Medication interaction hub

What Supplements Interact with Safinamide Mesylate?

Safinamide Mesylate brand name: Xadago. Every interaction below applies to the brands too.

81 Interactions 14 Major 56 Moderate 11 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Safinamide Mesylate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Safinamide Mesylate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

81 supplements and herbal ingredients have interactions with Safinamide Mesylate on file in the HelloPharmacist interaction database — 14 rated major, 56 moderate, and 11 minor. The most serious involve Brewer's Yeast, Fever Bark, Soy, Tyramine and Yohimbe.

Our assessment: with 14 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Safinamide Mesylate.

Major 14 Moderate 56 Minor 11 No known interaction 1,371

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Safinamide Mesylate: Top Interactions at a Glance

The Safinamide Mesylate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 81 interacting ingredients — plus 1,371 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Safinamide Mesylate Combinations Today

The Safinamide Mesylate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Likely Yohimbe + Safinamide Mesylatei

Concomitant use of MAOIs with yohimbe can result in additive effects.

Read the full interaction Major Likelihood Probable Cowhage + Safinamide Mesylatei

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.

Read the full interaction Moderate Likelihood Possible Phenylalanine + Safinamide Mesylatei

Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.

Read the full interaction Major Likelihood Likely Soy + Safinamide Mesylatei

Taking soy products containing high amounts of tyramine along with MAOIs can increase the risk of hypertensive crisis.

Read the full interaction Major Likelihood Probable Bitter Orange + Safinamide Mesylatei

Theoretically, taking MAOIs with synephrine-containing bitter orange preparations might increase the hypertensive effects of synephrine, potentially leading to...

Read the full interaction Minor Likelihood Possible Ashwagandha + Safinamide Mesylatei

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.

Read the full interaction
The complete list

Every Supplement Checked Against Safinamide Mesylate

All 1,452 ingredients in our database, ranked by severity — 81 with a Safinamide Mesylate interaction on file and 1,371 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Safinamide Mesylate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Yohimbe with Safinamide Mesylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of MAOIs with yohimbe can result in additive effects.

Full Yohimbe + Safinamide Mesylate answer

Can you take Cowhage with Safinamide Mesylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.

Full Cowhage + Safinamide Mesylate answer

Can you take Phenylalanine with Safinamide Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.

Full Phenylalanine + Safinamide Mesylate answer

Can you take Soy with Safinamide Mesylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Taking soy products containing high amounts of tyramine along with MAOIs can increase the risk of hypertensive crisis.

Full Soy + Safinamide Mesylate answer

Can you take Bitter Orange with Safinamide Mesylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking MAOIs with synephrine-containing bitter orange preparations might increase the hypertensive effects of synephrine, pot...

Full Bitter Orange + Safinamide Mesylate answer

Can you take Tianeptine with Safinamide Mesylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Tianeptine may increase the toxicity of MAOIs.

Full Tianeptine + Safinamide Mesylate answer

Can you take Wine with Safinamide Mesylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may cause hypertensive crisis.

Full Wine + Safinamide Mesylate answer

Can you take Coffee Charcoal with Safinamide Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Safinamide Mesylate answer

Can you take Ephedra with Safinamide Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of serious adverse effects.

Full Ephedra + Safinamide Mesylate answer

Can you take European Mandrake with Safinamide Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Safinamide Mesylate answer

Can you take Glucomannan with Safinamide Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Safinamide Mesylate answer

Can you take Panax Ginseng with Safinamide Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng can interfere with MAOI therapy.

Full Panax Ginseng + Safinamide Mesylate answer

Can you take Sida Cordifolia with Safinamide Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Sida cordifolia might increase the risk of hypertension when taken with MAOIs.

Full Sida Cordifolia + Safinamide Mesylate answer

Can you take 5-htp with Safinamide Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.

Full 5-htp + Safinamide Mesylate answer

Can you take Acetyl-l-carnitine with Safinamide Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstr...

Full Acetyl-l-carnitine + Safinamide Mesylate answer

Can you take Adrafinil with Safinamide Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk for serious adverse effects.

Full Adrafinil + Safinamide Mesylate answer

Can you take American Ginseng with Safinamide Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, American ginseng can interfere with MAOI therapy.

Full American Ginseng + Safinamide Mesylate answer

Can you take Ayahuasca with Safinamide Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase levels of serotonin, which may have additive effects with serotonergic drugs.

Full Ayahuasca + Safinamide Mesylate answer

Can you take Betel Nut with Safinamide Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that betel nut extract can inhibit monoamine oxidase.

Full Betel Nut + Safinamide Mesylate answer

Can you take Black Cohosh with Safinamide Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining serotonergic drugs with black cohosh might cause additive serotonergic effects.

Full Black Cohosh + Safinamide Mesylate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Safinamide Mesylate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Safinamide Mesylate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Safinamide Mesylate sits in 5 interaction categories. Open any one to see what the group means:

Monoamine Oxidase Inhibitors (Maois) 42 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

42 of the supplement ingredients on this page reach Safinamide Mesylate through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Safinamide Mesylate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Safinamide Mesylate through this category.

Dopamine Agonists 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Safinamide Mesylate through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Safinamide Mesylate through this category.

About Safinamide Mesylate

Safinamide is a monoamine oxidase B (MAO-B) inhibitor used alongside levodopa/carbidopa to help manage Parkinson's disease in people experiencing 'off' episodes.

Generic name: Safinamide Mesylate  ·  Brand name: Xadago.

See the full Safinamide drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Safinamide Mesylate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Safinamide Mesylate.

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Pharmacist Counseling Corner

Safinamide Mesylate & Supplements: Common Questions

What supplements interact with Safinamide Mesylate?
In our interaction database, 81 supplement and herbal ingredients have an interaction with Safinamide Mesylate on file — 14 rated major, 56 moderate, and 11 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Brewer's Yeast, Fever Bark, Soy.
Which Safinamide Mesylate supplement interactions are the most serious?
Focus on the major group: Brewer's Yeast, Fever Bark, Soy, Tyramine and Yohimbe, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Safinamide Mesylate?
That depends entirely on which supplement. The honest answer for Safinamide Mesylate is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Xadago have the same supplement interactions as Safinamide Mesylate?
Yes — Xadago all contain Safinamide Mesylate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Safinamide Mesylate and my other medications?
This page covers Safinamide Mesylate against supplements and herbal ingredients. Checking Safinamide Mesylate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Safinamide drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.