Hazelnut Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Hazelnut interacts with medications. The heart of this page is the interaction list — every drug Hazelnut is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Hazelnut is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Hazelnut against your medication
Add one medicationDrugs that interact with Hazelnut
0 medications have a known interaction with Hazelnut, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Hazelnut. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Hazelnut combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Hazelnut: Uses, Safety & Side Effects
Hazelnuts are a nutritious tree nut rich in healthy fats, fiber, vitamin E, and antioxidants, and eating them as part of a balanced diet may support heart health. They are mainly a food rather than a treatment, and the biggest safety concern is that they are a common cause of serious nut allergy.
- Scientific name
- Corylus avellana
- Family
- Betulaceae
- Part used
- Nut (kernel), nut oil, and sometimes leaves
- Common forms
- Whole nuts, hazelnut oil, hazelnut flour/meal, nut butter, and skin or leaf extracts in some supplements
- Heart and cholesterol health
- Source of healthy fats and protein
- Antioxidant support
- Blood sugar support
- General nutrition and snacking
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally safe as a food for most people, but a common cause of serious tree nut allergy.
When used in amounts commonly found in foods.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Hazelnuts come from trees and shrubs in the genus Corylus, most commonly Corylus avellana. The plant grows in temperate parts of Europe, Asia, and North America, and Turkey is one of the largest producers in the world.
People mostly use hazelnuts as a food. The nuts are eaten whole, roasted, ground into flour, made into nut butter, or pressed into oil. Hazelnut is also a popular flavoring in chocolate spreads, coffee drinks, and baked goods.
Beyond food, some people take hazelnuts or hazelnut products hoping for health benefits such as supporting heart health, providing antioxidants, and adding healthy fats to the diet.
How it works
Hazelnuts are rich in monounsaturated fats (the same kind found in olive oil), which may help with cholesterol levels. They also provide fiber, plant protein, vitamin E, and minerals such as magnesium and copper.
The skins and kernels contain antioxidant compounds like polyphenols and tocopherols. In laboratory studies, these compounds can neutralize free radicals and reduce markers of inflammation.
It is important to know that much of this is based on lab and animal research or on studies of overall diet. The exact way hazelnuts affect the human body, and how much you would need to eat for a benefit, is not fully established.
Does Hazelnut work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
Possibly Ineffective Obesity
Most clinical research shows that consuming hazelnuts or hazelnut oil does not improve weight loss.
Also studied for 3 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Coronary heart disease (CHD)
It is unclear if consuming hazelnuts as part of the diet reduces the risk for CHD.
Insufficient Reliable Evidence To Rate Dementia
Although there is interest in using oral hazelnut to prevent dementia, there is insufficient reliable information about the clinical effects of hazelnut for this purpose.
Insufficient Reliable Evidence To Rate Hyperlipidemia
It is unclear if consuming hazelnuts as part of the diet can lower lipid levels.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
For most people, hazelnuts are safe to eat as a normal food. The biggest concern is tree nut allergy. Hazelnut is one of the most common causes of nut allergy, and reactions can be severe and life-threatening. People with a known tree nut allergy should avoid hazelnuts entirely.
Some people who are allergic to birch pollen may also react to hazelnuts (a type of cross-reaction), often with itching or swelling in the mouth.
Hazelnuts are high in calories and fat, so large amounts may add up if you are watching your weight. Whole nuts can also be a choking hazard for young children.
Pregnancy and breastfeeding: Eating hazelnuts as a normal part of the diet is generally fine if you are not allergic and tolerate them well. Concentrated hazelnut extracts or supplements have not been well studied in pregnancy or breastfeeding, so it is best to avoid those unless your doctor or pharmacist approves.
If you are unsure whether hazelnut is right for you, check with a pharmacist or doctor, especially if you have allergies.
Side effects
When eaten as food by people who are not allergic, hazelnuts usually cause few side effects. Eating a lot at once may cause bloating, gas, or stomach upset because of the fat and fiber.
The most serious risk is an allergic reaction. Symptoms can include itching, hives, swelling of the lips, mouth, or throat, trouble breathing, and in severe cases a life-threatening reaction called anaphylaxis. Anyone with these symptoms needs emergency medical care right away.
Mold contamination of poorly stored nuts can sometimes be a concern, so store hazelnuts in a cool, dry place and discard any that smell off or taste bitter or rancid.
Hazelnut: Reported Adverse Effects
Documented safety reports on Hazelnut from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, hazelnut is well tolerated.
Serious Adverse Effects (Rare):
All routes of administration: Allergic reactions, including oral allergy syndrome and anaphylaxis.
Allergic rhinitis (hay fever) Dermatologic
Orally, hazelnut can cause atopic dermatitis in patients with a hazelnut allergy. In one case, hazelnut essence in hydroxyzine syrup was determined to be the likely cause of atopic dermatitis in a toddler.
Allergic rhinitis (hay fever) Immunologic
Orally, hazelnut can cause an allergic reaction in sensitive individuals, with severity ranging from oral allergy syndrome to anaphylaxis. The prevalence of hazelnut sensitization varies by geographic location, with hazelnut allergy reported more often in areas with greater birch tree pollen exposure. Hazelnut allergy is more common in adults than children, but children are more likely to develop severe reactions.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no official medical dose for hazelnuts. As a food, a small handful (about an ounce) is a common serving size in studies of nuts and heart health.
For any hazelnut supplement, oil, or extract, there is no standardized dose. Follow the directions on the product label and do not assume more is better.
Talk with a pharmacist or doctor before using concentrated hazelnut products, especially if you have allergies, are pregnant or breastfeeding, or take other medications.
Hazelnut & Pregnancy
Hazelnut & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 2 references that drive our Hazelnut monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Peroni DG, Dall'Agnola A, Piacentini GL, Boner AL. Worsening of atopic dermatitis by hazelnut essence contained in hydroxyzine syrup. Acta Paediatr 2007;96(11):1710. PubMed
- Valcour A, Lidholm J, Borres MP, Hamilton RG. Sensitization profiles to hazelnut allergens across the United States. Ann Allergy Asthma Immunol 2019;122(1):111-6.e1. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Hazelnut
7 brands in our database make a supplement containing Hazelnut.
Supplement products with Hazelnut
15 products in our database contain Hazelnut. Open any to see its full ingredient list and every drug interaction we check.
Hazelnut: Common Questions
What is Hazelnut used for, and does it work?
Does Hazelnut interact with prescription medications?
How are Hazelnut interactions rated?
Is it safe to take Hazelnut with my medications?
Where does this Hazelnut interaction information come from?
What are Hazelnuts mainly used for?
Are Hazelnuts good for your heart?
Can Hazelnuts cause an allergic reaction?
Are Hazelnuts safe to eat during pregnancy?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Hazelnut
A rotating sample of real supplements in our database that list Hazelnut — open any to see its full ingredients and every drug interaction we check.
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