Medication interaction hub

What Supplements Interact with Selegiline?

Selegiline brand names: Carbex, Eldepryl, Emsam, Zelapar. Every interaction below applies to the brands too.

102 Interactions 14 Major 75 Moderate 13 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Selegiline? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Selegiline against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

102 supplements and herbal ingredients have interactions with Selegiline on file in the HelloPharmacist interaction database — 14 rated major, 75 moderate, and 13 minor. The most serious involve Brewer's Yeast, Fever Bark, Soy, Tyramine and Yohimbe.

Our assessment: with 14 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Selegiline.

Major 14 Moderate 75 Minor 13 No known interaction 1,350

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Selegiline: Top Interactions at a Glance

The Selegiline supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 102 interacting ingredients — plus 1,350 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Selegiline Combinations Today

The Selegiline + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Phenylalanine + Selegilinei

Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.

Read the full interaction Major Likelihood Likely Soy + Selegilinei

Taking soy products containing high amounts of tyramine along with MAOIs can increase the risk of hypertensive crisis.

Read the full interaction Major Likelihood Likely Tyramine + Selegilinei

Concomitant use of tyramine with MAOIs may increase the risk of serious adverse effects from tyramine.

Read the full interaction Major Likelihood Probable Cowhage + Selegilinei

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.

Read the full interaction Major Likelihood Probable Wine + Selegilinei

Concomitant use may cause hypertensive crisis.

Read the full interaction Moderate Likelihood Possible Caffeine + Selegilinei

Theoretically, concomitant use might increase the risk of a hypertensive crisis.

Read the full interaction
The complete list

Every Supplement Checked Against Selegiline

All 1,452 ingredients in our database, ranked by severity — 102 with a Selegiline interaction on file and 1,350 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Selegiline?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Phenylalanine with Selegiline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.

Full Phenylalanine + Selegiline answer

Can you take Soy with Selegiline?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Taking soy products containing high amounts of tyramine along with MAOIs can increase the risk of hypertensive crisis.

Full Soy + Selegiline answer

Can you take Tyramine with Selegiline?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of tyramine with MAOIs may increase the risk of serious adverse effects from tyramine.

Full Tyramine + Selegiline answer

Can you take Cowhage with Selegiline?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.

Full Cowhage + Selegiline answer

Can you take Wine with Selegiline?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may cause hypertensive crisis.

Full Wine + Selegiline answer

Can you take Tarragon with Selegiline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that tarragon extract inhibits monoamine oxidase (MAO)-A and MAO-B enzymes.

Full Tarragon + Selegiline answer

Can you take Tragacanth with Selegiline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Selegiline answer

Can you take Vitex Agnus-castus with Selegiline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitex agnus-castus could interfere with dopamine agonists.

Full Vitex Agnus-castus + Selegiline answer

Can you take Yerba Mate with Selegiline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the caffeine in yerba mate might increase risk of a hypertensive crisis when used concomitantly with MAOIs.

Full Yerba Mate + Selegiline answer

Can you take Thyroid Extract with Selegiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Selegiline answer

Can you take Agar with Selegiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Selegiline answer

Can you take Algin with Selegiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Selegiline answer

Can you take Ashwagandha with Selegiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.

Full Ashwagandha + Selegiline answer

Can you take Black Psyllium with Selegiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Selegiline answer

Can you take Blond Psyllium with Selegiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Selegiline answer

Can you take Carob with Selegiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Selegiline answer

Can you take Celery with Selegiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.

Full Celery + Selegiline answer

Can you take Karaya Gum with Selegiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Selegiline answer

Can you take Marshmallow with Selegiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Selegiline answer

Can you take Rhodiola with Selegiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.

Full Rhodiola + Selegiline answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Selegiline is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Selegiline, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Selegiline sits in 8 interaction categories. Open any one to see what the group means:

Monoamine Oxidase Inhibitors (Maois) 42 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

42 of the supplement ingredients on this page reach Selegiline through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Selegiline through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Selegiline through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Selegiline through this category.

Dopamine Agonists 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Selegiline through this category.

Antidepressant Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Selegiline through this category.

Selegiline (Eldepryl) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Selegiline through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Selegiline through this category.

About Selegiline

Selegiline is a brain enzyme inhibitor used alongside levodopa/carbidopa to help people with Parkinson's disease get more consistent, longer-lasting relief from their symptoms.

Generic name: Selegiline  ·  Brand names: Carbex, Eldepryl, Emsam, Zelapar.

See the full Selegiline drug information

Related: does Selegiline deplete any nutrients?

Selegiline has 1 reported nutrient association in the research literature — see the Selegiline nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Selegiline

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Selegiline.

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Pharmacist Counseling Corner

Selegiline & Supplements: Common Questions

What supplements interact with Selegiline?
In our interaction database, 102 supplement and herbal ingredients have an interaction with Selegiline on file — 14 rated major, 75 moderate, and 13 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Brewer's Yeast, Fever Bark, Soy.
Which Selegiline supplement interactions are the most serious?
The 14 major-rated combinations — led by Brewer's Yeast, Fever Bark, Soy, Tyramine and Yohimbe — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Selegiline?
That depends entirely on which supplement. The honest answer for Selegiline is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Carbex have the same supplement interactions as Selegiline?
Yes — Carbex, Eldepryl, Emsam, Zelapar all contain Selegiline, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Selegiline deplete any vitamins or nutrients?
It might — Selegiline has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Selegiline nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Selegiline and my other medications?
This page covers Selegiline against supplements and herbal ingredients. Checking Selegiline against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Selegiline drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.