Herb & supplement monograph

Beth Root Drug Interactions, Uses, Safety & More

Check Beth Root against your medication

Add one medication
Beth Root
+
Start typing any prescription or over-the-counter drug name.
Reviewed by licensed pharmacists Sourced from Natural Medicines
Interaction report

Drugs that interact with Beth Root

0 medications have a known interaction with Beth Root, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Beth Root. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Beth Root combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Beth Root: Uses, Safety & Side Effects

The bottom line

Beth root is a traditional North American plant remedy historically used by Indigenous peoples and folk herbalists, mostly for menstrual and bleeding-related complaints. There is very little modern scientific evidence to show it works for any condition, and its safety has not been well studied, so caution is advised—especially during pregnancy and breastfeeding.

Scientific name
Trillium erectum
Family
Melanthiaceae
Part used
Dried root and rhizome
Common forms
Dried root, tincture, tea, powder, capsules
People commonly use it for
  • Heavy menstrual bleeding
  • Menstrual cramps
  • Childbirth and postpartum bleeding
  • Wounds and skin irritation
  • Diarrhea

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Little modern safety data exists, so use cautiously and talk to a healthcare provider first.

PregnancyLikely Unsafe

When used orally; avoid using. Beth root might have menstrual or uterine stimulant activity.

Read the full pregnancy detail
BreastfeedingLikely Unsafe

When used orally; avoid using. Beth root might have menstrual or uterine stimulant activity.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Beth root, also called birthroot or red trillium, comes from the plant Trillium erectum, a low-growing spring wildflower native to the woodlands of eastern North America. The part used in herbal medicine is the underground root and rhizome.

Native American communities and early American herbalists used beth root for a range of complaints, especially those involving the female reproductive system, bleeding, and childbirth. The name "birthroot" reflects its traditional use around labor and delivery.

Today it is sometimes sold as a dried root, tincture, tea, or capsule, but it is much less common than many other herbal products and is not widely studied.

Uses & effectiveness

Beth root has been used traditionally for heavy or painful menstrual periods, bleeding after childbirth, diarrhea, and as a topical remedy applied to wounds, ulcers, and skin irritation.

It is important to be honest here: there is very little modern scientific evidence to support any of these uses. Most of what is claimed about beth root comes from historical and folk traditions rather than well-designed human studies. Reliable clinical trials are lacking.

Because the evidence is so limited, beth root should not be relied on to treat heavy bleeding or any serious medical problem. Conditions like abnormal menstrual bleeding need a proper medical evaluation.

How it works

Beth root contains plant compounds including steroidal saponins, tannins, and other phytochemicals. Tannins are astringent, meaning they can tighten and dry tissues, which is one proposed reason the plant was used for bleeding and diarrhea.

Some of its saponins are chemically related to compounds that the body can use as building blocks, which led to historical interest in possible hormone-like effects. However, these ideas are based largely on the plant's chemistry and old traditional use, not on solid laboratory or human research.

In short, the way beth root might work in the body is not well understood, and the proposed mechanisms remain unproven.

Safety & precautions

The safety of beth root has not been carefully studied in modern research. Because so little is known, it should be used cautiously and only under guidance from a knowledgeable healthcare provider.

Pregnancy: Beth root has traditionally been used to stimulate the uterus and affect bleeding around childbirth. For this reason it should be avoided during pregnancy, as it could carry a risk to the pregnancy.

Breastfeeding: There is no reliable information about its safety while nursing, so it is best to avoid it during breastfeeding.

People with bleeding disorders, hormone-sensitive conditions, or any chronic illness, and those taking regular medications, should check with a pharmacist or doctor before using beth root. Also be aware that wild trillium plants are slow-growing and protected in some areas, raising sustainability concerns.

Side effects

Because beth root is not well studied, its full side effect profile is unknown. Based on its tannin and saponin content, possible effects include stomach upset, nausea, or vomiting, especially at higher amounts.

Saponin-containing plants can irritate the digestive tract, and large or unregulated doses could be harmful. As with any herbal product, allergic reactions are also possible. Stop using it and seek medical care if you notice signs such as rash, swelling, difficulty breathing, or severe stomach symptoms.

Beth Root: Reported Adverse Effects

Documented safety reports on Beth Root from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, ingestion of large amounts of the plant or volatile oil might produce GI irritation severe enough to cause vomiting. In pregnant women, the drastic purgative effects can cause reflex uterine contractions.

Topically, beth root causes extreme irritation.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established or standardized dose for beth root. It has not been studied enough to know a safe and effective amount, and the strength of products can vary widely.

If you choose to use a commercial product, follow the directions on the label and do not exceed them. Most importantly, talk with a pharmacist or doctor before starting, especially if you are pregnant, breastfeeding, have a medical condition, or take other medicines or supplements.

Pregnancy & Breastfeeding

Beth Root & Pregnancy

Likely Unsafe

When used orally; avoid using. Beth root might have menstrual or uterine stimulant activity.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Beth Root & Breastfeeding

Likely Unsafe

When used orally; avoid using. Beth root might have menstrual or uterine stimulant activity.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 references that drive our Beth Root monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Beth Root: Common Questions

Does Beth Root interact with prescription medications?
We do not currently list any known drug interactions for Beth Root. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Beth Root interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Beth Root with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Beth Root interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Beth Root used for?
Traditionally, Beth Root has been used for heavy or painful periods, bleeding after childbirth, diarrhea, and as a topical remedy for wounds and skin problems. However, there is little scientific proof that it works for these uses.
Is Beth Root safe to take?
Its safety has not been well studied in modern research, so it should be used with caution and ideally only under the guidance of a healthcare provider.
Can I use Beth Root during pregnancy or while breastfeeding?
No. Beth Root has historically been used to affect the uterus and bleeding, so it should be avoided during pregnancy, and there is no reliable safety information for breastfeeding, so it should be avoided then too.
Is Beth Root the same as red trillium?
Yes. Beth Root is another name for the plant Trillium erectum, which is also called birthroot or red trillium.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Have a question about Beth Root?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist