Cereus + Isocarboxazid
Isocarboxazid brand name: Marplan.
Cereus has a moderate interaction with Isocarboxazid. Theoretically, excessive doses of cereus may interact with MAOIs, because of the tyramine content.
Read the full interaction reportCereus and Isocarboxazid
Here is the interaction we found between these two, with the evidence behind it.
MONOAMINE OXIDASE INHIBITORS (MAOIs)
Why this applies to Isocarboxazid
Isocarboxazid falls under MONOAMINE OXIDASE INHIBITORS (MAOIs) — the group Cereus interacts with.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the concern with this pairing. Isocarboxazid (Marplan) is an MAO inhibitor, and one of its biggest cautions is with tyramine, a substance found in certain aged or fermented foods. Normally your body breaks tyramine down, but MAOIs block that cleanup. If tyramine builds up, it can trigger a dangerous spike in blood pressure (sometimes called a hypertensive crisis), with symptoms like a pounding headache, racing heart, sweating, or chest discomfort.
The worry here is that cereus may contain some tyramine, so very large or concentrated doses could theoretically add to that risk. I'll be honest though, this is based on the plant's chemistry, not solid human studies. Still, because Marplan is unforgiving with tyramine, please don't combine them without first checking with your doctor or pharmacist.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Cereus Also Interacts With Other Medications
Cereus has 9 moderate known drug interactions in our database — the Isocarboxazid one above is one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Cereus
We haven’t checked that one against Cereus yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Cereus. Pick one to open its full report.
See Every Supplement That Interacts With Isocarboxazid
This page covers Cereus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Isocarboxazid page lists 81 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Bitter Orange (major), Brewer's Yeast (major) and Cowhage (major).
By severity: 14 major · 55 moderate · 12 minor.
From our pharmacist’s overview on the Isocarboxazid page
“Isocarboxazid (Marplan) is an MAOI antidepressant, and that drug class carries some of the sharpest supplement and food hazards in the pharmacy, so read this list closely rather than skimming it. Fourteen of the 81 entries rate major, and most of the danger runs through tyramine.”
Reviewed by 2 · Jul 18, 2026
Taking Cereus as Part of a Dietary Supplement Product? Check It for Interactions
We hold 3 real supplement products containing Cereus, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cereus. Your product may carry other ingredients that interact with Isocarboxazid too, on top of Cereus — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Cereus and Isocarboxazid Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#917 of 1,452 supplements looked up here in the last 7 days
#1,712 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Cereus
What is Cereus?
- Heart palpitations
- Mild heart symptoms
- Anxiety and nervous tension
- Shortness of breath
- Fluid retention
Cereus (often called night-blooming cereus) is a cactus traditionally used in folk and homeopathic medicine for heart-related complaints like palpitations. High-quality human evidence supporting these uses is lacking, and because it may affect the heart, it should be used only under medical guidance. Pregnant and breastfeeding people should avoid it.
About Isocarboxazid
What Is Isocarboxazid Used For?
Brand name: Marplan
Marplan (isocarboxazid) is indicated for the treatment of depression — specifically, major depressive disorder. Because it carries serious risks, it is not a first-choice antidepressant. Marplan is generally reserved for patients who have not responded adequately to other antidepressants.
Clinical trials showed Marplan to be effective in adult outpatients with major depressive disorder, including those whose depression was accompanied by anxiety symptoms such as panic or phobias. Marplan is not approved for use in children or adolescents.
Other Drugs & Cereus
Browse every other medication we’ve checked against Cereus — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
9 interactions
No interaction 2,820 drugs checked — show the list
We also checked Cereus against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Abemaciclib ›
- Ivermectin ›
- Testosterone ›
- Losartan Potassium ›
- Acetaminophen ›
- Aspirin ›
- Metoprolol ›
- Rosuvastatin ›
- Escitalopram ›
- Rivaroxaban ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tirzepatide ›
- Methamphetamine ›
- Tadalafil ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Amitriptyline ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Isotretinoin ›
- Lisinopril ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bendamustine ›
- Bupropion ›
- Fluoxetine ›
- Doxycycline ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Codeine ›
- Naproxen ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Duloxetine ›
- Letrozole ›
- Citalopram ›
- Methylene Blue ›
- Buspirone ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,820 medications checked with no known interaction — see the full Cereus list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Isocarboxazid Is Linked to Lower Levels of One Nutrient
Natural Medicines records Isocarboxazid as a medicine that can lower these. This is not an interaction with Cereus — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Isocarboxazid nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Cereus and Isocarboxazid Together: Common Questions
Can you take Cereus with Isocarboxazid?
How serious is the Cereus and Isocarboxazid interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Isocarboxazid and Cereus?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.