FDA-filed SPL labeling · retrieved through openFDA

Esomeprazole

Esomeprazole is a proton pump inhibitor (acid-blocking medicine) used to treat conditions caused by too much stomach acid, including acid reflux, heartburn, and esophagus damage.

Brand names NexiumNexium 24HRAcid ReducerEsomeprazole strontiumgood sense esomeprazole magnesium +11 more
Drug class ⓘ Proton Pump Inhibitor
Rx/OTC Forms 8 Routes Oral · Intravenous
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 225 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveNov 30, 2024
Clinical labels in scope ⓘ225
AvailabilityRx/OTC
Earliest approval/marketing year ⓘ2001
FDA-listed product records ⓘ650
Boxed warningNone found in compared labels
How we combine label and product data →
✓No current FDA shortage listed · checked Sep 19, 2026 🚨Recall on record · 3
Other forms & routes:
Injection
⭐ Esomeprazole at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Esomeprazole is an effective, well-studied acid-blocker that helps heal the esophagus, relieve heartburn, and protect the stomach — but it works best when used for the right amount of time and not longer than needed. Common side effects are usually mild, but long-term use carries real risks including bone loss, low magnesium, and B12 deficiency. Always take it as directed, tell your pharmacist or doctor about all your other medications, and check in regularly if you've been on it for months or more.
How we write & review this content — our editorial policy →

📖 Esomeprazole: Patient Information Guide

A plain-language walkthrough of Esomeprazole — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Esomeprazole is used to treat and prevent several conditions linked to excess stomach acid:

  • Erosive esophagitis (EE) — healing damage to the esophagus caused by acid reflux, in adults and children as young as 1 month old
  • Maintenance after healing of EE — keeping the esophagus healed long-term in adults
  • GERD symptoms — heartburn and related discomfort in adults and children 1 year and older
  • NSAID-associated stomach ulcer prevention — protecting adults aged 60+ or those with a prior ulcer history who need anti-inflammatory pain medicines
  • H. pylori eradication — as part of a 3-drug regimen to eliminate this bacteria and prevent duodenal ulcer recurrence in adults
  • Pathological hypersecretory conditions — including Zollinger-Ellison syndrome, where the stomach overproduces acid
⚙️How it works▾

Esomeprazole belongs to a class of medicines called proton pump inhibitors (PPIs). It works by targeting and blocking a specific enzyme — called the H+/K+ ATPase — found on the acid-secreting cells lining the stomach. This enzyme is essentially the stomach's acid pump. By shutting it down, esomeprazole blocks the final step of acid production, reducing both baseline acid and the extra surge triggered by food, stress, or other factors.

The drug is activated inside the acid compartment of the stomach's own cells, which means it goes right where the action is. Its acid-lowering effect is dose-related — higher doses produce greater acid reduction — and it works regardless of what's triggering the acid.

💊How it's taken▾

Esomeprazole is taken by mouth, usually once daily for most conditions (twice daily for some complex conditions like Zollinger-Ellison syndrome). It should generally be taken before a meal — food can significantly reduce how much the body absorbs. Treatment length varies by condition: as short as 4 weeks for GERD symptoms, up to 4–8 weeks (sometimes longer) for healing esophagitis, and ongoing for certain acid-overproduction conditions.

  • Swallow capsules whole — don't crush or chew
  • If you can't swallow a capsule, mix the contents with applesauce or use a feeding tube as directed
  • Follow your prescriber's directions exactly — duration and timing matter
🤒Side effects — in detail▾

Most people tolerate esomeprazole well. The most common side effects include:

  • Headache
  • Diarrhea
  • Nausea
  • Gas or bloating
  • Stomach pain
  • Constipation
  • Dry mouth
  • Drowsiness (more common in children)

Serious reactions are less common but important: watch for signs of a severe allergic reaction (swelling, difficulty breathing), sudden changes in urination that could signal kidney problems, severe diarrhea that persists (possible C. diff infection), muscle cramps or irregular heartbeat (low magnesium), or skin and joint changes that could suggest lupus — and contact your doctor right away if any of these occur.

⚠️Warnings & precautions▾
  • Stomach cancer masking: Feeling better doesn't rule out cancer. In adults, your doctor should consider further evaluation if symptoms are atypical or don't fully resolve.
  • Bone fractures: Long-term or high-dose PPI use is linked to higher risk of hip, wrist, and spine fractures — important especially for older adults.
  • Low magnesium: Prolonged use can cause dangerously low magnesium, leading to muscle spasms, irregular heartbeat, and seizures.
  • C. diff diarrhea: PPI therapy may increase the risk of a serious gut infection called Clostridioides difficile — seek care for severe or persistent diarrhea.
  • Kidney inflammation (acute tubulointerstitial nephritis): A rare but serious reaction — stop the medicine and see your doctor if you notice signs of kidney problems.
  • Lupus: Esomeprazole can trigger or worsen both skin and systemic lupus erythematosus (an immune system condition); stop the medicine and see a specialist if this develops.
  • Vitamin B12 deficiency: Daily use for more than 3 years can impair B12 absorption — ask your doctor about monitoring.
  • Fundic gland polyps: Small, usually benign stomach growths become more likely with long-term use, especially beyond one year.
🔀What it interacts with▾

Esomeprazole can interact with several important medicines — always share your full medication list with your pharmacist or doctor:

  • Rilpivirine (HIV drug): Completely contraindicated — do not combine
  • Clopidogrel (blood thinner): Esomeprazole may blunt its effectiveness; avoid combining
  • Warfarin (blood thinner): May raise warfarin levels and bleeding risk; regular INR monitoring needed
  • Methotrexate (cancer/autoimmune drug): Esomeprazole can raise methotrexate to toxic levels, especially at high doses
  • Atazanavir / nelfinavir (HIV drugs): Esomeprazole lowers their blood levels, reducing antiviral effectiveness
  • Saquinavir (HIV drug): Esomeprazole may raise its levels, increasing toxicity risk
  • St. John's Wort / rifampin: These can significantly reduce esomeprazole's effectiveness; avoid combining

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Tell your doctor if you have a known allergy to esomeprazole, omeprazole, or related acid-blocking medicines
  • Tell your doctor if you take any HIV medications — multiple serious interactions exist
  • If you're pregnant or planning to become pregnant, discuss the risks and benefits; no well-controlled human pregnancy studies exist
  • Talk to your doctor before using esomeprazole while breastfeeding
  • Tell your doctor if you have severe liver disease — a lower dose may be needed
  • Tell your doctor about all supplements and herbal products, especially St. John's Wort
  • If you're scheduled for neuroendocrine tumor testing (CgA levels), stop esomeprazole at least 14 days before — it can cause falsely elevated results
  • Children under 1 year: esomeprazole is not recommended for GERD symptom treatment in this age group (efficacy not demonstrated)
🚑If you take too much▾

Taking too much esomeprazole may cause symptoms such as confusion, drowsiness, blurred vision, rapid heartbeat, nausea, sweating, flushing, headache, and dry mouth. There is no specific antidote, and dialysis is not expected to help remove it from the body.

If you think you or someone else has taken too much, call Poison Control right away at 1-800-222-1222 for guidance.

📡Pharmacodynamics — effects in the body▾

Esomeprazole measurably raises the pH (reduces the acidity) inside the stomach. In adults, once-daily dosing kept stomach pH above 4 (a meaningful acid-reduction threshold) for roughly 53–70% of a 24-hour period, depending on dose. In infants with GERD, once-daily dosing brought the time with pH above 4 from about 29% up to 69% by day 7 — similar to what's seen in adults.

During treatment, the stomach responds by releasing more gastrin (a hormone that normally signals acid production). Gastrin levels plateau within 2–3 months and return to normal within 4 weeks of stopping the medicine. This rise in gastrin also increases a marker called chromogranin A (CgA), which can interfere with certain lab tests for neuroendocrine tumors.

🔬Pharmacokinetics — how your body processes it▾

Esomeprazole is absorbed quickly after swallowing, with blood levels peaking at about 1.5 hours. Importantly, food reduces absorption by 43–53%, so taking it before eating matters. The body clears it with a half-life of roughly 1–1.5 hours, but blood levels build up significantly with repeated daily dosing — by day 5, exposure is about 90% higher than after a single dose. Esomeprazole is extensively bound to proteins in the blood and is not removed by dialysis.

📦How to store it▾

Store at 20° to 25°C (68° to 77°F). Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure if the esomeprazole magnesium delayed-release capsules product package is subdivided.

📄 Written from Esomeprazole’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

154

Supplements & herbs that interact with Esomeprazole

154 supplements and herbal products have documented interactions with Esomeprazole in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 3
  • Moderate · 102
  • Minor · 49
ACTIVATED CHARCOAL Major GRAPEFRUIT Major ST. JOHN'S WORT Major ACACIA RIGIDULA Moderate ADRAFINIL Moderate AFRICAN WILD POTATO Moderate AMERICAN ELDER Moderate ARTICHOKE Moderate +146 more
Every supplement checked against Esomeprazole — ranked by severity The full interaction hub: 3 major · 102 moderate · 49 minor · every one linked to its full report. Check Esomeprazole against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

9

Nutrient depletion considerations

Esomeprazole has been associated with lower levels of 9 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

Evidence & significance mix
  • Higher significance · 5
  • Moderate · 1
  • Unrated · 3
CALCIUM Insignificant Depletion FOLIC ACID Insignificant Depletion IRON Insignificant Depletion MAGNESIUM Major Depletion ZINC Insignificant Depletion VITAMIN B12 Moderate Depletion BETA-CAROTENE Insufficient Evidence CHROMIUM Insufficient Evidence +1 more
See the full Esomeprazole nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Esomeprazole — the kind of thing our pharmacy team would talk through with you at the counter.

What is esomeprazole actually doing in my body? ▾
It's blocking the 'acid pump' — a tiny enzyme in your stomach lining that releases acid. By shutting down that pump, esomeprazole cuts the amount of acid your stomach produces, giving irritated or damaged tissue a chance to heal. You'll usually start feeling relief within a few days, but full healing of the esophagus can take several weeks.
Should I take it before or after eating? ▾
Before eating is best — ideally at least 30 minutes before your first meal of the day. Food can reduce how much of the medicine your body absorbs by nearly half, so timing really does matter here. If you forget one morning and have already eaten, just take it as soon as you remember, but try to build the habit of taking it before breakfast.
Are there any medicines I should not take with esomeprazole? ▾
Yes — a few important ones. If you take the HIV drug rilpivirine, you cannot use esomeprazole at all. If you take clopidogrel (Plavix), warfarin, methotrexate, or any HIV medications, let your doctor or pharmacist know, because esomeprazole can affect how those drugs work in your body. It's also worth mentioning any herbal supplements like St. John's Wort, which can reduce esomeprazole's effectiveness.
Is it safe to use esomeprazole long-term? ▾
It can be, when there's a clear medical reason — but long-term use does carry some real risks worth knowing about. These include a higher chance of bone fractures (hip, wrist, spine), low magnesium levels, vitamin B12 deficiency, and small benign stomach growths called fundic gland polyps. The general advice is to use the lowest dose that works for the shortest time that's appropriate for your condition, and to check in with your doctor regularly.
What side effects are most likely, and which ones should make me call my doctor? ▾
The most common side effects are pretty mild — headache, diarrhea, nausea, gas, or stomach discomfort. Most people don't have any trouble with it at all. Call your doctor if you notice severe or ongoing diarrhea (which can rarely be a serious gut infection), signs of a kidney problem like changes in urination or leg swelling, muscle cramps or irregular heartbeat (possible low magnesium), or any new skin rash or joint pain, which could be a sign of a lupus-related reaction.
I'm pregnant — is esomeprazole safe to take? ▾
There aren't well-controlled studies specifically in pregnant women, so this is a conversation to have with your doctor. The available evidence from studies of a closely related medicine doesn't show a clear increase in birth defects, but the safety picture isn't complete. Your doctor will weigh the benefits against the risks for your specific situation and can guide you on what's safest for you and your baby.
Is Esomeprazole available over the counter? ▾
Both — Esomeprazole is sold both over the counter and by prescription, according to its FDA labeling. Lower strengths or certain forms are often available without a prescription, while higher strengths or specialized forms still require one. Ask your pharmacist which version is right for you.
When was Esomeprazole first available? ▾
Esomeprazole has been available in the United States since at least 2001, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Esomeprazole? ▾
Esomeprazole is supplied by 176 manufacturers listed in the FDA NDC Directory, including Bryant Ranch Prepack, A-S Medication Solutions, AstraZeneca Pharmaceuticals LP.

💬 Answers drafted from Esomeprazole’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

📊Esomeprazole supplement interactions154 checked — ranked by severity 🌿Drug & Supplement CheckerEsomeprazole vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Esomeprazole NDCs & costs 🅰️Browse Drugs A–ZLook up any medication

💊 How Esomeprazole comes

Esomeprazole is available in 8 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Delayed-release capsule

By mouth
Brands Acid Reducer Basic Care Esomeprazole Magnesium DG Health Esomeprazole Magnesium Equate Esomeprazole Magnesium Esomeprazole strontium Exchange Select Esomeprazole Magnesium Good Neighbor Pharmacy Esomeprazole Magnesium Good Sense Esomeprazole Magnesium Kirkland Signature Esomeprazole Magnesium Members Mark Esomeprazole Magnesium Nexium Nexium 24HR Nexium 24HR ClearMinis Signature Care Esomeprazole Magnesium Topcare Esomeprazole Magnesium Up and Up Esomeprazole Magnesium
Available strengths 2 strengths
20 mg 40 mg
487 FDA-listed product records ⓘ

Oral powder

By mouth
Brands Nexium
Available strengths 5 strengths
2.5 mg 5 mg 10 mg 20 mg 40 mg
35 FDA-listed product records ⓘ

Capsule

By mouth
Available strengths 2 strengths
20 mg 40 mg
24 FDA-listed product records ⓘ

Delayed-release tablet

By mouth
Brands Acid Reducer
Available strengths 1 strength
20 mg
20 FDA-listed product records ⓘ

Injection

Into a vein
Brands Nexium
Available strengths 3 strengths
20 mg/5 mL 40 mg 40 mg/5 mL
14 FDA-listed product records ⓘ

Oral suspension

By mouth
Available strengths 4 strengths
2.5 mg 5 mg 20 mg 40 mg
8 FDA-listed product records ⓘ

Tablet

By mouth
Brands Acid Reducer Nexium 24HR
Available strengths 1 strength
20 mg
8 FDA-listed product records ⓘ

Extended-release oral suspension

By mouth
Available strengths 1 strength
10 mg
3 FDA-listed product records ⓘ

📊 Esomeprazole across the U.S. market

How Esomeprazole appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

8
Dose forms ⓘ
176
Manufacturers
39
Brand names
650
FDA-listed product records ⓘ
2001
First marketed ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (49) · Pellet (2) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bryant Ranch Prepack8%
A-S Medication Solutions8%
AstraZeneca Pharmaceuticals LP6%
NuCare Pharmaceuticals,Inc.6%
Aurobindo Pharma Limited6%
Torrent Pharmaceuticals Limited4%
Other makers62%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Esomeprazole is used

A general measure of how commonly Esomeprazole is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Esomeprazole is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

663,042
Medicaid prescriptions filled (Q1–Q4 2025)
$52.2M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Esomeprazole prescribed? Of the 1,596 medications we measure, Esomeprazole ranks #226 by Medicaid prescriptions — more than 86% of them.

Where Esomeprazole ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #226 of 1,596
#221 Hydroxychloroquine 696,525 Rx #222 Paliperidone Injection 691,208 Rx #223 Sitagliptin 688,306 Rx #224 Ethinyl Estradiol / Le... 668,771 Rx #225 Mometasone 666,398 Rx #226 Esomeprazole 663,042 Rx #227 Pravastatin 660,709 Rx #228 Rivaroxaban 655,610 Rx #229 Polymyxin B and Trimet... 651,823 Rx #230 Magnesium Oxide 648,844 Rx #231 Alendronate 645,853 Rx

Utilization by Esomeprazole product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 40 mg delayed release oral capsule is the most-dispensed Esomeprazole product — about 60% of these Medicaid prescriptions.

esomeprazole 40 MG Delayed Release Oral Capsule Most dispensed

400,298 Medicaid prescriptions (Q1–Q4 2025) 60% of Esomeprazole prescriptions shown $8.6M gross reimbursement (before rebates) ≈ $22 per prescription (gross)

Summed across the 38 of 215 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 606730

esomeprazole 20 MG Delayed Release Oral Capsule

123,938 Medicaid prescriptions (Q1–Q4 2025) 19% of Esomeprazole prescriptions shown $2.3M gross reimbursement (before rebates) ≈ $18 per prescription (gross)

Summed across the 34 of 483 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 606726

esomeprazole 20 MG Granules for Oral Suspension

44,055 Medicaid prescriptions (Q1–Q4 2025) 7% of Esomeprazole prescriptions shown $13.1M gross reimbursement (before rebates) ≈ $297 per prescription (gross)

Summed across the 4 of 7 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 692576

esomeprazole 10 MG Granules for Oral Suspension

42,480 Medicaid prescriptions (Q1–Q4 2025) 6% of Esomeprazole prescriptions shown $12.6M gross reimbursement (before rebates) ≈ $297 per prescription (gross)

Summed across the 3 of 5 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 861568

esomeprazole 40 MG Granules for Oral Suspension

23,695 Medicaid prescriptions (Q1–Q4 2025) 4% of Esomeprazole prescriptions shown $7.3M gross reimbursement (before rebates) ≈ $309 per prescription (gross)

Summed across the 4 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 692578

esomeprazole 5 MG Granules for Oral Suspension

19,585 Medicaid prescriptions (Q1–Q4 2025) 3% of Esomeprazole prescriptions shown $5.7M gross reimbursement (before rebates) ≈ $291 per prescription (gross)

Summed across the 3 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1297761

esomeprazole 2.5 MG Granules for Oral Suspension

8,966 Medicaid prescriptions (Q1–Q4 2025) 1% of Esomeprazole prescriptions shown $2.5M gross reimbursement (before rebates) ≈ $284 per prescription (gross)

Summed across the 3 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1297658

esomeprazole 40 MG Injection

25 Medicaid prescriptions (Q1–Q4 2025) <1% of Esomeprazole prescriptions shown $1,254 gross reimbursement (before rebates) ≈ $50 per prescription (gross)

Summed across the 1 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 486501

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Esomeprazole, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 90 of 736 listed Esomeprazole NDCs with Medicaid activity.

🔍 Compare Esomeprazole products

A representative set of FDA-listed product records for Esomeprazole — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 200 of 650 products — FDA National Drug Code Directory. See every product, package size and price: browse all 650 Esomeprazole NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Esomeprazole RxCUI 283742 6 dose forms · 17 strengths
  1. Dose form (SCDF) Delayed Release Oral Capsule RxCUI 606725 In current FDA listings
    Clinical drug / strength (SCD) strontium 24.65 MG RxCUI 1810789 strontium 49.3 MG RxCUI 1810787 20 MG RxCUI 606726 40 MG RxCUI 606730
  2. Dose form (SCDF) Delayed Release Oral Tablet RxCUI 439356 In current FDA listings
    Clinical drug / strength (SCD) 20 MG RxCUI 433733 40 MG RxCUI 433787
  3. Dose form (SCDF) Granules for Oral Suspension RxCUI 1855312 In current FDA listings
    Clinical drug / strength (SCD) 2.5 MG RxCUI 1297658 5 MG RxCUI 1297761 10 MG RxCUI 861568 20 MG RxCUI 692576 40 MG RxCUI 692578
  4. Dose form (SCDF) Injection RxCUI 1728037 In current FDA listings
    Clinical drug / strength (SCD) 20 MG RxCUI 486499 40 MG RxCUI 486501
  5. Dose form (SCDF) Oral Capsule RxCUI 393463 In current FDA listings
    Clinical drug / strength (SCD) 20 MG RxCUI 391873 40 MG RxCUI 391874
  6. Dose form (SCDF) Oral Tablet RxCUI 393436 In current FDA listings
    Clinical drug / strength (SCD) 20 MG RxCUI 389175 40 MG RxCUI 389174

Look up RxCUI 283742 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Nexium Nexium 24HR Acid Reducer Esomeprazole strontium good sense esomeprazole magnesium basic care esomeprazole magnesium dg health esomeprazole magnesium Up and Up Esomeprazole Magnesium signature care esomeprazole magnesium equate esomeprazole magnesium topcare esomeprazole magnesium Nexium 24HR ClearMinis members mark esomeprazole magnesium kirkland signature esomeprazole magnesium Good Neighbor Pharmacy Esomeprazole Magnesium Exchange Select Esomeprazole Magnesium

🏭 Manufacturers & labelers

Bryant Ranch Prepack 31 A-S Medication Solutions 30 AstraZeneca Pharmaceuticals LP 23 NuCare Pharmaceuticals,Inc. 22 Aurobindo Pharma Limited 22 Torrent Pharmaceuticals Limited 14 Zydus Lifesciences Limited 11 Aurohealth LLC 11 Cipla USA Inc. 11 Dr. Reddy's Laboratories Inc 8 Amerisource Bergen 8 Camber Pharmaceuticals, Inc. 8 Ascend Laboratories, LLC 8 CVS Pharmacy 8 Rite Aid Corporation 8 Preferred Pharmaceuticals Inc. 8 Mylan Pharmaceuticals Inc. 8 Amazon.com Services LLC 7 Preferred Pharmaceuticals, Inc. 7 Remedyrepack Inc. 6 GlaxoSmithKline Consumer Healthcare Holdings (US) LLC 6 Proficient Rx LP 6 Lannett Company, Inc. 6 Walgreen Company 6

…and 16 more on the FDA NDC directory.

RxNorm drug class

Esomeprazole belongs to the Proton Pump Inhibitor class.

Pharmacologic class Proton Pump Inhibitor
Drug family (ATC) Proton pump inhibitors, Propionic acid derivatives
How it works Proton Pump Inhibitors, Cytochrome P450 2C19 Inhibitors

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Nov 30, 2024
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Esomeprazole.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Esomeprazole after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
225
NDC products indexed
650
Distinct labelers/manufacturers represented
176
Linked representative label ⓘ
Macleods Pharmaceuticals Limited
Linked label effective
Nov 30, 2024
Composite sections available
22
Linked SPL Set ID
d68c9247-91c7-4e0f-adc4-2cfa7446580f
Linked SPL Document ID
d68c9247-91c7-4e0f-adc4-2cfa7446580f
Open the linked representative label on DailyMed ↗

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 225 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Macleods Pharmaceuticals Limited is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.