Glutathione Interactions Overview

Additional Details

Is Glutathione Safe? Are There Any Warnings?

Glutathione is a tripeptide made from three amino acids: glycine, cysteine, and glutamic acid. It plays various roles in the body, including DNA synthesis, immune system function, and protection against oxidative damage. When taken orally or by inhalation in appropriate doses, glutathione is generally considered safe. However, it's important to note that there is insufficient reliable information available about its use during pregnancy and lactation, so it's best to avoid using it during these periods.

How Is Glutathione Thought to Work? What Is the Mechanism of Action?

Glutathione, primarily synthesized in the liver, is involved in multiple essential functions in the body. Here's a breakdown of its mechanism of action:

• Anti-cancer effects: Preliminary evidence suggests that glutathione intake from fruits and vegetables may be associated with a reduced risk of certain cancers, such as pharyngeal cancer.
• Anti-viral effects: Glutathione may inhibit the activity of enzymes that help flu viruses colonize cells in the mouth and throat. Animal studies have shown promising results, but more research is needed in humans.
• Antioxidant effects: Glutathione is known for its antioxidant properties, helping to reduce the production of harmful reactive oxygen species. It can protect cells against oxidative damage caused by these free radicals.
• Dermatologic effects: There is interest in using glutathione for skin lightening. Some studies have shown potential benefits in reducing melanin production and lightening the skin.
• Neuroprotective effects: Glutathione is synthesized by neurons and glial cells in the brain and has been suggested to protect against toxins and oxidative stress. It may play a role in neuroprotection, although more research is needed to fully understand its impact.

Pharmacokinetics

Glutathione is present in various foods, but oral intake does not seem to significantly increase its levels in the body. This suggests that oral glutathione might be inactivated by enzymes in the gut. Intravenous administration of glutathione has shown to increase plasma levels, but the effects are temporary. More research is being conducted to explore the use of glutathione precursors to enhance its levels in the body. The metabolism and absorption of glutathione are still not fully understood, and further studies are needed to investigate its pharmacokinetics.

Interaction Overview

There are currently no known interactions between glutathione and drugs or supplements. However, it's always a good idea to consult with a healthcare professional if you are taking any medications or other supplements to ensure there are no potential interactions.

Common Side Effects To Watch For

Glutathione is generally well tolerated. However, there have been reports of bronchoconstriction and shortness of breath when it is inhaled. It's important to monitor for any adverse effects and seek medical attention if serious symptoms occur.

Are Supplements Standardized?

There is insufficient reliable information available about the standardization of glutathione supplements. It is advisable to choose reputable brands and consult product labels for information on quality and standardized content.

Drugs that interact with Glutathione