Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

C4 Energy Zero Sugar Watermelon Ingredients & Drug Interactions

by Cellucor

C4 Energy Zero Sugar Watermelon label
See full label image
Liquid Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking C4 Energy Zero Sugar Watermelon against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

C4 Energy Zero Sugar Watermelon is a dietary supplement by Cellucor with 4 active ingredients. Its ingredients are commonly taken for high cholesterol, vitamin b3 deficiency (pellagra), heart health support.Based on those ingredients, 759 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Niacin, Sodium, Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against C4 Energy Zero Sugar Watermelon by Cellucor

Ask about any prescription or over-the-counter medication and we check it for interactions with C4 Energy Zero Sugar Watermelon by Cellucor — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of C4 Energy Zero Sugar Watermelon by Cellucor

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

C4 Energy Zero Sugar Watermelon has 3 active ingredients: niacin (a B vitamin), sodium, and vitamin B12. Niacin helps your body convert food into energy and plays a role in cell function.

Sodium is an electrolyte that supports nerve and muscle function. Vitamin B12 is essential for red blood cell formation, nerve function, and DNA synthesis.

The product also contains inactive ingredients—water, caffeine, malic acid, citric acid, sweeteners, and flavoring agents—that give it its form and taste.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: Energy to perform.
  • We looked for evidence on: Athletic performance, Physical performance, Fatigue, Endurance, Stamina, Exercise performance.
  • The closest evidence on file: Vitamin B12 is rated "Possibly Ineffective" for Physical performance (Natural Medicines).
  • Also on file: Niacin is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.
  • Also on file: Vitamin B12 is rated "Insufficient Reliable Evidence To Rate" for Fatigue.

The evidence we hold shows niacin is likely effective for pellagra (a deficiency disease) and possibly effective for improving cholesterol in people with HIV/AIDS-related dyslipidemia and metabolic syndrome. Vitamin B12 is effective for treating B12 deficiency and certain genetic conditions, and likely effective for cyanide poisoning.

Sodium's effectiveness ratings in our data apply to specific medical conditions like cystic fibrosis, not to general energy or performance use.

The evidence, ingredient by ingredient Niacin Sodium Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Niacin at the dietary amounts found in food is safe; however, high supplemental doses can cause flushing (a warm, tingling feeling in the face and upper body that up to 70% of users report), stomach upset, and more rarely, liver problems. Sodium in normal dietary amounts is fine, but excess intake is linked to high blood pressure and heart strain.

Vitamin B12 is generally very safe and well tolerated—excess is removed through urine. All three active ingredients are considered safe in pregnancy and lactation at normal recommended amounts, though high-dose niacin should be avoided in pregnancy unless prescribed by your doctor.

Side effects, ingredient by ingredient Niacin Sodium Vitamin B12

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Niacin, Vitamin B12, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 760 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take antihypertensive drugs (blood pressure medications), anticoagulants or antiplatelet drugs (blood thinners), liver-toxic medications, diabetes drugs, statins, gout medications (allopurinol or probenecid), corticosteroids, lithium, or metformin. These are the main drug types documented to interact with the ingredients in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

C4 Energy Zero Sugar is built around niacin, sodium, and B12—all found in food and essential at normal levels. If you take blood pressure medications, diabetes drugs, blood thinners, cholesterol medications, lithium, or gout drugs, check with your pharmacist before using this product.

This drink is energizing for people without those medication interactions, but those on prescription drugs should verify compatibility first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about C4 Energy Zero Sugar Watermelon, straight from the product label.

Brand Cellucor
Barcode (UPC) 842595118476
Net contents 12 Fluid Ounce(s); 355 Milliliter(s)
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 322590
Product type Vitamin
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for C4 Energy Zero Sugar Watermelon by Cellucor, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
12 fl. Oz.
Maximum serving Sizes:
12 fl. Oz.
Servings per container
1
UPC/BARCODE
842595118476
IngredientAmount% DV
Calories0 Calorie(s)--
Total Carbohydrates0 Gram(s)--
Niacin30 mg190%
Sodium25 mg1%
Vitamin B126 mcg250%
Added Sugars0 Gram(s)--
Total Sugars0 Gram(s)--
Total Fat0 Gram(s)--
Protein0 Gram(s)--

Other ingredients: Water, CarnoSyn, L-Citrulline, BetaPower, Phosphoric Acid, Malic Acid, Citric Acid, Natural Flavors, Caffeine Anhydrous, Sucralose, Sodium Benzoate, Potassium Sorbate, Acesulfame Potassium, Niacinamide, Potassium Citrate, N-Acetyl-L-Tyrosine, Cyanocobalamin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Watermelon Naturally flavored Betapower Carnosyn

Caffeine: 200 mg per 12 fl oz (1 bottle)

CarnoSyn Carnosine Synthesizer

Tap into the explosive energy of C4 to maximize performance and dominate life. Carnosyn This patented form of Beta-alanine has been clinically shown to fight fatigue and improve muscular endurance. Within minutes of drinking C4, you may feel a tingling sensation from Beta-alanine, signaling that your body is primed for superhuman performance. Studies have shown performance benefits of Beta-Alanine to be correlated with muscle carnosine concentrations, which increase with cumulative use. Betapower This clinically studied, natural form of betaine is derived from beets, a powerful superfood that supports hydration and physical performance.

200 mg caffeine

Formulation

No artificial colors Contains 0% juice

Not a significant source of saturated fat, trans fat, cholesterol, dietary fiber, vitamin D, calcium, iron, and potassium.

Made in the U.S.A. using strategically sourced domestic and imported ingredients and components.

Explosive energy + performance Performance energy drink

Non-carbonated formula

0 g sugar 0 calories

Brand IP Statement(s)

Energy to Perform

C4 is a trademark of and distributed by Nutrabolt

Natural Alternatives International (NAI) is the owner of patents as listed on www.carnosyn.com and registered trademark CarnoSyn. BetaPower is a trademark of DuPont and is used under license to Nutrabolt.

General Statements

CA CRV HI, ME, NY 5 cents or 10 cents

$10 thirsty for more? Joint C4 rewards & earn $10 credit today! C4rewards.com Instagram @C4energy

Precautions

Caution: Do not consume this product if you are pregnant or nursing.

Not intended for children. Recommended for adults.

Storage

Store in a cool, dry place. Do not freeze.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

C4 Energy Zero Sugar Watermelon by Cellucor label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

C4 Energy Zero Sugar Watermelon label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in C4 Energy Zero Sugar Watermelon by Cellucor

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size12 fl. Oz. Dosage formLiquid Servings per container1 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Niacin

Interacts with
727 drugs
30 mg per serving

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescr...

Niacin monograph & interactions

Sodium

Interacts with
205 drugs
25 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Vitamin B12

Interacts with
20 drugs
6 mcg per serving

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Protein

0 Gram(s) per serving

Other (inactive) ingredients: Water, CarnoSyn, L-Citrulline, BetaPower, Phosphoric Acid, Malic Acid, Citric Acid, Natural Flavors, Caffeine Anhydrous, Sucralose, Sodium Benzoate, Potassium Sorbate, Acesulfame Potassium, Niacinamide, Potassium Citrate, N-Acetyl-L-Tyrosine, Cyanocobalamin. These complete the product’s ingredient list but are not active constituents.

Interaction report

C4 Energy Zero Sugar Watermelon by Cellucor Drug Interactions

Want to check YOUR meds against C4 Energy Zero Sugar Watermelon?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
759Drugs
759 Moderate

Ingredients driving the most interactions

Niacin 727
Sodium 205
Vitamin B12 20

Individual Drug Interactions

The ingredients in C4 Energy Zero Sugar Watermelon interact with 759 drugs. Click any drug to see the details.

3 of the 4 ingredients in C4 Energy Zero Sugar Watermelon interact with drugs. Each result below shows which ingredient is responsible. Niacin Sodium Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in C4 Energy Zero Sugar Watermelon with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Niacin15 drug types · 727 drugs

Alcohol (Ethanol)

Concomitant use of alcohol and niacin might increase the risk of flushing and hepatotoxicity.
Alcohol can exacerbate the flushing and pruritus associated with niacin. Large doses of niacin might also exacerbate liver dysfunction associated with chronic alcohol use. A case report describes delirium and lactic acidosis in a patient taking niacin 3 grams daily who ingested 1 liter of wine. Advise patients to avoid large amounts of alcohol while taking niacin.

Likelihood Probable Evidence D
Allopurinol (Zyloprim)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as allopurinol.
Large doses of niacin can reduce urinary excretion of uric acid, potentially resulting in hyperuricemia. Doses of uricosurics such as allopurinol might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Anticoagulant/Antiplatelet Drugs

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Several cases of clotting factor synthesis deficiency and coagulopathy have been reported in patients taking sustained-release niacin. Also, thrombocytopenia has been reported in patients treated with niacin or niacin plus lovastatin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. In diabetes patients, niacin 4.5 grams daily for 5 weeks can increase plasma glucose by an average of 16% and glycated hemoglobin (HbA1c) by 21%. However, lower doses of 1.5 grams daily or less appear to have minimal effects on blood glucose. In some patients, glucose levels increase when niacin is started, but then return to baseline when a stable dose is reached. Up to 35% of patients with diabetes may need adjustments in hypoglycemic therapy when niacin is added.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
The vasodilating effects of niacin can cause hypotension. Furthermore, some clinical evidence suggests that a one-hour infusion of niacin can reduce systolic, diastolic, and mean blood pressure in hypertensive patients. This effect is not observed in normotensive patients.

Likelihood Possible Evidence B
Bile Acid Sequestrants

Bile acid sequestrants can bind niacin and decrease absorption. Separate administration by 4-6 hours to avoid an interaction.
In vitro studies show that colestipol (Colestid) binds about 98% of available niacin and cholestyramine (Questran) binds 10% to 30%.

Likelihood Possible Evidence D
Gemfibrozil (Lopid)

Theoretically, concomitant use of niacin and gemfibrozil might increase the risk of myopathy in some patients.
A case of myopathy from concomitant use of niacin and gemfibrozil has been reported. Niacin alone has also been associated with cases of myopathy. Using gemfibrozil with niacin might further increase the risk of developing myopathy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Niacin has been associated with cases of liver toxicity, especially when used in pharmacologic doses. Sustained-release niacin preparations appear to be associated with a higher risk of hepatotoxicity than immediate-release niacin.

Likelihood Possible Evidence D
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, concomitant use of niacin and statins might increase the risk of myopathy and rhabdomyolysis in some patients.
Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins. However, a significantly increased risk of myopathy has not been demonstrated in clinical trials, including those using an FDA-approved combination of lovastatin and niacin (Advicor).

Likelihood Possible Evidence D
Probenecid (Benemid)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as probenecid.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as probenecid might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Sulfinpyrazone (Anturane)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as sulfinpyrazone.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as sulfinpyrazone might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Thyroid Hormone

Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.
Clinical research and case reports suggests that taking niacin can reduce serum levels of thyroxine-binding globulin by up to 25% and moderately reduce levels of thyroxine (T4). Patients taking thyroid hormone for hypothyroidism might need dose adjustments when using niacin.

Likelihood Probable Evidence D
Transdermal Nicotine (Nicoderm)

Theoretically, concomitant use of niacin and transdermal nicotine might increase the risk of flushing and dizziness.
Niacin and nicotine can both cause flushing and dizziness.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that niacin may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 3.9 after taking niacin for two weeks. The patient's INR was previously stable, ranging between 2 and 3 in recent months, and no other medication changes were identified. The elevated INR returned to therapeutic range within 4 days following the discontinuation of niacin.

Likelihood Possible Evidence D
Aspirin

Large doses of aspirin might alter the clearance of niacin.
Aspirin is often used with niacin to reduce niacin-induced flushing. Doses of 80-975 mg aspirin have been used, but 325 mg appears to be optimal. Aspirin also seems to reduce the clearance of niacin by competing for glycine conjugation. Taking aspirin 1 gram seems to reduce niacin clearance by 45%. This is probably a dose-related effect and not clinically significant with the more common aspirin dose of 325 mg.

Likelihood Likely Evidence B
Niacin full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for C4 Energy Zero Sugar Watermelon, from the product label.

Cellucor

See all Cellucor products
Name
Nutrabolt
City
Austin
State
TX
ZipCode
78749
Phone Number
1-866-927-9686
Web Address
www.c4energy.com
Pharmacist Counseling Corner

C4 Energy Zero Sugar Watermelon by Cellucor: Common Questions

Does C4 Energy Zero Sugar Watermelon by Cellucor interact with any medications?
Yes. Based on its ingredients, C4 Energy Zero Sugar Watermelon has a known interaction with 759 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
C4 Energy Zero Sugar Watermelon contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this product interfere with my blood pressure medication?
Niacin and sodium both have documented moderate interactions with blood pressure drugs—niacin can lower blood pressure further, and high sodium intake may reduce how well your medications work. Check with your pharmacist before using this product, especially if you're on antihypertensive drugs.
What causes the flushing when taking niacin?
Niacin causes blood vessels to dilate (widen), triggering flushing—a warm, tingling feeling, often on the face and upper body. Up to 70% of people using niacin report this effect. It usually happens with larger doses and often fades within a couple of weeks of regular use.
Is vitamin B12 safe to take every day?
Yes, vitamin B12 is generally very well tolerated and safe. Your body removes excess through urine, so there's no established upper limit. It's needed in pregnancy and lactation and considered safe at recommended amounts.
Can I take this if I'm on metformin for diabetes?
Metformin can lower vitamin B12 levels over time with prolonged use, and niacin itself can raise blood sugar and interfere with diabetes medications. Talk with your pharmacist or doctor before using this product alongside metformin.
What are the common side effects of niacin in this drink?
The most common are flushing, stomach upset (nausea, heartburn, bloating, constipation or diarrhea), and elevated liver enzymes. Serious side effects like liver problems or muscle damage are rare but possible with high doses over time.
Is it safe to use this product while breastfeeding?
Niacin, sodium, and vitamin B12 are all considered safe in normal amounts during breastfeeding. However, high-dose niacin should be avoided unless directed by your doctor. Talk with your healthcare provider about whether this product fits your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

C4 Energy Zero Sugar Watermelon label
Go deeper

The Full Monographs Behind C4 Energy Zero Sugar Watermelon’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Niacin

Interacts with 727 drugs

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescription-strength niacin has been used to...

Read the full Niacin monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

C4 Energy Zero Sugar Watermelon's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 134 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Niacin 66 references
  1. Garg R, Malinow MR, Pettinger M, et al. Niacin treatment increases plasma homocysteine levels. Am Heart J 1999;138:1082-7.
  2. Anon. Inositol hexaniacinate. Altern Med Rev 1998;3:222-3.
  3. Knodel LC, Talbert RL. Adverse effects of hypolipidaemic drugs. Med Toxicol 1987;2:10-32. PubMed
  4. Guyton JR, Blazing MA, Hagar J, et al. Extended-release niacin vs gemfibrozil for the treatment of low levels of high-density lipoprotein cholesterol. Niaspan-Gemfibrozil Study Group. Arch Intern Med 2000;160:1177-84. PubMed
  5. Gibbons LW, Gonzalez V, Gordon N, Grundy S. The prevalence of side effects with regular and sustained-release nicotinic acid. Am J Med 1995;99:378-85. PubMed
  6. Whelan AM, Price SO, Fowler SF, Hainer BL. The effect of aspirin on niacin-induced cutaneous reactions. J Fam Pract 1992;34:165-8.
  7. Jungnickel PW, Maloley PA, Vander Tuin EL, et al. Effect of two aspirin pretreatment regimens on niacin-induced cutaneous reactions. J Gen Intern Med 1997;12:591-6. PubMed
  8. Capuzzi DM, Guyton JR, Morgan JM, et al. Efficacy and safety of an extended-release niacin (Niaspan): a long-term study. Am J Cardiol 1998;82:74-81;disc. 85U-6U. PubMed
  9. Gray DR, Morgan T, Chretien SD, Kashyap ML. Efficacy and safety of controlled-release niacin in dyslipoproteinemic veterans. Ann Intern Med 1994;121:252-8. PubMed
  10. McKenney JM, Proctor JD, Harris S, Chinchili VM. A comparison of the efficacy and toxic effects of sustained- vs immediate-release niacin in hypercholesterolemic patients. JAMA 1994;271:672-7. DOI
  11. Knopp RH, Alagona P, Davidson M, et al. Equivalent efficacy of a time-release form of niacin (Niaspan) given once-a-night versus plain niacin in the management of hyperlipidemia. Metabolism 1998;47:1097-104. PubMed
  12. Knopp RH. Clinical profiles of plain versus sustained-release niacin (Niaspan) and the physiologic rationale for nighttime dosing. Am J Cardiol 1998;82:24U-28U;discussion 39U-41U. PubMed
  13. Garg A, Grundy SM. Nicotinic acid as therapy for dyslipidemia in non-insulin-dependent diabetes mellitus. JAMA 1990;264:723-6. DOI
  14. Leighton RF, Gordon NF, Small GS, et al. Dental and gingival pain as side effects of niacin therapy. Chest 1998;114:1472-4. PubMed
  15. American Society of Health-System Pharmacists. ASHP Therapeutic Position Statement on the safe use of niacin in the management of dyslipidemias. Am J Health Syst Pharm 1997;54:2815-9. DOI
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Sodium 38 references
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See these in context on the Sodium monograph →

Vitamin B12 30 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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