Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

100% Pure Mangosteen Juice Ingredients & Drug Interactions

by EB Earth's Bounty

100% Pure Mangosteen Juice label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking 100% Pure Mangosteen Juice against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

100% Pure Mangosteen Juice is a dietary supplement by EB Earth's Bounty with 2 active ingredients. Its ingredients are commonly taken for antioxidant support, anti-inflammatory support, immune support.Based on those ingredients, 125 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Organic Mangosteen (Garcinia mangostana) fruit juice. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against 100% Pure Mangosteen Juice by EB Earth's Bounty

Ask about any prescription or over-the-counter medication and we check it for interactions with 100% Pure Mangosteen Juice by EB Earth's Bounty — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of 100% Pure Mangosteen Juice by EB Earth's Bounty

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product is 100% pure mangosteen fruit juice. That's the whole ingredient list — it's organic mangosteen juice and nothing else.

There's one active ingredient (the mangosteen fruit juice itself), and no inactive fillers or binders to worry about.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: antioxidant superfood and free radical protection.
  • We looked for evidence on: oxidative stress, general wellness, cellular health, immune support.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence is mixed. Mangosteen is possibly effective for periodontitis (gum disease), though the data isn't robust.

For androgenic alopecia (male-pattern baldness), Alzheimer's disease, and atopic dermatitis (eczema), the evidence we hold isn't established well enough to rate it.

The evidence, ingredient by ingredient Mangosteen

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Mangosteen is generally well tolerated when used as food, but long-term safety of concentrated supplements like this hasn't been well studied. In trials, people taking mangosteen extract reported mild tiredness, headache, dizziness, and gastrointestinal symptoms — constipation, nausea, diarrhea, abdominal bloating — though it's unclear whether mangosteen caused these or something else did.

It's also reported dry throat, cough, and flu-like symptoms in some cases. The safety data advises against using mangosteen supplements during pregnancy and breastfeeding because there isn't enough information to know it's safe.

Side effects, ingredient by ingredient Mangosteen

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Mangosteen.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 125 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product if you take blood thinners or antiplatelet drugs (like warfarin, clopidogrel, or aspirin) — the risk of bleeding is a Moderate concern. You should also mention it to your pharmacist if you're on donepezil (Aricept), since mangosteen may raise its levels in the brain.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood thinners or donepezil, check with us before starting this product. Mangosteen juice may be worth a try for gum disease if you're looking for a complementary option, but the evidence for other uses isn't solid.

Talk to your pharmacist about your specific medications first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about 100% Pure Mangosteen Juice, straight from the product label.

Brand EB Earth's Bounty
Net contents 16 fl. Oz.; 473 mL
Market status On market
Date entered into DSLD Nov 21, 2012
DSLD ID 15117
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for 100% Pure Mangosteen Juice by EB Earth's Bounty, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 fl. Oz.
Maximum serving Sizes:
1 fl. Oz.
Servings per container
31
IngredientAmount% DV
Calories5 {Calories}--
Total Carbohydrates1 g--
Sugar1 g--
Calories from Fat0 {Calories}--
Organic Mangosteen (Garcinia mangostana) fruit juice30000 mg--

Other ingredients: Organic Mangosteen juice

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Certified Organic

Certified Organic by Organic Certifiers

No preservatives, artificial flavors or colors of any kind.

Vegetarian & Vegan

General Statements

from Thailand

Mangosteen fruit is found in Thailand and surrounding areas. It is prized for its' unique health benefits. Mangosteen fruit contains xanthones and other unique anti-oxidants that help combat free radical cell damage caused by stress, illness and other factors. Earth's Bounty 100% Pure Mangosteen starts with fresh Mangosteen using only the valuable fruit, never the pit or seeds. From Mother Nature to you... Satsifaction Guaranteed.

Dietary supplement only.

Formula

Antioxidant Superfood

FDA Statement of Identity

Liquid Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.

General

Product #2305 PRM4

Seals/Symbols

Please Recycle

K KOSHER USDA ORGANIC

Suggested/Recommended/Usage/Directions

SUGGESTED USE: Take 1/2-1 fl. oz. (15-30ml) daily.

Shake well before using. Best served cold.

Precautions

See your Health Care Professional for use with any medical condition.

Do not use if safety seal at top is broken or missing.

Storage

May be stored at room temperature before opening. Refrigerate after opening.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

100% Pure Mangosteen Juice by EB Earth's Bounty label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

100% Pure Mangosteen Juice label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in 100% Pure Mangosteen Juice by EB Earth's Bounty

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.5 fl. Oz. Dosage formLiquid Servings per container31 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

1 g per serving

Organic Mangosteen (Garcinia mangostana) fruit juice

Interacts with
125 drugs
30000 mg per serving

Mangosteen is a tropical fruit whose rind is rich in plant compounds called xanthones that act as antioxidants. While it is popular in juices and supp...

Organic Mangosteen (Garcinia mangostana) fruit juice monograph & interactions

Other (inactive) ingredients: Organic Mangosteen juice. These complete the product’s ingredient list but are not active constituents.

Interaction report

100% Pure Mangosteen Juice by EB Earth's Bounty Drug Interactions

Want to check YOUR meds against 100% Pure Mangosteen Juice?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
125Drugs
122 Moderate 3 Minor

Ingredients driving the most interactions

Organic Mangosteen (Garcinia mangostana) fruit juice 125

Individual Drug Interactions

The ingredients in 100% Pure Mangosteen Juice interact with 125 drugs. Click any drug to see the details.

1 of the 2 ingredients in 100% Pure Mangosteen Juice interact with drugs. Each result below shows which ingredient is responsible. Organic Mangosteen (Garcinia mangostana) fruit juice

Each ingredient & the kinds of drugs it affects

For each ingredient in 100% Pure Mangosteen Juice with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Organic Mangosteen (Garcinia mangostana) fruit juice2 drug types · 125 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of mangosteen with anticoagulant or antiplatelet drugs may increase the risk of bleeding.
In vitro and animal research shows that gamma-mangostin, a constituent of mangosteen, is a potent and competitive antagonist of the serotonin 2A (5-HT2A) receptor. Antagonism of the 5-HT2A receptor is believed to reduce platelet aggregation.

Likelihood Possible Evidence D
Donepezil (Aricept)

Theoretically, concomitant use of mangosteen with donepezil might increase the effects of donepezil.
Animal research shows that concomitant use of an aqueous extract of mangosteen pericarp with donepezil increases brain concentrations of donepezil at 4 hours by 64% without associated effects on systemic exposure.

Likelihood Possible Evidence D
Organic Mangosteen (Garcinia mangostana) fruit juice full monograph & interactions
The maker

Brand information

Manufacturer and brand details for 100% Pure Mangosteen Juice, from the product label.

EB Earth's Bounty

See all EB Earth's Bounty products
Name
Earth's Bounty
City
Vancouver
State
WA
ZipCode
98682
Phone Number
800-736-5609
Web Address
www.earthsbounty.com
Pharmacist Counseling Corner

100% Pure Mangosteen Juice by EB Earth's Bounty: Common Questions

Does 100% Pure Mangosteen Juice by EB Earth's Bounty interact with any medications?
Yes. Based on its ingredients, 100% Pure Mangosteen Juice has a known interaction with 125 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
100% Pure Mangosteen Juice contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant or breastfeeding?
The safety data advises against it. There isn't enough information to know whether this product is safe for you or your baby during pregnancy or breastfeeding. Talk with your doctor or pharmacist about what's right for your situation.
Does this actually work for anything?
Mangosteen is possibly effective for periodontitis — a type of gum disease — though the evidence isn't overwhelming. For baldness, eczema, or Alzheimer's disease, we don't have solid evidence to support it.
What side effects should I watch for?
In trials, people reported mild tiredness, headache, dizziness, nausea, constipation, diarrhea, abdominal bloating, cough, and dry throat. It's not certain mangosteen caused all of these — people may have experienced them for other reasons — but it's worth knowing about.
Is this safe to use long-term?
Mangosteen is generally considered safe as food, but the long-term safety of concentrated supplements like juice hasn't been well studied, so we don't have solid data on that.
Are there any fillers or other ingredients in here?
No. This is 100% pure organic mangosteen juice — nothing else added.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if 100% Pure Mangosteen Juice is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

100% Pure Mangosteen Juice label
Go deeper

The Full Monographs Behind 100% Pure Mangosteen Juice’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Mangosteen

Interacts with 125 drugs

Mangosteen is a tropical fruit whose rind is rich in plant compounds called xanthones that act as antioxidants. While it is popular in juices and supplements for inflammation, immune support...

Read the full Mangosteen monograph →
Sources

Sources & How We Checked

100% Pure Mangosteen Juice's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Mangosteen 6 references
  1. Chairungsrilerd N, Furukawa K, Ohta T, et al. Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med 1996;62:471-2.
  2. Wong LP, Klemmer PJ. Severe lactic acidosis associated with juice of the mangosteen fruit Garcinia mangostana. Am J Kidney Dis 2008;51:829-33. PubMed
  3. Furukawa, K., Chairungsrilerd, N., Ohta, T., Nozoe, S., and Ohizumi, Y. [Novel types of receptor antagonists from the medicinal plant Garcinia mangostana]. Nippon Yakurigaku Zasshi 1997;110 Suppl 1:153P-158P. PubMed
  4. Chairungsrilerd, N., Furukawa, K., Tadano, T., Kisara, K., and Ohizumi, Y. Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice. Br J Pharmacol. 1998
  5. Suthammarak W, Numpraphrut P, Charoensakdi R, et al. Antioxidant-enhancing property of the polar fraction of mangosteen pericarp extract and evaluation of its safety in humans. Oxid Med Cell Longev 2016;2016:1293036. PubMed
  6. Bae M, Han SY, Kim ES, et al. Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice. Molecules 2021;26(17):5246. PubMed

See these in context on the Mangosteen monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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