Medication interaction hub

What Supplements Interact with Tranylcypromine?

Tranylcypromine brand name: Parnate. Every interaction below applies to the brands too.

81 Interactions 14 Major 55 Moderate 12 Minor
Curated & coded by · Clinical Pharmacist · Updated October 1, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Tranylcypromine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Tranylcypromine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Tranylcypromine (Parnate) belongs to the MAOI class of antidepressants, and I read its supplement list with real seriousness, since the highest-rated entries can turn dangerous quickly. The drug blocks the enzyme that normally clears tyramine, so tyramine-rich items like brewer's yeast, fermented soy, and even beer or wine can push blood pressure toward a hypertensive crisis, a true medical emergency. A second sizable group raises serotonin, and layering serotonin activity on top of an MAOI risks serotonin syndrome, an overload that can come on fast.

There is also a quieter cluster of fibers and charcoals that can blunt how much of an oral dose your body absorbs, so space those well apart from the medication and lean on the full report for specifics. Tell your pharmacist about every supplement you take, because with an MAOI the margin for surprises is thin. Fourteen of the 81 ingredients on file carry a major rating, alongside 55 moderate and 12 minor.

— , Clinical Pharmacist · July 18, 2026

Major 14 Moderate 55 Minor 12 No known interaction 1,371

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Tranylcypromine: Top Interactions at a Glance

The Tranylcypromine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 81 interacting ingredients — plus 1,371 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Tranylcypromine Combinations Today

The Tranylcypromine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Likely Yohimbe + Tranylcyprominei

Concomitant use of MAOIs with yohimbe can result in additive effects.

Read the full interaction Moderate Likelihood Possible Phenylalanine + Tranylcyprominei

Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.

Read the full interaction Major Likelihood Probable Bitter Orange + Tranylcyprominei

Theoretically, taking MAOIs with synephrine-containing bitter orange preparations might increase the hypertensive effects of synephrine, potentially leading to...

Read the full interaction Moderate Likelihood Possible Phenethylamine (pea) + Tranylcyprominei

Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of serotonergic adverse effects.

Read the full interaction Moderate Likelihood Possible Black Cohosh + Tranylcyprominei

Combining serotonergic drugs with black cohosh might cause additive serotonergic effects.

Read the full interaction Major Likelihood Probable Cowhage + Tranylcyprominei

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.

Read the full interaction
The complete list

Every Supplement Checked Against Tranylcypromine

All 1,452 ingredients in our database, ranked by severity — 81 with a Tranylcypromine interaction on file and 1,371 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Tranylcypromine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Yohimbe with Tranylcypromine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of MAOIs with yohimbe can result in additive effects.

Full Yohimbe + Tranylcypromine answer

Can you take Phenylalanine with Tranylcypromine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.

Full Phenylalanine + Tranylcypromine answer

Can you take Bitter Orange with Tranylcypromine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking MAOIs with synephrine-containing bitter orange preparations might increase the hypertensive effects of synephrine, pot...

Full Bitter Orange + Tranylcypromine answer

Can you take Phenethylamine (pea) with Tranylcypromine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of serotonergic adverse effects.

Full Phenethylamine (pea) + Tranylcypromine answer

Can you take Black Cohosh with Tranylcypromine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining serotonergic drugs with black cohosh might cause additive serotonergic effects.

Full Black Cohosh + Tranylcypromine answer

Can you take Ashwagandha with Tranylcypromine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.

Full Ashwagandha + Tranylcypromine answer

Can you take Black Psyllium with Tranylcypromine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Tranylcypromine answer

Can you take Blond Psyllium with Tranylcypromine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Tranylcypromine answer

Can you take Carob with Tranylcypromine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Tranylcypromine answer

Can you take Karaya Gum with Tranylcypromine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Tranylcypromine answer

Can you take Marshmallow with Tranylcypromine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Tranylcypromine answer

Can you take Rhodiola with Tranylcypromine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.

Full Rhodiola + Tranylcypromine answer

Can you take Xanthan Gum with Tranylcypromine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Tranylcypromine answer

Can you take Theanine with Tranylcypromine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting.

Full Theanine + Tranylcypromine answer

Can you take Brewer's Yeast with Tranylcypromine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking brewer's yeast with MAOIs might increase the risk of hypertension.

Full Brewer's Yeast + Tranylcypromine answer

Can you take Fever Bark with Tranylcypromine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of MAOIs with fever bark can result in additive effects.

Full Fever Bark + Tranylcypromine answer

Can you take Soy with Tranylcypromine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Taking soy products containing high amounts of tyramine along with MAOIs can increase the risk of hypertensive crisis.

Full Soy + Tranylcypromine answer

Can you take Tyramine with Tranylcypromine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of tyramine with MAOIs may increase the risk of serious adverse effects from tyramine.

Full Tyramine + Tranylcypromine answer

Can you take Activated Charcoal with Tranylcypromine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Tranylcypromine answer

Can you take Beer with Tranylcypromine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may cause hypertensive crisis.

Full Beer + Tranylcypromine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Tranylcypromine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Tranylcypromine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Tranylcypromine sits in 5 interaction categories. Open any one to see what the group means:

Monoamine Oxidase Inhibitors (Maois) 42 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

42 of the supplement ingredients on this page reach Tranylcypromine through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Tranylcypromine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Tranylcypromine through this category.

Antidepressant Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Tranylcypromine through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Tranylcypromine through this category.

About Tranylcypromine

Tranylcypromine is an MAOI antidepressant used to treat major depressive disorder in adults who haven't responded well to other antidepressants.

Generic name: Tranylcypromine  ·  Brand name: Parnate.

See the full Tranylcypromine drug information

Related: does Tranylcypromine deplete any nutrients?

Tranylcypromine has 1 reported nutrient association in the research literature — see the Tranylcypromine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Tranylcypromine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Tranylcypromine.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Tranylcypromine & Supplements: Common Questions

What supplements interact with Tranylcypromine?
In our interaction database, 81 supplement and herbal ingredients have an interaction with Tranylcypromine on file — 14 rated major, 55 moderate, and 12 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Brewer's Yeast, Fever Bark, Soy.
Which Tranylcypromine supplement interactions are the most serious?
The 14 major-rated combinations — led by Brewer's Yeast, Fever Bark, Soy, Tyramine and Yohimbe — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Tranylcypromine?
That depends entirely on which supplement. The honest answer for Tranylcypromine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Parnate have the same supplement interactions as Tranylcypromine?
Yes — Parnate all contain Tranylcypromine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Tranylcypromine deplete any vitamins or nutrients?
It might — Tranylcypromine has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Tranylcypromine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Tranylcypromine and my other medications?
This page covers Tranylcypromine against supplements and herbal ingredients. Checking Tranylcypromine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Tranylcypromine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 1, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.