • tell your doctor if you have or have ever had a mental illness such as schizophrenia (a mental illness that causes disturbed thinking, loss of interest in life, and strong or unusual emotions), bipolar disorder (mood that changes from depressed to abnormally excited), or psychosis; or if you have high or low blood pressure; dyskinesia (abnormal movements); or sleep problems. Also tell your doctor if you or a family member have or have had problems with the retina of your eyes or albinism (inherited condition that causes a lack of color in the skin, hair and eyes).

  • tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking safinamide, call your doctor.

  • tell your doctor if you are breast-feeding or plan to breastfeed.

  • you should know that safinamide may make you drowsy or may cause you to suddenly fall asleep during your regular daily activities. You might not feel drowsy or have any other warning signs before you suddenly fall asleep. Do not drive a car, operate machinery, work at heights, or participate in potentially dangerous activities at the beginning of your treatment until you know how the medication affects you. If you suddenly fall asleep while you are doing something such as watching television, talking, eating, or riding in a car, or if you become very drowsy, especially during the daytime, call your doctor. Do not drive, work in high places, or operate machinery until you talk to your doctor.

  • remember that alcohol can add to the drowsiness caused by this medication. Do not drink alcohol while you are taking safinamide.

  • you should know that some people who took medications such as safinamide developed gambling problems or other intense urges or behaviors that were compulsive or unusual for them, such as increased sexual urges or behaviors. Call your doctor if you have an urge to gamble that is difficult to control, you have intense urges, or you are unable to control your behavior. Tell your family members about this risk so that they can call the doctor even if you do not realize that your gambling or any other intense urges or unusual behaviors have become a problem.

You may experience a serious reaction if you eat foods that are high in tyramine during your treatment with safinamide. Tyramine is found in many foods and beverages, including meat, poultry, fish, or cheese that has been smoked, aged, improperly stored, or spoiled; certain fruits, vegetables, and beans; alcoholic beverages; and yeast products that have fermented. Your doctor or dietitian will tell you which foods you must avoid completely, and which foods you may eat in small amounts. If you eat a food that is high in tyramine while taking safinamide, contact your doctor.

Skip the missed dose and take your next dose at the usual time the next day. Do not take a double dose to make up for a missed one.

  • Safinamide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • difficulty falling asleep or staying asleep

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

    • worsening or more frequent body movements that you can not control

    • vision changes

    • hallucinations (seeing things or hearing voices that do not exist)

    • delusional beliefs (believing things that are not real)

    • agitation, hallucinations, fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea

  • Safinamide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide Safinamide may increase the hypoglycemic activities of Repaglinide.
Montelukast Montelukast The metabolism of Montelukast can be decreased when combined with Safinamide.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection Safinamide may increase the hypoglycemic activities of Insulin glargine.
Leflunomide Leflunomide Safinamide may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Delavirdine Delavirdine The metabolism of Delavirdine can be decreased when combined with Safinamide.
Nevirapine Nevirapine The metabolism of Nevirapine can be decreased when combined with Safinamide.
Atorvastatin Atorvastatin The metabolism of Safinamide can be decreased when combined with Atorvastatin.
Dolasetron Dolasetron The metabolism of Dolasetron can be decreased when combined with Safinamide.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Safinamide.
Anagrelide Anagrelide The metabolism of Anagrelide can be decreased when combined with Safinamide.
Candesartan Candesartan Safinamide may increase the hypotensive activities of Candesartan.
Cilostazol Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Safinamide.
Clopidogrel Clopidogrel The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Clopidogrel.
Diphenoxylate Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Safinamide.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Erythromycin can be decreased when combined with Safinamide.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Safinamide may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Guanfacine Guanfacine Safinamide may increase the hypotensive activities of Guanfacine.
Methylergonovine Methylergonovine The risk or severity of hypertension can be increased when Methylergometrine is combined with Safinamide.
Miglitol Miglitol Safinamide may increase the hypoglycemic activities of Miglitol.
Naratriptan Naratriptan The metabolism of Naratriptan can be decreased when combined with Safinamide.
Olsalazine Olsalazine The risk or severity of hypertension can be increased when Olsalazine is combined with Safinamide.
Paregoric Paregoric Safinamide may increase the analgesic activities of Morphine.
Penbutolol Penbutolol Safinamide may increase the hypotensive activities of Acebutolol.
Pentazocine Pentazocine The risk or severity of adverse effects can be increased when Pentazocine is combined with Safinamide.
Ranitidine Ranitidine The metabolism of Ranitidine can be decreased when combined with Safinamide.
Reserpine Reserpine The risk or severity of adverse effects can be increased when Safinamide is combined with Reserpine.
Rizatriptan Rizatriptan The metabolism of Rizatriptan can be decreased when combined with Safinamide.
Sumatriptan Sumatriptan The metabolism of Sumatriptan can be decreased when combined with Safinamide.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Safinamide.
Tizanidine Tizanidine The metabolism of Tizanidine can be decreased when combined with Safinamide.
Triamcinolone Triamcinolone The metabolism of Triamcinolone can be decreased when combined with Safinamide.
Zolmitriptan Zolmitriptan The metabolism of Zolmitriptan can be decreased when combined with Safinamide.
Hydromorphone Injection Hydromorphone Injection Safinamide may increase the serotonergic activities of Hydromorphone.
Meperidine Injection Meperidine Injection The risk or severity of serotonin syndrome and opioid toxicity can be increased when Safinamide is combined with Meperidine.
Metoclopramide Injection Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Safinamide.
Metronidazole Injection Metronidazole Injection The metabolism of Metronidazole can be decreased when combined with Safinamide.
Morphine Injection Morphine Injection Safinamide may increase the analgesic activities of Morphine.
Zidovudine Injection Zidovudine Injection Safinamide may decrease the excretion rate of Zidovudine which could result in a higher serum level.
Altretamine Altretamine Safinamide may increase the hypertensive activities of Amphetamine.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Safinamide.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Safinamide.
Enoxaparin Injection Enoxaparin Injection The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Enoxaparin.
Granisetron Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Safinamide.
Torsemide Torsemide Safinamide may increase the hypotensive activities of Torasemide.
Olanzapine Olanzapine The metabolism of Olanzapine can be decreased when combined with Safinamide.
Alosetron Alosetron The metabolism of Alosetron can be decreased when combined with Safinamide.
Entacapone Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Safinamide.
Eprosartan Eprosartan Safinamide may increase the hypotensive activities of Eprosartan.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Safinamide.
Meloxicam Meloxicam The metabolism of Meloxicam can be decreased when combined with Safinamide.
Oxcarbazepine Oxcarbazepine The risk or severity of adverse effects can be increased when Oxcarbazepine is combined with Safinamide.
Pantoprazole Pantoprazole The metabolism of Pantoprazole can be decreased when combined with Safinamide.
Telmisartan Telmisartan Safinamide may increase the hypotensive activities of Telmisartan.
Zaleplon Zaleplon The risk or severity of adverse effects can be increased when Zaleplon is combined with Safinamide.
Desloratadine Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Safinamide.
Linezolid Linezolid The risk or severity of serotonin syndrome can be increased when Safinamide is combined with Linezolid.
Pentosan Polysulfate Pentosan Polysulfate The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Pentosan polysulfate.
Trimipramine Trimipramine The metabolism of Safinamide can be decreased when combined with Trimipramine.
Glycopyrrolate Glycopyrrolate Safinamide may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Perindopril Perindopril Safinamide may increase the hypotensive activities of Perindopril.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of hypertension can be increased when Choline magnesium trisalicylate is combined with Safinamide.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Safinamide.
Dutasteride Dutasteride The metabolism of Safinamide can be decreased when combined with Dutasteride.
Epinephrine Injection Epinephrine Injection Safinamide may increase the hypertensive activities of Epinephrine.
Eplerenone Eplerenone The metabolism of Eplerenone can be decreased when combined with Safinamide.
Escitalopram Escitalopram The risk or severity of serotonin syndrome can be increased when Safinamide is combined with Escitalopram.
Olmesartan Olmesartan Safinamide may increase the hypotensive activities of Olmesartan.
Zonisamide Zonisamide The risk or severity of adverse effects can be increased when Zonisamide is combined with Safinamide.
Aripiprazole Aripiprazole The risk or severity of serotonin syndrome can be increased when Safinamide is combined with Aripiprazole.
Atomoxetine Atomoxetine The risk or severity of adverse effects can be increased when Safinamide is combined with Atomoxetine.
Dexmethylphenidate Dexmethylphenidate Safinamide may increase the hypertensive activities of Dexmethylphenidate.
Ezetimibe Ezetimibe Safinamide may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Atazanavir Atazanavir The metabolism of Atazanavir can be decreased when combined with Safinamide.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Safinamide.
Eletriptan Eletriptan The metabolism of Eletriptan can be decreased when combined with Safinamide.
Rosuvastatin Rosuvastatin Safinamide may decrease the excretion rate of Rosuvastatin which could result in a higher serum level.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Safinamide.
Aprepitant Aprepitant The metabolism of Aprepitant can be decreased when combined with Safinamide.
Tegaserod Tegaserod Safinamide may decrease the excretion rate of Tegaserod which could result in a higher serum level.
Tadalafil Tadalafil The metabolism of Tadalafil can be decreased when combined with Safinamide.
Frovatriptan Frovatriptan The metabolism of Frovatriptan can be decreased when combined with Safinamide.
Progesterone Progesterone The metabolism of Progesterone can be decreased when combined with Safinamide.
Apomorphine Injection Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Safinamide.
Protriptyline Protriptyline Protriptyline may increase the serotonergic activities of Safinamide.
Duloxetine Duloxetine Safinamide may increase the serotonergic activities of Duloxetine.
Norethindrone Norethindrone The metabolism of Safinamide can be decreased when combined with Norethisterone.
Trospium Trospium Safinamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan Bosentan Safinamide may increase the hypotensive activities of Bosentan.
Cinacalcet Cinacalcet The metabolism of Cinacalcet can be decreased when combined with Safinamide.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Safinamide.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Safinamide is combined with Eszopiclone.
Insulin Aspart (rDNA Origin) Injection Insulin Aspart (rDNA Origin) Injection Safinamide may increase the hypoglycemic activities of Insulin aspart.
Solifenacin Solifenacin Safinamide may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Voriconazole Voriconazole The metabolism of Voriconazole can be decreased when combined with Safinamide.
Dextroamphetamine Dextroamphetamine Safinamide may increase the hypertensive activities of Amphetamine.
Entecavir Entecavir The metabolism of Entecavir can be decreased when combined with Safinamide.
Pramlintide Injection Pramlintide Injection Safinamide may increase the hypoglycemic activities of Pramlintide.
Sodium Oxybate Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Safinamide.
Exenatide Injection Exenatide Injection Safinamide may increase the hypoglycemic activities of Exenatide.
Isocarboxazid Isocarboxazid The risk or severity of adverse effects can be increased when Isocarboxazid is combined with Safinamide.
Ramelteon Ramelteon The metabolism of Ramelteon can be decreased when combined with Safinamide.
Darifenacin Darifenacin The metabolism of Darifenacin can be decreased when combined with Safinamide.
Fentanyl Fentanyl The risk or severity of adverse effects can be increased when Safinamide is combined with Fentanyl.
Pregabalin Pregabalin The therapeutic efficacy of Safinamide can be increased when used in combination with Pregabalin.
Phenylephrine Phenylephrine Safinamide may increase the hypertensive activities of Phenylephrine.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Safinamide.
Felbamate Felbamate The risk or severity of adverse effects can be increased when Felbamate is combined with Safinamide.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection Safinamide may increase the hypoglycemic activities of Insulin detemir.
Ranolazine Ranolazine The metabolism of Ranolazine can be decreased when combined with Safinamide.
Rasagiline Rasagiline The risk or severity of adverse effects can be increased when Rasagiline is combined with Safinamide.
Imatinib Imatinib Safinamide may decrease the excretion rate of Imatinib which could result in a higher serum level.
Sitagliptin Sitagliptin Safinamide may increase the hypoglycemic activities of Sitagliptin.
Gefitinib Gefitinib Safinamide may decrease the excretion rate of Gefitinib which could result in a higher serum level.
Albuterol Albuterol The risk or severity of hypertension can be increased when Salbutamol is combined with Safinamide.
Paliperidone Paliperidone The therapeutic efficacy of Safinamide can be decreased when used in combination with Paliperidone.
Bortezomib Bortezomib The metabolism of Bortezomib can be decreased when combined with Safinamide.
Clofarabine Injection Clofarabine Injection Safinamide may increase the orthostatic hypotensive activities of Clofarabine.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection Safinamide may increase the hypoglycemic activities of Insulin glulisine.
Oxaliplatin Injection Oxaliplatin Injection Safinamide may decrease the excretion rate of Oxaliplatin which could result in a higher serum level.
Primaquine Primaquine The metabolism of Primaquine can be decreased when combined with Safinamide.
Aliskiren Aliskiren Safinamide may increase the hypotensive activities of Aliskiren.
Pemetrexed Injection Pemetrexed Injection The metabolism of Pemetrexed can be decreased when combined with Safinamide.
Dimenhydrinate Dimenhydrinate The risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Safinamide.
Lisdexamfetamine Lisdexamfetamine Safinamide may increase the hypertensive activities of Lisdexamfetamine.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Safinamide.
Sorafenib Sorafenib The metabolism of Sorafenib can be decreased when combined with Safinamide.
Sunitinib Sunitinib The metabolism of Sunitinib can be decreased when combined with Safinamide.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Safinamide.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Safinamide.
Levocetirizine Levocetirizine The risk or severity of adverse effects can be increased when Levocetirizine is combined with Safinamide.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Safinamide.
Mexiletine Mexiletine The metabolism of Mexiletine can be decreased when combined with Safinamide.
Ivermectin Ivermectin Safinamide may decrease the excretion rate of Ivermectin which could result in a higher serum level.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Safinamide.
Nilotinib Nilotinib Safinamide may decrease the excretion rate of Nilotinib which could result in a higher serum level.
Bexarotene Bexarotene The metabolism of Bexarotene can be decreased when combined with Safinamide.
Desmopressin Desmopressin The risk or severity of hypertension can be increased when Desmopressin is combined with Safinamide.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Safinamide.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Safinamide.
Etravirine Etravirine The metabolism of Etravirine can be decreased when combined with Safinamide.
Arsenic Trioxide Injection Arsenic Trioxide Injection Safinamide may increase the orthostatic hypotensive activities of Arsenic trioxide.
Mitoxantrone Injection Mitoxantrone Injection Safinamide may decrease the excretion rate of Mitoxantrone which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine Safinamide may increase the serotonergic activities of Desvenlafaxine.
Cevimeline Cevimeline The metabolism of Cevimeline can be decreased when combined with Safinamide.
Nebivolol Nebivolol Safinamide may increase the hypotensive activities of Nebivolol.
Tretinoin Tretinoin Safinamide may increase the orthostatic hypotensive activities of Tretinoin.
Bendamustine Injection Bendamustine Injection The metabolism of Bendamustine can be decreased when combined with Safinamide.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Safinamide.
Irinotecan Injection Irinotecan Injection Safinamide may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Safinamide.
Rufinamide Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Safinamide.
Midazolam Midazolam The metabolism of Midazolam can be decreased when combined with Safinamide.
Naltrexone Injection Naltrexone Injection The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Safinamide.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Safinamide.
Milnacipran Milnacipran Safinamide may increase the serotonergic activities of Milnacipran.
Dexlansoprazole Dexlansoprazole The metabolism of Dexlansoprazole can be decreased when combined with Safinamide.
Fesoterodine Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Safinamide.
Betaxolol Betaxolol Safinamide may increase the hypotensive activities of Betaxolol.
Iloperidone Iloperidone The therapeutic efficacy of Safinamide can be decreased when used in combination with Iloperidone.
Prasugrel Prasugrel The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Prasugrel.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Safinamide.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Safinamide.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Safinamide.
Pralatrexate Injection Pralatrexate Injection Safinamide may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Safinamide.
Saxagliptin Saxagliptin The metabolism of Safinamide can be decreased when combined with Saxagliptin.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Safinamide.
Tapentadol Tapentadol The risk or severity of adverse effects can be increased when Tapentadol is combined with Safinamide.
Topotecan Topotecan Safinamide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Pazopanib Pazopanib Safinamide may decrease the excretion rate of Pazopanib which could result in a higher serum level.
Asenapine Asenapine The metabolism of Asenapine can be decreased when combined with Safinamide.
Vigabatrin Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Safinamide.
Pitavastatin Pitavastatin Safinamide may decrease the excretion rate of Pitavastatin which could result in a higher serum level.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Safinamide.
Levonorgestrel Levonorgestrel The metabolism of Safinamide can be decreased when combined with Levonorgestrel.
Oxymorphone Oxymorphone The risk or severity of adverse effects can be increased when Oxymorphone is combined with Safinamide.
Dabigatran Dabigatran The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Dabigatran.
Liraglutide Injection Liraglutide Injection Safinamide may increase the hypoglycemic activities of Liraglutide.
Dalfampridine Dalfampridine The risk or severity of seizure can be increased when Safinamide is combined with Dalfampridine.
Fingolimod Fingolimod The metabolism of Fingolimod can be decreased when combined with Safinamide.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Safinamide.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Safinamide.
Lurasidone Lurasidone The therapeutic efficacy of Safinamide can be decreased when used in combination with Lurasidone.
Acetaminophen Injection Acetaminophen Injection Safinamide may increase the hepatotoxic activities of Acetaminophen.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Safinamide.
Denileukin Diftitox Injection Denileukin Diftitox Injection Safinamide may increase the orthostatic hypotensive activities of Aldesleukin.
Terbutaline Injection Terbutaline Injection The risk or severity of adverse effects can be increased when Safinamide is combined with Terbutaline.
Azilsartan Azilsartan Safinamide may increase the orthostatic hypotensive activities of Azilsartan medoxomil.
Linagliptin Linagliptin Safinamide may increase the hypoglycemic activities of Linagliptin.
Telaprevir Telaprevir Safinamide may decrease the excretion rate of Glecaprevir which could result in a higher serum level.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Safinamide.
Rivaroxaban Rivaroxaban The metabolism of Rivaroxaban can be decreased when combined with Safinamide.
Ticagrelor Ticagrelor The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Ticagrelor.
Clobazam Clobazam The metabolism of Clobazam can be decreased when combined with Safinamide.
Vemurafenib Vemurafenib Safinamide may decrease the excretion rate of Vemurafenib which could result in a higher serum level.
Vismodegib Vismodegib The metabolism of Vismodegib can be decreased when combined with Safinamide.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Safinamide.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Safinamide.
Crizotinib Crizotinib The metabolism of Crizotinib can be decreased when combined with Safinamide.
Cabergoline Cabergoline The metabolism of Cabergoline can be decreased when combined with Safinamide.
Ambrisentan Ambrisentan Safinamide may increase the hypotensive activities of Ambrisentan.
Fondaparinux Injection Fondaparinux Injection The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Fondaparinux.
Ezogabine Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Safinamide.
Iloprost Iloprost Safinamide may increase the orthostatic hypotensive activities of Iloprost.
Enzalutamide Enzalutamide The metabolism of Enzalutamide can be decreased when combined with Safinamide.
Mirabegron Mirabegron The metabolism of Mirabegron can be decreased when combined with Safinamide.
Teriflunomide Teriflunomide Safinamide may decrease the excretion rate of Teriflunomide which could result in a higher serum level.
Lorcaserin Lorcaserin Safinamide may increase the hypoglycemic activities of Mecasermin.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Safinamide.
Icosapent Ethyl Icosapent Ethyl The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Icosapent ethyl.
Alogliptin Alogliptin The metabolism of Alogliptin can be decreased when combined with Safinamide.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Safinamide.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Safinamide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Safinamide.
Apixaban Apixaban Safinamide may decrease the excretion rate of Apixaban which could result in a higher serum level.
Canagliflozin Canagliflozin Safinamide may increase the orthostatic hypotensive activities of Canagliflozin.
Methazolamide Methazolamide Safinamide may increase the orthostatic hypotensive activities of Methazolamide.
Dabrafenib Dabrafenib Safinamide may decrease the excretion rate of Dabrafenib which could result in a higher serum level.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Safinamide.
Dolutegravir Dolutegravir Safinamide may decrease the excretion rate of Dolutegravir which could result in a higher serum level.
Afatinib Afatinib Safinamide may decrease the excretion rate of Afatinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran Safinamide may increase the serotonergic activities of Levomilnacipran.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Safinamide.
Perampanel Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Safinamide.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Safinamide.
Ketorolac Injection Ketorolac Injection The metabolism of Safinamide can be decreased when combined with Ketorolac.
Obinutuzumab Injection Obinutuzumab Injection Safinamide may increase the orthostatic hypotensive activities of Obinutuzumab.
Simeprevir Simeprevir Safinamide may decrease the excretion rate of Simeprevir which could result in a higher serum level.
Sofosbuvir Sofosbuvir Safinamide may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin Safinamide may increase the orthostatic hypotensive activities of Dapagliflozin.
Apremilast Apremilast The metabolism of Safinamide can be decreased when combined with Apremilast.
Droxidopa Droxidopa Safinamide may increase the hypertensive activities of Droxidopa.
Albiglutide Injection Albiglutide Injection Safinamide may increase the hypoglycemic activities of Albiglutide.
Eslicarbazepine Eslicarbazepine The risk or severity of adverse effects can be increased when Safinamide is combined with Eslicarbazepine.
Idelalisib Idelalisib Safinamide may decrease the excretion rate of Idelalisib which could result in a higher serum level.
Testosterone Injection Testosterone Injection Safinamide may decrease the excretion rate of Testosterone which could result in a higher serum level.
Empagliflozin Empagliflozin Safinamide may increase the orthostatic hypotensive activities of Empagliflozin.
Vorapaxar Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Vorapaxar.
Hydrocodone Hydrocodone Safinamide may increase the serotonergic and central nervous system depressant (CNS depressant) activities of Hydrocodone.
Suvorexant Suvorexant Safinamide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Dulaglutide Injection Dulaglutide Injection Safinamide may increase the hypoglycemic activities of Dulaglutide.
Edoxaban Edoxaban The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Edoxaban.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Safinamide.
Methamphetamine Methamphetamine Safinamide may increase the hypertensive activities of Metamfetamine.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Safinamide.
Riociguat Riociguat Safinamide may increase the hypotensive activities of Riociguat.
Pirfenidone Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Safinamide.
Risperidone Injection Risperidone Injection The therapeutic efficacy of Safinamide can be decreased when used in combination with Risperidone.
Palbociclib Palbociclib Safinamide may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Insulin Human Inhalation Insulin Human Inhalation Safinamide may increase the hypoglycemic activities of Insulin human.
Lenvatinib Lenvatinib Safinamide may decrease the excretion rate of Lenvatinib which could result in a higher serum level.
Dinutuximab Injection Dinutuximab Injection Safinamide may increase the orthostatic hypotensive activities of Dinutuximab.
Haloperidol Injection Haloperidol Injection The risk or severity of CNS depression can be increased when Safinamide is combined with Haloperidol.
Amiloride Amiloride Safinamide may increase the orthostatic hypotensive activities of Amiloride.
Macitentan Macitentan Safinamide may increase the hypotensive activities of Macitentan.
Flibanserin Flibanserin The metabolism of Flibanserin can be decreased when combined with Safinamide.
Daclatasvir Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Safinamide.
Brexpiprazole Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Safinamide.
Ziprasidone Injection Ziprasidone Injection The risk or severity of adverse effects can be increased when Safinamide is combined with Ziprasidone.
Cariprazine Cariprazine The metabolism of Cariprazine can be decreased when combined with Safinamide.
Eluxadoline Eluxadoline The risk or severity of serotonin syndrome can be increased when Safinamide is combined with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection Safinamide may increase the hypoglycemic activities of Insulin degludec.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Safinamide.
Osimertinib Osimertinib Safinamide may decrease the excretion rate of Osimertinib which could result in a higher serum level.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Safinamide.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Safinamide may increase the orthostatic hypotensive activities of Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Dexamethasone can be decreased when combined with Safinamide.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Defibrotide.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Safinamide.
Venetoclax Venetoclax Safinamide may decrease the excretion rate of Venetoclax which could result in a higher serum level.
Cobicistat Cobicistat The metabolism of Cobicistat can be decreased when combined with Safinamide.
Midodrine Midodrine Safinamide may increase the hypertensive activities of Midodrine.
Selexipag Selexipag Safinamide may increase the hypotensive activities of Selexipag.
Pimavanserin Pimavanserin The therapeutic efficacy of Safinamide can be decreased when used in combination with Pimavanserin.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of adverse effects can be increased when Safinamide is combined with Diphenhydramine.
Furosemide Injection Furosemide Injection Safinamide may increase the orthostatic hypotensive activities of Furosemide.
Rucaparib Rucaparib Safinamide may decrease the excretion rate of Rucaparib which could result in a higher serum level.
Lixisenatide Injection Lixisenatide Injection Safinamide may increase the hypoglycemic activities of Lixisenatide.
Brigatinib Brigatinib Safinamide may decrease the excretion rate of Brigatinib which could result in a higher serum level.
Doxepin (Insomnia) Doxepin (Insomnia) Safinamide may increase the serotonergic activities of Doxepin.
Deutetrabenazine Deutetrabenazine The risk or severity of adverse effects can be increased when Safinamide is combined with Deutetrabenazine.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Safinamide.
Enasidenib Enasidenib The metabolism of Enasidenib can be decreased when combined with Safinamide.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Safinamide.
Delafloxacin Delafloxacin Safinamide may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib Abemaciclib Safinamide may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Betrixaban Betrixaban The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Betrixaban.
Letermovir Letermovir The metabolism of Letermovir can be decreased when combined with Safinamide.
Semaglutide Injection Semaglutide Injection Safinamide may increase the hypoglycemic activities of Semaglutide.
Tetrabenazine Tetrabenazine The risk or severity of adverse effects can be increased when Safinamide is combined with Tetrabenazine.
Ertugliflozin Ertugliflozin Safinamide may decrease the excretion rate of Ertugliflozin which could result in a higher serum level.
Buprenorphine Injection Buprenorphine Injection The risk or severity of serotonin syndrome and opioid toxicity can be increased when Buprenorphine is combined with Safinamide.
Lofexidine Lofexidine The therapeutic efficacy of Safinamide can be increased when used in combination with Lofexidine.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Safinamide.
Encorafenib Encorafenib The metabolism of Encorafenib can be decreased when combined with Safinamide.
Binimetinib Binimetinib The metabolism of Binimetinib can be decreased when combined with Safinamide.
Lusutrombopag Lusutrombopag Safinamide may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Safinamide.
Eravacycline Injection Eravacycline Injection The metabolism of Eravacycline can be decreased when combined with Safinamide.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Safinamide.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Safinamide.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Safinamide.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Safinamide.
Duvelisib Duvelisib Safinamide may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Stiripentol Stiripentol The metabolism of Stiripentol can be decreased when combined with Safinamide.
Talazoparib Talazoparib Safinamide may decrease the excretion rate of Talazoparib which could result in a higher serum level.
Glasdegib Glasdegib Safinamide may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Safinamide.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Safinamide.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Safinamide.
Acyclovir Ophthalmic Acyclovir Ophthalmic The metabolism of Acyclovir can be decreased when combined with Safinamide.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Caplacizumab.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Safinamide.
Esomeprazole Injection Esomeprazole Injection The metabolism of Esomeprazole can be decreased when combined with Safinamide.
Alpelisib Alpelisib The serum concentration of Alpelisib can be increased when it is combined with Safinamide.
Brexanolone Injection Brexanolone Injection The risk or severity of adverse effects can be increased when Safinamide is combined with Brexanolone.
Cladribine Cladribine Safinamide may decrease the excretion rate of Cladribine which could result in a higher serum level.
Solriamfetol Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Safinamide.
Darolutamide Darolutamide Safinamide may decrease the excretion rate of Darolutamide which could result in a higher serum level.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Safinamide.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Safinamide.
Pitolisant Pitolisant The serum concentration of Safinamide can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The metabolism of Fedratinib can be decreased when combined with Safinamide.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Safinamide.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Safinamide.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Safinamide.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Safinamide.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Safinamide.
Lumateperone Lumateperone The therapeutic efficacy of Safinamide can be decreased when used in combination with Lumateperone.
Lasmiditan Lasmiditan The risk or severity of serotonin syndrome can be increased when Safinamide is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Safinamide.
Tazemetostat Tazemetostat Safinamide may decrease the excretion rate of Tazemetostat which could result in a higher serum level.
Cenobamate Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Safinamide.
Ozanimod Ozanimod Safinamide may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Selumetinib Selumetinib Safinamide may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Safinamide.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Safinamide.
Ripretinib Ripretinib Safinamide may decrease the excretion rate of Ripretinib which could result in a higher serum level.
Selpercatinib Selpercatinib The risk or severity of hypertension can be increased when Safinamide is combined with Selpercatinib.
Lemborexant Lemborexant The metabolism of Lemborexant can be decreased when combined with Safinamide.
Fenfluramine Fenfluramine The risk or severity of serotonin syndrome can be increased when Fenfluramine is combined with Safinamide.
Fostemsavir Fostemsavir Safinamide may decrease the excretion rate of Fostemsavir which could result in a higher serum level.
Pralsetinib Pralsetinib Safinamide may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Safinamide can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Safinamide is combined with Naxitamab.
Viloxazine Viloxazine The risk or severity of adverse effects can be increased when Safinamide is combined with Viloxazine.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Safinamide.
Fenoprofen Fenoprofen The risk or severity of hypertension can be increased when Fenoprofen is combined with Safinamide.
Indomethacin Indomethacin The metabolism of Indomethacin can be decreased when combined with Safinamide.
Mefenamic Acid Mefenamic Acid The metabolism of Mefenamic acid can be decreased when combined with Safinamide.
Naproxen Naproxen The metabolism of Naproxen can be decreased when combined with Safinamide.
Tolmetin Tolmetin The risk or severity of hypertension can be increased when Tolmetin is combined with Safinamide.
Sulindac Sulindac The risk or severity of hypertension can be increased when Sulindac is combined with Safinamide.
Trazodone Trazodone Safinamide may increase the serotonergic activities of Trazodone.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Safinamide.
Metaxalone Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Safinamide.
Methotrexate Injection Methotrexate Injection Safinamide may decrease the excretion rate of Methotrexate which could result in a higher serum level.
Levorphanol Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Safinamide.
Primidone Primidone The metabolism of Primidone can be decreased when combined with Safinamide.
Methsuximide Methsuximide The metabolism of Methsuximide can be decreased when combined with Safinamide.
Diethylpropion Diethylpropion The risk or severity of adverse effects can be increased when Safinamide is combined with Diethylpropion.
Chlorpromazine Chlorpromazine The therapeutic efficacy of Chlorpromazine can be decreased when used in combination with Safinamide.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Safinamide.
Oxazepam Oxazepam The risk or severity of adverse effects can be increased when Oxazepam is combined with Safinamide.
Flurazepam Flurazepam The risk or severity of adverse effects can be increased when Flurazepam is combined with Safinamide.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Safinamide.
Lorazepam Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Safinamide.
Phenoxybenzamine Phenoxybenzamine Safinamide may increase the hypotensive activities of Phenoxybenzamine.
Carmustine Carmustine The metabolism of Carmustine can be decreased when combined with Safinamide.
Amantadine Amantadine The risk or severity of serotonin syndrome can be increased when Amantadine is combined with Safinamide.
Codeine Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Safinamide.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Safinamide.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Safinamide.
Bromocriptine Bromocriptine Bromocriptine may increase the hypertensive activities of Safinamide.
Metaproterenol Metaproterenol The risk or severity of adverse effects can be increased when Safinamide is combined with Orciprenaline.
Tranylcypromine Tranylcypromine The risk or severity of adverse effects can be increased when Tranylcypromine is combined with Safinamide.
Phenelzine Phenelzine The risk or severity of adverse effects can be increased when Phenelzine is combined with Safinamide.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Safinamide.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Safinamide.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Safinamide.
Prochlorperazine Prochlorperazine The therapeutic efficacy of Prochlorperazine can be decreased when used in combination with Safinamide.
Thioridazine Thioridazine The therapeutic efficacy of Thioridazine can be decreased when used in combination with Safinamide.
Trifluoperazine Trifluoperazine The therapeutic efficacy of Trifluoperazine can be decreased when used in combination with Safinamide.
Dapsone Dapsone The metabolism of Dapsone can be decreased when combined with Safinamide.
Sulfadiazine Sulfadiazine Safinamide may increase the hypoglycemic activities of Sulfadiazine.
Oxycodone Oxycodone Safinamide may increase the serotonergic and central nervous system depressant (CNS depressant) activities of Oxycodone.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Safinamide.
Oxybutynin Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Safinamide.
Benztropine Benztropine The metabolism of Benzatropine can be decreased when combined with Safinamide.
Maprotiline Maprotiline The risk or severity of adverse effects can be increased when Safinamide is combined with Maprotiline.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Safinamide.
Trihexyphenidyl Trihexyphenidyl Safinamide may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine Orphenadrine Safinamide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine Perphenazine The therapeutic efficacy of Perphenazine can be decreased when used in combination with Safinamide.
Azathioprine Azathioprine The metabolism of Azathioprine can be decreased when combined with Safinamide.
Fluphenazine Fluphenazine The therapeutic efficacy of Safinamide can be decreased when used in combination with Fluphenazine.
Phentermine Phentermine Safinamide may increase the hypertensive activities of Phentermine.
Methylphenidate Methylphenidate Safinamide may increase the hypertensive activities of Methylphenidate.
Amoxapine Amoxapine The metabolism of Amoxapine can be decreased when combined with Safinamide.
Sulfasalazine Sulfasalazine Safinamide may decrease the excretion rate of Sulfasalazine which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Hydrocortisone can be decreased when combined with Safinamide.
Doxorubicin Doxorubicin Safinamide may decrease the excretion rate of Doxorubicin which could result in a higher serum level.
Dactinomycin Dactinomycin Safinamide may decrease the excretion rate of Dactinomycin which could result in a higher serum level.
Carbamazepine Carbamazepine The risk or severity of adverse effects can be increased when Carbamazepine is combined with Safinamide.
Molindone Molindone The therapeutic efficacy of Safinamide can be decreased when used in combination with Molindone.
Methyldopa Methyldopa Safinamide may decrease the hypotensive activities of Methyldopa.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Safinamide.
Prazosin Prazosin Safinamide may increase the hypotensive activities of Prazosin.
Hydralazine Hydralazine Safinamide may increase the hypotensive activities of Hydralazine.
Warfarin Warfarin The metabolism of Warfarin can be decreased when combined with Safinamide.
Clonazepam Clonazepam The risk or severity of adverse effects can be increased when Clonazepam is combined with Safinamide.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Safinamide.
Promethazine Promethazine The risk or severity of extrapyramidal symptoms can be increased when Promethazine is combined with Safinamide.
Meclofenamate Meclofenamate The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Safinamide.
Daunorubicin Daunorubicin Safinamide may decrease the excretion rate of Daunorubicin which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Safinamide may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Loxapine Loxapine The therapeutic efficacy of Safinamide can be decreased when used in combination with Loxapine.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Safinamide.
Quinine Quinine The metabolism of Quinine can be decreased when combined with Safinamide.
Ethosuximide Ethosuximide The risk or severity of adverse effects can be increased when Ethosuximide is combined with Safinamide.
Triamterene Triamterene Safinamide may increase the orthostatic hypotensive activities of Triamterene.
Sulfinpyrazone Sulfinpyrazone The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide Safinamide may increase the hypotensive activities of Chlorothiazide.
Chlorthalidone Chlorthalidone Safinamide may increase the hypotensive activities of Chlorthalidone.
Metolazone Metolazone Safinamide may increase the hypotensive activities of Metolazone.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Safinamide.
Secobarbital Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Safinamide.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Safinamide.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Safinamide.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Safinamide.
Quinidine Quinidine Quinidine may increase the central nervous system depressant (CNS depressant) activities of Safinamide.
Procainamide Procainamide The metabolism of Procainamide can be decreased when combined with Safinamide.
Isoniazid Isoniazid The risk or severity of serotonin syndrome can be increased when Isoniazid is combined with Safinamide.
Disopyramide Disopyramide The metabolism of Disopyramide can be decreased when combined with Safinamide.
Valproic Acid Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Safinamide.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Safinamide.
Butabarbital Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Safinamide.
Chlorpropamide Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Safinamide.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Safinamide.
Tolazamide Tolazamide The metabolism of Tolazamide can be decreased when combined with Safinamide.
Dextromethorphan Dextromethorphan The risk or severity of serotonin syndrome can be increased when Safinamide is combined with Dextromethorphan.
Cyclobenzaprine Cyclobenzaprine Cyclobenzaprine may increase the serotonergic activities of Safinamide.
Baclofen Baclofen The risk or severity of hypotension can be increased when Baclofen is combined with Safinamide.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Safinamide.
Cyproheptadine Cyproheptadine Safinamide may increase the anticholinergic activities of Cyproheptadine.
Clemastine Clemastine Safinamide may increase the anticholinergic activities of Clemastine.
Chlorpheniramine Chlorpheniramine The risk or severity of adverse effects can be increased when Chlorpheniramine is combined with Safinamide.
Brompheniramine Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Safinamide.
Meclizine Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Safinamide.
Methyclothiazide Methyclothiazide Safinamide may increase the orthostatic hypotensive activities of Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide Safinamide may increase the hypotensive activities of Hydrochlorothiazide.
Dantrolene Dantrolene The risk or severity of adverse effects can be increased when Dantrolene is combined with Safinamide.
Chlorzoxazone Chlorzoxazone The metabolism of Chlorzoxazone can be decreased when combined with Safinamide.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Safinamide.
Methocarbamol Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Safinamide.
Folic Acid Folic Acid Safinamide may decrease the excretion rate of Folic acid which could result in a higher serum level.
Disulfiram Disulfiram The metabolism of Safinamide can be decreased when combined with Disulfiram.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The serum concentration of Propranolol can be increased when it is combined with Safinamide.
Minoxidil Minoxidil Safinamide may increase the hypotensive activities of Minoxidil.
Pseudoephedrine Pseudoephedrine Safinamide may increase the hypertensive activities of Pseudoephedrine.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Safinamide.
Spironolactone Spironolactone Safinamide may increase the orthostatic hypotensive activities of Spironolactone.
Amphotericin B Injection Amphotericin B Injection Safinamide may increase the orthostatic hypotensive activities of Amphotericin B.
Nadolol Nadolol Safinamide may increase the hypotensive activities of Nadolol.
Butorphanol Injection Butorphanol Injection The risk or severity of adverse effects can be increased when Butorphanol is combined with Safinamide.
Nalbuphine Injection Nalbuphine Injection The risk or severity of adverse effects can be increased when Nalbuphine is combined with Safinamide.
Allopurinol Allopurinol Safinamide may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Trimethobenzamide Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Safinamide.
Flavoxate Flavoxate Safinamide may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Papaverine Papaverine Safinamide may increase the orthostatic hypotensive activities of Papaverine.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Safinamide.
Dacarbazine Dacarbazine The metabolism of Dacarbazine can be decreased when combined with Safinamide.
Acetazolamide Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Safinamide.
Pyrantel Pyrantel The risk or severity of adverse effects can be increased when Safinamide is combined with Pyrantel.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be decreased when combined with Safinamide.
Captopril Captopril Safinamide may increase the hypotensive activities of Captopril.
Dipyridamole Dipyridamole Safinamide may increase the orthostatic hypotensive activities of Dipyridamole.
Isoxsuprine Isoxsuprine Safinamide may increase the orthostatic hypotensive activities of Isoxsuprine.
Ethacrynic Acid Ethacrynic Acid Safinamide may increase the orthostatic hypotensive activities of Etacrynic acid.
Metoprolol Metoprolol Safinamide may increase the hypotensive activities of Metoprolol.
Hydroxyzine Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Safinamide.
Thiothixene Thiothixene The therapeutic efficacy of Thiothixene can be decreased when used in combination with Safinamide.
Aspirin Aspirin The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Acetylsalicylic acid.
Salsalate Salsalate The risk or severity of hypertension can be increased when Salsalate is combined with Safinamide.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Safinamide.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Safinamide.
Triazolam Triazolam The metabolism of Triazolam can be decreased when combined with Safinamide.
Dicyclomine Dicyclomine Safinamide may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine Hyoscyamine Safinamide may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline Propantheline Safinamide may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim Trimethoprim The metabolism of Trimethoprim can be decreased when combined with Safinamide.
Diltiazem Diltiazem Safinamide may increase the hypotensive activities of Diltiazem.
Nifedipine Nifedipine Safinamide may increase the orthostatic hypotensive activities of Nifedipine.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Safinamide.
Verapamil Verapamil Safinamide may increase the orthostatic hypotensive activities of Verapamil.
Atenolol Atenolol Safinamide may increase the hypotensive activities of Atenolol.
Pindolol Pindolol Safinamide may increase the hypotensive activities of Pindolol.
Diflunisal Diflunisal The risk or severity of hypertension can be increased when Diflunisal is combined with Safinamide.
Piroxicam Piroxicam The metabolism of Piroxicam can be decreased when combined with Safinamide.
Bumetanide Bumetanide Safinamide may increase the orthostatic hypotensive activities of Bumetanide.
Etoposide Etoposide The metabolism of Etoposide can be decreased when combined with Safinamide.
Glyburide Glyburide Safinamide may decrease the excretion rate of Glyburide which could result in a higher serum level.
Glipizide Glipizide The metabolism of Glipizide can be decreased when combined with Safinamide.
Indapamide Indapamide Safinamide may increase the hypotensive activities of Indapamide.
Pentoxifylline Pentoxifylline The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Pentoxifylline.
Pentamidine Injection Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Safinamide.
Labetalol Labetalol Safinamide may increase the hypotensive activities of Labetalol.
Guanabenz Guanabenz Safinamide may increase the hypotensive activities of Guanabenz.
Ketoprofen Ketoprofen The risk or severity of hypertension can be increased when Ketoprofen is combined with Safinamide.
Pimozide Pimozide The therapeutic efficacy of Pimozide can be decreased when used in combination with Safinamide.
Enalapril Enalapril Safinamide may increase the hypotensive activities of Enalapril.
Flurbiprofen Flurbiprofen The metabolism of Flurbiprofen can be decreased when combined with Safinamide.
Amiodarone Amiodarone Safinamide may increase the orthostatic hypotensive activities of Amiodarone.
Buspirone Buspirone The risk or severity of hypertension can be increased when Safinamide is combined with Buspirone.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Safinamide.
Mesalamine Mesalamine The risk or severity of hypertension can be increased when Mesalazine is combined with Safinamide.
Diclofenac Diclofenac The metabolism of Diclofenac can be decreased when combined with Safinamide.
Fluoxetine Fluoxetine The risk or severity of serotonin syndrome can be increased when Safinamide is combined with Fluoxetine.
Nimodipine Nimodipine Safinamide may increase the hypotensive activities of Nimodipine.
Clozapine Clozapine Safinamide may increase the orthostatic hypotensive activities of Clozapine.
Estazolam Estazolam The risk or severity of adverse effects can be increased when Estazolam is combined with Safinamide.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Safinamide.
Clarithromycin Clarithromycin The metabolism of Clarithromycin can be decreased when combined with Safinamide.
Benazepril Benazepril Safinamide may increase the hypotensive activities of Benazepril.
Etodolac Etodolac The metabolism of Etodolac can be decreased when combined with Safinamide.
Felodipine Felodipine The metabolism of Felodipine can be decreased when combined with Safinamide.
Fosinopril Fosinopril Safinamide may increase the hypotensive activities of Fosinopril.
Nabumetone Nabumetone The metabolism of Nabumetone can be decreased when combined with Safinamide.
Pravastatin Pravastatin Safinamide may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Quinapril Quinapril Safinamide may increase the hypotensive activities of Quinapril.
Ramipril Ramipril Safinamide may increase the hypotensive activities of Ramipril.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Safinamide.
Amlodipine Amlodipine Safinamide may increase the hypotensive activities of Amlodipine.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be decreased when combined with Safinamide.
Lisinopril Lisinopril Safinamide may increase the hypotensive activities of Lisinopril.
Oxaprozin Oxaprozin The risk or severity of hypertension can be increased when Oxaprozin is combined with Safinamide.
Sotalol Sotalol The metabolism of Sotalol can be decreased when combined with Safinamide.
Bisoprolol Bisoprolol Safinamide may increase the hypotensive activities of Bisoprolol.
Zolpidem Zolpidem Safinamide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin Doxazosin Safinamide may increase the hypotensive activities of Doxazosin.
Terazosin Terazosin Safinamide may increase the hypotensive activities of Terazosin.
Isradipine Isradipine Safinamide may increase the hypotensive activities of Isradipine.
Omeprazole Omeprazole The metabolism of Omeprazole can be decreased when combined with Safinamide.
Cisapride Cisapride The metabolism of Cisapride can be decreased when combined with Safinamide.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Safinamide.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Safinamide.
Venlafaxine Venlafaxine Safinamide may increase the serotonergic activities of Venlafaxine.
Fluvoxamine Fluvoxamine Safinamide may increase the serotonergic activities of Fluvoxamine.
Nefazodone Nefazodone Safinamide may increase the serotonergic activities of Nefazodone.
Lamotrigine Lamotrigine The risk or severity of adverse effects can be increased when Lamotrigine is combined with Safinamide.
Losartan Losartan Safinamide may increase the hypotensive activities of Losartan.
Tramadol Tramadol The risk or severity of serotonin syndrome and seizure can be increased when Safinamide is combined with Tramadol.
Moexipril Moexipril Safinamide may increase the hypotensive activities of Moexipril.
Lansoprazole Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Safinamide.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Safinamide.
Nicardipine Nicardipine Safinamide may increase the hypotensive activities of Nicardipine.
Bupropion Bupropion The risk or severity of adverse effects can be increased when Safinamide is combined with Bupropion.
Ticlopidine Ticlopidine The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Saquinavir can be decreased when combined with Safinamide.
Metformin Metformin Safinamide may increase the hypoglycemic activities of Metformin.
Dalteparin Injection Dalteparin Injection The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Dalteparin.
Nisoldipine Nisoldipine The metabolism of Nisoldipine can be decreased when combined with Safinamide.
Lamivudine Lamivudine Safinamide may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole Safinamide may decrease the excretion rate of Riluzole which could result in a higher serum level.
Amifostine Injection Amifostine Injection Safinamide may increase the orthostatic hypotensive activities of Amifostine.
Acarbose Acarbose Safinamide may increase the hypoglycemic activities of Acarbose.
Glimepiride Glimepiride The metabolism of Glimepiride can be decreased when combined with Safinamide.
Indinavir Indinavir The metabolism of Indinavir can be decreased when combined with Safinamide.
Ritonavir Ritonavir The serum concentration of Ritonavir can be increased when it is combined with Safinamide.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Safinamide.
Clomipramine Clomipramine The metabolism of Safinamide can be decreased when combined with Clomipramine.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Safinamide.
Mirtazapine Mirtazapine Safinamide may increase the serotonergic activities of Mirtazapine.
Trandolapril Trandolapril Safinamide may increase the hypotensive activities of Trandolapril.
Topiramate Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Safinamide.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Safinamide.
Valsartan Valsartan Safinamide may increase the hypotensive activities of Valsartan.
Insulin Lispro Injection Insulin Lispro Injection Safinamide may increase the hypoglycemic activities of Insulin lispro.
Pramipexole Pramipexole Safinamide may increase the sedative activities of Pramipexole.
Donepezil Donepezil The metabolism of Donepezil can be decreased when combined with Safinamide.
Carvedilol Carvedilol Safinamide may increase the hypotensive activities of Carvedilol.
Flutamide Flutamide The metabolism of Flutamide can be decreased when combined with Safinamide.
Selegiline Selegiline The risk or severity of adverse effects can be increased when Selegiline is combined with Safinamide.
Sertraline Sertraline The risk or severity of serotonin syndrome can be increased when Safinamide is combined with Sertraline.
Propafenone Propafenone The metabolism of Propafenone can be decreased when combined with Safinamide.
Raloxifene Raloxifene Safinamide may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Irbesartan Irbesartan Safinamide may increase the hypotensive activities of Irbesartan.
Tamsulosin Tamsulosin Safinamide may increase the orthostatic hypotensive activities of Tamsulosin.
Ropinirole Ropinirole The risk or severity of adverse effects can be increased when Safinamide is combined with Ropinirole.
Finasteride Finasteride The metabolism of Safinamide can be decreased when combined with Finasteride.
Quetiapine Quetiapine The metabolism of Quetiapine can be decreased when combined with Safinamide.
Cetirizine Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Safinamide.
Paroxetine Paroxetine Safinamide may increase the serotonergic activities of Paroxetine.
Tolcapone Tolcapone Safinamide may increase the orthostatic hypotensive activities of Tolcapone.
Citalopram Citalopram The risk or severity of serotonin syndrome can be increased when Safinamide is combined with Citalopram.
Capecitabine Capecitabine The metabolism of Capecitabine can be decreased when combined with Safinamide.
Efavirenz Efavirenz The metabolism of Efavirenz can be decreased when combined with Safinamide.
Sildenafil Sildenafil The metabolism of Sildenafil can be decreased when combined with Safinamide.
Pioglitazone Pioglitazone Safinamide may increase the hypoglycemic activities of Pioglitazone.
Celecoxib Celecoxib The metabolism of Celecoxib can be decreased when combined with Safinamide.
Rosiglitazone Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Safinamide.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Safinamide.
Thalidomide Thalidomide Safinamide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Balsalazide Balsalazide The risk or severity of hypertension can be increased when Balsalazide is combined with Safinamide.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Safinamide.
Galantamine Galantamine The metabolism of Galantamine can be decreased when combined with Safinamide.
Levetiracetam Levetiracetam The risk or severity of adverse effects can be increased when Levetiracetam is combined with Safinamide.
Rabeprazole Rabeprazole The metabolism of Rabeprazole can be decreased when combined with Safinamide.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Safinamide.

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