Herb & supplement monograph

Hazelnut Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Hazelnut

0 medications have a known interaction with Hazelnut, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Hazelnut. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Hazelnut combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Hazelnut: Uses, Safety & Side Effects

The bottom line

Hazelnuts are a nutritious tree nut rich in healthy fats, fiber, vitamin E, and antioxidants, and eating them as part of a balanced diet may support heart health. They are mainly a food rather than a treatment, and the biggest safety concern is that they are a common cause of serious nut allergy.

Scientific name
Corylus avellana
Family
Betulaceae
Part used
Nut (kernel), nut oil, and sometimes leaves
Common forms
Whole nuts, hazelnut oil, hazelnut flour/meal, nut butter, and skin or leaf extracts in some supplements
People commonly use it for
  • Heart and cholesterol health
  • Source of healthy fats and protein
  • Antioxidant support
  • Blood sugar support
  • General nutrition and snacking

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally safe as a food for most people, but a common cause of serious tree nut allergy.

PregnancyLikely Safe

When used in amounts commonly found in foods.

Read the full pregnancy detail
BreastfeedingLikely Safe

When used in amounts commonly found in foods.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Hazelnuts come from trees and shrubs in the genus Corylus, most commonly Corylus avellana. The plant grows in temperate parts of Europe, Asia, and North America, and Turkey is one of the largest producers in the world.

People mostly use hazelnuts as a food. The nuts are eaten whole, roasted, ground into flour, made into nut butter, or pressed into oil. Hazelnut is also a popular flavoring in chocolate spreads, coffee drinks, and baked goods.

Beyond food, some people take hazelnuts or hazelnut products hoping for health benefits such as supporting heart health, providing antioxidants, and adding healthy fats to the diet.

How it works

Hazelnuts are rich in monounsaturated fats (the same kind found in olive oil), which may help with cholesterol levels. They also provide fiber, plant protein, vitamin E, and minerals such as magnesium and copper.

The skins and kernels contain antioxidant compounds like polyphenols and tocopherols. In laboratory studies, these compounds can neutralize free radicals and reduce markers of inflammation.

It is important to know that much of this is based on lab and animal research or on studies of overall diet. The exact way hazelnuts affect the human body, and how much you would need to eat for a benefit, is not fully established.

Effectiveness

Does Hazelnut work?

Evidence overview · 4 uses evaluated
1 Leans ineffective 3 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Ineffective Obesity
Rating & evidence shown verbatim from Natural Medicines

Most clinical research shows that consuming hazelnuts or hazelnut oil does not improve weight loss.

Also studied for 3 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Coronary heart disease (CHD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if consuming hazelnuts as part of the diet reduces the risk for CHD.

Insufficient Reliable Evidence To Rate Dementia
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral hazelnut to prevent dementia, there is insufficient reliable information about the clinical effects of hazelnut for this purpose.

Insufficient Reliable Evidence To Rate Hyperlipidemia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if consuming hazelnuts as part of the diet can lower lipid levels.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

For most people, hazelnuts are safe to eat as a normal food. The biggest concern is tree nut allergy. Hazelnut is one of the most common causes of nut allergy, and reactions can be severe and life-threatening. People with a known tree nut allergy should avoid hazelnuts entirely.

Some people who are allergic to birch pollen may also react to hazelnuts (a type of cross-reaction), often with itching or swelling in the mouth.

Hazelnuts are high in calories and fat, so large amounts may add up if you are watching your weight. Whole nuts can also be a choking hazard for young children.

Pregnancy and breastfeeding: Eating hazelnuts as a normal part of the diet is generally fine if you are not allergic and tolerate them well. Concentrated hazelnut extracts or supplements have not been well studied in pregnancy or breastfeeding, so it is best to avoid those unless your doctor or pharmacist approves.

If you are unsure whether hazelnut is right for you, check with a pharmacist or doctor, especially if you have allergies.

Side effects

When eaten as food by people who are not allergic, hazelnuts usually cause few side effects. Eating a lot at once may cause bloating, gas, or stomach upset because of the fat and fiber.

The most serious risk is an allergic reaction. Symptoms can include itching, hives, swelling of the lips, mouth, or throat, trouble breathing, and in severe cases a life-threatening reaction called anaphylaxis. Anyone with these symptoms needs emergency medical care right away.

Mold contamination of poorly stored nuts can sometimes be a concern, so store hazelnuts in a cool, dry place and discard any that smell off or taste bitter or rancid.

Hazelnut: Reported Adverse Effects

Documented safety reports on Hazelnut from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, hazelnut is well tolerated.

Serious Adverse Effects (Rare):

All routes of administration: Allergic reactions, including oral allergy syndrome and anaphylaxis.

Reports by condition
Allergic rhinitis (hay fever) Dermatologic

Orally, hazelnut can cause atopic dermatitis in patients with a hazelnut allergy. In one case, hazelnut essence in hydroxyzine syrup was determined to be the likely cause of atopic dermatitis in a toddler.

  1. Peroni DG, Dall'Agnola A, Piacentini GL, Boner AL. Worsening of atopic dermatitis by hazelnut essence contained in hydroxyzine syrup. Acta Paediatr 2007;96(11):1710.
Allergic rhinitis (hay fever) Immunologic

Orally, hazelnut can cause an allergic reaction in sensitive individuals, with severity ranging from oral allergy syndrome to anaphylaxis. The prevalence of hazelnut sensitization varies by geographic location, with hazelnut allergy reported more often in areas with greater birch tree pollen exposure. Hazelnut allergy is more common in adults than children, but children are more likely to develop severe reactions.

  1. Valcour A, Lidholm J, Borres MP, Hamilton RG. Sensitization profiles to hazelnut allergens across the United States. Ann Allergy Asthma Immunol 2019;122(1):111-6.e1.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official medical dose for hazelnuts. As a food, a small handful (about an ounce) is a common serving size in studies of nuts and heart health.

For any hazelnut supplement, oil, or extract, there is no standardized dose. Follow the directions on the product label and do not assume more is better.

Talk with a pharmacist or doctor before using concentrated hazelnut products, especially if you have allergies, are pregnant or breastfeeding, or take other medications.

Pregnancy & Breastfeeding

Hazelnut & Pregnancy

Likely Safe

When used in amounts commonly found in foods.

Hazelnut & Breastfeeding

Likely Safe

When used in amounts commonly found in foods.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 references that drive our Hazelnut monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Peroni DG, Dall'Agnola A, Piacentini GL, Boner AL. Worsening of atopic dermatitis by hazelnut essence contained in hydroxyzine syrup. Acta Paediatr 2007;96(11):1710. PubMed
  2. Valcour A, Lidholm J, Borres MP, Hamilton RG. Sensitization profiles to hazelnut allergens across the United States. Ann Allergy Asthma Immunol 2019;122(1):111-6.e1. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Product directory

Supplement products with Hazelnut

15 products in our database contain Hazelnut. Open any to see its full ingredient list and every drug interaction we check.

Cal/Mag with Whole Foods by NaturesPlus Tablet Or Pill 180 Tablet(s) View ingredients & interactions Cal/Mag with Whole Foods by NaturesPlus Tablet Or Pill 180 Tablet(s) View ingredients & interactions Kava Stress Relief by Yogi Other (e.g. Tea Bag) 16 Tea Bag(s) · 1.27 Ounce(s) · 36 Gram(s) View ingredients & interactions LungHealth by Dr. Garber's Liquid 2 fl. Oz. · 60 mL View ingredients & interactions Mixed EFAs by Biotics Research Corporation Liquid 8 fl. Oz. · 240 mL View ingredients & interactions Ultra-Mins by NaturesPlus Tablet Or Pill 180 Tablet(s) View ingredients & interactions Ultra-Mins by NaturesPlus Tablet Or Pill 180 Tablet(s) View ingredients & interactions Cal/Mag Mineral Supplement W/Whole Foods by Nature's Plus Source of Life Tablet Or Pill 180 Tablet(s) Off market View ingredients & interactions Men's Nutra Packs by Nature's Plus Unknown 30 Individual Pack(s) Off market View ingredients & interactions Source of Life Cal/Mag by Nature's Plus Tablet Or Pill 90 Tablet(s) Off market View ingredients & interactions Ultra-Mins by Natures Plus Tablet Or Pill 90 Tablet(s) Off market View ingredients & interactions Ultra-Mins by Natures Plus Tablet Or Pill 90 Tablet(s) Off market View ingredients & interactions Ultra-Mins Multiple Mineral With Whole Foods by Nature's Plus Tablet Or Pill 90 Tablet(s) Off market View ingredients & interactions Ultra-Mins Multiple Mineral With Whole Foods by Nature's Plus Tablet Or Pill 90 Tablet(s) Off market View ingredients & interactions Woman's Nutra Packs by Nature's Plus Other (e.g. Tea Bag) 30 Individual Pack(s) Off market View ingredients & interactions
Pharmacist Counseling Corner

Hazelnut: Common Questions

What is Hazelnut used for, and does it work?
People use Hazelnut for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Hazelnut interact with prescription medications?
We do not currently list any known drug interactions for Hazelnut. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Hazelnut interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Hazelnut with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Hazelnut interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What are Hazelnuts mainly used for?
They are mostly eaten as a nutritious food that provides healthy fats, fiber, protein, vitamin E, and antioxidants. Some people include them in their diet hoping to support heart and cholesterol health.
Are Hazelnuts good for your heart?
Diets that include tree nuts like Hazelnuts have been linked with better cholesterol and heart health in some studies, but this is mostly about nuts as part of an overall healthy diet rather than Hazelnut alone.
Can Hazelnuts cause an allergic reaction?
Yes. Hazelnut is one of the most common tree nut allergies and reactions can be severe, including swelling and trouble breathing. Anyone with a known nut allergy should avoid them and seek emergency care for serious symptoms.
Are Hazelnuts safe to eat during pregnancy?
Eating Hazelnuts as a normal food is generally fine during pregnancy if you are not allergic and tolerate them well. Concentrated extracts or supplements are not well studied, so check with your doctor before using those.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Hazelnut

A rotating sample of real supplements in our database that list Hazelnut — open any to see its full ingredients and every drug interaction we check.

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