Clary Sage Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Clary Sage interacts with medications. The heart of this page is the interaction list — every drug Clary Sage is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Clary Sage is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Clary Sage against your medication
Add one medicationDrugs that interact with Clary Sage
0 medications have a known interaction with Clary Sage, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Clary Sage. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Clary Sage combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Clary Sage: Uses, Safety & Side Effects
Clary sage is a Mediterranean herb most often used as an essential oil for aromatherapy and to ease stress or menstrual discomfort. Evidence for these uses is limited and mostly from small studies, and the oil should never be swallowed and should always be diluted before skin contact.
- Scientific name
- Salvia sclarea
- Family
- Lamiaceae
- Part used
- Flowering tops and leaves (essential oil)
- Common forms
- Essential oil, aromatherapy blends, diluted topical oils
- Stress and anxiety
- Menstrual cramps
- Menopause symptoms
- Aromatherapy and relaxation
- Skin care
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally considered safe as a diluted essential oil for aromatherapy, but it should not be taken by mouth.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Clary sage (Salvia sclarea) is a flowering herb in the mint family. It is native to the Mediterranean region and parts of Asia, and it is now grown in many countries for its fragrant essential oil.
The plant's flowering tops and leaves are steam-distilled to make an essential oil with a warm, herbal, slightly sweet smell. This oil is the form most people use today. Clary sage is popular in aromatherapy, in skin and hair products, and as a flavoring in some foods and beverages.
People most often use clary sage essential oil to help with relaxation, stress, and menstrual or menopausal discomfort. It is usually inhaled or applied to the skin after being diluted in a carrier oil.
How it works
Clary sage essential oil contains compounds such as linalyl acetate, linalool, and a compound called sclareol. These are thought to be responsible for its scent and its possible calming effects.
One idea is that inhaling pleasant aromas may influence the nervous system and mood through the sense of smell, which could explain reported relaxation. Some compounds also show antimicrobial and antioxidant effects in the laboratory.
It is important to know that most of these mechanisms come from test-tube and animal research. How well they apply to the human body is still not well understood.
Does Clary Sage work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Clary Sage, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 3 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Dysmenorrhea
Clinical research in young women with moderate to severe dysmenorrhea shows that use of an aromatic massage cream containing lavender, clary sage, and marjoram oils daily during a menstrual cycle modestly reduces pain. On the second and third days of the next cycle, pain was reduced by 45% to 60% compared with a reduction of 20% to 40% with a placebo cream containing a synthetic fragrance. However, the aromatic cream did not reduce pain on the first day of the cycle, when pain was most severe. It is not clear if these effects are due to topical application, aromatherapy, clary sage, the other ingredients, or a combination of these factors.
Insufficient Reliable Evidence To Rate Postoperative nausea and vomiting (PONV)
Preliminary clinical research in patients undergoing percutaneous nephrolithotomy shows that inhaling clary sage essential oil aromatherapy for 5 minutes immediately after the operation, and again 3 and 6 hours after, does not improve nausea or vomiting when compared with a control group not receiving aromatherapy.
Insufficient Reliable Evidence To Rate Postoperative pain
Preliminary clinical research in patients undergoing percutaneous nephrolithotomy shows that inhaling clary sage essential oil aromatherapy for 5 minutes immediately after the operation, and again 3 and 6 hours after, does not reduce pain when compared with a control group not receiving aromatherapy.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
When used as directed in aromatherapy, clary sage essential oil is generally considered safe for most adults. Like all essential oils, it is very concentrated and should always be diluted in a carrier oil before being applied to the skin. It should never be swallowed, as essential oils can be toxic when taken by mouth.
People with sensitive skin should do a small patch test first, since essential oils can cause irritation or allergic reactions. Keep the oil away from the eyes and out of reach of children and pets.
Pregnancy: Clary sage is traditionally avoided during pregnancy because it has long been associated with stimulating uterine activity, so pregnant people should not use it. Breastfeeding: There is not enough reliable safety information, so it is best to avoid clary sage while breastfeeding. If you have a hormone-sensitive condition, a seizure disorder, or any chronic illness, check with your doctor or pharmacist first.
Side effects
Clary sage essential oil is usually well tolerated when inhaled or used properly diluted on the skin. The most common side effects are skin irritation, redness, or allergic reactions, especially if it is used undiluted.
Inhaling strong aromas may cause headache or nausea in some sensitive people. Some users report feeling drowsy or relaxed, so use caution if you need to stay alert.
Serious problems are rare with proper aromatherapy use, but swallowing essential oils can cause poisoning and should be treated as a medical emergency.
Dosing
There is no official or standardized dose for clary sage, and it is not meant to be taken by mouth as a supplement.
For aromatherapy, people typically add a few drops to a diffuser or dilute a small amount in a carrier oil before applying it to the skin. Always follow the directions on the product label and do not exceed the suggested amount.
Because products vary in strength and quality, it is a good idea to check with a pharmacist or healthcare provider before using clary sage, especially if you have a health condition or take other medicines.
Clary Sage & Pregnancy
Clary Sage & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 2 references that drive our Clary Sage monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Ou, M. C., Hsu, T. F., Lai, A. C., Lin, Y. T., and Lin, C. C. Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial. J Obstet.Gynaecol.Res 2012;38(5):817-822. PubMed
- Amirhosseini M, Dehghan M, Mangolian Shahrbabaki P, Pakmanesh H. Effectiveness of aromatherapy for relief of pain, nausea, and vomiting after percutaneous nephrolithotomy: a randomized controlled trial. Complement Med Res 2020:1-9. Online ahead of print. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Clary Sage
15 brands in our database make a supplement containing Clary Sage.
Supplement products with Clary Sage
37 products in our database contain Clary Sage. Open any to see its full ingredient list and every drug interaction we check.
Clary Sage: Common Questions
What is Clary Sage used for, and does it work?
Does Clary Sage interact with prescription medications?
How are Clary Sage interactions rated?
Is it safe to take Clary Sage with my medications?
Where does this Clary Sage interaction information come from?
What is Clary Sage used for?
Can I take Clary Sage essential oil by mouth?
Is Clary Sage safe during pregnancy?
Does Clary Sage have side effects?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Clary Sage
A rotating sample of real supplements in our database that list Clary Sage — open any to see its full ingredients and every drug interaction we check.
- Full Spectrum Omega by Solgar
- Dyma-Burn Xtreme With Raspberry Ketones by Dymatize Nutrition
- Clary Sage by doTERRA
- Salvia sclarea (Clary Sage) 450 mg by TerraVita Premium Collection
- Clary Sage (Salvia sclarea) Strawberry Flavor by TerraVita
- D4 Thermal Shock by Cellucor
- Dyma-Burn Xtreme With Raspberry Ketones by Dymatize Nutrition
- Dyma-Burn Xtreme With Raspberry Ketones by Dymatize Nutrition
- Clary Sage (Salvia sclarea) Mint Flavor by TerraVita
- All In One Omega with Vitamin D3 by Puritan's Pride
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