Drug & supplement interaction

Octopamine + Rasagiline

Rasagiline brand name: Azilect.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Octopamine has a moderate interaction with Rasagiline. Octopamine is metabolized by monoamine oxidase.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Octopamine and Rasagiline

Here is the interaction we found between these two, with the evidence behind it.

Moderate

MONOAMINE OXIDASE INHIBITORS (MAOIs)

Why this applies to Rasagiline

Rasagiline falls under MONOAMINE OXIDASE INHIBITORS (MAOIs) — the group Octopamine interacts with.

Octopamine is metabolized by monoamine oxidase. Theoretically, concurrent use of MAOIs with octopamine might increase the effects and side effects of octopamine. Tell patients taking MAOIs to avoid using octopamine. Some MAOIs include phenelzine (Nardil), tranylcypromine (Parnate), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the concern with pairing octopamine with rasagiline (Azilect). Octopamine is a stimulant-like compound that your body normally clears using an enzyme called monoamine oxidase. Rasagiline works by blocking part of that very enzyme system. So if you take octopamine while on rasagiline, the octopamine isn't broken down as quickly and can build up, making its stimulant effects stronger than expected.

In real terms, that could mean a spike in blood pressure, a racing or pounding heart, headache, or jitteriness. To be fair, this is a theoretical caution based on how these substances behave, not on hard clinical studies. Still, because blood pressure changes can be serious, I'd skip octopamine-containing weight-loss or sports supplements and check with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Visentin V, Morin N, Fontana E, et al. Dual action of octopamine on glucose transport into adipocytes: inhibition via beta3-adrenoceptor activation and stimulation via oxidation by amine oxidases. J Pharmacol Exp Ther 2001;299:96-104.
  2. Fontana E, Morin N, Prévot D, Carpéné C. Effects of octopamine on lipolysis, glucose transport and amine oxidation in mammalian fat cells. Comp Biochem Physiol C Toxicol Pharmacol. 2000;125(1):33-44. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Octopamine Also Interacts With Other Medications

Octopamine has 180 moderate, 171 minor known drug interactions in our database — the Rasagiline one above is one of them. If you take anything else, check it against the full list below.

Moderate 180 Minor 171 No known interaction 2,479 (incl. Rasagiline)
Taking anything else?

Check Another of Your Medications Against Octopamine

Covers the 2,830 medications we’ve checked against Octopamine. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Rasagiline

This page covers Octopamine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Rasagiline page lists 173 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Bitter Orange (major), Brewer's Yeast (major) and Cowhage (major).

By severity: 14 major · 125 moderate · 34 minor.

From our pharmacist’s overview on the Rasagiline page

“Rasagiline (Azilect) treats Parkinson's disease by blocking monoamine oxidase, the same enzyme that clears tyramine from aged and fermented foods. That shared pathway explains most of the 14 major-rated interactions on this page.”

Reviewed by 2 · Jul 18, 2026

Open the Rasagiline interaction page

One more smart check

Taking Octopamine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 118 real supplement products containing Octopamine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Octopamine. Your product may carry other ingredients that interact with Rasagiline too, on top of Octopamine — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Octopamine and Rasagiline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Octopamine
Steady interest

#904 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Rasagiline
Steady interest

#2,237 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Octopamine

What is Octopamine?

  • Weight loss and fat burning
  • Boosting energy
  • Athletic performance
  • Appetite suppression

Octopamine is a stimulant-like compound found in small amounts in some plants (such as bitter orange) and made naturally in the body. It is marketed mostly in weight-loss and sports supplements, but human evidence that it actually helps with fat loss or performance is very limited. Because it can affect the heart and blood pressure and is banned in some sports, talk to a pharmacist or doctor before using it.

Read the full Octopamine monograph & all interactions
Medication

About Rasagiline

What Is Rasagiline Used For?

Brand name: Azilect

Rasagiline tablets — sold as Azilect, Rasagiline, and Rasagiline mesylate — are approved to treat Parkinson's disease (PD). They can be used on their own (monotherapy) or added to other Parkinson's medications, including levodopa.

When used alongside levodopa, rasagiline helps manage Parkinson's symptoms that are not fully controlled by levodopa alone. Your doctor may adjust your levodopa dose when the two are combined.

See full Rasagiline drug information
Keep checking

Other Drugs & Octopamine

Browse every other medication we’ve checked against Octopamine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
180Moderate
171Minor
2,478No known interaction
180 Moderate 171 Minor 2,478 No interaction
Moderate

180 interactions

Showing 60 of 180 moderate interactions — see all 180 on the Octopamine page.

Minor

171 interactions

Showing 60 of 171 minor interactions — see all 171 on the Octopamine page.

No interaction 2,478 drugs checked — show the list

We also checked Octopamine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,478 medications checked with no known interaction — see the full Octopamine list.

See the full Octopamine interactions page
See every supplement checked against Rasagiline, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Octopamine monograph › Uses, safety, and every drug interaction in one place Rasagiline supplement interactions › Every supplement checked against Rasagiline, ranked by severity Rasagiline drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Octopamine and Rasagiline Together: Common Questions

Can you take Octopamine with Rasagiline?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Octopamine and Rasagiline interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Rasagiline and Octopamine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.