Interactions on record — worth a quick check against your medications. Based on 8 of 9 ingredients. Check your meds →
Dietary supplement

P6 Ingredients & Drug Interactions

by Cellucor

P6 label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking P6 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

P6 is a dietary supplement by Cellucor with 9 active ingredients. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 1,441 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Adaptest Ashwagandha (Withania somnifera) root extract, Tribulus alatus fruit extract, Saw Palmetto fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against P6 by Cellucor

Ask about any prescription or over-the-counter medication and we check it for interactions with P6 by Cellucor — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of P6 by Cellucor

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 9 active ingredients.
  • “P6 Extreme(TM) Blend” is a proprietary blend — the label gives one combined amount (1,114 mg) without saying how much of each component you get.

P6 contains 9 ingredients total, of which saw palmetto fruit extract, tribulus alatus fruit extract, stinging nettle root extract, ashwagandha root extract, wild yam root extract, and clary sage whole plant extract are the active herbal components. Agaricus bisporus, ovine placenta powder, and myrica rubra bark extract are also included.

The inactive ingredients—capsule shell, magnesium stearate, and silica—are standard excipients that help form and stabilize the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Male sexual function and prostate health.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Erectile dysfunction (ED), Male infertility, Premature ejaculation, Prostatitis, Sexual desire — and 4 related terms.
  • The strongest evidence on file: Tribulus is rated "Possibly Effective" for Sexual dysfunction (Natural Medicines).
  • Also on file: Saw Palmetto is rated "Possibly Ineffective" for Benign prostatic hyperplasia (BPH).
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Benign prostatic hyperplasia (BPH), Erectile dysfunction (ED), Premature ejaculation, Male infertility.

The evidence for P6's effectiveness is mixed and depends on what you're taking it for. Saw palmetto is possibly ineffective for benign prostatic hyperplasia (enlarged prostate) but possibly effective for certain urological procedures (TURP).

Tribulus is possibly effective for sexual dysfunction but possibly ineffective for athletic performance. Ashwagandha is possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder.

Wild yam is possibly ineffective for menopausal symptoms. For several conditions—chronic bronchitis, hair loss, urinary tract symptoms, hay fever, anemia, asthma, and gallbladder disease—the evidence we hold is insufficient to rate these ingredients' usefulness.

Clary sage's effectiveness hasn't been established in our data for the conditions listed.

The evidence, ingredient by ingredient Tribulus Saw Palmetto Agaricus Mushroom Stinging Nettle Ashwagandha Wild Yam Bayberry Clary Sage

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of the herbal ingredients in P6 are generally well tolerated when used as directed in healthy adults. However, serious adverse effects have been reported in rare cases.

Saw palmetto may cause abdominal pain, constipation, decreased sexual desire, diarrhea, dizziness, fatigue, headache, nausea, and rhinitis; a few case reports describe skin reactions and cardiac issues. Tribulus is usually well tolerated but rare reports include liver and kidney injury, seizures, and painful erection; gastrointestinal complaints like nausea, diarrhea, and cramping can occur.

Stinging nettle may cause constipation or diarrhea, and a rare case of liver disease has been reported. Ashwagandha may cause diarrhea, nausea, and vomiting (though these don't occur at typical doses), and rare reports include liver failure and intracranial hemorrhage.

Wild yam is generally well tolerated but may cause fever, headache, upset stomach, vomiting, and in one rare case, a blood clot in the eye. Clary sage should not be taken by mouth and is generally safe only as a diluted essential oil for aromatherapy.

Side effects, ingredient by ingredient Tribulus Saw Palmetto Agaricus Mushroom Stinging Nettle Ashwagandha Wild Yam Bayberry Clary Sage

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 8 matched ingredients can interact with medications — Tribulus, Stinging Nettle, Ashwagandha, Wild Yam, Saw Palmetto, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,442 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking P6, double-check your medications against these drug types: contraceptive drugs and estrogens (saw palmetto may reduce their effectiveness), blood thinners and antiplatelet drugs (saw palmetto and stinging nettle), antihypertensive drugs (tribulus and ashwagandha may increase low blood pressure risk), antidiabetes drugs (tribulus, stinging nettle, and ashwagandha may increase low blood sugar risk), lithium (tribulus and stinging nettle may increase levels), benzodiazepines and CNS depressants (ashwagandha may increase drowsiness), immunosuppressants (ashwagandha may weaken them), thyroid hormone (ashwagandha may amplify effects), and hepatotoxic drugs (ashwagandha may increase liver damage risk). If you take any of these, run them through the checker below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

P6 is designed to support male sexual function and urinary health, but the evidence is limited and mixed. If you take any prescription medications—especially blood pressure drugs, diabetes medications, blood thinners, birth control, thyroid hormone, sedatives, or lithium—you need to check this product against your exact medications before starting.

Talk with your pharmacist or doctor, particularly if you're pregnant, breastfeeding, or have liver or heart concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about P6, straight from the product label.

Brand Cellucor
Barcode (UPC) 810390024773
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2015
DSLD ID 41954
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for P6 by Cellucor, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
90
UPC/BARCODE
810390024773
IngredientAmount% DV
Saw Palmetto fruit extract0 NP--
Tribulus alatus fruit extract250 mg--
Agaricus bisporus fruit extract0 NP--
Stinging Nettle root extract0 NP--
Ovine Placenta powder0 NP--
P6 Extreme(TM) Blend1114 mg--
Adaptest Ashwagandha (Withania somnifera) root extract0 NP--
Wild Yam root extract0 NP--
Myrica rubra bark extract0 NP--
Clary Sage whole plant extract0 NP--

Other ingredients: Capsule Shell, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

SUGGESTED USE: Take one serving (2 capsules) in the morning with or without food. Take one serving (2 capsules) in the evening before bed with or without food.

Precautions

DO NOT EXCEED 4 CAPSULES PER DAY. USE ONLY AS DIRECTED. WARNING: THIS PRODUCT IS ONLY INTENDED TO BE CONSUMED BY HEALTHY, ADULT MEN, 18 YEARS OF AGE OR OLDER.

NOT FOR USE BY WOMEN, especially those who are pregnant or nursing. Do not use this product if you have any serious medical condition. Before using this product, consult with a licensed, qualified, health care professional, including but not limited to, if you suspect you have or have been treated for, diagnosed with or have a family history of any medical condition, or if you are using any prescription or over the counter medication.

Immediately discontinue use and contact a medical doctor if you experience any adverse reaction to this product. Do not exceed recommendations for Suggested Use. Use only as directed. Do not use if safety seal is broken or missing.

KEEP OUT OF REACH OF CHILDREN.

Contains: Milk.

Formula

THIS PRODUCT IS ONLY INTENDED TO BE CONSUMED BY HEALTHY, ADULT MEN, 18 YEARS OF AGE OR OLDER.

Contains: Milk.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

101290

Seals/Symbols

CELLUCOR(R)

G4 CHROME SERIES(TM)

MANUFACTURED BY GMP COMPLIANT FACILITY

nutrabolt(TM)

General Statements

ERGOGENIC TESTOSTERONE BOOSTER*

STRENGTH* - LEAN MUSCLE* - VIRILITY*

FDA Statement of Identity

DIETARY SUPPLEMENT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

P6 by Cellucor label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

P6 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in P6 by Cellucor

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Tribulus alatus fruit extract

Interacts with
259 drugs
250 mg per serving

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus alatus fruit extract monograph & interactions

Other (inactive) ingredients: Capsule Shell, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

P6 by Cellucor Drug Interactions

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Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,441Drugs
1,035 Moderate 406 Minor

Ingredients driving the most interactions

Adaptest Ashwagandha (Withania somnifera) root extract 1,372
Tribulus alatus fruit extract 259
Saw Palmetto fruit extract 174
Stinging Nettle root extract 164
Agaricus bisporus fruit extract 86

Individual Drug Interactions

The ingredients in P6 interact with 1,441 drugs. Click any drug to see the details.

6 of the 9 ingredients in P6 interact with drugs. Each result below shows which ingredient is responsible. Adaptest Ashwagandha (Withania somnifera) root extract Tribulus alatus fruit extract Saw Palmetto fruit extract Stinging Nettle root extract Agaricus bisporus fruit extract Wild Yam root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in P6 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Adaptest Ashwagandha (Withania somnifera) root extract10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Adaptest Ashwagandha (Withania somnifera) root extract full monograph & interactions

Tribulus alatus fruit extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus alatus fruit extract full monograph & interactions

Saw Palmetto fruit extract3 drug types · 174 drugs

Anticoagulant/Antiplatelet Drugs

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.

Likelihood Possible Evidence D
Contraceptive Drugs

Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.

Likelihood Possible Evidence B
Estrogens

Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.

Likelihood Possible Evidence B
Saw Palmetto fruit extract full monograph & interactions

Stinging Nettle root extract4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D
Stinging Nettle root extract full monograph & interactions

Agaricus bisporus fruit extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.

Likelihood Possible Evidence D
Agaricus bisporus fruit extract full monograph & interactions

Wild Yam root extract1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Wild Yam root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for P6, from the product label.

Cellucor

See all Cellucor products
Name
Nutrabolt
Street Address
3891 S. Traditions Dr.
City
Bryan
State
TX
ZipCode
77807
Phone Number
1.866.927.9686
Web Address
www.cellucor.com
Pharmacist Counseling Corner

P6 by Cellucor: Common Questions

Does P6 by Cellucor interact with any medications?
Yes. Based on its ingredients, P6 has a known interaction with 1,441 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
P6 contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take P6 if I'm on birth control?
Saw palmetto in this product may reduce how well contraceptive drugs work because of its antiestrogenic effects. Talk with your pharmacist or doctor before starting—don't skip or change your birth control based on this alone, but you need personalized advice on whether it's safe for you.
Is P6 safe if I'm pregnant or breastfeeding?
Saw palmetto, tribulus, and ashwagandha are traditionally thought to pose risks during pregnancy and are advised against. Stinging nettle, wild yam, and clary sage also lack enough safety data in pregnancy and lactation. You should not take this product if you're pregnant or breastfeeding without talking to your doctor first.
What does each ingredient in P6 actually do?
Saw palmetto and stinging nettle are used for prostate and urinary issues, though evidence is limited. Tribulus is included for sexual function (possibly effective). Ashwagandha is possibly effective for anxiety, stress, and sleep. Wild yam is used for hormonal balance but is possibly ineffective for menopausal symptoms. Clary sage is included but its effectiveness for the conditions listed hasn't been established in our data.
What are the most common side effects?
Saw palmetto may cause abdominal pain, constipation, diarrhea, nausea, dizziness, and fatigue. Tribulus can cause nausea, diarrhea, and cramping. Stinging nettle may cause constipation or diarrhea. Ashwagandha may cause diarrhea, nausea, and vomiting, though these are uncommon at typical doses. Most side effects are mild and reversible.
Can P6 affect my blood pressure or blood sugar?
Yes. Tribulus and ashwagandha may lower blood pressure, and tribulus, stinging nettle, and ashwagandha may lower blood sugar. If you take blood pressure or diabetes medications, you need to check with your pharmacist before starting, as the combination could increase your risk of dangerously low readings.
Does P6 interact with blood thinners like warfarin?
Stinging nettle contains vitamin K, which can interfere with warfarin (Coumadin) and reduce its effectiveness. Saw palmetto may also increase bleeding risk. If you take any blood thinner, check this product with your pharmacist or doctor first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

P6 label
Go deeper

The Full Monographs Behind P6’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph → Herb & supplement monograph

Saw Palmetto

Interacts with 174 drugs

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...

Read the full Saw Palmetto monograph → Herb & supplement monograph

Agaricus Mushroom

Interacts with 86 drugs

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not...

Read the full Agaricus Mushroom monograph → Herb & supplement monograph

Stinging Nettle

Interacts with 164 drugs

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...

Read the full Stinging Nettle monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph → Herb & supplement monograph

Bayberry

Bayberry is a traditional herb used mainly as an astringent for diarrhea, sore throats, and minor skin or gum problems, but there is very little modern human research to confirm it works. It...

Read the full Bayberry monograph → Herb & supplement monograph

Clary Sage

Clary sage is a Mediterranean herb most often used as an essential oil for aromatherapy and to ease stress or menstrual discomfort. Evidence for these uses is limited and mostly from small s...

Read the full Clary Sage monograph →
Sources

Sources & How We Checked

P6's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 104 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Saw Palmetto 22 references
  1. Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA 1998;280:1604-9. PubMed
  2. Carraro JC, Raynaud JP, Koch G, et al. Comparison of phytotherapy (Permixon) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate 1996;29:231-40. DOI
  3. Di Silverio F, D'Eramo G, Lubrano C, et al. Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign prostatic hypertrophy patients. Eur Urol 1992;21:309-14. PubMed
  4. Stepanov VN, Siniakova LA, Sarrazin B, Raynaud JP. Efficacy and tolerability of the lipidosterolic extract of Serenoa repens (Permixon) in benign prostatic hyperplasia: a double-blind comparison of two dosage regimens. Adv Ther 1999;16:231-41.
  5. Cheema P, El-Mefty O, Jazieh AR. Intraoperative haemorrhage associated with the use of extract of Saw Palmetto herb: a case report and review of literature. J Intern Med 2001;250:167-9. PubMed
  6. Jibrin I, Erinle A, Saidi A, Aliyu ZY. Saw palmetto-induced pancreatitis. South Med J 2006;99:611-2. PubMed
  7. Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002
  8. Avins AL, Bent S, Staccone S, et al. A detailed safety assessment of a saw palmetto extract. Complement Ther Med 2008;16:147-54. PubMed
  9. Morgia, G., Mucciardi, G., Gali, A., Madonia, M., Marchese, F., Di, Benedetto A., Romano, G., Bonvissuto, G., Castelli, T., Macchione, L., and Magno, C. Treatment of chronic prostatitis/chronic pelvic pain syndrome category IIIA with Serenoa repens plus
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Tribulus 10 references
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Agaricus Mushroom 5 references
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Stinging Nettle 23 references
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Ashwagandha 32 references
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Wild Yam 7 references
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Bayberry 3 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

See these in context on the Bayberry monograph →

Clary Sage 2 references
  1. Ou, M. C., Hsu, T. F., Lai, A. C., Lin, Y. T., and Lin, C. C. Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial. J Obstet.Gynaecol.Res 2012;38(5):817-822. PubMed
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