Medication interaction hub

What Supplements Interact with Rasagiline?

Rasagiline brand name: Azilect. Every interaction below applies to the brands too.

173 Interactions 14 Major 125 Moderate 34 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Rasagiline? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Rasagiline against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Rasagiline (Azilect) treats Parkinson's disease by blocking monoamine oxidase, the same enzyme that clears tyramine from aged and fermented foods. That shared pathway explains most of the 14 major-rated interactions on this page. Brewer's yeast and fermented soy sit in a group of tyramine sources that can drive blood pressure dangerously high, and a smaller set of serotonin-boosting supplements adds a risk of serotonin syndrome. This list warrants genuine care, and those majors are the entries to understand first.

The 125 moderate and 34 minor entries are broader but milder. Activated charcoal also rates major, since it can soak up an oral dose before your body absorbs it, so keep it well apart from rasagiline. Most of the moderates, seventy-nine ingredients, share the CYP1A2 pathway that processes rasagiline and can shift its blood level, while roughly twenty can make skin more sensitive to sun. A pharmacist can sort which of these apply to what you actually take.

— , Clinical Pharmacist · July 18, 2026

Major 14 Moderate 125 Minor 34 No known interaction 1,279

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Rasagiline: Top Interactions at a Glance

The most significant Rasagiline supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 173 interacting ingredients — plus 1,279 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Rasagiline + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Brewer's Yeast + Rasagilinei

Theoretically, taking brewer's yeast with MAOIs might increase the risk of hypertension.

Read the full interaction Major Likelihood Likely Fever Bark + Rasagilinei

Concomitant use of MAOIs with fever bark can result in additive effects.

Read the full interaction Major Likelihood Likely Soy + Rasagilinei

Taking soy products containing high amounts of tyramine along with MAOIs can increase the risk of hypertensive crisis.

Read the full interaction Major Likelihood Likely Tyramine + Rasagilinei

Concomitant use of tyramine with MAOIs may increase the risk of serious adverse effects from tyramine.

Read the full interaction Major Likelihood Likely Yohimbe + Rasagilinei

Concomitant use of MAOIs with yohimbe can result in additive effects.

Read the full interaction Major Likelihood Probable Activated Charcoal + Rasagilinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Rasagiline

All 1,452 ingredients in our database, ranked by severity — 173 with a Rasagiline interaction on file and 1,279 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Rasagiline?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Yohimbe with Rasagiline?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of MAOIs with yohimbe can result in additive effects.

Full Yohimbe + Rasagiline answer

Can you take Cowhage with Rasagiline?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.

Full Cowhage + Rasagiline answer

Can you take Hemp with Rasagiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.

Full Hemp + Rasagiline answer

Can you take Hibiscus Sabdariffa with Rasagiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP1A2 substrates.

Full Hibiscus Sabdariffa + Rasagiline answer

Can you take Karaya Gum with Rasagiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Rasagiline answer

Can you take Licorice with Rasagiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.

Full Licorice + Rasagiline answer

Can you take Marshmallow with Rasagiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Rasagiline answer

Can you take Moringa with Rasagiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, moringa might decrease the levels and clinical effects of CYP1A2 substrates.

Full Moringa + Rasagiline answer

Can you take Peppermint with Rasagiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, peppermint might increase the levels of CYP1A2 substrates.

Full Peppermint + Rasagiline answer

Can you take Rhodiola with Rasagiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.

Full Rhodiola + Rasagiline answer

Can you take Turmeric with Rasagiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, turmeric might increase levels of drugs metabolized by CYP1A2.

Full Turmeric + Rasagiline answer

Can you take Xanthan Gum with Rasagiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Rasagiline answer

Can you take Chrysin with Rasagiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, chrysin might increase levels of drugs metabolized by CYP1A2.

Full Chrysin + Rasagiline answer

Can you take Diindolylmethane with Rasagiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.

Full Diindolylmethane + Rasagiline answer

Can you take Hops with Rasagiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Hops extract does not seem to affect the metabolism of CYP1A2 substrates.

Full Hops + Rasagiline answer

Can you take Kava with Rasagiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if kava inhibits CYP1A2; research is conflicting.

Full Kava + Rasagiline answer

Can you take Red Clover with Rasagiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.

Full Red Clover + Rasagiline answer

Can you take Rosemary with Rasagiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.

Full Rosemary + Rasagiline answer

Can you take Theanine with Rasagiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting.

Full Theanine + Rasagiline answer

Can you take Turpentine Oil with Rasagiline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. There is some concern that turpentine oil can inhibit CYP1A2 enzyme activity by up to 90% via induction of inflammation and subsequent downr...

Full Turpentine Oil + Rasagiline answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Rasagiline is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Rasagiline, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Rasagiline sits in 8 interaction categories. Open any one to see what the group means:

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Rasagiline through this category.

Monoamine Oxidase Inhibitors (Maois) 42 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

42 of the supplement ingredients on this page reach Rasagiline through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Rasagiline through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Rasagiline through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Rasagiline through this category.

Dopamine Agonists 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Rasagiline through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Rasagiline through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Rasagiline through this category.

About Rasagiline

Rasagiline is an MAO-B inhibitor (a type of enzyme blocker) used to treat Parkinson's disease, available as tablets under brand names including Azilect, Rasagiline, and Rasagiline mesylate.

Generic name: Rasagiline  ·  Brand name: Azilect.

See the full Rasagiline drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Rasagiline

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Rasagiline.

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Pharmacist Counseling Corner

Rasagiline & Supplements: Common Questions

What supplements interact with Rasagiline?
In our interaction database, 173 supplement and herbal ingredients have an interaction with Rasagiline on file — 14 rated major, 125 moderate, and 34 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Brewer's Yeast, Fever Bark, Soy.
Which Rasagiline supplement interactions are the most serious?
The 14 major-rated combinations — led by Brewer's Yeast, Fever Bark, Soy, Tyramine and Yohimbe — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Rasagiline?
That depends entirely on which supplement. The honest answer for Rasagiline is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Azilect have the same supplement interactions as Rasagiline?
Yes — Azilect all contain Rasagiline, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Rasagiline and my other medications?
This page covers Rasagiline against supplements and herbal ingredients. Checking Rasagiline against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Rasagiline drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.