Drug & supplement interaction

Fumitory + Isocarboxazid

Isocarboxazid brand name: Marplan.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Fumitory and Isocarboxazid in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Fumitory and Isocarboxazid

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Isocarboxazid and Fumitory in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Fumitory at all — not against Isocarboxazid, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Fumitory safety at a glance

Fumitory overall Use caution Generally used short-term in small amounts, but human safety data are limited.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Lack of safety data means it should be avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Isocarboxazid and Fumitory? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Isocarboxazid’s Own FDA Label Lists

This is not an interaction — none of it involves Fumitory. These are the most notable effects listed in the ADVERSE REACTIONS section of Isocarboxazid’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both.

  • Dry mouth
  • Dizziness
  • Nausea

From the ADVERSE REACTIONS section of the FDA label for Isocarboxazid. Read the label on DailyMed › Fumitory’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Fumitory side to compare — that is a limit of the record, not a statement that Fumitory has no side effects.

Everything else you take

See Every Supplement That Interacts With Isocarboxazid

This page covers Fumitory only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Isocarboxazid page lists 81 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Bitter Orange (major), Brewer's Yeast (major) and Cowhage (major).

By severity: 14 major · 55 moderate · 12 minor.

From our pharmacist’s overview on the Isocarboxazid page

“Isocarboxazid (Marplan) is an MAOI antidepressant, and that drug class carries some of the sharpest supplement and food hazards in the pharmacy, so read this list closely rather than skimming it. Fourteen of the 81 entries rate major, and most of the danger runs through tyramine.”

Reviewed by 2 · Jul 18, 2026

Open the Isocarboxazid interaction page

One more smart check

Taking Fumitory as Part of a Dietary Supplement Product? Check It for Interactions

We hold 46 real supplement products containing Fumitory, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Fumitory. Even though Fumitory itself has no known interaction with Isocarboxazid, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Fumitory and Isocarboxazid Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fumitory
Top half

#682 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Isocarboxazid
Steady interest

#2,307 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Fumitory is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fumitory reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Fumitory and Isocarboxazid records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Fumitory

What is Fumitory?

  • Digestive and bile-flow complaints
  • Mild liver and gallbladder support
  • Skin conditions like eczema
  • Mild constipation
  • Cleansing or 'detox' tonics

Fumitory is a traditional European herb used mainly for digestive and minor liver or gallbladder complaints, but solid human evidence is very limited. It may cause side effects at higher doses, and its safety is not well established, so talk with your pharmacist or doctor before using it and avoid it during pregnancy and breastfeeding.

Fumaria officinalis · Papaveraceae · Aerial parts (flowering tops, leaves, and stems) · Tea, dried herb, liquid extract, tincture, capsules

An interaction check asks whether these two react with each other — it does not ask whether Fumitory is a good idea for someone in your situation. Here is what our Fumitory record says about it on its own.

Fumitory: dosing

There is no well-established standardized dose for Fumitory. Traditional use involves teas or liquid extracts made from the dried herb, but exact amounts vary widely between products.Because a reliable, evidence-based dose has not been set, the safest approach is to follow the directions on the product label and not exceed them.

From our Fumitory monograph — the full record covers uses, side effects and every documented interaction.

Read the full Fumitory monograph & all interactions
Medication

About Isocarboxazid

What Is Isocarboxazid Used For?

Brand name: Marplan

Marplan (isocarboxazid) is indicated for the treatment of depression — specifically, major depressive disorder. Because it carries serious risks, it is not a first-choice antidepressant. Marplan is generally reserved for patients who have not responded adequately to other antidepressants.

Clinical trials showed Marplan to be effective in adult outpatients with major depressive disorder, including those whose depression was accompanied by anxiety symptoms such as panic or phobias. Marplan is not approved for use in children or adolescents.

See full Isocarboxazid drug information
Keep checking

Other Drugs & Fumitory

Browse every other medication we’ve checked against Fumitory — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Fumitory against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Fumitory list.

See the full Fumitory interactions page
See every supplement checked against Isocarboxazid, ranked by severity
Evidence & sources

Fumitory References

The 1 sources that drive our Fumitory monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Fumitory is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Fumitory — MedlinePlus / RxList Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Fumitory and Isocarboxazid Together: Common Questions

Is it safe to take Fumitory with Isocarboxazid?
We do not list a known interaction between Fumitory and Isocarboxazid. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Isocarboxazid interact with any supplements?
Yes. Isocarboxazid has documented interactions with 81 supplements in our database — Fumitory is not one of them. The Isocarboxazid interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Fumitory monograph Uses, safety profile, and every drug interaction in one place Isocarboxazid drug information The full plain-English guide to this medication Isocarboxazid supplement interactions Every supplement checked against Isocarboxazid, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Isocarboxazid and Fumitory?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.