Herb & supplement monograph

Peanut Oil Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Peanut Oil

0 medications have a known interaction with Peanut Oil, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Peanut Oil. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Peanut Oil combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Peanut Oil: Uses, Safety & Side Effects

The bottom line

Peanut oil is a food-grade oil pressed from peanuts, used mainly for cooking and as a skin or massage oil. It is generally considered safe as a food, but people with peanut allergy should be cautious, especially with crude (less-refined) oils, and there is little strong evidence for medicinal benefits.

Scientific name
Arachis hypogaea
Family
Fabaceae
Part used
Oil pressed from the seeds (peanuts)
Common forms
Cooking oil, topical/massage oil, ingredient in skin and hair products, carrier oil, some injectable medication formulations
People commonly use it for
  • Cooking and frying
  • Skin moisturizing and massage
  • Carrier oil for other ingredients
  • Earwax softening (folk use)
  • Dry or chapped skin

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally safe as a food, but it can trigger reactions in people with peanut allergy.

PregnancyUse caution

Fine in normal food amounts; avoid concentrated supplemental or medicinal use unless cleared by your doctor.

BreastfeedingInsufficient reliable information

There is insufficient reliable information available about the safety of medicinal amounts of peanut oil during pregnancy and breast-feeding; avoid us...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Peanut oil is a vegetable oil pressed from peanuts, which are the seeds of the peanut plant (Arachis hypogaea). Despite the name, peanuts are legumes, not true nuts. The plant is grown widely in warm regions around the world, including parts of Asia, Africa, and the southern United States.

Most people know peanut oil as a cooking oil, valued for its mild flavor and high smoke point, which makes it popular for frying. It also shows up as a base or "carrier" oil in skin lotions, hair products, and massage oils, and it is used as an ingredient in a few medications and supplements.

Peanut oil comes in different grades. Refined peanut oil has had most of the peanut proteins removed during processing, while crude, cold-pressed, or gourmet oils keep more of these proteins and may carry more allergy risk.

How it works

Peanut oil is made up mostly of fats, including monounsaturated and polyunsaturated fatty acids. Diets that replace saturated and trans fats with unsaturated fats are linked with better heart-health markers, though this is a general principle about fats and not unique to peanut oil.

The oil also contains small amounts of vitamin E and plant compounds that act as antioxidants. On the skin, oils like peanut oil form a barrier that helps slow water loss, which is why they can feel moisturizing.

Much of what is known comes from general nutrition science and laboratory work rather than large studies on peanut oil itself, so specific health claims should be viewed with caution.

Effectiveness

Does Peanut Oil work?

Evidence overview · 6 uses evaluated
6 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Peanut Oil, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 6 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Constipation
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using rectal peanut oil for constipation, there is insufficient reliable information about the clinical effects of peanut for this purpose.

Insufficient Reliable Evidence To Rate Coronary heart disease (CHD)
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral peanut oil to prevent CHD, there is insufficient reliable information about the clinical effects of peanut for this purpose.

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

It is unclear if dietary peanut oil reduces the risk of developing diabetes.

Insufficient Reliable Evidence To Rate Hyperlipidemia
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral peanut oil for hyperlipidemia, there is insufficient reliable information about the clinical effects of peanut for this purpose.

Insufficient Reliable Evidence To Rate Joint pain
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using topical peanut oil for joint pain, there is insufficient reliable information about the clinical effects of peanut for this purpose.

Insufficient Reliable Evidence To Rate Overall mortality
Rating & evidence shown verbatim from Natural Medicines

It is unclear if dietary peanut oil reduces the risk of overall mortality.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

As a food, peanut oil is generally recognized as safe for most people. The biggest concern is peanut allergy, which can be severe and even life-threatening. Highly refined peanut oil has had most allergy-causing proteins removed and is usually tolerated by people with peanut allergy, but crude, cold-pressed, or gourmet oils may still contain enough protein to trigger a reaction. If you have a peanut allergy, talk to your doctor before using any peanut oil and avoid it on your skin unless cleared.

Like all oils, peanut oil is high in calories. Using a lot of it can contribute to excess calorie intake.

Pregnancy and breastfeeding: Using peanut oil in normal amounts as a food is generally considered fine if you are not allergic. There is not enough information to recommend concentrated medicinal or supplemental doses during pregnancy or breastfeeding, so it is best to be cautious and check with your doctor first.

Side effects

For most people, peanut oil used in food causes no problems. Eating large amounts of any oil may cause stomach upset or loose stools.

The most serious risk is an allergic reaction in people sensitive to peanuts. Signs can include itching, hives, swelling, stomach upset, trouble breathing, or, in severe cases, a life-threatening reaction called anaphylaxis. Seek emergency care right away if these occur.

Applied to the skin, peanut oil may occasionally cause irritation or a rash, especially in sensitive or allergic individuals.

Peanut Oil: Reported Adverse Effects

Documented safety reports on Peanut Oil from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Allergic rhinitis (hay fever) Immunologic

Peanut oil can cause a severe allergic reaction in individuals allergic to the Fabaceae family. Members of this family include peanuts and soybeans. Peanut allergy is the number one cause of fatal food-induced anaphylaxis with hypersensitivity in 6% to 8% of children and 1% of adults. Various peanut protein allergens have been identified. Refined peanut oil, without contamination with peanut protein, is not allergenic. However, contamination of refined peanut oil can produce allergic reactions.

  1. Akhtar S, Khalid N, Ahmed I, Shahzad A, Suleria HA. Physicochemical characteristics, functional properties, and nutritional benefits of peanut oil: a review. Crit Rev Food Sci Nutr. 2014;54(12):1562-75.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established medicinal dose for peanut oil. As a cooking oil, it is used in normal culinary amounts, like any other vegetable oil.

If you are using a product that contains peanut oil for skin care or another purpose, follow the directions on the label. Because needs and tolerance vary, and because of allergy concerns, it is a good idea to check with your pharmacist or doctor before using peanut oil for any health-related reason.

Pregnancy & Breastfeeding

Peanut Oil & Breastfeeding

Insufficient reliable information

There is insufficient reliable information available about the safety of medicinal amounts of peanut oil during pregnancy and breast-feeding; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 1 references that drive our Peanut Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Akhtar S, Khalid N, Ahmed I, Shahzad A, Suleria HA. Physicochemical characteristics, functional properties, and nutritional benefits of peanut oil: a review. Crit Rev Food Sci Nutr. 2014;54(12):1562-75. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Peanut Oil

7 brands in our database make a supplement containing Peanut Oil.

Pharmacist Counseling Corner

Peanut Oil: Common Questions

What is Peanut Oil used for, and does it work?
People use Peanut Oil for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Peanut Oil interact with prescription medications?
We do not currently list any known drug interactions for Peanut Oil. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Peanut Oil interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Peanut Oil with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Peanut Oil interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Is Peanut Oil safe if I have a peanut allergy?
Highly refined Peanut Oil is usually tolerated because most of the allergy-causing protein is removed, but cold-pressed, crude, or gourmet oils may still trigger reactions. If you have a peanut allergy, talk to your doctor before using any Peanut Oil.
Is Peanut Oil a healthy cooking oil?
Peanut Oil is made mostly of unsaturated fats and has a high smoke point, which makes it useful for frying. Using it in place of saturated or trans fats can fit into a balanced diet, but like all oils it is high in calories.
Can I use Peanut Oil on my skin or hair?
Peanut Oil is commonly used as a moisturizer, massage oil, and ingredient in cosmetics, and it can help soften and protect skin. Do a small patch test first, and avoid it if you have a peanut allergy.
Does Peanut Oil treat any medical conditions?
There is no strong evidence that Peanut Oil treats or prevents specific diseases. It is best thought of as a food and skin-care oil rather than a medicine.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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