Apixaban
Generic name: Pronounced as (a pix' a ban)
Medical Content Reviewed By HelloPharmacist Staff
Last Revised - 06/15/2020
On this page
- Why is this medication prescribed?
- How should this medicine be used?
- Other uses for this medicine
- What special precautions should I follow?
- What special dietary instructions should I follow?
- What should I do if I forget a dose?
- What side effects can this medication cause?
- What should I know about STORAGE and DISPOSAL of this medication?
- What should I do in case of OVERDOSE?
- What OTHER INFORMATION should I know?
- Drug interactions
IMPORTANT WARNING
If you have atrial fibrillation (a condition in which the heart beats irregularly, increasing the chance of clots forming in the body, and possibly causing strokes) and are taking apixaban to help prevent strokes or serious blood clots, you are at a higher risk of having a stroke after you stop taking this medication. Do not stop taking apixaban without talking to your doctor. Continue to take apixaban even if you feel well. Be sure to refill your prescription before you run out of medication so that you will not miss any doses of apixaban. If you need to stop taking apixaban, your doctor may prescribe another anticoagulant ('blood thinner') to help prevent a blood clot from forming and causing you to have a stroke.
If you have epidural or spinal anesthesia or a spinal puncture while taking a 'blood thinner' such as apixaban, you are at risk of having a blood clot form in or around your spine that could cause you to become paralyzed. Tell your doctor if you have an epidural catheter that is left in your body or have or have ever had repeated epidural or spinal punctures, spinal deformity, or spinal surgery. Tell your doctor and pharmacist if you are taking any of the following: anagrelide (Agrylin); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, others), indomethacin (Indocin, Tivorbex), ketoprofen, and naproxen (Aleve, Anaprox, others); cilostazol (Pletal); clopidogrel (Plavix); dipyridamole (Persantine); eptifibatide (Integrilin); heparin; prasugrel (Effient); ticagrelor (Brilinta); ticlopidine; tirofiban (Aggrastat), and warfarin (Coumadin, Jantoven). If you experience any of the following symptoms, call your doctor immediately: muscle weakness (especially in your legs and feet), numbness or tingling (especially in your legs), or loss of control of your bowels or bladder.
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with apixaban and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.
Talk to your doctor about the risks of taking apixaban.
Why is this medication prescribed?
Apixaban is used help prevent strokes or blood clots in people who have atrial fibrillation (a condition in which the heart beats irregularly, increasing the chance of clots forming in the body and possibly causing strokes) that is not caused by heart valve disease. Apixaban is also used to prevent deep vein thrombosis (DVT; a blood clot, usually in the leg) and pulmonary embolism (PE; a blood clot in the lung) in people who are having hip replacement or knee replacement surgery. Apixaban is also used to treat DVT and PE and may be continued to prevent DVT and PE from happening again after the initial treatment is completed. Apixaban is in a class of medications called factor Xa inhibitors. It works by blocking the action of a certain natural substance that helps blood clots to form.
How should this medicine be used?
Apixaban comes as a tablet to take by mouth. It is usually taken with or without food twice a day. When apixaban is taken to prevent DVT and PE after hip or knee replacement surgery, the first dose should be taken at least 12 to 24 hours after surgery. Apixaban is usually taken for 35 days after a hip replacement surgery and for 12 days after knee replacement surgery. Take apixaban at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take apixaban exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
If you are unable to swallow the tablets, you can crush them and mix with water, apple juice, or applesauce. Swallow the mixture right after you prepare it. Apixaban can also be given in certain types of feeding tubes. Ask your doctor if you should take this medication in your feeding tube. Follow your doctor's directions carefully.
Continue to take apixaban even if you feel well. Do not stop taking apixaban without talking to your doctor. If you stop taking apixaban, your risk of a blood clot may increase.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking apixaban,
-
tell your doctor and pharmacist if you are allergic to apixaban, any other medications, or any of the ingredients in apixaban tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
-
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); clarithromycin (Biaxin, in Prevpac); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); phenytoin (Dilantin, Phenytek); rifampin (Rifadin, Rimactane, in Rifadin, in Rifater); ritonavir (Norvir, in Kaletra); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); and serotonin and norepinephrine reuptake inhibitors (SNRIs) such as duloxetine (Cymbalta), desvenlafaxine (Khedezla, Pristiq), milnacipran (Fetzima, Savella), and venlafaxine (Effexor). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with apixaban, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
-
tell your doctor what herbal products you are taking, especially St. John's wort.
-
you should know that apixaban may interact with certain medications that may be used to treat you if you have a stroke or other medical emergency. In case of an emergency, you or a family member should tell the doctor or emergency room staff who treat you that you are taking apixaban.
-
tell your doctor if you have an artificial heart valve or if you have heavy bleeding anywhere in your body that cannot be stopped. Your doctor will probably tell you not to take apixaban.
-
tell your doctor if you have or have ever had any type of bleeding problem, antiphospholipid syndrome (APS; a condition that causes blood clots), or kidney or liver disease.
-
tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking apixaban, call your doctor.
-
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking apixaban. Your doctor may tell you to stop taking apixaban before the surgery or procedure. If you need to stop taking apixaban because you are having surgery, your doctor may prescribe a different medication to prevent blood clots during this time. Your doctor will tell you when you should start taking apixaban again after your surgery. Follow these directions carefully.
-
Call your doctor right away if you fall or injure yourself, especially if you hit your head. Your doctor may need to check you.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
-
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
-
bleeding gums
-
nosebleeds
-
heavy vaginal bleeding
-
red, pink, or brown urine
-
red or black, tarry stools
-
coughing up or vomiting blood or material that looks like coffee grounds
-
swelling or joint pain
-
headache
-
rash
-
chest pain or tightness
-
swelling of the face or tongue
-
trouble breathing
-
wheezing
-
feeling dizzy or faint
-
-
Apixaban prevents blood from clotting normally, so it may take longer than usual for you to stop bleeding if you are cut or injured. This medication may also cause you to bruise or bleed more easily. Call your doctor right away if bleeding or bruising is unusual, severe, or cannot be controlled.
-
Apixaban may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
-
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom).
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include the following:
-
unusual bleeding or bruising
-
red, brown, or pink urine
-
red or black, tarry stools
-
coughing up or vomiting blood or material that looks like coffee grounds
What OTHER INFORMATION should I know?
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Drug interactions
Drug | Interaction |
---|---|
Repaglinide | Repaglinide The metabolism of Apixaban can be decreased when combined with Repaglinide. |
Montelukast | Montelukast The metabolism of Apixaban can be decreased when combined with Montelukast. |
Leflunomide | Leflunomide The metabolism of Apixaban can be decreased when combined with Leflunomide. |
Delavirdine | Delavirdine The metabolism of Apixaban can be decreased when combined with Delavirdine. |
Nevirapine | Nevirapine The metabolism of Apixaban can be decreased when combined with Nevirapine. |
Atorvastatin | Atorvastatin The metabolism of Apixaban can be decreased when combined with Atorvastatin. |
Anagrelide | Anagrelide The risk or severity of adverse effects can be increased when Anagrelide is combined with Apixaban. |
Calcium Carbonate | Calcium Carbonate The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Apixaban. |
Candesartan | Candesartan The metabolism of Apixaban can be decreased when combined with Candesartan. |
Cilostazol | Cilostazol The risk or severity of adverse effects can be increased when Cilostazol is combined with Apixaban. |
Clopidogrel | Clopidogrel The risk or severity of adverse effects can be increased when Clopidogrel is combined with Apixaban. |
Erythromycin and Sulfisoxazole | Erythromycin and Sulfisoxazole The risk or severity of bleeding can be increased when Erythromycin is combined with Apixaban. |
Estrogen and Progestin (Oral Contraceptives) | Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the anticoagulant activities of Apixaban. |
Fenofibrate | Fenofibrate The metabolism of Apixaban can be decreased when combined with Fenofibrate. |
Olsalazine | Olsalazine The risk or severity of bleeding and hemorrhage can be increased when Olsalazine is combined with Apixaban. |
Paregoric | Paregoric The metabolism of Apixaban can be decreased when combined with Morphine. |
Reserpine | Reserpine The serum concentration of Apixaban can be increased when it is combined with Reserpine. |
Tacrolimus | Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Apixaban. |
Triamcinolone | Triamcinolone The therapeutic efficacy of Apixaban can be decreased when used in combination with Triamcinolone. |
Doxycycline Injection | Doxycycline Injection The risk or severity of bleeding can be increased when Doxycycline is combined with Apixaban. |
Fluconazole Injection | Fluconazole Injection The metabolism of Apixaban can be decreased when combined with Fluconazole. |
Hydromorphone Injection | Hydromorphone Injection The metabolism of Apixaban can be decreased when combined with Hydromorphone. |
Interferon Beta-1b Injection | Interferon Beta-1b Injection The risk or severity of bleeding can be increased when Apixaban is combined with Interferon beta-1b. |
Interferon Gamma-1b Injection | Interferon Gamma-1b Injection The risk or severity of bleeding can be increased when Apixaban is combined with Interferon gamma-1b. |
Metronidazole Injection | Metronidazole Injection The metabolism of Apixaban can be decreased when combined with Metronidazole. |
Morphine Injection | Morphine Injection The metabolism of Apixaban can be decreased when combined with Morphine. |
Zidovudine Injection | Zidovudine Injection The metabolism of Apixaban can be decreased when combined with Zidovudine. |
Altretamine | Altretamine The risk or severity of bleeding and hemorrhage can be increased when Amphetamine is combined with Apixaban. |
Cefuroxime | Cefuroxime The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefuroxime. |
Cyclosporine | Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Apixaban. |
Ondansetron | Ondansetron The metabolism of Apixaban can be decreased when combined with Ondansetron. |
Enoxaparin Injection | Enoxaparin Injection Apixaban may increase the anticoagulant activities of Enoxaparin. |
Torsemide | Torsemide The metabolism of Apixaban can be decreased when combined with Torasemide. |
Olanzapine | Olanzapine The metabolism of Apixaban can be decreased when combined with Olanzapine. |
Alosetron | Alosetron The metabolism of Apixaban can be decreased when combined with Alosetron. |
Hydroxychloroquine | Hydroxychloroquine The metabolism of Apixaban can be decreased when combined with Hydroxychloroquine. |
Meloxicam | Meloxicam The risk or severity of bleeding and hemorrhage can be increased when Meloxicam is combined with Apixaban. |
Oxcarbazepine | Oxcarbazepine The metabolism of Apixaban can be increased when combined with Oxcarbazepine. |
Pantoprazole | Pantoprazole Pantoprazole may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Telmisartan | Telmisartan Telmisartan may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Temozolomide | Temozolomide The risk or severity of bleeding can be increased when Apixaban is combined with Temozolomide. |
Zaleplon | Zaleplon The metabolism of Apixaban can be decreased when combined with Zaleplon. |
Anakinra | Anakinra The metabolism of Apixaban can be increased when combined with Anakinra. |
Linezolid | Linezolid The risk or severity of bleeding and hemorrhage can be increased when Linezolid is combined with Apixaban. |
Pentosan Polysulfate | Pentosan Polysulfate Apixaban may increase the anticoagulant activities of Pentosan polysulfate. |
Trimipramine | Trimipramine The metabolism of Apixaban can be decreased when combined with Trimipramine. |
Etanercept Injection | Etanercept Injection The metabolism of Apixaban can be increased when combined with Etanercept. |
Modafinil | Modafinil The metabolism of Apixaban can be decreased when combined with Modafinil. |
Tenofovir | Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Apixaban. |
Choline Magnesium Trisalicylate | Choline Magnesium Trisalicylate The risk or severity of bleeding and hemorrhage can be increased when Choline magnesium trisalicylate is combined with Apixaban. |
Sirolimus | Sirolimus The metabolism of Sirolimus can be decreased when combined with Apixaban. |
Dutasteride | Dutasteride The metabolism of Apixaban can be decreased when combined with Dutasteride. |
Epinephrine Injection | Epinephrine Injection The metabolism of Apixaban can be decreased when combined with Epinephrine. |
Epirubicin | Epirubicin The risk or severity of bleeding can be increased when Apixaban is combined with Epirubicin. |
Eplerenone | Eplerenone The metabolism of Apixaban can be decreased when combined with Eplerenone. |
Escitalopram | Escitalopram The risk or severity of bleeding can be increased when Escitalopram is combined with Apixaban. |
Zonisamide | Zonisamide The serum concentration of Apixaban can be increased when it is combined with Zonisamide. |
Adalimumab Injection | Adalimumab Injection The metabolism of Apixaban can be increased when combined with Adalimumab. |
Aripiprazole | Aripiprazole The metabolism of Apixaban can be decreased when combined with Aripiprazole. |
Atazanavir | Atazanavir The metabolism of Apixaban can be decreased when combined with Atazanavir. |
Almotriptan | Almotriptan The metabolism of Apixaban can be decreased when combined with Almotriptan. |
Eletriptan | Eletriptan The metabolism of Apixaban can be decreased when combined with Eletriptan. |
Rosuvastatin | Rosuvastatin The metabolism of Apixaban can be decreased when combined with Rosuvastatin. |
Vardenafil | Vardenafil The serum concentration of Vardenafil can be increased when it is combined with Apixaban. |
Aprepitant | Aprepitant The metabolism of Apixaban can be decreased when combined with Aprepitant. |
Memantine | Memantine The metabolism of Apixaban can be decreased when combined with Memantine. |
Tegaserod | Tegaserod The serum concentration of Apixaban can be increased when it is combined with Tegaserod. |
Tadalafil | Tadalafil The metabolism of Apixaban can be decreased when combined with Tadalafil. |
Progesterone | Progesterone Progesterone may decrease the anticoagulant activities of Apixaban. |
Apomorphine Injection | Apomorphine Injection The metabolism of Apixaban can be decreased when combined with Apomorphine. |
Infliximab Injection | Infliximab Injection The metabolism of Apixaban can be increased when combined with Infliximab. |
Oxandrolone | Oxandrolone The metabolism of Apixaban can be decreased when combined with Oxandrolone. |
Rifaximin | Rifaximin The metabolism of Apixaban can be increased when combined with Rifaximin. |
Duloxetine | Duloxetine The risk or severity of hemorrhage can be increased when Duloxetine is combined with Apixaban. |
Norethindrone | Norethindrone Norethisterone may decrease the anticoagulant activities of Apixaban. |
Bosentan | Bosentan The metabolism of Apixaban can be increased when combined with Bosentan. |
Cefditoren | Cefditoren The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefdinir. |
Erlotinib | Erlotinib The metabolism of Apixaban can be decreased when combined with Erlotinib. |
Eszopiclone | Eszopiclone The metabolism of Apixaban can be decreased when combined with Eszopiclone. |
Voriconazole | Voriconazole The metabolism of Apixaban can be decreased when combined with Voriconazole. |
Dextroamphetamine | Dextroamphetamine The risk or severity of bleeding and hemorrhage can be increased when Amphetamine is combined with Apixaban. |
Peginterferon Alfa-2a Injection | Peginterferon Alfa-2a Injection The risk or severity of bleeding can be increased when Apixaban is combined with Peginterferon alfa-2a. |
Peginterferon Alfa-2b (PEG-Intron) | Peginterferon Alfa-2b (PEG-Intron) The risk or severity of bleeding can be increased when Apixaban is combined with Peginterferon alfa-2b. |
Isocarboxazid | Isocarboxazid The risk or severity of bleeding and hemorrhage can be increased when Isocarboxazid is combined with Apixaban. |
Ramelteon | Ramelteon The metabolism of Apixaban can be decreased when combined with Ramelteon. |
Fentanyl | Fentanyl The metabolism of Apixaban can be decreased when combined with Fentanyl. |
Deferasirox | Deferasirox The risk or severity of gastrointestinal bleeding can be increased when Apixaban is combined with Deferasirox. |
Tipranavir | Tipranavir The risk or severity of bleeding and hemorrhage can be increased when Tipranavir is combined with Apixaban. |
Felbamate | Felbamate The metabolism of Apixaban can be decreased when combined with Felbamate. |
Ranolazine | Ranolazine The serum concentration of Apixaban can be increased when it is combined with Ranolazine. |
Abatacept Injection | Abatacept Injection The metabolism of Apixaban can be increased when combined with Abatacept. |
Rasagiline | Rasagiline The risk or severity of bleeding and hemorrhage can be increased when Rasagiline is combined with Apixaban. |
Imatinib | Imatinib The metabolism of Apixaban can be decreased when combined with Imatinib. |
Sitagliptin | Sitagliptin The metabolism of Apixaban can be decreased when combined with Sitagliptin. |
Gefitinib | Gefitinib Gefitinib may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Paliperidone | Paliperidone The serum concentration of Apixaban can be increased when it is combined with Paliperidone. |
Bortezomib | Bortezomib The metabolism of Apixaban can be decreased when combined with Bortezomib. |
Clofarabine Injection | Clofarabine Injection The risk or severity of bleeding can be increased when Apixaban is combined with Clofarabine. |
Oxaliplatin Injection | Oxaliplatin Injection The risk or severity of bleeding can be increased when Apixaban is combined with Oxaliplatin. |
Posaconazole | Posaconazole The serum concentration of Apixaban can be increased when it is combined with Posaconazole. |
Rituximab Injection | Rituximab Injection The risk or severity of bleeding can be increased when Apixaban is combined with Rituximab. |
Bismuth Subsalicylate | Bismuth Subsalicylate The risk or severity of bleeding can be increased when Bismuth subsalicylate is combined with Apixaban. |
Darunavir | Darunavir The risk or severity of bleeding can be increased when Darunavir is combined with Apixaban. |
Pemetrexed Injection | Pemetrexed Injection The risk or severity of bleeding can be increased when Apixaban is combined with Pemetrexed. |
Nabilone | Nabilone The metabolism of Apixaban can be decreased when combined with Nabilone. |
Vorinostat | Vorinostat The risk or severity of bleeding can be increased when Apixaban is combined with Vorinostat. |
Sorafenib | Sorafenib The metabolism of Apixaban can be decreased when combined with Sorafenib. |
Sunitinib | Sunitinib The metabolism of Apixaban can be decreased when combined with Sunitinib. |
Dronabinol | Dronabinol Dronabinol may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Lapatinib | Lapatinib The serum concentration of Apixaban can be increased when it is combined with Lapatinib. |
Dasatinib | Dasatinib The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Apixaban. |
Omega-3 Fatty Acids | Omega-3 Fatty Acids Omega-3 fatty acids may increase the anticoagulant activities of Apixaban. |
Armodafinil | Armodafinil The metabolism of Apixaban can be decreased when combined with Armodafinil. |
Azacitidine Injection | Azacitidine Injection The risk or severity of bleeding can be increased when Apixaban is combined with Azacitidine. |
Temsirolimus | Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Apixaban. |
Nelarabine Injection | Nelarabine Injection The risk or severity of bleeding can be increased when Apixaban is combined with Nelarabine. |
Lenalidomide | Lenalidomide The risk or severity of bleeding can be increased when Apixaban is combined with Lenalidomide. |
Nilotinib | Nilotinib The serum concentration of Apixaban can be increased when it is combined with Nilotinib. |
Toremifene | Toremifene The risk or severity of bleeding can be increased when Toremifene is combined with Apixaban. |
Bexarotene | Bexarotene The metabolism of Apixaban can be decreased when combined with Bexarotene. |
Budesonide | Budesonide The metabolism of Apixaban can be increased when combined with Budesonide. |
Chloramphenicol Injection | Chloramphenicol Injection The metabolism of Apixaban can be decreased when combined with Chloramphenicol. |
Decitabine Injection | Decitabine Injection The risk or severity of bleeding can be increased when Apixaban is combined with Decitabine. |
Etravirine | Etravirine The metabolism of Apixaban can be decreased when combined with Etravirine. |
Arsenic Trioxide Injection | Arsenic Trioxide Injection The risk or severity of bleeding can be increased when Apixaban is combined with Arsenic trioxide. |
Mitoxantrone Injection | Mitoxantrone Injection The risk or severity of bleeding can be increased when Apixaban is combined with Mitoxantrone. |
Desvenlafaxine | Desvenlafaxine The risk or severity of hemorrhage can be increased when Desvenlafaxine is combined with Apixaban. |
Nebivolol | Nebivolol The metabolism of Apixaban can be decreased when combined with Nebivolol. |
Tretinoin | Tretinoin The metabolism of Apixaban can be decreased when combined with Tretinoin. |
Bendamustine Injection | Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Apixaban. |
Flecainide | Flecainide The metabolism of Apixaban can be decreased when combined with Flecainide. |
Certolizumab Injection | Certolizumab Injection The metabolism of Apixaban can be increased when combined with Certolizumab pegol. |
Ixabepilone Injection | Ixabepilone Injection The risk or severity of bleeding can be increased when Apixaban is combined with Ixabepilone. |
Irinotecan Injection | Irinotecan Injection The metabolism of Apixaban can be decreased when combined with Irinotecan. |
Praziquantel | Praziquantel The metabolism of Apixaban can be decreased when combined with Praziquantel. |
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) | Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of bleeding can be increased when Apixaban is combined with Alemtuzumab. |
Silodosin | Silodosin The serum concentration of Apixaban can be increased when it is combined with Silodosin. |
Midazolam | Midazolam The metabolism of Apixaban can be decreased when combined with Midazolam. |
Dexrazoxane Injection | Dexrazoxane Injection The risk or severity of bleeding can be increased when Apixaban is combined with Dexrazoxane. |
Eltrombopag | Eltrombopag Eltrombopag may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Ibritumomab Injection | Ibritumomab Injection The risk or severity of adverse effects can be increased when Apixaban is combined with Ibritumomab tiuxetan. |
Milnacipran | Milnacipran The risk or severity of hemorrhage can be increased when Milnacipran is combined with Apixaban. |
Dexlansoprazole | Dexlansoprazole The metabolism of Apixaban can be decreased when combined with Dexlansoprazole. |
Iloperidone | Iloperidone The metabolism of Apixaban can be decreased when combined with Iloperidone. |
Prasugrel | Prasugrel Apixaban may increase the anticoagulant activities of Prasugrel. |
Lacosamide | Lacosamide The metabolism of Apixaban can be decreased when combined with Lacosamide. |
Everolimus | Everolimus The serum concentration of Apixaban can be increased when it is combined with Everolimus. |
Tolvaptan (low blood sodium) | Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Apixaban. |
Dronedarone | Dronedarone The metabolism of Dronedarone can be decreased when combined with Apixaban. |
Saxagliptin | Saxagliptin The metabolism of Apixaban can be decreased when combined with Saxagliptin. |
Romidepsin Injection | Romidepsin Injection The serum concentration of Apixaban can be increased when it is combined with Romidepsin. |
Tapentadol | Tapentadol The metabolism of Apixaban can be decreased when combined with Tapentadol. |
Topotecan | Topotecan The serum concentration of Topotecan can be increased when it is combined with Apixaban. |
Golimumab Injection | Golimumab Injection The metabolism of Apixaban can be increased when combined with Golimumab. |
Pazopanib | Pazopanib The metabolism of Apixaban can be decreased when combined with Pazopanib. |
Pitavastatin | Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Apixaban. |
Albendazole | Albendazole The metabolism of Apixaban can be decreased when combined with Albendazole. |
Ulipristal | Ulipristal The therapeutic efficacy of Apixaban can be decreased when used in combination with Ulipristal. |
Levonorgestrel | Levonorgestrel Levonorgestrel may decrease the anticoagulant activities of Apixaban. |
Dabigatran | Dabigatran Apixaban may increase the anticoagulant activities of Dabigatran. |
Tocilizumab Injection | Tocilizumab Injection The metabolism of Apixaban can be increased when combined with Tocilizumab. |
Eribulin Injection | Eribulin Injection The risk or severity of bleeding can be increased when Apixaban is combined with Eribulin. |
Cabazitaxel Injection | Cabazitaxel Injection The metabolism of Apixaban can be decreased when combined with Cabazitaxel. |
Ceftaroline Injection | Ceftaroline Injection The therapeutic efficacy of Apixaban can be decreased when used in combination with Ceftaroline fosamil. |
Vilazodone | Vilazodone The metabolism of Vilazodone can be decreased when combined with Apixaban. |
Denileukin Diftitox Injection | Denileukin Diftitox Injection The risk or severity of bleeding can be increased when Apixaban is combined with Aldesleukin. |
Busulfan Injection | Busulfan Injection The risk or severity of bleeding can be increased when Apixaban is combined with Busulfan. |
Linagliptin | Linagliptin The serum concentration of Apixaban can be increased when it is combined with Linagliptin. |
Rilpivirine | Rilpivirine Rilpivirine may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Telaprevir | Telaprevir The serum concentration of Apixaban can be increased when it is combined with Glecaprevir. |
Potassium Iodide | Potassium Iodide Potassium Iodide may increase the anticoagulant activities of Apixaban. |
Cyclophosphamide Injection | Cyclophosphamide Injection The metabolism of Apixaban can be decreased when combined with Cyclophosphamide. |
Abiraterone | Abiraterone The metabolism of Apixaban can be decreased when combined with Abiraterone. |
Rivaroxaban | Rivaroxaban Apixaban may increase the anticoagulant activities of Rivaroxaban. |
Ticagrelor | Ticagrelor Apixaban may increase the anticoagulant activities of Ticagrelor. |
Brentuximab Vedotin Injection | Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Apixaban. |
Ruxolitinib | Ruxolitinib The risk or severity of bleeding can be increased when Apixaban is combined with Ruxolitinib. |
Vandetanib | Vandetanib Vandetanib may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Clobazam | Clobazam The serum concentration of Apixaban can be increased when it is combined with Clobazam. |
Vemurafenib | Vemurafenib The serum concentration of Apixaban can be increased when it is combined with Vemurafenib. |
Vismodegib | Vismodegib Vismodegib may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Ivacaftor | Ivacaftor The serum concentration of Apixaban can be increased when it is combined with Ivacaftor. |
Axitinib | Axitinib The metabolism of Axitinib can be decreased when combined with Apixaban. |
Crizotinib | Crizotinib The metabolism of Apixaban can be decreased when combined with Crizotinib. |
Melphalan Injection | Melphalan Injection The risk or severity of bleeding can be increased when Apixaban is combined with Melphalan. |
Cabergoline | Cabergoline The serum concentration of Cabergoline can be increased when it is combined with Apixaban. |
Ambrisentan | Ambrisentan The serum concentration of Apixaban can be increased when it is combined with Ambrisentan. |
Fondaparinux Injection | Fondaparinux Injection Apixaban may increase the anticoagulant activities of Fondaparinux. |
Collagenase Clostridium Histolyticum Injection | Collagenase Clostridium Histolyticum Injection The risk or severity of adverse effects can be increased when Apixaban is combined with Collagenase clostridium histolyticum. |
Carfilzomib Injection | Carfilzomib Injection The serum concentration of Apixaban can be increased when it is combined with Carfilzomib. |
Iloprost | Iloprost Apixaban may increase the anticoagulant activities of Iloprost. |
Enzalutamide | Enzalutamide The serum concentration of Apixaban can be increased when it is combined with Enzalutamide. |
Mirabegron | Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Apixaban. |
Regorafenib | Regorafenib The serum concentration of Apixaban can be increased when it is combined with Regorafenib. |
Bosutinib | Bosutinib The metabolism of Apixaban can be decreased when combined with Bosutinib. |
Teriflunomide | Teriflunomide Teriflunomide may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Cabozantinib (thyroid cancer) | Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Apixaban. |
Icosapent Ethyl | Icosapent Ethyl The risk or severity of adverse effects can be increased when Icosapent ethyl is combined with Apixaban. |
Tofacitinib | Tofacitinib The risk or severity of bleeding can be increased when Apixaban is combined with Tofacitinib. |
Ponatinib | Ponatinib The metabolism of Apixaban can be decreased when combined with Ponatinib. |
Pomalidomide | Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Apixaban. |
Ado-trastuzumab Emtansine Injection | Ado-trastuzumab Emtansine Injection The metabolism of Apixaban can be decreased when combined with Trastuzumab emtansine. |
Canagliflozin | Canagliflozin The serum concentration of Apixaban can be increased when it is combined with Canagliflozin. |
Dabrafenib | Dabrafenib The serum concentration of Apixaban can be decreased when it is combined with Dabrafenib. |
Ospemifene | Ospemifene The metabolism of Apixaban can be decreased when combined with Ospemifene. |
Trametinib | Trametinib The metabolism of Apixaban can be decreased when combined with Trametinib. |
Dolutegravir | Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Apixaban. |
Afatinib | Afatinib The serum concentration of Apixaban can be increased when it is combined with Afatinib. |
Levomilnacipran | Levomilnacipran The risk or severity of hemorrhage can be increased when Levomilnacipran is combined with Apixaban. |
Vortioxetine | Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Apixaban. |
Perampanel | Perampanel The metabolism of Perampanel can be decreased when combined with Apixaban. |
Ibrutinib | Ibrutinib The risk or severity of bleeding and hemorrhage can be increased when Ibrutinib is combined with Apixaban. |
Lomitapide | Lomitapide The serum concentration of Lomitapide can be increased when it is combined with Apixaban. |
Ketorolac Injection | Ketorolac Injection The risk or severity of bleeding and hemorrhage can be increased when Ketorolac is combined with Apixaban. |
Obinutuzumab Injection | Obinutuzumab Injection The risk or severity of bleeding and hemorrhage can be increased when Apixaban is combined with Obinutuzumab. |
Simeprevir | Simeprevir Simeprevir may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Sofosbuvir | Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Apixaban. |
Dapagliflozin | Dapagliflozin The metabolism of Apixaban can be decreased when combined with Dapagliflozin. |
Apremilast | Apremilast The metabolism of Apixaban can be increased when combined with Apremilast. |
Ceritinib | Ceritinib The metabolism of Apixaban can be decreased when combined with Ceritinib. |
Siltuximab Injection | Siltuximab Injection The metabolism of Apixaban can be increased when combined with Siltuximab. |
Eslicarbazepine | Eslicarbazepine The metabolism of Apixaban can be decreased when combined with Eslicarbazepine. |
Belinostat Injection | Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Apixaban. |
Idelalisib | Idelalisib The serum concentration of Idelalisib can be increased when it is combined with Apixaban. |
Testosterone Injection | Testosterone Injection Testosterone may increase the anticoagulant activities of Apixaban. |
Oritavancin Injection | Oritavancin Injection The metabolism of Apixaban can be decreased when combined with Oritavancin. |
Vorapaxar | Vorapaxar Apixaban may increase the anticoagulant activities of Vorapaxar. |
Suvorexant | Suvorexant The serum concentration of Apixaban can be increased when it is combined with Suvorexant. |
Edoxaban | Edoxaban Apixaban may increase the anticoagulant activities of Edoxaban. |
Peginterferon Beta-1a Injection | Peginterferon Beta-1a Injection The risk or severity of bleeding can be increased when Apixaban is combined with Peginterferon beta-1a. |
Olaparib | Olaparib The metabolism of Apixaban can be decreased when combined with Olaparib. |
Blinatumomab Injection | Blinatumomab Injection The risk or severity of bleeding can be increased when Apixaban is combined with Blinatumomab. |
Riociguat | Riociguat The metabolism of Riociguat can be decreased when combined with Apixaban. |
Nintedanib | Nintedanib The risk or severity of bleeding can be increased when Apixaban is combined with Nintedanib. |
Secukinumab Injection | Secukinumab Injection The metabolism of Apixaban can be increased when combined with Secukinumab. |
Risperidone Injection | Risperidone Injection The metabolism of Apixaban can be decreased when combined with Risperidone. |
Palbociclib | Palbociclib Palbociclib may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Lenvatinib | Lenvatinib The metabolism of Apixaban can be decreased when combined with Lenvatinib. |
Naloxegol | Naloxegol The metabolism of Apixaban can be decreased when combined with Naloxegol. |
Panobinostat | Panobinostat The serum concentration of Apixaban can be increased when it is combined with Panobinostat. |
Dinutuximab Injection | Dinutuximab Injection The risk or severity of bleeding can be increased when Apixaban is combined with Dinutuximab. |
Haloperidol Injection | Haloperidol Injection The serum concentration of Apixaban can be increased when it is combined with Haloperidol. |
Deoxycholic Acid Injection | Deoxycholic Acid Injection The risk or severity of bleeding and bruising can be increased when Apixaban is combined with Deoxycholic acid. |
Isavuconazonium Injection | Isavuconazonium Injection The serum concentration of Apixaban can be increased when it is combined with Isavuconazonium. |
Flibanserin | Flibanserin The serum concentration of Apixaban can be increased when it is combined with Flibanserin. |
Rolapitant | Rolapitant The serum concentration of Apixaban can be increased when it is combined with Rolapitant. |
Daclatasvir | Daclatasvir The serum concentration of Apixaban can be increased when it is combined with Daclatasvir. |
Ziprasidone Injection | Ziprasidone Injection The metabolism of Apixaban can be decreased when combined with Ziprasidone. |
Cobimetinib | Cobimetinib The serum concentration of Apixaban can be increased when it is combined with Cobimetinib. |
Trabectedin Injection | Trabectedin Injection The metabolism of Apixaban can be decreased when combined with Trabectedin. |
Osimertinib | Osimertinib The serum concentration of Osimertinib can be increased when it is combined with Apixaban. |
Alectinib | Alectinib Alectinib may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Rifapentine | Rifapentine The metabolism of Apixaban can be increased when combined with Rifapentine. |
Lesinurad | Lesinurad The metabolism of Lesinurad can be decreased when combined with Apixaban. |
Dexamethasone Injection | Dexamethasone Injection Dexamethasone may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Defibrotide Injection | Defibrotide Injection Apixaban may increase the anticoagulant activities of Defibrotide. |
Brivaracetam Injection | Brivaracetam Injection The metabolism of Apixaban can be decreased when combined with Brivaracetam. |
Venetoclax | Venetoclax The serum concentration of Apixaban can be increased when it is combined with Venetoclax. |
Cobicistat | Cobicistat The metabolism of Apixaban can be decreased when combined with Cobicistat. |
Selexipag | Selexipag The metabolism of Selexipag can be decreased when combined with Apixaban. |
Obeticholic Acid | Obeticholic Acid The risk or severity of bleeding and bruising can be increased when Apixaban is combined with Obeticholic acid. |
Diphenhydramine Injection | Diphenhydramine Injection The metabolism of Apixaban can be decreased when combined with Diphenhydramine. |
Rucaparib | Rucaparib The serum concentration of Apixaban can be increased when it is combined with Rucaparib. |
Brigatinib | Brigatinib The metabolism of Apixaban can be decreased when combined with Brigatinib. |
Doxepin (Insomnia) | Doxepin (Insomnia) The metabolism of Apixaban can be decreased when combined with Doxepin. |
Deutetrabenazine | Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Apixaban. |
Valbenazine | Valbenazine The metabolism of Valbenazine can be decreased when combined with Apixaban. |
Deflazacort | Deflazacort The metabolism of Apixaban can be increased when combined with Deflazacort. |
Safinamide | Safinamide Safinamide may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Midostaurin | Midostaurin The metabolism of Apixaban can be increased when combined with Midostaurin. |
Neratinib | Neratinib The serum concentration of Apixaban can be increased when it is combined with Neratinib. |
Enasidenib | Enasidenib The metabolism of Apixaban can be decreased when combined with Enasidenib. |
Inotuzumab Ozogamicin Injection | Inotuzumab Ozogamicin Injection The serum concentration of Apixaban can be increased when it is combined with Inotuzumab ozogamicin. |
Copanlisib Injection | Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Apixaban. |
Delafloxacin | Delafloxacin The metabolism of Apixaban can be increased when combined with Delafloxacin. |
Abemaciclib | Abemaciclib Abemaciclib may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Betrixaban | Betrixaban Apixaban may increase the anticoagulant activities of Betrixaban. |
Acalabrutinib | Acalabrutinib The metabolism of Apixaban can be decreased when combined with Acalabrutinib. |
Gemtuzumab Ozogamicin Injection | Gemtuzumab Ozogamicin Injection The risk or severity of bleeding can be increased when Apixaban is combined with Gemtuzumab ozogamicin. |
Letermovir | Letermovir Letermovir may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Ertugliflozin | Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Apixaban. |
Buprenorphine Injection | Buprenorphine Injection Buprenorphine may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Apalutamide | Apalutamide The serum concentration of Apixaban can be increased when it is combined with Apalutamide. |
Penicillamine | Penicillamine The risk or severity of bleeding can be increased when Apixaban is combined with Penicillamine. |
Fostamatinib | Fostamatinib Fostamatinib may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Avatrombopag | Avatrombopag Avatrombopag may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Baricitinib | Baricitinib Baricitinib may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Eliglustat | Eliglustat The serum concentration of Eliglustat can be increased when it is combined with Apixaban. |
Binimetinib | Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Apixaban. |
Ivosidenib | Ivosidenib The serum concentration of Apixaban can be increased when it is combined with Ivosidenib. |
Lusutrombopag | Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Apixaban. |
Elagolix | Elagolix The metabolism of Elagolix can be decreased when combined with Apixaban. |
Doravirine | Doravirine The metabolism of Doravirine can be decreased when combined with Apixaban. |
Cannabidiol | Cannabidiol Cannabidiol may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Dacomitinib | Dacomitinib The metabolism of Apixaban can be decreased when combined with Dacomitinib. |
Duvelisib | Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Apixaban. |
Omadacycline | Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Apixaban. |
Sarecycline | Sarecycline The serum concentration of Apixaban can be increased when it is combined with Sarecycline. |
Stiripentol | Stiripentol The metabolism of Apixaban can be decreased when combined with Stiripentol. |
Talazoparib | Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Apixaban. |
Gilteritinib | Gilteritinib Gilteritinib may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Glasdegib | Glasdegib Glasdegib may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Lorlatinib | Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Apixaban. |
Larotrectinib | Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Apixaban. |
Paclitaxel (with albumin) Injection | Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Apixaban. |
Rifamycin | Rifamycin The metabolism of Apixaban can be increased when combined with Rifamycin. |
Emapalumab-lzsg Injection | Emapalumab-lzsg Injection The metabolism of Apixaban can be increased when combined with Emapalumab. |
Siponimod | Siponimod The metabolism of Siponimod can be decreased when combined with Apixaban. |
Caplacizumab-yhdp Injection | Caplacizumab-yhdp Injection The risk or severity of adverse effects can be increased when Caplacizumab is combined with Apixaban. |
Erdafitinib | Erdafitinib The serum concentration of Apixaban can be increased when it is combined with Erdafitinib. |
Esomeprazole Injection | Esomeprazole Injection The metabolism of Apixaban can be decreased when combined with Esomeprazole. |
Alpelisib | Alpelisib The serum concentration of Apixaban can be decreased when it is combined with Alpelisib. |
Cladribine | Cladribine The risk or severity of bleeding can be increased when Apixaban is combined with Cladribine. |
Darolutamide | Darolutamide The serum concentration of Apixaban can be increased when it is combined with Darolutamide. |
Triclabendazole | Triclabendazole The metabolism of Apixaban can be decreased when combined with Triclabendazole. |
Entrectinib | Entrectinib The serum concentration of Apixaban can be increased when it is combined with Entrectinib. |
Istradefylline | Istradefylline The metabolism of Istradefylline can be decreased when combined with Apixaban. |
Pitolisant | Pitolisant The serum concentration of Apixaban can be decreased when it is combined with Pitolisant. |
Fedratinib | Fedratinib Fedratinib may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Lefamulin | Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Apixaban. |
Phenytoin Injection | Phenytoin Injection The metabolism of Apixaban can be decreased when combined with Phenytoin. |
Fosphenytoin Injection | Fosphenytoin Injection The metabolism of Apixaban can be decreased when combined with Fosphenytoin. |
Enfortumab vedotin-ejfv Injection | Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Apixaban. |
Voxelotor | Voxelotor The metabolism of Voxelotor can be decreased when combined with Apixaban. |
Avapritinib | Avapritinib The metabolism of Avapritinib can be decreased when combined with Apixaban. |
Lasmiditan | Lasmiditan The serum concentration of Apixaban can be increased when it is combined with Lasmiditan. |
Ubrogepant | Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Apixaban. |
Calcium Acetate | Calcium Acetate The therapeutic efficacy of Calcium acetate can be decreased when used in combination with Apixaban. |
Tazemetostat | Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Apixaban. |
Cenobamate | Cenobamate The serum concentration of Apixaban can be decreased when it is combined with Cenobamate. |
Ozanimod | Ozanimod The metabolism of Ozanimod can be decreased when combined with Apixaban. |
Selumetinib | Selumetinib The metabolism of Selumetinib can be decreased when combined with Apixaban. |
Rimegepant | Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Apixaban. |
Tucatinib | Tucatinib Apixaban may decrease the excretion rate of Tucatinib which could result in a higher serum level. |
Remdesivir Injection | Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Apixaban. |
Ripretinib | Ripretinib Ripretinib may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Selpercatinib | Selpercatinib The serum concentration of Apixaban can be increased when it is combined with Selpercatinib. |
Capmatinib | Capmatinib The serum concentration of Apixaban can be increased when it is combined with Capmatinib. |
Lemborexant | Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Apixaban. |
Fostemsavir | Fostemsavir Fostemsavir may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Belantamab Mafodotin-blmf Injection | Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Apixaban. |
Pralsetinib | Pralsetinib Pralsetinib may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Opicapone | Opicapone The metabolism of Apixaban can be decreased when combined with Opicapone. |
Satralizumab-mwge Injection | Satralizumab-mwge Injection The serum concentration of Apixaban can be decreased when it is combined with Satralizumab. |
Progestin-Only (drospirenone) Oral Contraceptives | Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may decrease the anticoagulant activities of Apixaban. |
Vitamin E (Alpha-Tocopherol) | Vitamin E (Alpha-Tocopherol) Vitamin E may increase the anticoagulant activities of Apixaban. |
Theophylline | Theophylline The metabolism of Apixaban can be decreased when combined with Theophylline. |
Fenoprofen | Fenoprofen The risk or severity of bleeding and hemorrhage can be increased when Fenoprofen is combined with Apixaban. |
Indomethacin | Indomethacin The risk or severity of bleeding and hemorrhage can be increased when Indomethacin is combined with Apixaban. |
Mefenamic Acid | Mefenamic Acid The risk or severity of bleeding and hemorrhage can be increased when Mefenamic acid is combined with Apixaban. |
Naproxen | Naproxen The risk or severity of bleeding and hemorrhage can be increased when Naproxen is combined with Apixaban. |
Tolmetin | Tolmetin The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Apixaban. |
Sulindac | Sulindac The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Apixaban. |
Trazodone | Trazodone The risk or severity of bleeding can be increased when Trazodone is combined with Apixaban. |
Hydroxyurea | Hydroxyurea The risk or severity of bleeding can be increased when Apixaban is combined with Hydroxyurea. |
Floxuridine | Floxuridine The metabolism of Apixaban can be decreased when combined with Floxuridine. |
Phenobarbital | Phenobarbital The metabolism of Apixaban can be decreased when combined with Phenobarbital. |
Methotrexate Injection | Methotrexate Injection The risk or severity of bleeding can be increased when Apixaban is combined with Methotrexate. |
Primidone | Primidone The metabolism of Apixaban can be decreased when combined with Primidone. |
Methsuximide | Methsuximide The metabolism of Apixaban can be decreased when combined with Methsuximide. |
Diazepam | Diazepam The metabolism of Apixaban can be decreased when combined with Diazepam. |
Carmustine | Carmustine The risk or severity of bleeding can be increased when Apixaban is combined with Carmustine. |
Tranylcypromine | Tranylcypromine The risk or severity of bleeding and hemorrhage can be increased when Tranylcypromine is combined with Apixaban. |
Phenelzine | Phenelzine The risk or severity of bleeding and hemorrhage can be increased when Phenelzine is combined with Apixaban. |
Procarbazine | Procarbazine The risk or severity of bleeding and hemorrhage can be increased when Procarbazine is combined with Apixaban. |
Thioguanine | Thioguanine The risk or severity of bleeding can be increased when Apixaban is combined with Tioguanine. |
Thioridazine | Thioridazine The metabolism of Apixaban can be decreased when combined with Thioridazine. |
Dapsone | Dapsone The metabolism of Apixaban can be decreased when combined with Dapsone. |
Sulfadiazine | Sulfadiazine The metabolism of Apixaban can be decreased when combined with Sulfadiazine. |
Oxycodone | Oxycodone The metabolism of Apixaban can be decreased when combined with Oxycodone. |
Methadone | Methadone The metabolism of Apixaban can be decreased when combined with Methadone. |
Oxybutynin | Oxybutynin The metabolism of Apixaban can be decreased when combined with Oxybutynin. |
Ibuprofen | Ibuprofen The risk or severity of bleeding and gastrointestinal bleeding can be increased when Ibuprofen is combined with Apixaban. |
Sulfasalazine | Sulfasalazine The risk or severity of bleeding and hemorrhage can be increased when Sulfasalazine is combined with Apixaban. |
Hydrocortisone | Hydrocortisone The metabolism of Apixaban can be increased when combined with Hydrocortisone. |
Lomustine | Lomustine The risk or severity of bleeding can be increased when Apixaban is combined with Lomustine. |
Doxorubicin | Doxorubicin The risk or severity of bleeding can be increased when Apixaban is combined with Doxorubicin. |
Cytarabine | Cytarabine The risk or severity of bleeding can be increased when Apixaban is combined with Cytarabine. |
Mechlorethamine | Mechlorethamine The risk or severity of bleeding can be increased when Apixaban is combined with Mechlorethamine. |
Dactinomycin | Dactinomycin The serum concentration of Apixaban can be increased when it is combined with Dactinomycin. |
Carbamazepine | Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Apixaban. |
Clonidine | Clonidine The metabolism of Apixaban can be decreased when combined with Clonidine. |
Cimetidine | Cimetidine The metabolism of Apixaban can be decreased when combined with Cimetidine. |
Warfarin | Warfarin Apixaban may increase the anticoagulant activities of Warfarin. |
Loperamide | Loperamide The serum concentration of Apixaban can be increased when it is combined with Loperamide. |
Promethazine | Promethazine The metabolism of Apixaban can be decreased when combined with Promethazine. |
Meclofenamate | Meclofenamate The risk or severity of bleeding and hemorrhage can be increased when Meclofenamic acid is combined with Apixaban. |
Daunorubicin | Daunorubicin The metabolism of Apixaban can be increased when combined with Daunorubicin. |
Griseofulvin | Griseofulvin The metabolism of Apixaban can be increased when combined with Griseofulvin. |
Digoxin | Digoxin The serum concentration of Digoxin can be increased when it is combined with Apixaban. |
Loxapine | Loxapine The serum concentration of Apixaban can be increased when it is combined with Loxapine. |
Chloroquine | Chloroquine The metabolism of Apixaban can be decreased when combined with Chloroquine. |
Quinine | Quinine The therapeutic efficacy of Apixaban can be increased when used in combination with Quinine. |
Sulfinpyrazone | Sulfinpyrazone The risk or severity of adverse effects can be increased when Sulfinpyrazone is combined with Apixaban. |
Chlorothiazide | Chlorothiazide The therapeutic efficacy of Apixaban can be decreased when used in combination with Chlorothiazide. |
Isosorbide | Isosorbide The therapeutic efficacy of Apixaban can be decreased when used in combination with Isosorbide. |
Clindamycin Injection | Clindamycin Injection The metabolism of Apixaban can be decreased when combined with Clindamycin. |
Secobarbital | Secobarbital The metabolism of Apixaban can be increased when combined with Secobarbital. |
Amitriptyline | Amitriptyline The metabolism of Apixaban can be decreased when combined with Amitriptyline. |
Imipramine | Imipramine The metabolism of Imipramine can be decreased when combined with Apixaban. |
Probenecid | Probenecid The metabolism of Apixaban can be decreased when combined with Probenecid. |
Quinidine | Quinidine The therapeutic efficacy of Apixaban can be increased when used in combination with Quinidine. |
Isoniazid | Isoniazid The metabolism of Apixaban can be decreased when combined with Isoniazid. |
Rifampin | Rifampin The metabolism of Apixaban can be increased when combined with Rifampicin. |
Valproic Acid | Valproic Acid The metabolism of Apixaban can be decreased when combined with Valproic acid. |
Tamoxifen | Tamoxifen The risk or severity of bleeding can be increased when Tamoxifen is combined with Apixaban. |
Mitomycin | Mitomycin The risk or severity of bleeding can be increased when Apixaban is combined with Mitomycin. |
Levothyroxine | Levothyroxine The metabolism of Apixaban can be decreased when combined with Levothyroxine. |
Methimazole | Methimazole The metabolism of Apixaban can be decreased when combined with Methimazole. |
Propylthiouracil | Propylthiouracil Propylthiouracil may increase the anticoagulant activities of Apixaban. |
Chlorpropamide | Chlorpropamide The metabolism of Apixaban can be decreased when combined with Chlorpropamide. |
Tolbutamide | Tolbutamide The metabolism of Apixaban can be decreased when combined with Tolbutamide. |
Tolazamide | Tolazamide The metabolism of Apixaban can be decreased when combined with Tolazamide. |
Dextromethorphan | Dextromethorphan The metabolism of Apixaban can be decreased when combined with Dextromethorphan. |
Chlorpheniramine | Chlorpheniramine The metabolism of Apixaban can be decreased when combined with Chlorpheniramine. |
Methyclothiazide | Methyclothiazide The therapeutic efficacy of Apixaban can be decreased when used in combination with Methyclothiazide. |
Hydrochlorothiazide | Hydrochlorothiazide The therapeutic efficacy of Apixaban can be decreased when used in combination with Hydrochlorothiazide. |
Carisoprodol | Carisoprodol The metabolism of Apixaban can be decreased when combined with Carisoprodol. |
Disulfiram | Disulfiram The metabolism of Apixaban can be decreased when combined with Disulfiram. |
Propranolol (Cardiovascular) | Propranolol (Cardiovascular) The metabolism of Apixaban can be decreased when combined with Propranolol. |
Nortriptyline | Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Apixaban. |
Spironolactone | Spironolactone The metabolism of Apixaban can be decreased when combined with Spironolactone. |
Mercaptopurine | Mercaptopurine The risk or severity of bleeding can be increased when Apixaban is combined with Mercaptopurine. |
Clomiphene | Clomiphene The serum concentration of Apixaban can be increased when it is combined with Clomifene. |
Fluorouracil Injection | Fluorouracil Injection The metabolism of Apixaban can be decreased when combined with Fluorouracil. |
Colchicine | Colchicine The metabolism of Apixaban can be decreased when combined with Colchicine. |
Cefaclor | Cefaclor The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefaclor. |
Cefadroxil | Cefadroxil The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefadroxil. |
Cefazolin Injection | Cefazolin Injection The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefazolin. |
Cephalexin | Cephalexin The therapeutic efficacy of Apixaban can be decreased when used in combination with Cephalexin. |
Cefoxitin Injection | Cefoxitin Injection The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefoxitin. |
Dacarbazine | Dacarbazine The risk or severity of bleeding can be increased when Apixaban is combined with Dacarbazine. |
Cefotaxime Injection | Cefotaxime Injection The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefotaxime. |
Ketoconazole | Ketoconazole The metabolism of Apixaban can be decreased when combined with Ketoconazole. |
Thiotepa Injection | Thiotepa Injection The risk or severity of bleeding can be increased when Apixaban is combined with Thiotepa. |
Vincristine Injection | Vincristine Injection The metabolism of Vincristine can be decreased when combined with Apixaban. |
Dipyridamole | Dipyridamole Apixaban may increase the anticoagulant activities of Dipyridamole. |
Vinblastine | Vinblastine The serum concentration of Apixaban can be increased when it is combined with Vinblastine. |
Hydroxyzine | Hydroxyzine The metabolism of Apixaban can be decreased when combined with Hydroxyzine. |
Aspirin | Aspirin Apixaban may increase the anticoagulant activities of Acetylsalicylic acid. |
Salsalate | Salsalate The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Apixaban. |
Chlorambucil | Chlorambucil The risk or severity of bleeding can be increased when Apixaban is combined with Chlorambucil. |
Alprazolam | Alprazolam The metabolism of Apixaban can be decreased when combined with Alprazolam. |
Triazolam | Triazolam The metabolism of Apixaban can be decreased when combined with Triazolam. |
Trimethoprim | Trimethoprim The metabolism of Apixaban can be decreased when combined with Trimethoprim. |
Diltiazem | Diltiazem The metabolism of Apixaban can be decreased when combined with Diltiazem. |
Nifedipine | Nifedipine The metabolism of Apixaban can be decreased when combined with Nifedipine. |
Timolol | Timolol The metabolism of Apixaban can be decreased when combined with Timolol. |
Verapamil | Verapamil The metabolism of Apixaban can be decreased when combined with Verapamil. |
Cisplatin Injection | Cisplatin Injection The metabolism of Apixaban can be decreased when combined with Cisplatin. |
Diflunisal | Diflunisal The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Apixaban. |
Piroxicam | Piroxicam The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Apixaban. |
Streptozocin | Streptozocin The risk or severity of bleeding can be increased when Apixaban is combined with Streptozocin. |
Etoposide | Etoposide The metabolism of Apixaban can be decreased when combined with Etoposide. |
Glyburide | Glyburide The metabolism of Apixaban can be decreased when combined with Glyburide. |
Glipizide | Glipizide The metabolism of Apixaban can be decreased when combined with Glipizide. |
Pentoxifylline | Pentoxifylline The risk or severity of adverse effects can be increased when Pentoxifylline is combined with Apixaban. |
Pentamidine Injection | Pentamidine Injection The metabolism of Apixaban can be decreased when combined with Pentamidine. |
Ceftriaxone Injection | Ceftriaxone Injection The therapeutic efficacy of Apixaban can be decreased when used in combination with Ceftriaxone. |
Labetalol | Labetalol The metabolism of Apixaban can be decreased when combined with Labetalol. |
Gemfibrozil | Gemfibrozil The metabolism of Apixaban can be decreased when combined with Gemfibrozil. |
Ceftazidime Injection | Ceftazidime Injection The therapeutic efficacy of Apixaban can be decreased when used in combination with Ceftazidime. |
Ketoprofen | Ketoprofen The risk or severity of bleeding and hemorrhage can be increased when Ketoprofen is combined with Apixaban. |
Cefotetan Injection | Cefotetan Injection The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefotetan. |
Pimozide | Pimozide The metabolism of Pimozide can be decreased when combined with Apixaban. |
Flurbiprofen | Flurbiprofen The risk or severity of bleeding and hemorrhage can be increased when Flurbiprofen is combined with Apixaban. |
Amiodarone | Amiodarone The metabolism of Amiodarone can be decreased when combined with Apixaban. |
Buspirone | Buspirone The metabolism of Apixaban can be decreased when combined with Buspirone. |
Lovastatin | Lovastatin The metabolism of Lovastatin can be decreased when combined with Apixaban. |
Ciprofloxacin | Ciprofloxacin The metabolism of Apixaban can be decreased when combined with Ciprofloxacin. |
Mesalamine | Mesalamine The risk or severity of bleeding and hemorrhage can be increased when Mesalazine is combined with Apixaban. |
Diclofenac | Diclofenac The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Apixaban. |
Fluoxetine | Fluoxetine The risk or severity of hemorrhage can be increased when Fluoxetine is combined with Apixaban. |
Interferon Alfa-2b Injection | Interferon Alfa-2b Injection The risk or severity of bleeding can be increased when Apixaban is combined with Interferon alfa-2b. |
Cefixime | Cefixime The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefixime. |
Clozapine | Clozapine The metabolism of Apixaban can be decreased when combined with Clozapine. |
Idarubicin | Idarubicin The risk or severity of bleeding can be increased when Apixaban is combined with Idarubicin. |
Fludarabine Injection | Fludarabine Injection The risk or severity of bleeding can be increased when Apixaban is combined with Fludarabine. |
Pentostatin Injection | Pentostatin Injection The risk or severity of bleeding can be increased when Apixaban is combined with Pentostatin. |
Clarithromycin | Clarithromycin The metabolism of Apixaban can be decreased when combined with Clarithromycin. |
Etodolac | Etodolac The risk or severity of bleeding and hemorrhage can be increased when Etodolac is combined with Apixaban. |
Felodipine | Felodipine The metabolism of Felodipine can be decreased when combined with Apixaban. |
Nabumetone | Nabumetone The risk or severity of bleeding and hemorrhage can be increased when Nabumetone is combined with Apixaban. |
Pravastatin | Pravastatin Pravastatin may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Simvastatin | Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Apixaban. |
Teniposide Injection | Teniposide Injection The metabolism of Apixaban can be decreased when combined with Teniposide. |
Itraconazole | Itraconazole The metabolism of Apixaban can be decreased when combined with Itraconazole. |
Oxaprozin | Oxaprozin The risk or severity of bleeding and hemorrhage can be increased when Oxaprozin is combined with Apixaban. |
Atovaquone | Atovaquone The metabolism of Apixaban can be decreased when combined with Atovaquone. |
Rifabutin | Rifabutin The metabolism of Apixaban can be increased when combined with Rifabutin. |
Bisoprolol | Bisoprolol The serum concentration of Apixaban can be increased when it is combined with Bisoprolol. |
Zolpidem | Zolpidem The metabolism of Apixaban can be decreased when combined with Zolpidem. |
Doxazosin | Doxazosin The metabolism of Apixaban can be decreased when combined with Doxazosin. |
Omeprazole | Omeprazole Omeprazole may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Cisapride | Cisapride The metabolism of Apixaban can be decreased when combined with Cisapride. |
Fluvastatin | Fluvastatin The metabolism of Apixaban can be decreased when combined with Fluvastatin. |
Venlafaxine | Venlafaxine Venlafaxine may increase the antiplatelet activities of Apixaban. |
Fluvoxamine | Fluvoxamine The risk or severity of hemorrhage can be increased when Fluvoxamine is combined with Apixaban. |
Nefazodone | Nefazodone The risk or severity of hemorrhage can be increased when Nefazodone is combined with Apixaban. |
Losartan | Losartan The metabolism of Apixaban can be decreased when combined with Losartan. |
Vinorelbine Injection | Vinorelbine Injection The risk or severity of bleeding can be increased when Apixaban is combined with Vinorelbine. |
Carboplatin Injection | Carboplatin Injection The risk or severity of bleeding can be increased when Apixaban is combined with Carboplatin. |
Lansoprazole | Lansoprazole The metabolism of Apixaban can be decreased when combined with Lansoprazole. |
Ifosfamide Injection | Ifosfamide Injection The risk or severity of bleeding can be increased when Ifosfamide is combined with Apixaban. |
Nicardipine | Nicardipine The metabolism of Apixaban can be decreased when combined with Nicardipine. |
Bupropion | Bupropion The metabolism of Apixaban can be decreased when combined with Bupropion. |
Ticlopidine | Ticlopidine The risk or severity of adverse effects can be increased when Ticlopidine is combined with Apixaban. |
Saquinavir | Saquinavir The metabolism of Saquinavir can be decreased when combined with Apixaban. |
Dalteparin Injection | Dalteparin Injection Apixaban may increase the anticoagulant activities of Dalteparin. |
Nisoldipine | Nisoldipine The metabolism of Apixaban can be decreased when combined with Nisoldipine. |
Glimepiride | Glimepiride The metabolism of Apixaban can be decreased when combined with Glimepiride. |
Anastrozole | Anastrozole The metabolism of Apixaban can be decreased when combined with Anastrozole. |
Gemcitabine Injection | Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Apixaban. |
Indinavir | Indinavir The metabolism of Apixaban can be decreased when combined with Indinavir. |
Ritonavir | Ritonavir The serum concentration of Apixaban can be increased when it is combined with Ritonavir. |
Docetaxel Injection | Docetaxel Injection The metabolism of Apixaban can be decreased when combined with Docetaxel. |
Clomipramine | Clomipramine The metabolism of Clomipramine can be decreased when combined with Apixaban. |
Zafirlukast | Zafirlukast The metabolism of Apixaban can be decreased when combined with Zafirlukast. |
Topiramate | Topiramate The metabolism of Apixaban can be decreased when combined with Topiramate. |
Zileuton | Zileuton The metabolism of Apixaban can be decreased when combined with Zileuton. |
Valsartan | Valsartan The metabolism of Apixaban can be decreased when combined with Valsartan. |
Donepezil | Donepezil The metabolism of Apixaban can be decreased when combined with Donepezil. |
Nelfinavir | Nelfinavir The metabolism of Apixaban can be decreased when combined with Nelfinavir. |
Fexofenadine | Fexofenadine The serum concentration of Apixaban can be increased when it is combined with Fexofenadine. |
Azithromycin | Azithromycin The risk or severity of adverse effects can be increased when Azithromycin is combined with Apixaban. |
Loratadine | Loratadine The metabolism of Apixaban can be decreased when combined with Loratadine. |
Carvedilol | Carvedilol The serum concentration of Apixaban can be increased when it is combined with Carvedilol. |
Nilutamide | Nilutamide The metabolism of Apixaban can be decreased when combined with Nilutamide. |
Flutamide | Flutamide The metabolism of Apixaban can be decreased when combined with Flutamide. |
Selegiline | Selegiline The metabolism of Apixaban can be decreased when combined with Selegiline. |
Bicalutamide | Bicalutamide The metabolism of Apixaban can be decreased when combined with Bicalutamide. |
Sertraline | Sertraline The risk or severity of bleeding can be increased when Sertraline is combined with Apixaban. |
Propafenone | Propafenone The serum concentration of Apixaban can be increased when it is combined with Propafenone. |
Letrozole | Letrozole The metabolism of Apixaban can be decreased when combined with Letrozole. |
Raloxifene | Raloxifene The metabolism of Apixaban can be decreased when combined with Raloxifene. |
Irbesartan | Irbesartan The metabolism of Apixaban can be decreased when combined with Irbesartan. |
Finasteride | Finasteride The metabolism of Apixaban can be decreased when combined with Finasteride. |
Quetiapine | Quetiapine The metabolism of Apixaban can be decreased when combined with Quetiapine. |
Cefepime Injection | Cefepime Injection The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefepime. |
Cefprozil | Cefprozil The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefprozil. |
Cefpodoxime | Cefpodoxime The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefpodoxime. |
Paroxetine | Paroxetine The risk or severity of hemorrhage can be increased when Paroxetine is combined with Apixaban. |
Tolcapone | Tolcapone The metabolism of Apixaban can be decreased when combined with Tolcapone. |
Citalopram | Citalopram The risk or severity of hemorrhage can be increased when Citalopram is combined with Apixaban. |
Capecitabine | Capecitabine The metabolism of Apixaban can be decreased when combined with Capecitabine. |
Efavirenz | Efavirenz The metabolism of Apixaban can be increased when combined with Efavirenz. |
Sildenafil | Sildenafil The risk or severity of hemorrhage can be increased when Apixaban is combined with Sildenafil. |
Pioglitazone | Pioglitazone The metabolism of Apixaban can be decreased when combined with Pioglitazone. |
Celecoxib | Celecoxib The risk or severity of bleeding and hemorrhage can be increased when Celecoxib is combined with Apixaban. |
Rosiglitazone | Rosiglitazone The metabolism of Apixaban can be decreased when combined with Rosiglitazone. |
Tolterodine | Tolterodine The metabolism of Apixaban can be decreased when combined with Tolterodine. |
Thalidomide | Thalidomide The metabolism of Apixaban can be increased when combined with Thalidomide. |
Balsalazide | Balsalazide The risk or severity of bleeding and hemorrhage can be increased when Balsalazide is combined with Apixaban. |
Nateglinide | Nateglinide The metabolism of Apixaban can be decreased when combined with Nateglinide. |
Rabeprazole | Rabeprazole Rabeprazole may decrease the excretion rate of Apixaban which could result in a higher serum level. |
Terbinafine | Terbinafine The metabolism of Apixaban can be decreased when combined with Terbinafine. |
Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists