Tranylcypromine
77 interactions 7 explained in plain English
Also sold as:
Parnate
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Hydromorphone Rectal
Linezolid Injection
Sertraline
Droxidopa
Diphenhydramine Topical
Palonosetron Injection
Contraindicated
Tranylcypromine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome and an increased risk of CNS depression Details Tranylcypromine Amitriptyline Elavil Explained Neurotoxicity, seizures, or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Tranylcypromine Sertraline Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) or CNS toxicit... Details Tranylcypromine Albuterol Oral Inhalation Accuneb® Explained Increased risk of hypertensive reaction, including intracerebral hemorrhage Details Tranylcypromine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome or opioid-related toxicity and an increased risk of CNS depression Details Tranylcypromine Butorphanol Injection Butorphic An increased risk of serotonin syndrome and an increased risk of CNS depression Details Tranylcypromine Butorphanol Nasal Spray Stadol® NS An increased risk of serotonin syndrome and an increased risk of CNS depression Details Tranylcypromine Clonidine Transdermal Patch Catapres Increased risk of hypertensive reaction, including intracerebral hemorrhage Details Tranylcypromine Deutetrabenazine Austedo Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Tranylcypromine Diethylpropion Tenuate Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Tranylcypromine Diphenhydramine Injection Banophen Increased risk of anticholinergic effects and an increased risk of CNS depression Details Tranylcypromine Diphenhydramine Topical Afterbite with Antihistamine Increased risk of anticholinergic effects and an increased risk of CNS depression Details Tranylcypromine Dolasetron Anzemet An increased risk of serotonin syndrome Details Tranylcypromine Dolasetron Injection Anzemet An increased risk of serotonin syndrome Details Tranylcypromine Droxidopa Northera Increased risk of hypertensive reaction, including intracerebral hemorrhage Details Tranylcypromine Entacapone Comtan Decreased catecholamine metabolism and risk for hypertensive crisis Details Tranylcypromine Fentanyl Transdermal Patch Duragesic® Potentiation of opioid effects, an increased risk of serotonin syndrome and an increased risk of CNS depression Details Tranylcypromine Granisetron Transdermal Patch Sancuso An increased risk of serotonin syndrome Details Tranylcypromine Granisetron Injection Granisol An increased risk of serotonin syndrome Details Tranylcypromine Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome or opioid toxicity and an increased risk of CNS depression Details Tranylcypromine Hydromorphone Rectal available generically Increased risk of serotonin syndrome or opioid toxicity and an increased risk of CNS depression Details Tranylcypromine Ketotifen Alaway Increased risk of anticholinergic effects Details Tranylcypromine Ketotifen Ophthalmic Alaway Increased risk of anticholinergic effects Details Tranylcypromine Levodopa Oral Inhalation Inbrija An increased risk of severe or life-threatening reactions, like hypertensive crisis Details Tranylcypromine Linezolid Injection Zyvox An increased risk of hypertensive crisis (headache, palpitation, neck stiffness) or seizure Details Tranylcypromine Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Tranylcypromine Maprotiline Ludiomil® An increased risk of severe or life threatening reactions, like serotonergic syndrome, neurotoxicity, seizures Details Tranylcypromine Methylphenidate Adhansia XR® An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Tranylcypromine Methylphenidate Transdermal Patch Daytrana An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Tranylcypromine Morphine Injection Astramorph® PF Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details Tranylcypromine Nalbuphine Injection Nubain® An increased risk of serotonin syndrome and an increased risk of CNS depression Details Tranylcypromine Opicapone Ongentys Increased risk of arrhythmias, increased heart rate, and excessive changes in blood pressure Details Tranylcypromine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome DetailsMajor
Tranylcypromine Aripiprazole Injection Abilify An increased risk of CNS depression Details Tranylcypromine Asenapine Transdermal Patch Secuado An increased risk of CNS depression Details Tranylcypromine Atropine Ophthalmic Atropine Care 1% Potential to cause hypertensive crisis Details Tranylcypromine Cetirizine Injection Aller-Tec An increased risk of CNS depression Details Tranylcypromine Cetirizine Ophthalmic Zerviate An increased risk of CNS depression Details Tranylcypromine Diazepam Nasal Spray Valtoco An increased risk of CNS depression Details Tranylcypromine Diazepam Rectal Diastat An increased risk of CNS depression DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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