Medication interaction hub

What Supplements Interact with Phenelzine Sulfate?

Phenelzine Sulfate brand name: Nardil. Every interaction below applies to the brands too.

144 Interactions 18 Major 111 Moderate 15 Minor
Curated & coded by · Clinical Pharmacist · Updated October 1, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Phenelzine Sulfate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Phenelzine Sulfate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Few medications demand as much dietary and supplement care as phenelzine sulfate (Nardil), an older MAOI antidepressant, and this list backs that up, with 18 of its 144 recorded interactions rated major. The two dominant themes are sedation and blood pressure. The largest group, 78 ingredients including alcohol, deepens phenelzine's drowsiness and slowed reflexes, while another 42 stack onto its MAO-blocking action, so tyramine sources such as brewer's yeast and fermented soy can set off a dangerous blood pressure spike.

A further 20 ingredients raise serotonin on top of a drug that already does, which can lead to serotonin syndrome, an overload marked by agitation and fever. A smaller set of 17 can blunt absorption of oral doses, so keep those well separated in time. The 111 moderate and 15 minor entries mostly echo these same themes at lower intensity, but the 18 major ratings are the ones to understand first.

— , Clinical Pharmacist · July 18, 2026

Major 18 Moderate 111 Minor 15 No known interaction 1,308

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Phenelzine Sulfate: Top Interactions at a Glance

The Phenelzine Sulfate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 144 interacting ingredients — plus 1,308 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Phenelzine Sulfate Combinations Today

The Phenelzine Sulfate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Likely Yohimbe + Phenelzine Sulfatei

Concomitant use of MAOIs with yohimbe can result in additive effects.

Read the full interaction Major Likelihood Probable Cowhage + Phenelzine Sulfatei

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.

Read the full interaction Major Likelihood Likely Soy + Phenelzine Sulfatei

Taking soy products containing high amounts of tyramine along with MAOIs can increase the risk of hypertensive crisis.

Read the full interaction Moderate Likelihood Possible Melatonin + Phenelzine Sulfatei

Theoretically, taking melatonin might increase the sedative effects of CNS depressants.

Read the full interaction Moderate Likelihood Possible Cocoa + Phenelzine Sulfatei

Theoretically, concomitant use might increase the risk of a hypertensive crisis.

Read the full interaction Major Likelihood Likely Beer + Phenelzine Sulfatei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Phenelzine Sulfate

All 1,452 ingredients in our database, ranked by severity — 144 with a Phenelzine Sulfate interaction on file and 1,308 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Phenelzine Sulfate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Yohimbe with Phenelzine Sulfate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of MAOIs with yohimbe can result in additive effects.

Full Yohimbe + Phenelzine Sulfate answer

Can you take Cowhage with Phenelzine Sulfate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.

Full Cowhage + Phenelzine Sulfate answer

Can you take Soy with Phenelzine Sulfate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Taking soy products containing high amounts of tyramine along with MAOIs can increase the risk of hypertensive crisis.

Full Soy + Phenelzine Sulfate answer

Can you take Melatonin with Phenelzine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin might increase the sedative effects of CNS depressants.

Full Melatonin + Phenelzine Sulfate answer

Can you take Cocoa with Phenelzine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of a hypertensive crisis.

Full Cocoa + Phenelzine Sulfate answer

Can you take Greater Celandine with Phenelzine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically taking monoamine oxidase inhibitors (MAOIs) with greater celandine might increase the risk of serotonergic side effects includ...

Full Greater Celandine + Phenelzine Sulfate answer

Can you take Green Coffee with Phenelzine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of a hypertensive crisis.

Full Green Coffee + Phenelzine Sulfate answer

Can you take Green Tea with Phenelzine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of a hypertensive crisis.

Full Green Tea + Phenelzine Sulfate answer

Can you take Griffonia Simplicifolia with Phenelzine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Griffonia simplicifolia seed extract with CNS depressants might increase the risk of additive CNS depression.

Full Griffonia Simplicifolia + Phenelzine Sulfate answer

Can you take Guar Gum with Phenelzine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Phenelzine Sulfate answer

Can you take Guarana with Phenelzine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of a hypertensive crisis.

Full Guarana + Phenelzine Sulfate answer

Can you take Guarumo with Phenelzine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In an animal study, an aqueous extract of guarumo depressed the central nervous system, inducing significant motor incoordination and muscle...

Full Guarumo + Phenelzine Sulfate answer

Can you take Gum Arabic with Phenelzine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Phenelzine Sulfate answer

Can you take Hawaiian Baby Woodrose with Phenelzine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use may increase the risk for serotonergic adverse effects.

Full Hawaiian Baby Woodrose + Phenelzine Sulfate answer

Can you take Hesperidin with Phenelzine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with CNS depressants may cause additive sedative effects.

Full Hesperidin + Phenelzine Sulfate answer

Can you take Hops with Phenelzine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.

Full Hops + Phenelzine Sulfate answer

Can you take Hordenine with Phenelzine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hordenine is structurally similar to tyramine In vitro research shows that hordenine is a selective substrate for monoamine oxidase-B in the...

Full Hordenine + Phenelzine Sulfate answer

Can you take Hydrazine Sulfate with Phenelzine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with other MAOIs might increase the effects and adverse effects associated with MAOIs.

Full Hydrazine Sulfate + Phenelzine Sulfate answer

Can you take Iboga with Phenelzine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking iboga with serotonergic drugs might increase levels of serotonin, resulting in additive effects with serotonergic drug...

Full Iboga + Phenelzine Sulfate answer

Can you take Ilex Guayusa with Phenelzine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of a hypertensive crisis.

Full Ilex Guayusa + Phenelzine Sulfate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Phenelzine Sulfate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Phenelzine Sulfate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Phenelzine Sulfate sits in 6 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Phenelzine Sulfate through this category.

Monoamine Oxidase Inhibitors (Maois) 42 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

42 of the supplement ingredients on this page reach Phenelzine Sulfate through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Phenelzine Sulfate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Phenelzine Sulfate through this category.

Antidepressant Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Phenelzine Sulfate through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Phenelzine Sulfate through this category.

About Phenelzine Sulfate

Phenelzine is an MAO inhibitor antidepressant used for certain types of depression, usually after other antidepressants have not worked.

Generic name: Phenelzine Sulfate  ·  Brand name: Nardil.

See the full Phenelzine drug information

Related: does Phenelzine Sulfate deplete any nutrients?

Phenelzine Sulfate has 1 reported nutrient association in the research literature — see the Phenelzine Sulfate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Phenelzine Sulfate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Phenelzine Sulfate.

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Pharmacist Counseling Corner

Phenelzine Sulfate & Supplements: Common Questions

What supplements interact with Phenelzine Sulfate?
Our database currently documents 144 ingredients with a known Phenelzine Sulfate interaction (18 major, 111 moderate, 15 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 144. The highest-ranked right now: Beer, Brewer's Yeast, Fever Bark.
Which Phenelzine Sulfate supplement interactions are the most serious?
Focus on the major group: Beer, Brewer's Yeast, Fever Bark, Soy and Tyramine, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Phenelzine Sulfate?
Plenty of supplements coexist fine with Phenelzine Sulfate; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Nardil have the same supplement interactions as Phenelzine Sulfate?
Yes — Nardil all contain Phenelzine Sulfate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Phenelzine Sulfate deplete any vitamins or nutrients?
It might — Phenelzine Sulfate has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Phenelzine Sulfate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Phenelzine Sulfate and my other medications?
This page covers Phenelzine Sulfate against supplements and herbal ingredients. Checking Phenelzine Sulfate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Phenelzine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 1, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.