Cursed Buttercup + Phenelzine Sulfate
Phenelzine Sulfate brand name: Nardil.
We found no known interaction between Cursed Buttercup and Phenelzine Sulfate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Cursed Buttercup and Phenelzine Sulfate
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Phenelzine Sulfate and Cursed Buttercup in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Cursed Buttercup at all — not against Phenelzine Sulfate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Cursed Buttercup safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Cursed Buttercup in Pregnancy & Breastfeeding
When used orally or topically. Oral use of cursed buttercup might stimulate uterine activity.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Phenelzine Sulfate
This page covers Cursed Buttercup only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Phenelzine Sulfate page lists 144 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Bitter Orange (major) and Brewer's Yeast (major).
By severity: 18 major · 111 moderate · 15 minor.
From our pharmacist’s overview on the Phenelzine Sulfate page
“Few medications demand as much dietary and supplement care as phenelzine sulfate (Nardil), an older MAOI antidepressant, and this list backs that up, with 18 of its 144 recorded interactions rated major. The two dominant themes are sedation and blood pressure.”
Reviewed by 2 · Jul 18, 2026
Where Cursed Buttercup and Phenelzine Sulfate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#909 of 1,452 supplements looked up here in the last 7 days
#1,125 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cursed Buttercup reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Cursed Buttercup and Phenelzine Sulfate records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Cursed Buttercup
What is Cursed Buttercup?
- Traditional topical use for skin and joint complaints
- Folk remedy for warts and skin growths (as a counterirritant)
- Historical use for fevers
- Traditional use for swelling or pain
Cursed Buttercup is a toxic wetland plant that can cause severe skin blistering and dangerous poisoning if eaten. It is not a safe or proven dietary supplement, and there is no reliable evidence supporting any medicinal use. Do not take it internally or apply it to your skin without medical supervision—in practice, it is best avoided entirely.
Ranunculus sceleratus · Ranunculaceae · Whole plant (leaves, stems, flowers); historically used topically · Fresh plant poultice or crushed leaves in traditional practice; not sold as a standardized supplement
An interaction check asks whether these two react with each other — it does not ask whether Cursed Buttercup is a good idea for someone in your situation. Here is what our Cursed Buttercup record says about it on its own.
Cursed Buttercup: dosing
There is no established or safe dose of Cursed Buttercup. It is not a recognized dietary supplement, and no reputable product provides standardized, tested amounts.Because the plant is toxic, the safest approach is to not use it at all.
From our Cursed Buttercup monograph — the full record covers uses, side effects and every documented interaction.
About Phenelzine
What Is Phenelzine Used For?
Brand name: Nardil
Phenelzine is used to treat depression — specifically the types described as atypical, nonendogenous, or neurotic depression. This often includes people who have a mix of anxiety and depression, or who have phobic or hypochondriacal features (strong fears about illness or physical symptoms).
It is generally not the first antidepressant a doctor will try. It is best suited for patients who have already tried other antidepressants without enough relief. There is less evidence supporting its use in severe depression with classic biological features (called endogenous depression).
Most-Reported Side Effects for Phenelzine Sulfate
From FAERS, the FDA’s public side-effect reporting system (1,563 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Cursed Buttercup
Browse every other medication we’ve checked against Cursed Buttercup — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Cursed Buttercup against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Tadalafil ›
- Abemaciclib ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Ibuprofen ›
- Tirzepatide ›
- Methamphetamine ›
- Semaglutide ›
- Warfarin Sodium ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Amitriptyline ›
- Bendamustine ›
- Acyclovir ›
- Methotrexate ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Pregabalin ›
- Lamotrigine ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Gabapentin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Omeprazole ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Cursed Buttercup list.
Cursed Buttercup References
The 2 references that drive our Cursed Buttercup monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Phenelzine Sulfate Is Linked to Lower Levels of One Nutrient
Natural Medicines records Phenelzine Sulfate as a medicine that can lower these. This is not an interaction with Cursed Buttercup — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Phenelzine Sulfate nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Cursed Buttercup and Phenelzine Sulfate Together: Common Questions
Is it safe to take Cursed Buttercup with Phenelzine Sulfate?
Does Phenelzine Sulfate interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Phenelzine Sulfate and Cursed Buttercup?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.