Interactions on record — worth a quick check against your medications. Based on 5 of 7 ingredients. Check your meds →
Dietary supplement

All In One Omega with Vitamin D3 Ingredients & Drug Interactions

by Puritan's Pride

All In One Omega with Vitamin D3 label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking All In One Omega with Vitamin D3 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

All In One Omega with Vitamin D3 is a dietary supplement by Puritan's Pride with 7 active ingredients. Its ingredients are commonly taken for antioxidant support, skin health and aging, eye health.Based on those ingredients, 997 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D, Astaxanthin, Ester Omega . Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against All In One Omega with Vitamin D3 by Puritan's Pride

Ask about any prescription or over-the-counter medication and we check it for interactions with All In One Omega with Vitamin D3 by Puritan's Pride — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of All In One Omega with Vitamin D3 by Puritan's Pride

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 11 of its 11 active ingredients.
  • “Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (500 mg) without saying how much of each component you get.
  • “Ester Omega ” is listed as a grouped ingredient — the label gives one combined amount (2,400 mg) without saying how much of each component you get.

This product contains 11 ingredients, of which the active components are the omega fatty acids (omega-3, omega-5, omega-6, omega-7, and omega-9), vitamin D, and astaxanthin. The omega fatty acids come from fish oil and are the heart of an omega supplement—eicosapentaenoic acid and docosahexaenoic acid are the two main omega-3s.

Vitamin D is included as a separate nutrient to support bone and immune health. Astaxanthin is a carotenoid antioxidant derived from algae.

The remaining 7 inactive ingredients—gelatin, glycerin, clary sage oil, corn oil, mixed natural tocopherols, rosemary extract, and thyme oil—are fillers, binders, and preservatives that keep the softgel stable.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Familial hypophosphatemia — rated "Effective" (Vitamin D) (Natural Medicines).
  • On file: Osteomalacia — rated "Effective" (Vitamin D) (Natural Medicines).
  • On file: Renal osteodystrophy — rated "Effective" (Vitamin D) (Natural Medicines).
  • On file: Rickets — rated "Effective" (Vitamin D) (Natural Medicines).
  • On file: Hypoparathyroidism — rated "Effective" (Vitamin D) (Natural Medicines).

Vitamin D is effective for specific medical conditions: familial hypophosphatemia, osteomalacia (soft bones from vitamin D deficiency), renal osteodystrophy (bone disease related to kidney problems), rickets, and hypoparathyroidism. For astaxanthin, the evidence is insufficient to rate its use for age-related cognitive decline, age-related macular degeneration, aging skin, Alzheimer disease, athletic performance, or carpal tunnel syndrome.

Omega-6 fatty acids are rated possibly ineffective for hyperlipidemia (high cholesterol), child development, cardiovascular disease, and multiple sclerosis. Evidence for the other omega fatty acids in this product is not established in our data.

The evidence, ingredient by ingredient Astaxanthin Vitamin D Omega-6 Fatty Acids Fish Oil Docosahexaenoic Acid (dha)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D is generally safe at recommended doses, but very high doses over long periods can cause toxicity—symptoms include high blood calcium levels, weak bones in adults, and stunted growth in children. During pregnancy, vitamin D is likely safe at recommended amounts, though it should be used only under a doctor's guidance; it's likely safe while breastfeeding.

Astaxanthin is generally well tolerated in studies, but long-term safety data are limited—it should be avoided during pregnancy and while breastfeeding due to insufficient safety data. The most common side effects from astaxanthin are abdominal pain, diarrhea, and red-colored stool; at higher doses (40 mg daily), severe stomach pain has been reported.

Omega-6 fatty acids from diet are fine, but the safety of concentrated supplements is not well established; the balance between omega-6 and omega-3 intake matters for heart health.

Side effects, ingredient by ingredient Astaxanthin Vitamin D Omega-6 Fatty Acids Fish Oil Docosahexaenoic Acid (dha)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Vitamin D, Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 744 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you take any of these: heart rhythm medications like verapamil, diltiazem, or digoxin; the cholesterol drug atorvastatin; thiazide diuretics for blood pressure; the psoriasis medication calcipotriene; or any drugs broken down by the liver enzymes CYP3A4 or CYP2B6. The vitamin D and astaxanthin in this product may affect how these work.

We could not check interaction data for most of the omega fatty acids in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product is useful if your doctor has recommended vitamin D supplementation for bone health or a vitamin D deficiency. Because vitamin D interacts with several heart and blood pressure medications and can cause problems at high doses, anyone taking cardiac drugs, thiazide diuretics, or atorvastatin should check with their pharmacist before starting.

Talk to your pharmacist about your medications and which ingredients in this product might affect them.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about All In One Omega with Vitamin D3, straight from the product label.

Brand Puritan's Pride
Barcode (UPC) 025077500734
Net contents 60 Rapid Release Softgel(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 286438
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for All In One Omega with Vitamin D3 by Puritan's Pride, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
UPC/BARCODE
025077500734
IngredientAmount% DV
Eicosapentaenoic Acid202 mg--
Docosahexaenoic Acid180 mg--
Cholesterol25 mg8%
Total Fat2.5 Gram(s)3%
Polyunsaturated Fat0.5 Gram(s)--
Monounsaturated Fat1 Gram(s)--
Astaxanthin20 mcg--
Saturated Fat0.5 Gram(s)3%
Omega-3 Fatty Acids500 mg--
Calories25 Calorie(s)--
Vitamin D5 mcg25%
Other Omega-3 Fatty Acids77 mg--
Omega-6 Fatty Acids48 mg--
Omega-9 Fatty Acids384 mg--
Ester Omega 2400 mg--
Omega-5 Fatty Acids1.9 mg--
Omega-7 Fatty Acids192 mg--

Other ingredients: Gelatin, Glycerin, Clary Sage Oil, Corn Oil, Mixed Natural Tocopherols, Rosemary Extract, Thyme Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Contains fish (salmon) ingredients.

Warning: If you are pregnant, nursing, taking any medications, including blood thinners, planning any medical or surgical procedure or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Suggested/Recommended/Usage/Directions

Directions: For adults, take two (2) softgels daily, preferably with a meal.

Storage

Store at room temperature.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

To reorder item #50073 www.puritan.com 1-800-645-1030

Brand IP Statement(s)

Copyright 2019 Puritan's Pride, Inc.

Seals/Symbols

QA Quality Assured

Formula

All in one Omega containing Omega 3,5,6,7 & 9

Ester-Omega

Formulation

Purified to eliminate mercury

Supports heart health

USA 3004329138 EEC

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

All In One Omega with Vitamin D3 by Puritan's Pride label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

All In One Omega with Vitamin D3 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in All In One Omega with Vitamin D3 by Puritan's Pride

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Astaxanthin

Interacts with
671 drugs
20 mcg per serving

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Vitamin D

Interacts with
715 drugs
5 mcg per serving Form: Cholecalciferol, Vitamin D3

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D monograph & interactions

Omega-6 Fatty Acids

No known
interactions
48 mg per serving

Omega-6 fatty acids are essential fats your body needs but cannot make on its own, and most people get plenty from everyday foods like vegetable oils,...

Omega-6 Fatty Acids monograph & interactions

Omega-9 Fatty Acids

384 mg per serving

Ester Omega

Interacts with
327 drugs
2400 mg per serving Form: Wild Alaskan Salmon Oil

Fish oil provides omega-3 fatty acids (EPA and DHA) that are best known for lowering high triglyceride levels. The evidence for other heart and health...

Ester Omega monograph & interactions

Omega-5 Fatty Acids

1.9 mg per serving

Omega-7 Fatty Acids

192 mg per serving

Other (inactive) ingredients: Gelatin, Glycerin, Clary Sage Oil, Corn Oil, Mixed Natural Tocopherols, Rosemary Extract, Thyme Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

All In One Omega with Vitamin D3 by Puritan's Pride Drug Interactions

Want to check YOUR meds against All In One Omega with Vitamin D3?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
997Drugs
994 Moderate 3 Minor

Ingredients driving the most interactions

Vitamin D 715
Astaxanthin 671
Ester Omega 327

Individual Drug Interactions

The ingredients in All In One Omega with Vitamin D3 interact with 997 drugs. Click any drug to see the details.

3 of the 7 ingredients in All In One Omega with Vitamin D3 interact with drugs. Each result below shows which ingredient is responsible. Vitamin D Astaxanthin Ester Omega

Each ingredient & the kinds of drugs it affects

For each ingredient in All In One Omega with Vitamin D3 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D8 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D full monograph & interactions

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions

Ester Omega 9 drug types · 327 drugs

Antihypertensive Drugs

Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.
Clinical evidence indicates that fish oils can modestly lower blood pressure and might have additive effects in patients treated with antihypertensives.

Likelihood Probable Evidence B
Contraceptive Drugs

Theoretically, taking fish oil with contraceptive drugs might decrease the triglyceride-lowering effects of fish oil.
There is some evidence that contraceptive drugs might interfere with the triglyceride lowering effects of fish oils.

Likelihood Probable Evidence B
Cyclosporine (Neoral, Sandimmune)

Taking fish oil with cyclosporine might increase levels and adverse effects of cyclosporine.
In kidney transplant recipients on a general immunosuppressive regimen, taking omega-3 fatty acids daily seems to increase peak blood levels of cyclosporine when compared with placebo. This increase was as much as 20% after one month. However, the area under the curve was not significantly affected.

Likelihood Probable Evidence B
Orlistat (Xenical, Alli)

Theoretically, taking fish oil with orlistat might decrease the absorption of fish oil fatty acids.
Orlistat binds lipase in the gastrointestinal tract and reduces fat absorption. Theoretically, taking fish oil with orlistat might decrease absorption of fish oil fatty acids. To avoid this potential interaction, recommend separating administration of orlistat and fish oil by at least 2 hours.

Likelihood Probable Evidence D
Sirolimus (Rapamune)

Taking fish oil with sirolimus might increase levels and adverse effects of sirolimus.
Pharmacokinetic research shows that omega-3 fatty acids increase exposure to sirolimus in kidney transplant patients on a calcineurin inhibitor-free immunosuppressive regimen. A 25% dose reduction in sirolimus was required to keep patients within the expected trough-concentration window. Researchers hypothesize that this may be due to inhibition of cytochrome P450 3A4 (CYP3A4) by fish oil, although this has not been confirmed in clinical research.

Likelihood Probable Evidence B
Tacrolimus (Prograf)

Taking fish oil with tacrolimus might increase levels and adverse effects of tacrolimus.
In a small group of patients, taking fish oil 2.6 grams (Omacor) daily for 4 weeks increased the 8-hour area under the curve of tacrolimus by 25% when compared with baseline. Peak levels were increased by approximately 22%. Researchers hypothesize that this may be due either to an increase in bioavailability or to inhibition of cytochrome P450 3A4 (CYP3A4) by fish oil, although this has not been confirmed in clinical research.

Likelihood Probable Evidence B
Anticoagulant/Antiplatelet Drugs

Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, evidence is conflicting.
While fish oil may not be a potent inhibitor of platelet function, high doses of fish oil might have antiplatelet effects. Theoretically, concomitant use of fish oil with anticoagulant or antiplatelet drugs may increase the risk of bleeding. However, the most rigorous research shows that short-term doses of fish oil 10 grams daily or long-term doses of 1.5 grams daily for up to 52 weeks does not increase the risk of bleeding or affect coagulation parameters in chronically ill and vulnerable patients. Other controlled research shows that fish oil does not affect platelet function or increase the risk of bleeding. Some research even suggests that perioperative fish oil use decreases bleeding risk. Some research suggests fish oil does not have additive antiplatelet effects when combined with aspirin, but other clinical evidence suggests that adding fish oil to low-dose aspirin treatment increases antiplatelet effects in patients who are aspirin-resistant. Also, some clinical research seems to show that fish oil has additive antiplatelet effects when used with aspirin and clopidogrel compared to aspirin and clopidogrel alone.

Likelihood Unlikely Evidence B
Platinum Agents

Theoretically, taking fish oil with platinum agents can cause resistance to platinum agents, potentially decreasing their effectiveness.
Platinum-induced fatty acids (PIFAs) are fatty acids secreted from human and mouse stem cells when exposed to platinum-based chemotherapy. Animal research suggests that PIFAs cause resistance to chemotherapy by stimulating lysophospholipid production in the spleen, which interferes with the DNA damage caused by certain chemotherapy drugs. One PIFA, known as 16:4(n-3), has been found in both raw fish and some commercially available fish oil products. Mackerel and herring have high PIFA concentrations, while salmon and tuna have low PIFA concentrations. Levels of PIFA in commercial fish oil products ranged from 0.2- 5.7 microMol. Animal research shows that PIFA-containing fish oil products cause resistance to cisplatin, fluorouracil, irinotecan, and oxaliplatin. It is unclear if all commercially available fish oil products contain PIFAs. Additionally, it is argued that levels of PIFA found in some fish oil products are too low to be of clinical concern. Furthermore, a lack of chemotherapy resistance in countries with high fish intake, such as Greenland, Japan, and Norway, suggest that this interaction may not be clinically significant.

Likelihood Unlikely Evidence D
Warfarin (Coumadin)

Fish oil may have antiplatelet effects and might increase the risk of bleeding if used with warfarin.
Fish oil has antiplatelet effects at high doses. Case reports show elevated INR in patients taking warfarin and fish oil 1-2 grams daily. However, some clinical research shows that taking fish oil 3-6 grams daily does not significantly increase INR in patients taking warfarin.

Likelihood Unlikely Evidence B
Ester Omega full monograph & interactions
The maker

Brand information

Manufacturer and brand details for All In One Omega with Vitamin D3, from the product label.

Puritan's Pride

See all Puritan's Pride products
Name
Puritan's Pride, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
1-800-645-1030
Web Address
www.puritan.com
Pharmacist Counseling Corner

All In One Omega with Vitamin D3 by Puritan's Pride: Common Questions

Does All In One Omega with Vitamin D3 by Puritan's Pride interact with any medications?
Yes. Based on its ingredients, All In One Omega with Vitamin D3 has a known interaction with 997 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
All In One Omega with Vitamin D3 contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
Vitamin D at recommended doses is likely safe during pregnancy and breastfeeding, but use it only under your doctor's guidance. Astaxanthin is not recommended during pregnancy or breastfeeding—there isn't enough safety data. Talk to your doctor or pharmacist before starting this product if you're pregnant or nursing.
What are the most common side effects?
Astaxanthin, one of the active ingredients, most commonly causes abdominal pain, diarrhea, and red-colored stool. At higher doses, severe stomach pain has been reported in a small number of cases. Vitamin D is generally well tolerated at recommended doses.
Does this really work for anti-aging or cognitive health?
Vitamin D is proven effective for specific bone and mineral disorders. Astaxanthin's effectiveness for anti-aging, cognitive decline, age-related macular degeneration, and other aging-related conditions hasn't been established—we don't have reliable evidence to rate it for those uses.
What is astaxanthin and why is it in here?
Astaxanthin is a carotenoid antioxidant from algae. It's included in this formula as an add-on nutrient, though its proven benefits in humans are limited.
Can I take very high doses of vitamin D for faster results?
No—vitamin D toxicity can happen with excessive doses over time. Very high doses can raise your blood calcium to dangerous levels, weaken your bones, and cause other serious problems. Stick to recommended doses and follow your doctor's guidance.
Are there any fillers or other ingredients I should know about?
The product contains 7 inactive ingredients: gelatin, glycerin, clary sage oil, corn oil, mixed natural tocopherols, rosemary extract, and thyme oil. These are binders, fillers, and preservatives that keep the softgel stable.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if All In One Omega with Vitamin D3 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

All In One Omega with Vitamin D3 label
Go deeper

The Full Monographs Behind All In One Omega with Vitamin D3’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph → Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph → Herb & supplement monograph

Omega-6 Fatty Acids

Omega-6 fatty acids are essential fats your body needs but cannot make on its own, and most people get plenty from everyday foods like vegetable oils, nuts, and seeds. Supplements such as ev...

Read the full Omega-6 Fatty Acids monograph → Herb & supplement monograph

Fish Oil

Interacts with 327 drugs

Fish oil provides omega-3 fatty acids (EPA and DHA) that are best known for lowering high triglyceride levels. The evidence for other heart and health benefits is mixed, and it is generally...

Read the full Fish Oil monograph → Herb & supplement monograph

Docosahexaenoic Acid (dha)

Interacts with 375 drugs

DHA is an omega-3 fatty acid found in fatty fish and algae that is a building block for the brain, nervous system, and eyes. It is widely used and generally well tolerated, with the stronges...

Read the full Docosahexaenoic Acid (dha) monograph →
Sources

Sources & How We Checked

All In One Omega with Vitamin D3's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 255 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
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Docosahexaenoic Acid (dha) 49 references
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Vitamin D 26 references
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Omega-6 Fatty Acids 20 references
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Fish Oil 157 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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