Apixaban

Generic name: Pronounced as (a pix' a ban)
Brand names
  • Eliquis®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 06/15/2020

If you have atrial fibrillation (a condition in which the heart beats irregularly, increasing the chance of clots forming in the body, and possibly causing strokes) and are taking apixaban to help prevent strokes or serious blood clots, you are at a higher risk of having a stroke after you stop taking this medication. Do not stop taking apixaban without talking to your doctor. Continue to take apixaban even if you feel well. Be sure to refill your prescription before you run out of medication so that you will not miss any doses of apixaban. If you need to stop taking apixaban, your doctor may prescribe another anticoagulant ('blood thinner') to help prevent a blood clot from forming and causing you to have a stroke.

If you have epidural or spinal anesthesia or a spinal puncture while taking a 'blood thinner' such as apixaban, you are at risk of having a blood clot form in or around your spine that could cause you to become paralyzed. Tell your doctor if you have an epidural catheter that is left in your body or have or have ever had repeated epidural or spinal punctures, spinal deformity, or spinal surgery. Tell your doctor and pharmacist if you are taking any of the following: anagrelide (Agrylin); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, others), indomethacin (Indocin, Tivorbex), ketoprofen, and naproxen (Aleve, Anaprox, others); cilostazol (Pletal); clopidogrel (Plavix); dipyridamole (Persantine); eptifibatide (Integrilin); heparin; prasugrel (Effient); ticagrelor (Brilinta); ticlopidine; tirofiban (Aggrastat), and warfarin (Coumadin, Jantoven). If you experience any of the following symptoms, call your doctor immediately: muscle weakness (especially in your legs and feet), numbness or tingling (especially in your legs), or loss of control of your bowels or bladder.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with apixaban and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Talk to your doctor about the risks of taking apixaban.

Apixaban is used help prevent strokes or blood clots in people who have atrial fibrillation (a condition in which the heart beats irregularly, increasing the chance of clots forming in the body and possibly causing strokes) that is not caused by heart valve disease. Apixaban is also used to prevent deep vein thrombosis (DVT; a blood clot, usually in the leg) and pulmonary embolism (PE; a blood clot in the lung) in people who are having hip replacement or knee replacement surgery. Apixaban is also used to treat DVT and PE and may be continued to prevent DVT and PE from happening again after the initial treatment is completed. Apixaban is in a class of medications called factor Xa inhibitors. It works by blocking the action of a certain natural substance that helps blood clots to form.

Apixaban comes as a tablet to take by mouth. It is usually taken with or without food twice a day. When apixaban is taken to prevent DVT and PE after hip or knee replacement surgery, the first dose should be taken at least 12 to 24 hours after surgery. Apixaban is usually taken for 35 days after a hip replacement surgery and for 12 days after knee replacement surgery. Take apixaban at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take apixaban exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you are unable to swallow the tablets, you can crush them and mix with water, apple juice, or applesauce. Swallow the mixture right after you prepare it. Apixaban can also be given in certain types of feeding tubes. Ask your doctor if you should take this medication in your feeding tube. Follow your doctor's directions carefully.

Continue to take apixaban even if you feel well. Do not stop taking apixaban without talking to your doctor. If you stop taking apixaban, your risk of a blood clot may increase.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking apixaban,

  • tell your doctor and pharmacist if you are allergic to apixaban, any other medications, or any of the ingredients in apixaban tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); clarithromycin (Biaxin, in Prevpac); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); phenytoin (Dilantin, Phenytek); rifampin (Rifadin, Rimactane, in Rifadin, in Rifater); ritonavir (Norvir, in Kaletra); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); and serotonin and norepinephrine reuptake inhibitors (SNRIs) such as duloxetine (Cymbalta), desvenlafaxine (Khedezla, Pristiq), milnacipran (Fetzima, Savella), and venlafaxine (Effexor). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with apixaban, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • you should know that apixaban may interact with certain medications that may be used to treat you if you have a stroke or other medical emergency. In case of an emergency, you or a family member should tell the doctor or emergency room staff who treat you that you are taking apixaban.

  • tell your doctor if you have an artificial heart valve or if you have heavy bleeding anywhere in your body that cannot be stopped. Your doctor will probably tell you not to take apixaban.

  • tell your doctor if you have or have ever had any type of bleeding problem, antiphospholipid syndrome (APS; a condition that causes blood clots), or kidney or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking apixaban, call your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking apixaban. Your doctor may tell you to stop taking apixaban before the surgery or procedure. If you need to stop taking apixaban because you are having surgery, your doctor may prescribe a different medication to prevent blood clots during this time. Your doctor will tell you when you should start taking apixaban again after your surgery. Follow these directions carefully.

  • Call your doctor right away if you fall or injure yourself, especially if you hit your head. Your doctor may need to check you.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

    • bleeding gums

    • nosebleeds

    • heavy vaginal bleeding

    • red, pink, or brown urine

    • red or black, tarry stools

    • coughing up or vomiting blood or material that looks like coffee grounds

    • swelling or joint pain

    • headache

    • rash

    • chest pain or tightness

    • swelling of the face or tongue

    • trouble breathing

    • wheezing

    • feeling dizzy or faint

  • Apixaban prevents blood from clotting normally, so it may take longer than usual for you to stop bleeding if you are cut or injured. This medication may also cause you to bruise or bleed more easily. Call your doctor right away if bleeding or bruising is unusual, severe, or cannot be controlled.

  • Apixaban may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • unusual bleeding or bruising

  • red, brown, or pink urine

  • red or black, tarry stools

  • coughing up or vomiting blood or material that looks like coffee grounds

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The metabolism of Apixaban can be decreased when combined with Repaglinide.
Montelukast Montelukast The metabolism of Apixaban can be decreased when combined with Montelukast.
Leflunomide Leflunomide The metabolism of Apixaban can be decreased when combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Apixaban can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Apixaban can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Apixaban can be decreased when combined with Atorvastatin.
Anagrelide Anagrelide The risk or severity of adverse effects can be increased when Anagrelide is combined with Apixaban.
Calcium Carbonate Calcium Carbonate The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Apixaban.
Candesartan Candesartan The metabolism of Apixaban can be decreased when combined with Candesartan.
Cilostazol Cilostazol The risk or severity of adverse effects can be increased when Cilostazol is combined with Apixaban.
Clopidogrel Clopidogrel The risk or severity of adverse effects can be increased when Clopidogrel is combined with Apixaban.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The risk or severity of bleeding can be increased when Erythromycin is combined with Apixaban.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the anticoagulant activities of Apixaban.
Fenofibrate Fenofibrate The metabolism of Apixaban can be decreased when combined with Fenofibrate.
Olsalazine Olsalazine The risk or severity of bleeding and hemorrhage can be increased when Olsalazine is combined with Apixaban.
Paregoric Paregoric The metabolism of Apixaban can be decreased when combined with Morphine.
Reserpine Reserpine The serum concentration of Apixaban can be increased when it is combined with Reserpine.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Apixaban.
Triamcinolone Triamcinolone The therapeutic efficacy of Apixaban can be decreased when used in combination with Triamcinolone.
Doxycycline Injection Doxycycline Injection The risk or severity of bleeding can be increased when Doxycycline is combined with Apixaban.
Fluconazole Injection Fluconazole Injection The metabolism of Apixaban can be decreased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The metabolism of Apixaban can be decreased when combined with Hydromorphone.
Interferon Beta-1b Injection Interferon Beta-1b Injection The risk or severity of bleeding can be increased when Apixaban is combined with Interferon beta-1b.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The risk or severity of bleeding can be increased when Apixaban is combined with Interferon gamma-1b.
Metronidazole Injection Metronidazole Injection The metabolism of Apixaban can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The metabolism of Apixaban can be decreased when combined with Morphine.
Zidovudine Injection Zidovudine Injection The metabolism of Apixaban can be decreased when combined with Zidovudine.
Altretamine Altretamine The risk or severity of bleeding and hemorrhage can be increased when Amphetamine is combined with Apixaban.
Cefuroxime Cefuroxime The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefuroxime.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Apixaban.
Ondansetron Ondansetron The metabolism of Apixaban can be decreased when combined with Ondansetron.
Enoxaparin Injection Enoxaparin Injection Apixaban may increase the anticoagulant activities of Enoxaparin.
Torsemide Torsemide The metabolism of Apixaban can be decreased when combined with Torasemide.
Olanzapine Olanzapine The metabolism of Apixaban can be decreased when combined with Olanzapine.
Alosetron Alosetron The metabolism of Apixaban can be decreased when combined with Alosetron.
Hydroxychloroquine Hydroxychloroquine The metabolism of Apixaban can be decreased when combined with Hydroxychloroquine.
Meloxicam Meloxicam The risk or severity of bleeding and hemorrhage can be increased when Meloxicam is combined with Apixaban.
Oxcarbazepine Oxcarbazepine The metabolism of Apixaban can be increased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Apixaban which could result in a higher serum level.
Telmisartan Telmisartan Telmisartan may decrease the excretion rate of Apixaban which could result in a higher serum level.
Temozolomide Temozolomide The risk or severity of bleeding can be increased when Apixaban is combined with Temozolomide.
Zaleplon Zaleplon The metabolism of Apixaban can be decreased when combined with Zaleplon.
Anakinra Anakinra The metabolism of Apixaban can be increased when combined with Anakinra.
Linezolid Linezolid The risk or severity of bleeding and hemorrhage can be increased when Linezolid is combined with Apixaban.
Pentosan Polysulfate Pentosan Polysulfate Apixaban may increase the anticoagulant activities of Pentosan polysulfate.
Trimipramine Trimipramine The metabolism of Apixaban can be decreased when combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Apixaban can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Apixaban can be decreased when combined with Modafinil.
Tenofovir Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Apixaban.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of bleeding and hemorrhage can be increased when Choline magnesium trisalicylate is combined with Apixaban.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Apixaban.
Dutasteride Dutasteride The metabolism of Apixaban can be decreased when combined with Dutasteride.
Epinephrine Injection Epinephrine Injection The metabolism of Apixaban can be decreased when combined with Epinephrine.
Epirubicin Epirubicin The risk or severity of bleeding can be increased when Apixaban is combined with Epirubicin.
Eplerenone Eplerenone The metabolism of Apixaban can be decreased when combined with Eplerenone.
Escitalopram Escitalopram The risk or severity of bleeding can be increased when Escitalopram is combined with Apixaban.
Zonisamide Zonisamide The serum concentration of Apixaban can be increased when it is combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Apixaban can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Apixaban can be decreased when combined with Aripiprazole.
Atazanavir Atazanavir The metabolism of Apixaban can be decreased when combined with Atazanavir.
Almotriptan Almotriptan The metabolism of Apixaban can be decreased when combined with Almotriptan.
Eletriptan Eletriptan The metabolism of Apixaban can be decreased when combined with Eletriptan.
Rosuvastatin Rosuvastatin The metabolism of Apixaban can be decreased when combined with Rosuvastatin.
Vardenafil Vardenafil The serum concentration of Vardenafil can be increased when it is combined with Apixaban.
Aprepitant Aprepitant The metabolism of Apixaban can be decreased when combined with Aprepitant.
Memantine Memantine The metabolism of Apixaban can be decreased when combined with Memantine.
Tegaserod Tegaserod The serum concentration of Apixaban can be increased when it is combined with Tegaserod.
Tadalafil Tadalafil The metabolism of Apixaban can be decreased when combined with Tadalafil.
Progesterone Progesterone Progesterone may decrease the anticoagulant activities of Apixaban.
Apomorphine Injection Apomorphine Injection The metabolism of Apixaban can be decreased when combined with Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Apixaban can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Apixaban can be decreased when combined with Oxandrolone.
Rifaximin Rifaximin The metabolism of Apixaban can be increased when combined with Rifaximin.
Duloxetine Duloxetine The risk or severity of hemorrhage can be increased when Duloxetine is combined with Apixaban.
Norethindrone Norethindrone Norethisterone may decrease the anticoagulant activities of Apixaban.
Bosentan Bosentan The metabolism of Apixaban can be increased when combined with Bosentan.
Cefditoren Cefditoren The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefdinir.
Erlotinib Erlotinib The metabolism of Apixaban can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The metabolism of Apixaban can be decreased when combined with Eszopiclone.
Voriconazole Voriconazole The metabolism of Apixaban can be decreased when combined with Voriconazole.
Dextroamphetamine Dextroamphetamine The risk or severity of bleeding and hemorrhage can be increased when Amphetamine is combined with Apixaban.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The risk or severity of bleeding can be increased when Apixaban is combined with Peginterferon alfa-2a.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The risk or severity of bleeding can be increased when Apixaban is combined with Peginterferon alfa-2b.
Isocarboxazid Isocarboxazid The risk or severity of bleeding and hemorrhage can be increased when Isocarboxazid is combined with Apixaban.
Ramelteon Ramelteon The metabolism of Apixaban can be decreased when combined with Ramelteon.
Fentanyl Fentanyl The metabolism of Apixaban can be decreased when combined with Fentanyl.
Deferasirox Deferasirox The risk or severity of gastrointestinal bleeding can be increased when Apixaban is combined with Deferasirox.
Tipranavir Tipranavir The risk or severity of bleeding and hemorrhage can be increased when Tipranavir is combined with Apixaban.
Felbamate Felbamate The metabolism of Apixaban can be decreased when combined with Felbamate.
Ranolazine Ranolazine The serum concentration of Apixaban can be increased when it is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Apixaban can be increased when combined with Abatacept.
Rasagiline Rasagiline The risk or severity of bleeding and hemorrhage can be increased when Rasagiline is combined with Apixaban.
Imatinib Imatinib The metabolism of Apixaban can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The metabolism of Apixaban can be decreased when combined with Sitagliptin.
Gefitinib Gefitinib Gefitinib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Paliperidone Paliperidone The serum concentration of Apixaban can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The metabolism of Apixaban can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection The risk or severity of bleeding can be increased when Apixaban is combined with Clofarabine.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of bleeding can be increased when Apixaban is combined with Oxaliplatin.
Posaconazole Posaconazole The serum concentration of Apixaban can be increased when it is combined with Posaconazole.
Rituximab Injection Rituximab Injection The risk or severity of bleeding can be increased when Apixaban is combined with Rituximab.
Bismuth Subsalicylate Bismuth Subsalicylate The risk or severity of bleeding can be increased when Bismuth subsalicylate is combined with Apixaban.
Darunavir Darunavir The risk or severity of bleeding can be increased when Darunavir is combined with Apixaban.
Pemetrexed Injection Pemetrexed Injection The risk or severity of bleeding can be increased when Apixaban is combined with Pemetrexed.
Nabilone Nabilone The metabolism of Apixaban can be decreased when combined with Nabilone.
Vorinostat Vorinostat The risk or severity of bleeding can be increased when Apixaban is combined with Vorinostat.
Sorafenib Sorafenib The metabolism of Apixaban can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Apixaban can be decreased when combined with Sunitinib.
Dronabinol Dronabinol Dronabinol may decrease the excretion rate of Apixaban which could result in a higher serum level.
Lapatinib Lapatinib The serum concentration of Apixaban can be increased when it is combined with Lapatinib.
Dasatinib Dasatinib The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Apixaban.
Omega-3 Fatty Acids Omega-3 Fatty Acids Omega-3 fatty acids may increase the anticoagulant activities of Apixaban.
Armodafinil Armodafinil The metabolism of Apixaban can be decreased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection The risk or severity of bleeding can be increased when Apixaban is combined with Azacitidine.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Apixaban.
Nelarabine Injection Nelarabine Injection The risk or severity of bleeding can be increased when Apixaban is combined with Nelarabine.
Lenalidomide Lenalidomide The risk or severity of bleeding can be increased when Apixaban is combined with Lenalidomide.
Nilotinib Nilotinib The serum concentration of Apixaban can be increased when it is combined with Nilotinib.
Toremifene Toremifene The risk or severity of bleeding can be increased when Toremifene is combined with Apixaban.
Bexarotene Bexarotene The metabolism of Apixaban can be decreased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Apixaban can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Apixaban can be decreased when combined with Chloramphenicol.
Decitabine Injection Decitabine Injection The risk or severity of bleeding can be increased when Apixaban is combined with Decitabine.
Etravirine Etravirine The metabolism of Apixaban can be decreased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of bleeding can be increased when Apixaban is combined with Arsenic trioxide.
Mitoxantrone Injection Mitoxantrone Injection The risk or severity of bleeding can be increased when Apixaban is combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The risk or severity of hemorrhage can be increased when Desvenlafaxine is combined with Apixaban.
Nebivolol Nebivolol The metabolism of Apixaban can be decreased when combined with Nebivolol.
Tretinoin Tretinoin The metabolism of Apixaban can be decreased when combined with Tretinoin.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Apixaban.
Flecainide Flecainide The metabolism of Apixaban can be decreased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Apixaban can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The risk or severity of bleeding can be increased when Apixaban is combined with Ixabepilone.
Irinotecan Injection Irinotecan Injection The metabolism of Apixaban can be decreased when combined with Irinotecan.
Praziquantel Praziquantel The metabolism of Apixaban can be decreased when combined with Praziquantel.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of bleeding can be increased when Apixaban is combined with Alemtuzumab.
Silodosin Silodosin The serum concentration of Apixaban can be increased when it is combined with Silodosin.
Midazolam Midazolam The metabolism of Apixaban can be decreased when combined with Midazolam.
Dexrazoxane Injection Dexrazoxane Injection The risk or severity of bleeding can be increased when Apixaban is combined with Dexrazoxane.
Eltrombopag Eltrombopag Eltrombopag may decrease the excretion rate of Apixaban which could result in a higher serum level.
Ibritumomab Injection Ibritumomab Injection The risk or severity of adverse effects can be increased when Apixaban is combined with Ibritumomab tiuxetan.
Milnacipran Milnacipran The risk or severity of hemorrhage can be increased when Milnacipran is combined with Apixaban.
Dexlansoprazole Dexlansoprazole The metabolism of Apixaban can be decreased when combined with Dexlansoprazole.
Iloperidone Iloperidone The metabolism of Apixaban can be decreased when combined with Iloperidone.
Prasugrel Prasugrel Apixaban may increase the anticoagulant activities of Prasugrel.
Lacosamide Lacosamide The metabolism of Apixaban can be decreased when combined with Lacosamide.
Everolimus Everolimus The serum concentration of Apixaban can be increased when it is combined with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Apixaban.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Apixaban.
Saxagliptin Saxagliptin The metabolism of Apixaban can be decreased when combined with Saxagliptin.
Romidepsin Injection Romidepsin Injection The serum concentration of Apixaban can be increased when it is combined with Romidepsin.
Tapentadol Tapentadol The metabolism of Apixaban can be decreased when combined with Tapentadol.
Topotecan Topotecan The serum concentration of Topotecan can be increased when it is combined with Apixaban.
Golimumab Injection Golimumab Injection The metabolism of Apixaban can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Apixaban can be decreased when combined with Pazopanib.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Apixaban.
Albendazole Albendazole The metabolism of Apixaban can be decreased when combined with Albendazole.
Ulipristal Ulipristal The therapeutic efficacy of Apixaban can be decreased when used in combination with Ulipristal.
Levonorgestrel Levonorgestrel Levonorgestrel may decrease the anticoagulant activities of Apixaban.
Dabigatran Dabigatran Apixaban may increase the anticoagulant activities of Dabigatran.
Tocilizumab Injection Tocilizumab Injection The metabolism of Apixaban can be increased when combined with Tocilizumab.
Eribulin Injection Eribulin Injection The risk or severity of bleeding can be increased when Apixaban is combined with Eribulin.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Apixaban can be decreased when combined with Cabazitaxel.
Ceftaroline Injection Ceftaroline Injection The therapeutic efficacy of Apixaban can be decreased when used in combination with Ceftaroline fosamil.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Apixaban.
Denileukin Diftitox Injection Denileukin Diftitox Injection The risk or severity of bleeding can be increased when Apixaban is combined with Aldesleukin.
Busulfan Injection Busulfan Injection The risk or severity of bleeding can be increased when Apixaban is combined with Busulfan.
Linagliptin Linagliptin The serum concentration of Apixaban can be increased when it is combined with Linagliptin.
Rilpivirine Rilpivirine Rilpivirine may decrease the excretion rate of Apixaban which could result in a higher serum level.
Telaprevir Telaprevir The serum concentration of Apixaban can be increased when it is combined with Glecaprevir.
Potassium Iodide Potassium Iodide Potassium Iodide may increase the anticoagulant activities of Apixaban.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Apixaban can be decreased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Apixaban can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban Apixaban may increase the anticoagulant activities of Rivaroxaban.
Ticagrelor Ticagrelor Apixaban may increase the anticoagulant activities of Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Apixaban.
Ruxolitinib Ruxolitinib The risk or severity of bleeding can be increased when Apixaban is combined with Ruxolitinib.
Vandetanib Vandetanib Vandetanib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Clobazam Clobazam The serum concentration of Apixaban can be increased when it is combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Apixaban can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib Vismodegib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Ivacaftor Ivacaftor The serum concentration of Apixaban can be increased when it is combined with Ivacaftor.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Apixaban.
Crizotinib Crizotinib The metabolism of Apixaban can be decreased when combined with Crizotinib.
Melphalan Injection Melphalan Injection The risk or severity of bleeding can be increased when Apixaban is combined with Melphalan.
Cabergoline Cabergoline The serum concentration of Cabergoline can be increased when it is combined with Apixaban.
Ambrisentan Ambrisentan The serum concentration of Apixaban can be increased when it is combined with Ambrisentan.
Fondaparinux Injection Fondaparinux Injection Apixaban may increase the anticoagulant activities of Fondaparinux.
Collagenase Clostridium Histolyticum Injection Collagenase Clostridium Histolyticum Injection The risk or severity of adverse effects can be increased when Apixaban is combined with Collagenase clostridium histolyticum.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Apixaban can be increased when it is combined with Carfilzomib.
Iloprost Iloprost Apixaban may increase the anticoagulant activities of Iloprost.
Enzalutamide Enzalutamide The serum concentration of Apixaban can be increased when it is combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Apixaban.
Regorafenib Regorafenib The serum concentration of Apixaban can be increased when it is combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Apixaban can be decreased when combined with Bosutinib.
Teriflunomide Teriflunomide Teriflunomide may decrease the excretion rate of Apixaban which could result in a higher serum level.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Apixaban.
Icosapent Ethyl Icosapent Ethyl The risk or severity of adverse effects can be increased when Icosapent ethyl is combined with Apixaban.
Tofacitinib Tofacitinib The risk or severity of bleeding can be increased when Apixaban is combined with Tofacitinib.
Ponatinib Ponatinib The metabolism of Apixaban can be decreased when combined with Ponatinib.
Pomalidomide Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Apixaban.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Apixaban can be decreased when combined with Trastuzumab emtansine.
Canagliflozin Canagliflozin The serum concentration of Apixaban can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The serum concentration of Apixaban can be decreased when it is combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Apixaban can be decreased when combined with Ospemifene.
Trametinib Trametinib The metabolism of Apixaban can be decreased when combined with Trametinib.
Dolutegravir Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Apixaban.
Afatinib Afatinib The serum concentration of Apixaban can be increased when it is combined with Afatinib.
Levomilnacipran Levomilnacipran The risk or severity of hemorrhage can be increased when Levomilnacipran is combined with Apixaban.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Apixaban.
Perampanel Perampanel The metabolism of Perampanel can be decreased when combined with Apixaban.
Ibrutinib Ibrutinib The risk or severity of bleeding and hemorrhage can be increased when Ibrutinib is combined with Apixaban.
Lomitapide Lomitapide The serum concentration of Lomitapide can be increased when it is combined with Apixaban.
Ketorolac Injection Ketorolac Injection The risk or severity of bleeding and hemorrhage can be increased when Ketorolac is combined with Apixaban.
Obinutuzumab Injection Obinutuzumab Injection The risk or severity of bleeding and hemorrhage can be increased when Apixaban is combined with Obinutuzumab.
Simeprevir Simeprevir Simeprevir may decrease the excretion rate of Apixaban which could result in a higher serum level.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Apixaban.
Dapagliflozin Dapagliflozin The metabolism of Apixaban can be decreased when combined with Dapagliflozin.
Apremilast Apremilast The metabolism of Apixaban can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Apixaban can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Apixaban can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Apixaban can be decreased when combined with Eslicarbazepine.
Belinostat Injection Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Apixaban.
Idelalisib Idelalisib The serum concentration of Idelalisib can be increased when it is combined with Apixaban.
Testosterone Injection Testosterone Injection Testosterone may increase the anticoagulant activities of Apixaban.
Oritavancin Injection Oritavancin Injection The metabolism of Apixaban can be decreased when combined with Oritavancin.
Vorapaxar Vorapaxar Apixaban may increase the anticoagulant activities of Vorapaxar.
Suvorexant Suvorexant The serum concentration of Apixaban can be increased when it is combined with Suvorexant.
Edoxaban Edoxaban Apixaban may increase the anticoagulant activities of Edoxaban.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The risk or severity of bleeding can be increased when Apixaban is combined with Peginterferon beta-1a.
Olaparib Olaparib The metabolism of Apixaban can be decreased when combined with Olaparib.
Blinatumomab Injection Blinatumomab Injection The risk or severity of bleeding can be increased when Apixaban is combined with Blinatumomab.
Riociguat Riociguat The metabolism of Riociguat can be decreased when combined with Apixaban.
Nintedanib Nintedanib The risk or severity of bleeding can be increased when Apixaban is combined with Nintedanib.
Secukinumab Injection Secukinumab Injection The metabolism of Apixaban can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The metabolism of Apixaban can be decreased when combined with Risperidone.
Palbociclib Palbociclib Palbociclib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Lenvatinib Lenvatinib The metabolism of Apixaban can be decreased when combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Apixaban can be decreased when combined with Naloxegol.
Panobinostat Panobinostat The serum concentration of Apixaban can be increased when it is combined with Panobinostat.
Dinutuximab Injection Dinutuximab Injection The risk or severity of bleeding can be increased when Apixaban is combined with Dinutuximab.
Haloperidol Injection Haloperidol Injection The serum concentration of Apixaban can be increased when it is combined with Haloperidol.
Deoxycholic Acid Injection Deoxycholic Acid Injection The risk or severity of bleeding and bruising can be increased when Apixaban is combined with Deoxycholic acid.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Apixaban can be increased when it is combined with Isavuconazonium.
Flibanserin Flibanserin The serum concentration of Apixaban can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The serum concentration of Apixaban can be increased when it is combined with Rolapitant.
Daclatasvir Daclatasvir The serum concentration of Apixaban can be increased when it is combined with Daclatasvir.
Ziprasidone Injection Ziprasidone Injection The metabolism of Apixaban can be decreased when combined with Ziprasidone.
Cobimetinib Cobimetinib The serum concentration of Apixaban can be increased when it is combined with Cobimetinib.
Trabectedin Injection Trabectedin Injection The metabolism of Apixaban can be decreased when combined with Trabectedin.
Osimertinib Osimertinib The serum concentration of Osimertinib can be increased when it is combined with Apixaban.
Alectinib Alectinib Alectinib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Rifapentine Rifapentine The metabolism of Apixaban can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Apixaban.
Dexamethasone Injection Dexamethasone Injection Dexamethasone may decrease the excretion rate of Apixaban which could result in a higher serum level.
Defibrotide Injection Defibrotide Injection Apixaban may increase the anticoagulant activities of Defibrotide.
Brivaracetam Injection Brivaracetam Injection The metabolism of Apixaban can be decreased when combined with Brivaracetam.
Venetoclax Venetoclax The serum concentration of Apixaban can be increased when it is combined with Venetoclax.
Cobicistat Cobicistat The metabolism of Apixaban can be decreased when combined with Cobicistat.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Apixaban.
Obeticholic Acid Obeticholic Acid The risk or severity of bleeding and bruising can be increased when Apixaban is combined with Obeticholic acid.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Apixaban can be decreased when combined with Diphenhydramine.
Rucaparib Rucaparib The serum concentration of Apixaban can be increased when it is combined with Rucaparib.
Brigatinib Brigatinib The metabolism of Apixaban can be decreased when combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Apixaban can be decreased when combined with Doxepin.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Apixaban.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Apixaban.
Deflazacort Deflazacort The metabolism of Apixaban can be increased when combined with Deflazacort.
Safinamide Safinamide Safinamide may decrease the excretion rate of Apixaban which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Apixaban can be increased when combined with Midostaurin.
Neratinib Neratinib The serum concentration of Apixaban can be increased when it is combined with Neratinib.
Enasidenib Enasidenib The metabolism of Apixaban can be decreased when combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Apixaban can be increased when it is combined with Inotuzumab ozogamicin.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Apixaban.
Delafloxacin Delafloxacin The metabolism of Apixaban can be increased when combined with Delafloxacin.
Abemaciclib Abemaciclib Abemaciclib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Betrixaban Betrixaban Apixaban may increase the anticoagulant activities of Betrixaban.
Acalabrutinib Acalabrutinib The metabolism of Apixaban can be decreased when combined with Acalabrutinib.
Gemtuzumab Ozogamicin Injection Gemtuzumab Ozogamicin Injection The risk or severity of bleeding can be increased when Apixaban is combined with Gemtuzumab ozogamicin.
Letermovir Letermovir Letermovir may decrease the excretion rate of Apixaban which could result in a higher serum level.
Ertugliflozin Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Apixaban.
Buprenorphine Injection Buprenorphine Injection Buprenorphine may decrease the excretion rate of Apixaban which could result in a higher serum level.
Apalutamide Apalutamide The serum concentration of Apixaban can be increased when it is combined with Apalutamide.
Penicillamine Penicillamine The risk or severity of bleeding can be increased when Apixaban is combined with Penicillamine.
Fostamatinib Fostamatinib Fostamatinib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Avatrombopag Avatrombopag Avatrombopag may decrease the excretion rate of Apixaban which could result in a higher serum level.
Baricitinib Baricitinib Baricitinib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Eliglustat Eliglustat The serum concentration of Eliglustat can be increased when it is combined with Apixaban.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Apixaban.
Ivosidenib Ivosidenib The serum concentration of Apixaban can be increased when it is combined with Ivosidenib.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Apixaban.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Apixaban.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Apixaban.
Cannabidiol Cannabidiol Cannabidiol may decrease the excretion rate of Apixaban which could result in a higher serum level.
Dacomitinib Dacomitinib The metabolism of Apixaban can be decreased when combined with Dacomitinib.
Duvelisib Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Apixaban.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Apixaban.
Sarecycline Sarecycline The serum concentration of Apixaban can be increased when it is combined with Sarecycline.
Stiripentol Stiripentol The metabolism of Apixaban can be decreased when combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Apixaban.
Gilteritinib Gilteritinib Gilteritinib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Glasdegib Glasdegib Glasdegib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Apixaban.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Apixaban.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Apixaban.
Rifamycin Rifamycin The metabolism of Apixaban can be increased when combined with Rifamycin.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Apixaban can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Apixaban.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of adverse effects can be increased when Caplacizumab is combined with Apixaban.
Erdafitinib Erdafitinib The serum concentration of Apixaban can be increased when it is combined with Erdafitinib.
Esomeprazole Injection Esomeprazole Injection The metabolism of Apixaban can be decreased when combined with Esomeprazole.
Alpelisib Alpelisib The serum concentration of Apixaban can be decreased when it is combined with Alpelisib.
Cladribine Cladribine The risk or severity of bleeding can be increased when Apixaban is combined with Cladribine.
Darolutamide Darolutamide The serum concentration of Apixaban can be increased when it is combined with Darolutamide.
Triclabendazole Triclabendazole The metabolism of Apixaban can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The serum concentration of Apixaban can be increased when it is combined with Entrectinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Apixaban.
Pitolisant Pitolisant The serum concentration of Apixaban can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib Fedratinib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Lefamulin Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Apixaban.
Phenytoin Injection Phenytoin Injection The metabolism of Apixaban can be decreased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Apixaban can be decreased when combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Apixaban.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Apixaban.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Apixaban.
Lasmiditan Lasmiditan The serum concentration of Apixaban can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Apixaban.
Calcium Acetate Calcium Acetate The therapeutic efficacy of Calcium acetate can be decreased when used in combination with Apixaban.
Tazemetostat Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Apixaban.
Cenobamate Cenobamate The serum concentration of Apixaban can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Apixaban.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Apixaban.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Apixaban.
Tucatinib Tucatinib Apixaban may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Apixaban.
Ripretinib Ripretinib Ripretinib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Selpercatinib Selpercatinib The serum concentration of Apixaban can be increased when it is combined with Selpercatinib.
Capmatinib Capmatinib The serum concentration of Apixaban can be increased when it is combined with Capmatinib.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Apixaban.
Fostemsavir Fostemsavir Fostemsavir may decrease the excretion rate of Apixaban which could result in a higher serum level.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Apixaban.
Pralsetinib Pralsetinib Pralsetinib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Opicapone Opicapone The metabolism of Apixaban can be decreased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Apixaban can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may decrease the anticoagulant activities of Apixaban.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) Vitamin E may increase the anticoagulant activities of Apixaban.
Theophylline Theophylline The metabolism of Apixaban can be decreased when combined with Theophylline.
Fenoprofen Fenoprofen The risk or severity of bleeding and hemorrhage can be increased when Fenoprofen is combined with Apixaban.
Indomethacin Indomethacin The risk or severity of bleeding and hemorrhage can be increased when Indomethacin is combined with Apixaban.
Mefenamic Acid Mefenamic Acid The risk or severity of bleeding and hemorrhage can be increased when Mefenamic acid is combined with Apixaban.
Naproxen Naproxen The risk or severity of bleeding and hemorrhage can be increased when Naproxen is combined with Apixaban.
Tolmetin Tolmetin The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Apixaban.
Sulindac Sulindac The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Apixaban.
Trazodone Trazodone The risk or severity of bleeding can be increased when Trazodone is combined with Apixaban.
Hydroxyurea Hydroxyurea The risk or severity of bleeding can be increased when Apixaban is combined with Hydroxyurea.
Floxuridine Floxuridine The metabolism of Apixaban can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Apixaban can be decreased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The risk or severity of bleeding can be increased when Apixaban is combined with Methotrexate.
Primidone Primidone The metabolism of Apixaban can be decreased when combined with Primidone.
Methsuximide Methsuximide The metabolism of Apixaban can be decreased when combined with Methsuximide.
Diazepam Diazepam The metabolism of Apixaban can be decreased when combined with Diazepam.
Carmustine Carmustine The risk or severity of bleeding can be increased when Apixaban is combined with Carmustine.
Tranylcypromine Tranylcypromine The risk or severity of bleeding and hemorrhage can be increased when Tranylcypromine is combined with Apixaban.
Phenelzine Phenelzine The risk or severity of bleeding and hemorrhage can be increased when Phenelzine is combined with Apixaban.
Procarbazine Procarbazine The risk or severity of bleeding and hemorrhage can be increased when Procarbazine is combined with Apixaban.
Thioguanine Thioguanine The risk or severity of bleeding can be increased when Apixaban is combined with Tioguanine.
Thioridazine Thioridazine The metabolism of Apixaban can be decreased when combined with Thioridazine.
Dapsone Dapsone The metabolism of Apixaban can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The metabolism of Apixaban can be decreased when combined with Sulfadiazine.
Oxycodone Oxycodone The metabolism of Apixaban can be decreased when combined with Oxycodone.
Methadone Methadone The metabolism of Apixaban can be decreased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Apixaban can be decreased when combined with Oxybutynin.
Ibuprofen Ibuprofen The risk or severity of bleeding and gastrointestinal bleeding can be increased when Ibuprofen is combined with Apixaban.
Sulfasalazine Sulfasalazine The risk or severity of bleeding and hemorrhage can be increased when Sulfasalazine is combined with Apixaban.
Hydrocortisone Hydrocortisone The metabolism of Apixaban can be increased when combined with Hydrocortisone.
Lomustine Lomustine The risk or severity of bleeding can be increased when Apixaban is combined with Lomustine.
Doxorubicin Doxorubicin The risk or severity of bleeding can be increased when Apixaban is combined with Doxorubicin.
Cytarabine Cytarabine The risk or severity of bleeding can be increased when Apixaban is combined with Cytarabine.
Mechlorethamine Mechlorethamine The risk or severity of bleeding can be increased when Apixaban is combined with Mechlorethamine.
Dactinomycin Dactinomycin The serum concentration of Apixaban can be increased when it is combined with Dactinomycin.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Apixaban.
Clonidine Clonidine The metabolism of Apixaban can be decreased when combined with Clonidine.
Cimetidine Cimetidine The metabolism of Apixaban can be decreased when combined with Cimetidine.
Warfarin Warfarin Apixaban may increase the anticoagulant activities of Warfarin.
Loperamide Loperamide The serum concentration of Apixaban can be increased when it is combined with Loperamide.
Promethazine Promethazine The metabolism of Apixaban can be decreased when combined with Promethazine.
Meclofenamate Meclofenamate The risk or severity of bleeding and hemorrhage can be increased when Meclofenamic acid is combined with Apixaban.
Daunorubicin Daunorubicin The metabolism of Apixaban can be increased when combined with Daunorubicin.
Griseofulvin Griseofulvin The metabolism of Apixaban can be increased when combined with Griseofulvin.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Apixaban.
Loxapine Loxapine The serum concentration of Apixaban can be increased when it is combined with Loxapine.
Chloroquine Chloroquine The metabolism of Apixaban can be decreased when combined with Chloroquine.
Quinine Quinine The therapeutic efficacy of Apixaban can be increased when used in combination with Quinine.
Sulfinpyrazone Sulfinpyrazone The risk or severity of adverse effects can be increased when Sulfinpyrazone is combined with Apixaban.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Apixaban can be decreased when used in combination with Chlorothiazide.
Isosorbide Isosorbide The therapeutic efficacy of Apixaban can be decreased when used in combination with Isosorbide.
Clindamycin Injection Clindamycin Injection The metabolism of Apixaban can be decreased when combined with Clindamycin.
Secobarbital Secobarbital The metabolism of Apixaban can be increased when combined with Secobarbital.
Amitriptyline Amitriptyline The metabolism of Apixaban can be decreased when combined with Amitriptyline.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Apixaban.
Probenecid Probenecid The metabolism of Apixaban can be decreased when combined with Probenecid.
Quinidine Quinidine The therapeutic efficacy of Apixaban can be increased when used in combination with Quinidine.
Isoniazid Isoniazid The metabolism of Apixaban can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Apixaban can be increased when combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Apixaban can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The risk or severity of bleeding can be increased when Tamoxifen is combined with Apixaban.
Mitomycin Mitomycin The risk or severity of bleeding can be increased when Apixaban is combined with Mitomycin.
Levothyroxine Levothyroxine The metabolism of Apixaban can be decreased when combined with Levothyroxine.
Methimazole Methimazole The metabolism of Apixaban can be decreased when combined with Methimazole.
Propylthiouracil Propylthiouracil Propylthiouracil may increase the anticoagulant activities of Apixaban.
Chlorpropamide Chlorpropamide The metabolism of Apixaban can be decreased when combined with Chlorpropamide.
Tolbutamide Tolbutamide The metabolism of Apixaban can be decreased when combined with Tolbutamide.
Tolazamide Tolazamide The metabolism of Apixaban can be decreased when combined with Tolazamide.
Dextromethorphan Dextromethorphan The metabolism of Apixaban can be decreased when combined with Dextromethorphan.
Chlorpheniramine Chlorpheniramine The metabolism of Apixaban can be decreased when combined with Chlorpheniramine.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Apixaban can be decreased when used in combination with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Apixaban can be decreased when used in combination with Hydrochlorothiazide.
Carisoprodol Carisoprodol The metabolism of Apixaban can be decreased when combined with Carisoprodol.
Disulfiram Disulfiram The metabolism of Apixaban can be decreased when combined with Disulfiram.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Apixaban can be decreased when combined with Propranolol.
Nortriptyline Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Apixaban.
Spironolactone Spironolactone The metabolism of Apixaban can be decreased when combined with Spironolactone.
Mercaptopurine Mercaptopurine The risk or severity of bleeding can be increased when Apixaban is combined with Mercaptopurine.
Clomiphene Clomiphene The serum concentration of Apixaban can be increased when it is combined with Clomifene.
Fluorouracil Injection Fluorouracil Injection The metabolism of Apixaban can be decreased when combined with Fluorouracil.
Colchicine Colchicine The metabolism of Apixaban can be decreased when combined with Colchicine.
Cefaclor Cefaclor The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefaclor.
Cefadroxil Cefadroxil The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefadroxil.
Cefazolin Injection Cefazolin Injection The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefazolin.
Cephalexin Cephalexin The therapeutic efficacy of Apixaban can be decreased when used in combination with Cephalexin.
Cefoxitin Injection Cefoxitin Injection The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefoxitin.
Dacarbazine Dacarbazine The risk or severity of bleeding can be increased when Apixaban is combined with Dacarbazine.
Cefotaxime Injection Cefotaxime Injection The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefotaxime.
Ketoconazole Ketoconazole The metabolism of Apixaban can be decreased when combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The risk or severity of bleeding can be increased when Apixaban is combined with Thiotepa.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be decreased when combined with Apixaban.
Dipyridamole Dipyridamole Apixaban may increase the anticoagulant activities of Dipyridamole.
Vinblastine Vinblastine The serum concentration of Apixaban can be increased when it is combined with Vinblastine.
Hydroxyzine Hydroxyzine The metabolism of Apixaban can be decreased when combined with Hydroxyzine.
Aspirin Aspirin Apixaban may increase the anticoagulant activities of Acetylsalicylic acid.
Salsalate Salsalate The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Apixaban.
Chlorambucil Chlorambucil The risk or severity of bleeding can be increased when Apixaban is combined with Chlorambucil.
Alprazolam Alprazolam The metabolism of Apixaban can be decreased when combined with Alprazolam.
Triazolam Triazolam The metabolism of Apixaban can be decreased when combined with Triazolam.
Trimethoprim Trimethoprim The metabolism of Apixaban can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The metabolism of Apixaban can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Apixaban can be decreased when combined with Nifedipine.
Timolol Timolol The metabolism of Apixaban can be decreased when combined with Timolol.
Verapamil Verapamil The metabolism of Apixaban can be decreased when combined with Verapamil.
Cisplatin Injection Cisplatin Injection The metabolism of Apixaban can be decreased when combined with Cisplatin.
Diflunisal Diflunisal The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Apixaban.
Piroxicam Piroxicam The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Apixaban.
Streptozocin Streptozocin The risk or severity of bleeding can be increased when Apixaban is combined with Streptozocin.
Etoposide Etoposide The metabolism of Apixaban can be decreased when combined with Etoposide.
Glyburide Glyburide The metabolism of Apixaban can be decreased when combined with Glyburide.
Glipizide Glipizide The metabolism of Apixaban can be decreased when combined with Glipizide.
Pentoxifylline Pentoxifylline The risk or severity of adverse effects can be increased when Pentoxifylline is combined with Apixaban.
Pentamidine Injection Pentamidine Injection The metabolism of Apixaban can be decreased when combined with Pentamidine.
Ceftriaxone Injection Ceftriaxone Injection The therapeutic efficacy of Apixaban can be decreased when used in combination with Ceftriaxone.
Labetalol Labetalol The metabolism of Apixaban can be decreased when combined with Labetalol.
Gemfibrozil Gemfibrozil The metabolism of Apixaban can be decreased when combined with Gemfibrozil.
Ceftazidime Injection Ceftazidime Injection The therapeutic efficacy of Apixaban can be decreased when used in combination with Ceftazidime.
Ketoprofen Ketoprofen The risk or severity of bleeding and hemorrhage can be increased when Ketoprofen is combined with Apixaban.
Cefotetan Injection Cefotetan Injection The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefotetan.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Apixaban.
Flurbiprofen Flurbiprofen The risk or severity of bleeding and hemorrhage can be increased when Flurbiprofen is combined with Apixaban.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Apixaban.
Buspirone Buspirone The metabolism of Apixaban can be decreased when combined with Buspirone.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Apixaban.
Ciprofloxacin Ciprofloxacin The metabolism of Apixaban can be decreased when combined with Ciprofloxacin.
Mesalamine Mesalamine The risk or severity of bleeding and hemorrhage can be increased when Mesalazine is combined with Apixaban.
Diclofenac Diclofenac The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Apixaban.
Fluoxetine Fluoxetine The risk or severity of hemorrhage can be increased when Fluoxetine is combined with Apixaban.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The risk or severity of bleeding can be increased when Apixaban is combined with Interferon alfa-2b.
Cefixime Cefixime The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefixime.
Clozapine Clozapine The metabolism of Apixaban can be decreased when combined with Clozapine.
Idarubicin Idarubicin The risk or severity of bleeding can be increased when Apixaban is combined with Idarubicin.
Fludarabine Injection Fludarabine Injection The risk or severity of bleeding can be increased when Apixaban is combined with Fludarabine.
Pentostatin Injection Pentostatin Injection The risk or severity of bleeding can be increased when Apixaban is combined with Pentostatin.
Clarithromycin Clarithromycin The metabolism of Apixaban can be decreased when combined with Clarithromycin.
Etodolac Etodolac The risk or severity of bleeding and hemorrhage can be increased when Etodolac is combined with Apixaban.
Felodipine Felodipine The metabolism of Felodipine can be decreased when combined with Apixaban.
Nabumetone Nabumetone The risk or severity of bleeding and hemorrhage can be increased when Nabumetone is combined with Apixaban.
Pravastatin Pravastatin Pravastatin may decrease the excretion rate of Apixaban which could result in a higher serum level.
Simvastatin Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Apixaban.
Teniposide Injection Teniposide Injection The metabolism of Apixaban can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Apixaban can be decreased when combined with Itraconazole.
Oxaprozin Oxaprozin The risk or severity of bleeding and hemorrhage can be increased when Oxaprozin is combined with Apixaban.
Atovaquone Atovaquone The metabolism of Apixaban can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Apixaban can be increased when combined with Rifabutin.
Bisoprolol Bisoprolol The serum concentration of Apixaban can be increased when it is combined with Bisoprolol.
Zolpidem Zolpidem The metabolism of Apixaban can be decreased when combined with Zolpidem.
Doxazosin Doxazosin The metabolism of Apixaban can be decreased when combined with Doxazosin.
Omeprazole Omeprazole Omeprazole may decrease the excretion rate of Apixaban which could result in a higher serum level.
Cisapride Cisapride The metabolism of Apixaban can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Apixaban can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine Venlafaxine may increase the antiplatelet activities of Apixaban.
Fluvoxamine Fluvoxamine The risk or severity of hemorrhage can be increased when Fluvoxamine is combined with Apixaban.
Nefazodone Nefazodone The risk or severity of hemorrhage can be increased when Nefazodone is combined with Apixaban.
Losartan Losartan The metabolism of Apixaban can be decreased when combined with Losartan.
Vinorelbine Injection Vinorelbine Injection The risk or severity of bleeding can be increased when Apixaban is combined with Vinorelbine.
Carboplatin Injection Carboplatin Injection The risk or severity of bleeding can be increased when Apixaban is combined with Carboplatin.
Lansoprazole Lansoprazole The metabolism of Apixaban can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The risk or severity of bleeding can be increased when Ifosfamide is combined with Apixaban.
Nicardipine Nicardipine The metabolism of Apixaban can be decreased when combined with Nicardipine.
Bupropion Bupropion The metabolism of Apixaban can be decreased when combined with Bupropion.
Ticlopidine Ticlopidine The risk or severity of adverse effects can be increased when Ticlopidine is combined with Apixaban.
Saquinavir Saquinavir The metabolism of Saquinavir can be decreased when combined with Apixaban.
Dalteparin Injection Dalteparin Injection Apixaban may increase the anticoagulant activities of Dalteparin.
Nisoldipine Nisoldipine The metabolism of Apixaban can be decreased when combined with Nisoldipine.
Glimepiride Glimepiride The metabolism of Apixaban can be decreased when combined with Glimepiride.
Anastrozole Anastrozole The metabolism of Apixaban can be decreased when combined with Anastrozole.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Apixaban.
Indinavir Indinavir The metabolism of Apixaban can be decreased when combined with Indinavir.
Ritonavir Ritonavir The serum concentration of Apixaban can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Apixaban can be decreased when combined with Docetaxel.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Apixaban.
Zafirlukast Zafirlukast The metabolism of Apixaban can be decreased when combined with Zafirlukast.
Topiramate Topiramate The metabolism of Apixaban can be decreased when combined with Topiramate.
Zileuton Zileuton The metabolism of Apixaban can be decreased when combined with Zileuton.
Valsartan Valsartan The metabolism of Apixaban can be decreased when combined with Valsartan.
Donepezil Donepezil The metabolism of Apixaban can be decreased when combined with Donepezil.
Nelfinavir Nelfinavir The metabolism of Apixaban can be decreased when combined with Nelfinavir.
Fexofenadine Fexofenadine The serum concentration of Apixaban can be increased when it is combined with Fexofenadine.
Azithromycin Azithromycin The risk or severity of adverse effects can be increased when Azithromycin is combined with Apixaban.
Loratadine Loratadine The metabolism of Apixaban can be decreased when combined with Loratadine.
Carvedilol Carvedilol The serum concentration of Apixaban can be increased when it is combined with Carvedilol.
Nilutamide Nilutamide The metabolism of Apixaban can be decreased when combined with Nilutamide.
Flutamide Flutamide The metabolism of Apixaban can be decreased when combined with Flutamide.
Selegiline Selegiline The metabolism of Apixaban can be decreased when combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Apixaban can be decreased when combined with Bicalutamide.
Sertraline Sertraline The risk or severity of bleeding can be increased when Sertraline is combined with Apixaban.
Propafenone Propafenone The serum concentration of Apixaban can be increased when it is combined with Propafenone.
Letrozole Letrozole The metabolism of Apixaban can be decreased when combined with Letrozole.
Raloxifene Raloxifene The metabolism of Apixaban can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Apixaban can be decreased when combined with Irbesartan.
Finasteride Finasteride The metabolism of Apixaban can be decreased when combined with Finasteride.
Quetiapine Quetiapine The metabolism of Apixaban can be decreased when combined with Quetiapine.
Cefepime Injection Cefepime Injection The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefepime.
Cefprozil Cefprozil The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefprozil.
Cefpodoxime Cefpodoxime The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefpodoxime.
Paroxetine Paroxetine The risk or severity of hemorrhage can be increased when Paroxetine is combined with Apixaban.
Tolcapone Tolcapone The metabolism of Apixaban can be decreased when combined with Tolcapone.
Citalopram Citalopram The risk or severity of hemorrhage can be increased when Citalopram is combined with Apixaban.
Capecitabine Capecitabine The metabolism of Apixaban can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Apixaban can be increased when combined with Efavirenz.
Sildenafil Sildenafil The risk or severity of hemorrhage can be increased when Apixaban is combined with Sildenafil.
Pioglitazone Pioglitazone The metabolism of Apixaban can be decreased when combined with Pioglitazone.
Celecoxib Celecoxib The risk or severity of bleeding and hemorrhage can be increased when Celecoxib is combined with Apixaban.
Rosiglitazone Rosiglitazone The metabolism of Apixaban can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The metabolism of Apixaban can be decreased when combined with Tolterodine.
Thalidomide Thalidomide The metabolism of Apixaban can be increased when combined with Thalidomide.
Balsalazide Balsalazide The risk or severity of bleeding and hemorrhage can be increased when Balsalazide is combined with Apixaban.
Nateglinide Nateglinide The metabolism of Apixaban can be decreased when combined with Nateglinide.
Rabeprazole Rabeprazole Rabeprazole may decrease the excretion rate of Apixaban which could result in a higher serum level.
Terbinafine Terbinafine The metabolism of Apixaban can be decreased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

Still Confused? Ask the pharmacist a question here!