Drug & supplement interaction

Cannabis + Isocarboxazid

Isocarboxazid brand name: Marplan.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Cannabis and Isocarboxazid in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Cannabis and Isocarboxazid

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Isocarboxazid and Cannabis in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cannabis safety at a glance

Cannabis overall Use caution Can cause impairment, dependence, and mental health effects; use carefully and under medical guidance where legal.
Pregnancy Unsafe When used orally or inhaled. Constituents in cannabis pass through the placenta and can reduce fetal growth and increase the risk for preterm birth. Cannabis us... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally or inhaled. Delta-9-tetrahydrocannabinol (THC) is concentrated and excreted in breast milk for longer than 6 weeks after cessation of cannabis... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Isocarboxazid and Cannabis? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Isocarboxazid

Interactions in our licensed database are recorded against drug classes, not just single drug names. Isocarboxazid is filed under 5 classifications — including monoamine oxidase inhibitors (maois), antidepressant drugs, serotonergic drugs. Cannabis has documented interactions with 18 drug classes — the most serious being warfarin (coumadin) (major), alcohol (ethanol) (moderate) and anesthesia (moderate) — and none of Isocarboxazid’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Cannabis Does Interact With Other Medications

Cannabis has 2 major, 1,109 moderate, 25 minor known drug interactions in our database — Isocarboxazid isn’t one of them. If you take anything else, check it against the full list below.

Major 2 Moderate 1,109 Minor 25 No known interaction 1,694 (incl. Isocarboxazid)
Taking anything else?

Check Another of Your Medications Against Cannabis

Covers the 2,830 medications we’ve checked against Cannabis. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Cannabis and Isocarboxazid May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Dry mouth / Nausea Additional detail

    Cannabis

    “Smoking and ingesting cannabis can cause xerostomia, nausea, and vomiting (13,18,2619,61896,96384,96813,113016). Vaping cannabis has been reported to cause sore throat and bad taste in up to 35% of patients. Cannabis has also been reported to cause oral candidiasis. There have been 2 case reports of tongue candidiasis attributed to dry mouth after heavy cannabis use.”

    Cannabis · Natural Medicines adverse-effect record, reported in burns.

    6 sources cited
    1. 13. Robbers JE, Speedie MK, Tyler VE. Pharmacognosy and Pharmacobiotechnology. Baltimore, MD: Williams & Wilkins, 1996.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    3. 2619. Hebel SK, ed. Drug Facts and Comparisons. 52nd ed. St. Louis: Facts and Comparisons, 1998.
    4. 61896. Lynch, M. E. and Campbell, F. Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials. Br.J.Clin.Pharmacol. 2011;72(5):735-744. PubMed
    5. 96384. Whiting PF, Wolff RF, Deshpande S, et al. Cannabinoids for medical use: A systematic review and meta-analysis. JAMA. 2015;313(24):2456-73. PubMed
    6. 96813. Lotan I, Treves TA, Roditi Y, Djaldetti R. Cannabis (medical marijuana) treatment for motor and non-motor symptoms of Parkinson disease: an open-label observational study. Clin Neuropharmacol. 2014;37(2):41-4. PubMed

    Isocarboxazid

    Listed in the ADVERSE REACTIONS section of the FDA label for Isocarboxazid. Read the label on DailyMed ›

  • Dizziness Additional detail

    Cannabis

    “Orally, edible cannabis products reported to contain 50 mg or more of delta-9-tetrahydrocannabinol (THC) have been associated with myocardial infarction (MI) and ventricular arrhythmia. An epidemiological study in adults 18-74 years old suggests daily cannabis use is associated with a 25% increased odds of MI when compared with non-use, with lower odds for less than daily use, regardless of prior history of cigarette…”

    Cannabis · Natural Medicines adverse-effect record, reported in arrhythmia.

    6 sources cited
    1. 103796. Monte AA, K Shelton SK, Mills E., Acute Illness Associated With Cannabis Use, by Route of Exposure: An Observational Study. Ann Intern Med. 2019 Apr 16;170(8):531-537. PubMed
    2. 113092. Jeffers AM, Glantz S, Byers AL, Keyhani S. Association of Cannabis Use With Cardiovascular Outcomes Among US Adults. J Am Heart Assoc. 2024 Mar 5;13(5):e030178. PubMed
    3. 91909. Mittleman MA, Lewis RA, Maclure M, Sherwood JB, Muller JE. Triggering myocardial infarction by marijuana. Circulation. 2001;103(23):2805-9. PubMed
    4. 61840. Cappelli, F., Lazzeri, C., Gensini, G. F., and Valente, S. Cannabis: a trigger for acute myocardial infarction? A case report. J Cardiovasc.Med.(Hagerstown.) 2008;9(7):725-728. PubMed
    5. 96378. Goyal H, Awad HH, Ghali JK. Role of cannabis in cardiovascular disorders. J Thorac Dis. 2017;9(7):2079-2092. PubMed
    6. 104491. Lawin D, Lawrenz T, Tego A, Stellbrink C. Cannabis-induced recurrent myocardial infarction in a 21-year-old man: a case report. Eur Heart J Case Rep. 2020;4(3):1-5. PubMed

    Isocarboxazid

    Listed in the ADVERSE REACTIONS section of the FDA label for Isocarboxazid. Read the label on DailyMed ›

Reported for Cannabis but not commonly for Isocarboxazid: a stroke or mini-stroke, a severe skin reaction, low blood pressure and an electrolyte imbalance.

Effects for Isocarboxazid come from the ADVERSE REACTIONS section of its FDA label; effects for Cannabis come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Cannabis in Pregnancy & Breastfeeding

Pregnancy Unsafe

When used orally or inhaled. Constituents in cannabis pass through the placenta and can reduce fetal growth and increase the risk for preterm birth. Cannabis use during pregnancy is also associated with placental abruption, stillbirth, preterm delivery, fetal abnormalities, congenital birth defects of various organ systems, low birth weight, small for gestational age, increased need for neonatal intensive care, and childhood leukemia. Prenatal cannabis use has also been associated with long-term adverse developmental effects in the offspring, such as worsened cognition, increased risk for neurodevelopmental disorders such as autism spectrum disorder and attention deficit hyperactivity disorder, and increased risk for psychological issues during adolescence. Due to the observational nature of these studies, it is unclear if cannabis causes these adverse effects. Umbilical artery Doppler scans also show that cannabis use can increase placental vascular resistance. Cannabis use during pregnancy has been associated with increased risk of anemia and hypertension in the mother. The rate of negative fetal outcomes due to cannabis use during pregnancy may have been previously underestimated due to reliance on maternal self-reporting of use. Recent programs requiring maternal urine toxicology testing have increased awareness of maternal cannabis use and suggest that negative fetal outcomes occur more frequently than previously recorded.

Lactation Likely Unsafe

When used orally or inhaled. Delta-9-tetrahydrocannabinol (THC) is concentrated and excreted in breast milk for longer than 6 weeks after cessation of cannabis use. Prolonged cannabis use during lactation has been associated with delayed motor development. Observational research in mothers who successfully abstained from cannabis use for 6 weeks (confirmed by a negative THC urine screen) after smoking cannabis prenatally at least twice weekly, found that THC levels in breastmilk increased during the first 2 weeks of abstinence and then decreased but remained detectable at 6 weeks. For patients planning to breastfeed, recommend abstaining from cannabis use prenatally and during lactation. Recommendations to discard breastmilk until THC levels are undetectable are not practical, as this may take more than 6 weeks.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Isocarboxazid Is Prescribed For, and What Cannabis Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Isocarboxazid is a prescription medicine with approved uses on its FDA label. Cannabis is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Isocarboxazid is prescribed for: Marplan (isocarboxazid) is indicated for the treatment of depression — specifically, major depressive disorder. Because it carries serious risks, it is not a first-choice antidepressant. Marplan is generally reserved for patients who have not responded adequately to other antidepressants. Clinical trials showed Marplan to be effective in adult outpatients with major depressive disorder, including those whose depression was accompanied by anxiety symptoms such as panic or phobias.

Read the rest of what Isocarboxazid is prescribed for

Marplan is not approved for use in children or adolescents.

Cannabis has been studied for:

  • Depression studied, not established Cannabis has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Cannabis for depression

    It is unclear if non-inhaled cannabis is beneficial for depression.

  • Anxiety studied, not established Cannabis has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Cannabis for anxiety

    It is unclear if non-inhaled cannabis is beneficial for anxiety.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Isocarboxazid on your own; if you are taking Cannabis for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Cannabis or Isocarboxazid

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Cannabis or Isocarboxazid, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Isocarboxazid

This page covers Cannabis only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Isocarboxazid page lists 81 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Bitter Orange (major), Brewer's Yeast (major) and Cowhage (major).

By severity: 14 major · 55 moderate · 12 minor.

From our pharmacist’s overview on the Isocarboxazid page

“Isocarboxazid (Marplan) is an MAOI antidepressant, and that drug class carries some of the sharpest supplement and food hazards in the pharmacy, so read this list closely rather than skimming it. Fourteen of the 81 entries rate major, and most of the danger runs through tyramine.”

Reviewed by 2 · Jul 18, 2026

Open the Isocarboxazid interaction page

One more smart check

Taking Cannabis as Part of a Dietary Supplement Product? Check It for Interactions

We hold 21 real supplement products containing Cannabis, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cannabis. Even though Cannabis itself has no known interaction with Isocarboxazid, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cannabis and Isocarboxazid Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cannabis
Top 25%

#235 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Isocarboxazid
Steady interest

#2,573 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cannabis reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cannabis and Isocarboxazid records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cannabis

What is Cannabis?

Cannabis
  • Chronic pain
  • Nausea and vomiting from chemotherapy
  • Muscle spasticity (e.g., multiple sclerosis)
  • Anxiety and stress
  • Sleep problems
  • Appetite stimulation

Cannabis contains many active compounds, mainly THC (which causes a 'high') and CBD (which does not). Some uses, such as chemotherapy-related nausea, certain seizure disorders, and muscle spasticity, have meaningful evidence, while many other popular uses are not well proven. It can cause real side effects and impairment, so talk to your doctor or pharmacist and follow your local laws before using it.

Cannabis sativa · Cannabaceae · Dried flowers (buds), leaves, and extracted resins/oils · Dried flower for smoking or vaporizing, edibles, oils and tinctures, capsules, topical creams, prescription products (e.g., dronabinol, nabilone, cannabidiol)

An interaction check asks whether these two react with each other — it does not ask whether Cannabis is a good idea for someone in your situation. Here is what our Cannabis record says about it on its own.

Cannabis: dosing

There is no single standard dose for cannabis. The right amount depends on the product, its strength, the THC and CBD content, how it is taken, and the person using it. Products can vary a lot in potency, which makes consistent dosing difficult.A common harm-reduction approach is to 'start low and go slow,' meaning begin with a small amount and wait to see how it affects you before taking more. This is especially important with edibles, which can take an hour or more to work.For prescription cannabis-based medicines, follow your doctor's instructions exactly.

From our Cannabis monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cannabis monograph & all interactions
Medication

About Isocarboxazid

What Is Isocarboxazid Used For?

Brand name: Marplan

Marplan (isocarboxazid) is indicated for the treatment of depression — specifically, major depressive disorder. Because it carries serious risks, it is not a first-choice antidepressant. Marplan is generally reserved for patients who have not responded adequately to other antidepressants.

Clinical trials showed Marplan to be effective in adult outpatients with major depressive disorder, including those whose depression was accompanied by anxiety symptoms such as panic or phobias. Marplan is not approved for use in children or adolescents.

See full Isocarboxazid drug information
Keep checking

Other Drugs & Cannabis

Browse every other medication we’ve checked against Cannabis — both the ones with a known interaction and the ones without. Select any drug for the full detail.

2Major
1,109Moderate
25Minor
1,693No known interaction
2 Major 1,109 Moderate 25 Minor 1,693 No interaction
Major

2 interactions

Moderate

1,109 interactions

Showing 60 of 1,109 moderate interactions — see all 1,109 on the Cannabis page.

Minor

25 interactions

No interaction 1,693 drugs checked — show the list

We also checked Cannabis against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,693 medications checked with no known interaction — see the full Cannabis list.

See the full Cannabis interactions page
See every supplement checked against Isocarboxazid, ranked by severity
Evidence & sources

Cannabis References

The 261 references that drive our Cannabis monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Robbers JE, Speedie MK, Tyler VE. Pharmacognosy and Pharmacobiotechnology. Baltimore, MD: Williams & Wilkins, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Johnson MA, Robin P, Smith RP, Morrisona D, et al. Large lung bullae in marijuana smokers. Thorax 2000;55:340-2.. PubMed
  4. Hebel SK, ed. Drug Facts and Comparisons. 52nd ed. St. Louis: Facts and Comparisons, 1998.
  5. Tyrey L. Delta 9-Tetrahydrocannabinol: a potent inhibitor of episodic luteinizing hormone secretion. J Pharmacol Exp Ther 1980;213:306-8. DOI
  6. Briggs GB, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
  7. Solowij N, Stephens RS, Roffman RA, et al. Cognitive functioning of long-term heavy cannabis users seeking treatment. JAMA 2002;287:1123-31.. PubMed
  8. Marinol Prescribing Information. Solvay Pharmaceuticals, Rev March 2008. Available at: http://www.solvaypharmaceuticals-us.com/static/wma/pdf/1/3/2/5/0/004InsertText500012RevMar2008.pdf (Accessed 2 July 2009).
  9. Yamreudeewong W, Wong HK, Brausch LM, Pulley KR. Probable interaction between warfarin and marijuana smoking. Ann Pharmacother 2009;43:1347-53. PubMed
  10. Ware MA, Wang T, Shapiro S, et al. Smoked cannabis for chronic neuropathic pain: a randomized controlled trial. CMAJ 2010;182:e694-e701. PubMed
  11. Pellinen, P., Honkakoski, P., Stenback, F., Niemitz, M., Alhava, E., Pelkonen, O., Lang, M. A., and Pasanen, M. Cocaine N-demethylation and the metabolism-related hepatotoxicity can be prevented by cytochrome P450 3A inhibitors. Eur.J Pharmacol 1-3-1994;2 PubMed
  12. Johnson, E. M. Substance abuse and women's health. Public Health Rep. 1987;102(4 Suppl):42-48.
  13. Astley, S. J. and Little, R. E. Maternal marijuana use during lactation and infant development at one year. Neurotoxicol.Teratol. 1990;12(2):161-168. PubMed
  14. Levy, R., Schurr, A., Nathan, I., Dvilanski, A., and Livne, A. Impairment of ADP-induced platelet aggregation by hashish components. Thromb.Haemost. 12-31-1976;36(3):634-640. DOI
  15. Payne, R. J. and Brand, S. N. The toxicity of intravenously used marihuana. JAMA 7-28-1975;233(4):351-354. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cannabis and Isocarboxazid Together: Common Questions

Is it safe to take Cannabis with Isocarboxazid?
We do not list a known interaction between Cannabis and Isocarboxazid. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Cannabis and Isocarboxazid have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Cannabis and Isocarboxazid used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Cannabis in each. That is a conversation for your prescriber, especially if Isocarboxazid is being adjusted to a target.
How was the Cannabis and Isocarboxazid combination checked?
Interactions in our licensed database are recorded against drug classes. Isocarboxazid is filed under 5 classifications, and Cannabis has documented interactions with 18 drug classes — none of Isocarboxazid's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Cannabis interact with any other medications?
Yes. Cannabis has 1,136 documented drug interactions in our database — Isocarboxazid is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Isocarboxazid interact with any supplements?
Yes. Isocarboxazid has documented interactions with 81 supplements in our database — Cannabis is not one of them. The Isocarboxazid interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cannabis monograph Uses, safety profile, and every drug interaction in one place Isocarboxazid drug information The full plain-English guide to this medication Isocarboxazid supplement interactions Every supplement checked against Isocarboxazid, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 261 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Isocarboxazid and Cannabis?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.