Drug & supplement interaction

Cascarilla + Isocarboxazid

Isocarboxazid brand name: Marplan.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Cascarilla and Isocarboxazid in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Cascarilla and Isocarboxazid

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Isocarboxazid and Cascarilla in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Cascarilla at all — not against Isocarboxazid, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cascarilla safety at a glance

Cascarilla overall Use caution Limited safety data exist, so use modest amounts and discuss with a healthcare professional first.
Pregnancy Avoid Not enough safety information is available, so avoid use during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so it is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Isocarboxazid and Cascarilla? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Isocarboxazid’s Own FDA Label Lists

This is not an interaction — none of it involves Cascarilla. These are the most notable effects listed in the ADVERSE REACTIONS section of Isocarboxazid’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both.

  • Dry mouth
  • Dizziness
  • Nausea

From the ADVERSE REACTIONS section of the FDA label for Isocarboxazid. Read the label on DailyMed › Cascarilla’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Cascarilla side to compare — that is a limit of the record, not a statement that Cascarilla has no side effects.

Everything else you take

See Every Supplement That Interacts With Isocarboxazid

This page covers Cascarilla only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Isocarboxazid page lists 81 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Bitter Orange (major), Brewer's Yeast (major) and Cowhage (major).

By severity: 14 major · 55 moderate · 12 minor.

From our pharmacist’s overview on the Isocarboxazid page

“Isocarboxazid (Marplan) is an MAOI antidepressant, and that drug class carries some of the sharpest supplement and food hazards in the pharmacy, so read this list closely rather than skimming it. Fourteen of the 81 entries rate major, and most of the danger runs through tyramine.”

Reviewed by 2 · Jul 18, 2026

Open the Isocarboxazid interaction page

How much people look this up

Where Cascarilla and Isocarboxazid Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cascarilla
Steady interest

#1,156 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Isocarboxazid
Steady interest

#2,132 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Cascarilla is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cascarilla reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cascarilla and Isocarboxazid records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cascarilla

What is Cascarilla?

  • Digestive upset and poor appetite
  • Bitter tonic for the stomach
  • Mild fever or chills (traditional)
  • Flavoring agent
  • Aromatic/incense use

Cascarilla is the aromatic, bitter bark of a Caribbean shrub (Croton eluteria) that has long been used as a digestive bitter and a flavoring. Modern scientific evidence for any health benefit is very limited, so it should be viewed as a traditional remedy rather than a proven treatment. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Croton eluteria · Euphorbiaceae · Dried bark (and an essential oil distilled from it) · Tincture, bitters, tea, essential oil, and a flavoring in some liqueurs and tobacco products

An interaction check asks whether these two react with each other — it does not ask whether Cascarilla is a good idea for someone in your situation. Here is what our Cascarilla record says about it on its own.

Cascarilla: dosing

There is no well-established or standardized medicinal dose for cascarilla. Traditional use typically involves small amounts of bark steeped as a tea or a few drops of tincture used as a bitter.Because product strengths vary widely, the safest approach is to follow the directions on the product label and not exceed them.

From our Cascarilla monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cascarilla monograph & all interactions
Medication

About Isocarboxazid

What Is Isocarboxazid Used For?

Brand name: Marplan

Marplan (isocarboxazid) is indicated for the treatment of depression — specifically, major depressive disorder. Because it carries serious risks, it is not a first-choice antidepressant. Marplan is generally reserved for patients who have not responded adequately to other antidepressants.

Clinical trials showed Marplan to be effective in adult outpatients with major depressive disorder, including those whose depression was accompanied by anxiety symptoms such as panic or phobias. Marplan is not approved for use in children or adolescents.

See full Isocarboxazid drug information
Keep checking

Other Drugs & Cascarilla

Browse every other medication we’ve checked against Cascarilla — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Cascarilla against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Cascarilla list.

See the full Cascarilla interactions page
See every supplement checked against Isocarboxazid, ranked by severity
Evidence & sources

Cascarilla References

The 3 sources that drive our Cascarilla monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Cascarilla is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Croton eluteria (Cascarilla) — U.S. National Library of Medicine, PubChem Source
  2. Herbs at a Glance — NIH National Center for Complementary and Integrative Health Source
  3. Herbs and Supplements — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cascarilla and Isocarboxazid Together: Common Questions

Is it safe to take Cascarilla with Isocarboxazid?
We do not list a known interaction between Cascarilla and Isocarboxazid. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Isocarboxazid interact with any supplements?
Yes. Isocarboxazid has documented interactions with 81 supplements in our database — Cascarilla is not one of them. The Isocarboxazid interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cascarilla monograph Uses, safety profile, and every drug interaction in one place Isocarboxazid drug information The full plain-English guide to this medication Isocarboxazid supplement interactions Every supplement checked against Isocarboxazid, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Isocarboxazid and Cascarilla?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.