Medication interaction hub

What Supplements Interact with Isocarboxazid?

Isocarboxazid brand name: Marplan. Every interaction below applies to the brands too.

81 Interactions 14 Major 55 Moderate 12 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Isocarboxazid? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Isocarboxazid against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Isocarboxazid (Marplan) is an MAOI antidepressant, and that drug class carries some of the sharpest supplement and food hazards in the pharmacy, so read this list closely rather than skimming it. Fourteen of the 81 entries rate major, and most of the danger runs through tyramine. Fermented soy, beer, and wine all contain it, and because isocarboxazid blocks the enzyme that normally breaks tyramine down, the combination can push blood pressure to crisis levels.

A second cluster of roughly 20 ingredients acts on serotonin, and stacking those with an MAOI raises the risk of serotonin syndrome, a dangerous overload of that chemical. Another 17 can change how oral medicines are absorbed; activated charcoal in particular can pull the drug out of your system. The 55 moderate and 12 minor entries are gentler, but with this medication, check every product on this page with your pharmacist first.

— , Clinical Pharmacist · July 18, 2026

Major 14 Moderate 55 Minor 12 No known interaction 1,371

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Isocarboxazid: Top Interactions at a Glance

The Isocarboxazid supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 81 interacting ingredients — plus 1,371 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Isocarboxazid Combinations Today

The Isocarboxazid + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Probable Cowhage + Isocarboxazidi

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.

Read the full interaction Major Likelihood Probable Bitter Orange + Isocarboxazidi

Theoretically, taking MAOIs with synephrine-containing bitter orange preparations might increase the hypertensive effects of synephrine, potentially leading to...

Read the full interaction Moderate Likelihood Possible Phenylalanine + Isocarboxazidi

Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.

Read the full interaction Major Likelihood Likely Soy + Isocarboxazidi

Taking soy products containing high amounts of tyramine along with MAOIs can increase the risk of hypertensive crisis.

Read the full interaction Major Likelihood Likely Yohimbe + Isocarboxazidi

Concomitant use of MAOIs with yohimbe can result in additive effects.

Read the full interaction Moderate Likelihood Possible Griffonia Simplicifolia + Isocarboxazidi

Theoretically, taking Griffonia simplicifolia seed extract with antidepressant drugs might increase the risk of serotonergic adverse effects, such as serotonin...

Read the full interaction
The complete list

Every Supplement Checked Against Isocarboxazid

All 1,452 ingredients in our database, ranked by severity — 81 with a Isocarboxazid interaction on file and 1,371 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Isocarboxazid?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cowhage with Isocarboxazid?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.

Full Cowhage + Isocarboxazid answer

Can you take Bitter Orange with Isocarboxazid?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking MAOIs with synephrine-containing bitter orange preparations might increase the hypertensive effects of synephrine, pot...

Full Bitter Orange + Isocarboxazid answer

Can you take Phenylalanine with Isocarboxazid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.

Full Phenylalanine + Isocarboxazid answer

Can you take Soy with Isocarboxazid?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Taking soy products containing high amounts of tyramine along with MAOIs can increase the risk of hypertensive crisis.

Full Soy + Isocarboxazid answer

Can you take Yohimbe with Isocarboxazid?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of MAOIs with yohimbe can result in additive effects.

Full Yohimbe + Isocarboxazid answer

Can you take Tianeptine with Isocarboxazid?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Tianeptine may increase the toxicity of MAOIs.

Full Tianeptine + Isocarboxazid answer

Can you take Wine with Isocarboxazid?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may cause hypertensive crisis.

Full Wine + Isocarboxazid answer

Can you take Coffee Charcoal with Isocarboxazid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Isocarboxazid answer

Can you take Ephedra with Isocarboxazid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of serious adverse effects.

Full Ephedra + Isocarboxazid answer

Can you take European Mandrake with Isocarboxazid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Isocarboxazid answer

Can you take Glucomannan with Isocarboxazid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Isocarboxazid answer

Can you take Panax Ginseng with Isocarboxazid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng can interfere with MAOI therapy.

Full Panax Ginseng + Isocarboxazid answer

Can you take Sida Cordifolia with Isocarboxazid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Sida cordifolia might increase the risk of hypertension when taken with MAOIs.

Full Sida Cordifolia + Isocarboxazid answer

Can you take 5-htp with Isocarboxazid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.

Full 5-htp + Isocarboxazid answer

Can you take Acetyl-l-carnitine with Isocarboxazid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstr...

Full Acetyl-l-carnitine + Isocarboxazid answer

Can you take Adrafinil with Isocarboxazid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk for serious adverse effects.

Full Adrafinil + Isocarboxazid answer

Can you take American Ginseng with Isocarboxazid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, American ginseng can interfere with MAOI therapy.

Full American Ginseng + Isocarboxazid answer

Can you take Ayahuasca with Isocarboxazid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase levels of serotonin, which may have additive effects with serotonergic drugs.

Full Ayahuasca + Isocarboxazid answer

Can you take Betel Nut with Isocarboxazid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that betel nut extract can inhibit monoamine oxidase.

Full Betel Nut + Isocarboxazid answer

Can you take Black Cohosh with Isocarboxazid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining serotonergic drugs with black cohosh might cause additive serotonergic effects.

Full Black Cohosh + Isocarboxazid answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Isocarboxazid is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Isocarboxazid, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Isocarboxazid sits in 5 interaction categories. Open any one to see what the group means:

Monoamine Oxidase Inhibitors (Maois) 42 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

42 of the supplement ingredients on this page reach Isocarboxazid through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Isocarboxazid through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Isocarboxazid through this category.

Antidepressant Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Isocarboxazid through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Isocarboxazid through this category.

About Isocarboxazid

Isocarboxazid is a monoamine oxidase inhibitor (MAOI) antidepressant used to treat depression.

Generic name: Isocarboxazid  ·  Brand name: Marplan.

See the full Isocarboxazid drug information

Related: does Isocarboxazid deplete any nutrients?

Isocarboxazid has 1 reported nutrient association in the research literature — see the Isocarboxazid nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Isocarboxazid

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Isocarboxazid.

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Pharmacist Counseling Corner

Isocarboxazid & Supplements: Common Questions

What supplements interact with Isocarboxazid?
Our database currently documents 81 ingredients with a known Isocarboxazid interaction (14 major, 55 moderate, 12 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 81. The highest-ranked right now: Brewer's Yeast, Fever Bark, Soy.
Which Isocarboxazid supplement interactions are the most serious?
Focus on the major group: Brewer's Yeast, Fever Bark, Soy, Tyramine and Yohimbe, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Isocarboxazid?
Plenty of supplements coexist fine with Isocarboxazid; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Marplan have the same supplement interactions as Isocarboxazid?
Yes — Marplan all contain Isocarboxazid, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Isocarboxazid deplete any vitamins or nutrients?
It might — Isocarboxazid has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Isocarboxazid nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Isocarboxazid and my other medications?
This page covers Isocarboxazid against supplements and herbal ingredients. Checking Isocarboxazid against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Isocarboxazid drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.