Peanut Oil Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Peanut Oil interacts with medications. The heart of this page is the interaction list — every drug Peanut Oil is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Peanut Oil is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Peanut Oil against your medication
Add one medicationDrugs that interact with Peanut Oil
0 medications have a known interaction with Peanut Oil, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Peanut Oil. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Peanut Oil combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Peanut Oil: Uses, Safety & Side Effects
Peanut oil is a food-grade oil pressed from peanuts, used mainly for cooking and as a skin or massage oil. It is generally considered safe as a food, but people with peanut allergy should be cautious, especially with crude (less-refined) oils, and there is little strong evidence for medicinal benefits.
- Scientific name
- Arachis hypogaea
- Family
- Fabaceae
- Part used
- Oil pressed from the seeds (peanuts)
- Common forms
- Cooking oil, topical/massage oil, ingredient in skin and hair products, carrier oil, some injectable medication formulations
- Cooking and frying
- Skin moisturizing and massage
- Carrier oil for other ingredients
- Earwax softening (folk use)
- Dry or chapped skin
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally safe as a food, but it can trigger reactions in people with peanut allergy.
Fine in normal food amounts; avoid concentrated supplemental or medicinal use unless cleared by your doctor.
There is insufficient reliable information available about the safety of medicinal amounts of peanut oil during pregnancy and breast-feeding; avoid us...
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Peanut oil is a vegetable oil pressed from peanuts, which are the seeds of the peanut plant (Arachis hypogaea). Despite the name, peanuts are legumes, not true nuts. The plant is grown widely in warm regions around the world, including parts of Asia, Africa, and the southern United States.
Most people know peanut oil as a cooking oil, valued for its mild flavor and high smoke point, which makes it popular for frying. It also shows up as a base or "carrier" oil in skin lotions, hair products, and massage oils, and it is used as an ingredient in a few medications and supplements.
Peanut oil comes in different grades. Refined peanut oil has had most of the peanut proteins removed during processing, while crude, cold-pressed, or gourmet oils keep more of these proteins and may carry more allergy risk.
How it works
Peanut oil is made up mostly of fats, including monounsaturated and polyunsaturated fatty acids. Diets that replace saturated and trans fats with unsaturated fats are linked with better heart-health markers, though this is a general principle about fats and not unique to peanut oil.
The oil also contains small amounts of vitamin E and plant compounds that act as antioxidants. On the skin, oils like peanut oil form a barrier that helps slow water loss, which is why they can feel moisturizing.
Much of what is known comes from general nutrition science and laboratory work rather than large studies on peanut oil itself, so specific health claims should be viewed with caution.
Does Peanut Oil work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Peanut Oil, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 6 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Constipation
Although there is interest in using rectal peanut oil for constipation, there is insufficient reliable information about the clinical effects of peanut for this purpose.
Insufficient Reliable Evidence To Rate Coronary heart disease (CHD)
Although there is interest in using oral peanut oil to prevent CHD, there is insufficient reliable information about the clinical effects of peanut for this purpose.
Insufficient Reliable Evidence To Rate Diabetes
It is unclear if dietary peanut oil reduces the risk of developing diabetes.
Insufficient Reliable Evidence To Rate Hyperlipidemia
Although there is interest in using oral peanut oil for hyperlipidemia, there is insufficient reliable information about the clinical effects of peanut for this purpose.
Insufficient Reliable Evidence To Rate Joint pain
Although there is interest in using topical peanut oil for joint pain, there is insufficient reliable information about the clinical effects of peanut for this purpose.
Insufficient Reliable Evidence To Rate Overall mortality
It is unclear if dietary peanut oil reduces the risk of overall mortality.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
As a food, peanut oil is generally recognized as safe for most people. The biggest concern is peanut allergy, which can be severe and even life-threatening. Highly refined peanut oil has had most allergy-causing proteins removed and is usually tolerated by people with peanut allergy, but crude, cold-pressed, or gourmet oils may still contain enough protein to trigger a reaction. If you have a peanut allergy, talk to your doctor before using any peanut oil and avoid it on your skin unless cleared.
Like all oils, peanut oil is high in calories. Using a lot of it can contribute to excess calorie intake.
Pregnancy and breastfeeding: Using peanut oil in normal amounts as a food is generally considered fine if you are not allergic. There is not enough information to recommend concentrated medicinal or supplemental doses during pregnancy or breastfeeding, so it is best to be cautious and check with your doctor first.
Side effects
For most people, peanut oil used in food causes no problems. Eating large amounts of any oil may cause stomach upset or loose stools.
The most serious risk is an allergic reaction in people sensitive to peanuts. Signs can include itching, hives, swelling, stomach upset, trouble breathing, or, in severe cases, a life-threatening reaction called anaphylaxis. Seek emergency care right away if these occur.
Applied to the skin, peanut oil may occasionally cause irritation or a rash, especially in sensitive or allergic individuals.
Peanut Oil: Reported Adverse Effects
Documented safety reports on Peanut Oil from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Reports by conditionAllergic rhinitis (hay fever) Immunologic
Peanut oil can cause a severe allergic reaction in individuals allergic to the Fabaceae family. Members of this family include peanuts and soybeans. Peanut allergy is the number one cause of fatal food-induced anaphylaxis with hypersensitivity in 6% to 8% of children and 1% of adults. Various peanut protein allergens have been identified. Refined peanut oil, without contamination with peanut protein, is not allergenic. However, contamination of refined peanut oil can produce allergic reactions.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no established medicinal dose for peanut oil. As a cooking oil, it is used in normal culinary amounts, like any other vegetable oil.
If you are using a product that contains peanut oil for skin care or another purpose, follow the directions on the label. Because needs and tolerance vary, and because of allergy concerns, it is a good idea to check with your pharmacist or doctor before using peanut oil for any health-related reason.
Peanut Oil & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 1 references that drive our Peanut Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Akhtar S, Khalid N, Ahmed I, Shahzad A, Suleria HA. Physicochemical characteristics, functional properties, and nutritional benefits of peanut oil: a review. Crit Rev Food Sci Nutr. 2014;54(12):1562-75. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Peanut Oil
7 brands in our database make a supplement containing Peanut Oil.
Supplement products with Peanut Oil
10 products in our database contain Peanut Oil. Open any to see its full ingredient list and every drug interaction we check.
Peanut Oil: Common Questions
What is Peanut Oil used for, and does it work?
Does Peanut Oil interact with prescription medications?
How are Peanut Oil interactions rated?
Is it safe to take Peanut Oil with my medications?
Where does this Peanut Oil interaction information come from?
Is Peanut Oil safe if I have a peanut allergy?
Is Peanut Oil a healthy cooking oil?
Can I use Peanut Oil on my skin or hair?
Does Peanut Oil treat any medical conditions?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Peanut Oil
A rotating sample of real supplements in our database that list Peanut Oil — open any to see its full ingredients and every drug interaction we check.
- Vitality Capsules by Pharmaton
- Pudin Hara Pearls by Dabur
- Chocolate Peanut Caramel Crunch Nutrition Bars by iSatori
- Pr by Liquid Labs
- Whey Protein Chocolate Nutter Butter by GHOST
- Frosted Cinnamon Caramel Crunch Nutrition Bars by iSatori
- Becadexamin by GSK
- Pr by Liquid Labs
- Te by Liquid Labs
- Patriot's Whey Chubby Choco Nutz by 'Merica Labz
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