Drug & supplement interaction

Beta-methylphenethylamine (bmpea) + Selegiline

Selegiline brand names: Carbex, Eldepryl, Emsam, Zelapar.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Beta-methylphenethylamine (bmpea) and Selegiline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Beta-methylphenethylamine (bmpea) and Selegiline

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Selegiline and Beta-methylphenethylamine (bmpea) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Beta-methylphenethylamine (bmpea) safety at a glance

Beta-methylpheneth... overall Avoid BMPEA is an unapproved synthetic stimulant linked to safety concerns and is best avoided.
Pregnancy Possibly Unsafe When used orally. BMPEA is an amphetamine-like compound that has been shown to have stimulant properties and is associated with severe cardiovascular adverse ef... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. BMPEA is an amphetamine-like compound that has been shown to have stimulant properties and is associated with severe cardiovascular adverse ef... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Selegiline and Beta-methylphenethylamine (bmpea)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Selegiline

Interactions in our licensed database are recorded against drug classes, not just single drug names. Selegiline is filed under 8 classifications — including monoamine oxidase inhibitors (maois), dopamine agonists, antidepressant drugs. Beta-methylphenethylamine (bmpea) has documented interactions with 3 drug classes — the most serious being cytochrome p450 2d6 (cyp2d6) substrates (moderate), cytochrome p450 3a4 (cyp3a4) substrates (moderate) and stimulant drugs (moderate) — and none of Selegiline’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Beta-methylphenethylamine (bmpea) Does Interact With Other Medications

Beta-methylphenethylamine (bmpea) has 813 moderate known drug interactions in our database — Selegiline isn’t one of them. If you take anything else, check it against the full list below.

Moderate 813 No known interaction 2,017 (incl. Selegiline)
Taking anything else?

Check Another of Your Medications Against Beta-methylphenethylamine (bmpea)

Covers the 2,830 medications we’ve checked against Beta-methylphenethylamine (bmpea). Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Beta-methylphenethylamine (bmpea) and Selegiline May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on Additional detail

    Beta-methylphenethylamine (bmpea)

    “BMPEA is an amphetamine derivative which can cause serious stimulant adverse effects.

    Most Common Adverse Effects:

    Hypertension and tachycardia.

    Serious Adverse Effects (Rare):

    Cardiac arrest, stroke.”

    Beta-methylphenethylamine (bmpea) · Natural Medicines adverse-effect record, reported in cardiac arrest.

    Selegiline

    Listed in the ADVERSE REACTIONS section of the FDA label for Selegiline. Read the label on DailyMed ›

  • A fast or pounding heartbeat Additional detail

    Beta-methylphenethylamine (bmpea)

    “Hemorrhagic stroke was reported in a healthy 53-year-old female who took a specific supplement (Jacked Power, MM sports) 30 minutes prior to exercise. It was not labeled as containing BMPEA, but testing showed a level of 290 mg per dose.”

    Beta-methylphenethylamine (bmpea) · Natural Medicines adverse-effect record, reported in cardiac arrest.

    2 sources cited
    1. 89219. Cohen PA, Zeijlon R, Nardin R, Keizers PH, Venhuis B. Hemorrhagic Stroke Probably Caused by Exercise Combined With a Sports Supplement Containing ß-Methylphenyl-ethylamine (BMPEA): A Case Report. Ann Intern Med. 2015 Jun 16;162(12):879-80. doi: 10.7326/L1 DOI
    2. 21079. Venhuis B, Keizers P, van Riel A, de Kaste D. A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events. Drug Test Anal. 2014 Jun;6(6):578-81. doi: 10.1002/dta.1664. Epub 2014 May 6. PubMed

    Selegiline

    Listed in the ADVERSE REACTIONS section of the FDA label for Selegiline. Read the label on DailyMed ›

Reported for Beta-methylphenethylamine (bmpea) but not commonly for Selegiline: a stroke or mini-stroke.

Effects for Selegiline come from the ADVERSE REACTIONS section of its FDA label; effects for Beta-methylphenethylamine (bmpea) come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 3,469 voluntary FDA FAERS reports for Selegiline that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Beta-methylphenethylamine (bmpea) in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. BMPEA is an amphetamine-like compound that has been shown to have stimulant properties and is associated with severe cardiovascular adverse effects.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Selegiline

This page covers Beta-methylphenethylamine (bmpea) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Selegiline page lists 102 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Bitter Orange (major), Brewer's Yeast (major) and Cowhage (major).

By severity: 14 major · 75 moderate · 13 minor.

Open the Selegiline interaction page

How much people look this up

Where Beta-methylphenethylamine (bmpea) and Selegiline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Beta-methylphenethylamine (bmpea)
Steady interest

#1,271 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Selegiline
Steady interest

#2,235 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Beta-methylphenethylamine (bmpea) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Beta-methylphenethylamine (bmpea) and Selegiline records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Beta-methylphenethylamine (bmpea)

What is Beta-methylphenethylamine (bmpea)?

  • Weight loss
  • Pre-workout energy
  • Athletic performance
  • Appetite suppression
  • Mental focus

Beta-methylphenethylamine (BMPEA) is a synthetic stimulant chemically similar to amphetamine that has been found in some weight-loss and sports supplements, often without being clearly listed on the label. It is not an approved or well-studied dietary ingredient, and regulators have warned that it may carry real cardiovascular risks. Because of safety concerns and the lack of human research, it is best avoided.

Synthetic chemical; also reported as a constituent of some Acacia species · Capsules, tablets, and powders sold as pre-workout, weight-loss, or 'energy' supplements

An interaction check asks whether these two react with each other — it does not ask whether Beta-methylphenethylamine (bmpea) is a good idea for someone in your situation. Here is what our Beta-methylphenethylamine (bmpea) record says about it on its own.

Beta-methylphenethylamine (bmpea): dosing

There is no established or recommended dose for BMPEA, and no safe dose has been determined through research. It is not an approved ingredient, so any amount in a supplement is unregulated and may not match what the label says.We do not recommend taking BMPEA.

From our Beta-methylphenethylamine (bmpea) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Beta-methylphenethylamine (bmpea) monograph & all interactions
Medication

About Selegiline

What Is Selegiline Used For?

Brand names: Carbex, Eldepryl, Emsam, Zelapar

Selegiline is used as an add-on treatment for people with Parkinson's disease who are already taking levodopa/carbidopa but are finding that the medication's effects are wearing off or becoming less reliable. It is not used alone — it only works as part of a combination approach.

In clinical studies, adding selegiline helped reduce the amount of daily levodopa needed, cut down on "off" time (periods when symptoms break through), and improved things like tremor, speech, movement, and overall daily function.

Most-Reported Side Effects for Selegiline

From FAERS, the FDA’s public side-effect reporting system (3,526 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hallucination 230 reports
Insomnia 206 reports
Dizziness 196 reports
Fall 186 reports
Application site erythema 185 reports
See full Selegiline drug information
Keep checking

Other Drugs & Beta-methylphenethylamine (bmpea)

Browse every other medication we’ve checked against Beta-methylphenethylamine (bmpea) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
813Moderate
0Minor
2,016No known interaction
813 Moderate 2,016 No interaction
Moderate

813 interactions

Showing 60 of 813 moderate interactions — see all 813 on the Beta-methylphenethylamine (bmpea) page.

No interaction 2,016 drugs checked — show the list

We also checked Beta-methylphenethylamine (bmpea) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,016 medications checked with no known interaction — see the full Beta-methylphenethylamine (bmpea) list.

See the full Beta-methylphenethylamine (bmpea) interactions page
See every supplement checked against Selegiline, ranked by severity
Evidence & sources

Beta-methylphenethylamine (bmpea) References

The 5 references that drive our Beta-methylphenethylamine (bmpea) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Venhuis B, Keizers P, van Riel A, de Kaste D. A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events. Drug Test Anal. 2014 Jun;6(6):578-81. doi: 10.1002/dta.1664. Epub 2014 May 6. PubMed
  2. Cohen PA, Bloszies C, Yee C, Gerona R. An amphetamine isomer whose efficacy and safety in humans has never been studied, ß-methylphenylethylamine (BMPEA), is found in multiple dietary supplements. Drug Test Anal. 2015 Apr 7. PubMed
  3. Cohen PA, Zeijlon R, Nardin R, Keizers PH, Venhuis B. Hemorrhagic Stroke Probably Caused by Exercise Combined With a Sports Supplement Containing ß-Methylphenyl-ethylamine (BMPEA): A Case Report. Ann Intern Med. 2015 Jun 16;162(12):879-80. doi: 10.7326/L1 DOI
  4. Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
  5. Brown DH, Hansson R, Oosthuizen F, et al. ß-Methylphenylethylamines: common fragmentation pathways with amphetamines in electrospray ionization collision-induced dissociation. Drug Test Anal 2016;8:344-50.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Beta-methylphenethylamine (bmpea) and Selegiline Together: Common Questions

Is it safe to take Beta-methylphenethylamine (bmpea) with Selegiline?
We do not list a known interaction between Beta-methylphenethylamine (bmpea) and Selegiline. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Beta-methylphenethylamine (bmpea) and Selegiline have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Beta-methylphenethylamine (bmpea) and Selegiline combination checked?
Interactions in our licensed database are recorded against drug classes. Selegiline is filed under 8 classifications, and Beta-methylphenethylamine (bmpea) has documented interactions with 3 drug classes — none of Selegiline's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Beta-methylphenethylamine (bmpea) interact with any other medications?
Yes. Beta-methylphenethylamine (bmpea) has 813 documented drug interactions in our database — Selegiline is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Selegiline interact with any supplements?
Yes. Selegiline has documented interactions with 102 supplements in our database — Beta-methylphenethylamine (bmpea) is not one of them. The Selegiline interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Beta-methylphenethylamine (bmpea) monograph Uses, safety profile, and every drug interaction in one place Selegiline drug information The full plain-English guide to this medication Selegiline supplement interactions Every supplement checked against Selegiline, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Selegiline and Beta-methylphenethylamine (bmpea)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.