Drug-induced nutrient depletion

Medications That May Deplete BETA-CAROTENE

Vitamin A supports vision, immune function, and skin health. See which medications carry a reported association, how strong the evidence is, and what to discuss with your pharmacist.

26Medications
26Depletion records
About BETA-CAROTENE

Vitamin A supports vision, immune function, and skin health.

Common food sources: Liver and fish oils; Dairy and eggs; Orange and yellow vegetables (as beta-carotene); Leafy greens.

Ask your provider before supplementing vitamin A — status testing is not routine, and intake from food plus multivitamins is often already adequate.

Caution: Avoid high-dose vitamin A in pregnancy or when trying to conceive unless a clinician directs it.

HelloPharmacist pharmacist-reviewed education. The medication records below are licensed clinical data, shown as published.

Deep dive: Beta-carotene — uses, safety & drug interactions

The evidence

Medications associated with BETA-CAROTENE depletion

Each record is shown as published in our licensed clinical database. Open a medication for its full nutrient report.

Cholestyramine

Insignificant Depletion

Brand names include Questran

Bile acid sequestrants may modestly reduce absorption of beta-carotene.

Cholestyramine (Questran) and colestipol (Colestid) can reduce absorption of fat-soluble vitamins, including beta-carotene. Serum levels of beta-carotene can be reduced, but this is probably only in proportion to the lowering of cholesterol (on which beta-carotene is transported). Supplements are not usually needed.
Taking Cholestyramine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is a plant pigment your body converts into vitamin A, which supports healthy vision, skin, and immune function. Cholestyramine works in your gut by binding to bile acids, and because beta-carotene is a fat-soluble nutrient, some of it may get caught up in that process and absorbed a little less efficiently. Here is the reassuring part: any dip in blood levels appears to be tied to the expected drop in cholesterol (which normally carries beta-carotene through the bloodstream), not a true shortage of the nutrient itself. For most people on cholestyramine, a supplement is not needed, but feel free to mention it to your pharmacist or doctor if you have concerns.

References (5)
  1. Hathcock JN. Metabolic mechanisms of drug-nutrient interactions. Fed Proc 1985;44:124-9.
  2. Elinder LS, Hadell K, Johansson J, et al. Probucol treatment decreases serum concentrations of diet-derived antioxidants. Arterioscler Thromb Vasc Biol 1995;15:1057-63. PubMed
  3. Knodel LC, Talbert RL. Adverse effects of hypolipidaemic drugs. Med Toxicol 1987;2:10-32. PubMed
  4. Tonstad S, Silverstein M, Aksnes L, Ose L. Low dose colestipol in adolescents with familial hypercholesterolemia. Arch Dis Child 1996;74:157-60.
  5. Matsui MS, Rozovski SJ. Drug-nutrient interaction. Clin Ther 1982;4:423-40.

Full nutrient report for Cholestyramine →

Colchicine

Insignificant Depletion

Brand names include Colsalide Improved, Mitigare, Colcrys

Colchicine might modestly reduce absorption and levels of beta-carotene.

Limited evidence suggests that short-term treatment with colchicine 1.9-3.9 mg daily can reduce absorption and serum levels of beta-carotene. Theoretically. this is due to disruption of intestinal mucosal function. Long-term use of 1 to 2 mg daily does not affect beta-carotene levels. Advise patients that this is unlikely to be clinically significant.
Taking Colchicine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is a pigment found in colorful vegetables that your body converts into vitamin A, which supports healthy vision, skin, and immune function. At higher doses used short-term, colchicine can mildly interfere with the gut lining's ability to absorb nutrients, and some studies showed a small dip in beta-carotene levels. That said, people taking the typical long-term dose of 1 to 2 mg daily do not appear to see any meaningful change, and this is generally considered an insignificant concern for most patients. No action is needed for the majority of people, but if you have questions about your diet or any supplements, your pharmacist is a great place to start.

References (2)
  1. Race TF, Paes IC, Faloon WW. Intestinal malabsorption induced by oral colchicine. Comparison with neomycin and cathartic agents. Am J Med Sci 1970;259:32-41. PubMed
  2. Ehrenfeld M, Levy M, Sharon P, et al. Gastrointestinal effects of long-term colchicine therapy in patients with recurrent polyserositis (Familial Mediterranean Fever). Dig Dis Sci 1982;27:723-7. PubMed

Full nutrient report for Colchicine →

Colchicine, Probenecid

Insignificant Depletion

Brand names include ColBenemid

Colchicine might modestly reduce absorption and levels of beta-carotene.

Limited evidence suggests that short-term treatment with colchicine 1.9-3.9 mg daily can reduce absorption and serum levels of beta-carotene. Theoretically. this is due to disruption of intestinal mucosal function. Long-term use of 1 to 2 mg daily does not affect beta-carotene levels. Advise patients that this is unlikely to be clinically significant.
Taking Colchicine, Probenecid? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is a plant pigment your body converts into vitamin A, which supports healthy vision, skin, and immune function. At higher doses used short-term, colchicine may mildly interfere with how the intestinal lining absorbs beta-carotene, but at the typical long-term doses most people take, studies have not found a meaningful drop in levels. Given the insignificant rating here, this is not something most patients need to act on, though you are always welcome to mention it to your pharmacist if you have questions.

References (2)
  1. Race TF, Paes IC, Faloon WW. Intestinal malabsorption induced by oral colchicine. Comparison with neomycin and cathartic agents. Am J Med Sci 1970;259:32-41. PubMed
  2. Ehrenfeld M, Levy M, Sharon P, et al. Gastrointestinal effects of long-term colchicine therapy in patients with recurrent polyserositis (Familial Mediterranean Fever). Dig Dis Sci 1982;27:723-7. PubMed

Full nutrient report for Colchicine, Probenecid →

Colestipol

Insignificant Depletion

Brand names include Colestid

Bile acid sequestrants may modestly reduce absorption of beta-carotene.

Cholestyramine (Questran) and colestipol (Colestid) can reduce absorption of fat-soluble vitamins, including beta-carotene. Serum levels of beta-carotene can be reduced, but this is probably only in proportion to the lowering of cholesterol (on which beta-carotene is transported). Supplements are not usually needed.
Taking Colestipol? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is a plant pigment your body converts into vitamin A, which supports healthy vision, skin, and immune function. Colestipol works in the gut to trap bile acids and lower cholesterol, and because beta-carotene is a fat-soluble nutrient that rides along with cholesterol in the bloodstream, lower cholesterol levels can mean slightly lower beta-carotene readings on a blood test. Researchers believe this reflects the cholesterol drop itself rather than a true nutritional shortfall, which is why this is rated insignificant. For most people taking colestipol, no extra beta-carotene is needed, but if you have questions about your diet or lab results, your pharmacist or doctor is a great first call.

References (5)
  1. Hathcock JN. Metabolic mechanisms of drug-nutrient interactions. Fed Proc 1985;44:124-9.
  2. Elinder LS, Hadell K, Johansson J, et al. Probucol treatment decreases serum concentrations of diet-derived antioxidants. Arterioscler Thromb Vasc Biol 1995;15:1057-63. PubMed
  3. Knodel LC, Talbert RL. Adverse effects of hypolipidaemic drugs. Med Toxicol 1987;2:10-32. PubMed
  4. Tonstad S, Silverstein M, Aksnes L, Ose L. Low dose colestipol in adolescents with familial hypercholesterolemia. Arch Dis Child 1996;74:157-60.
  5. Matsui MS, Rozovski SJ. Drug-nutrient interaction. Clin Ther 1982;4:423-40.

Full nutrient report for Colestipol →

Mineral Oil

Insignificant Depletion

Brand names include Kondremul Plain

Mineral oil might modestly reduce absorption and levels of beta-carotene.

Mineral oil is a laxative and reduces absorption of fat-soluble vitamins, including beta-carotene. This is not likely to be clinically significant when mineral oil is used for 4 months or less.
Taking Mineral Oil? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is a plant pigment your body converts into vitamin A, which supports healthy vision, skin, and immune function. Because mineral oil is not digested or absorbed, it can carry fat-soluble nutrients like beta-carotene through the gut before they get a chance to absorb properly. That said, for short-term use of four months or less, this effect is considered insignificant for most people, so a supplement is generally not needed. If you use mineral oil regularly over a longer stretch, it is worth mentioning to your pharmacist just to be safe.

References (3)
  1. Hathcock JN. Metabolic mechanisms of drug-nutrient interactions. Fed Proc 1985;44:124-9.
  2. Becker GL. The case against mineral oil. Am J Digestive Dis 1952;19:344-8. PubMed
  3. Clark JH, Russell GJ, Fitzgerald JF, et al. Serum beta-carotene, retinol, and alpha-tocopherol levels during mineral oil therapy for constipation. Am J Dis Child 1987;141:1210-2.

Full nutrient report for Mineral Oil →

Neomycin

Insignificant Depletion

Brand names include Mycifradin, Neo-Fradin, Myciguent

Neomycin might modestly reduce levels of beta-carotene.

Oral neomycin sulfate in doses of 4-12 grams per day causes malabsorption and can reduce beta-carotene absorption. However, this is not likely to be clinically significant with short-term neomycin use.
Taking Neomycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is a plant pigment your body converts into vitamin A, which supports your vision, immune system, and skin. Neomycin, especially at the high doses sometimes used to prepare the gut before surgery, can interfere with how your intestines absorb nutrients like beta-carotene. That said, this effect is considered insignificant, and short-term use at typical doses is not expected to cause any real problem for most people. No action is needed, but if you have questions about your specific situation, your pharmacist or doctor is a great place to start.

References (1)
  1. Jacobson ED, Faloon WW. Malasorptive effects of neomycin in commonly used doses. JAMA 1961;175:187-90.

Full nutrient report for Neomycin →

Niacin, Simvastatin

Insignificant Depletion

Brand names include Simcor

Simvastatin might modestly reduce levels of beta-carotene.

Clinical research shows that simvastatin can reduce serum levels of circulating beta-carotene, but this is probably only in proportion to the lowering of cholesterol (on which beta-carotene is transported). Supplements are not usually needed.
Taking Niacin, Simvastatin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is a plant pigment your body converts into vitamin A, which supports healthy vision, skin, and immune function. Because beta-carotene hitches a ride in the bloodstream on cholesterol particles, simvastatin's job of lowering cholesterol can bring beta-carotene levels down a little along with it. That said, this is rated as insignificant, meaning the drop tends to track with the cholesterol reduction rather than reflecting a true shortage in your body. Most people on simvastatin do not need to do anything about this, but if you have questions or eat a very limited diet, your pharmacist or doctor is a great person to check with.

References (2)
  1. Jula, A., Marniemi, J., Huupponen, R., Virtanen, A., Rastas, M., and Ronnemaa, T. Effects of diet and simvastatin on serum lipids, insulin, and antioxidants in hypercholesterolemic men: a randomized controlled trial. JAMA 2-6-2002;287(5):598-605. PubMed
  2. Tonstad S, Silverstein M, Aksnes L, Ose L. Low dose colestipol in adolescents with familial hypercholesterolemia. Arch Dis Child 1996;74:157-60.

Full nutrient report for Niacin, Simvastatin →

Orlistat

Major Depletion

Brand names include Xenical, Alli

Orlistat can decrease absorption of beta-carotene and other fat-soluble vitamins.

Orlistat blocks the enzyme that breaks down fat for absorption. Theoretically, in addition to reducing fat absorption, it might also reduce absorption of fat-soluble vitamins like beta-carotene. Recommend that patients take a multivitamin supplement, and separate the dosing time by at least 2 hours from orlistat.
Taking Orlistat? A supplement is needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Orlistat works by blocking fat digestion in your gut, which is exactly how it helps with weight loss. The catch is that beta-carotene, a nutrient your body converts into vitamin A to support your eyes, skin, and immune system, needs fat to be absorbed properly. Because orlistat cuts fat absorption so significantly, it can pull beta-carotene out of the picture too. Given the major rating here, most long-term users are advised to take a daily multivitamin, just be sure to take it at least two hours apart from your orlistat dose so it can actually absorb. Ask your pharmacist or doctor what works best for your routine.

References (1)
  1. Roche Laboratories, Inc. Package insert for Xenical. April 1999.

Full nutrient report for Orlistat →

Polymyxin B , Neomycin

Insignificant Depletion

Brand names include Neosporin G.U. Irrigant

Neomycin might modestly reduce levels of beta-carotene.

Oral neomycin sulfate in doses of 4-12 grams per day causes malabsorption and can reduce beta-carotene absorption. However, this is not likely to be clinically significant with short-term neomycin use.
Taking Polymyxin B , Neomycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is a plant pigment your body converts into vitamin A, which supports healthy vision, skin, and immune function. The neomycin component of this combination can interfere with how your gut absorbs certain nutrients, including beta-carotene, particularly at high doses taken over time. That said, this is rated insignificant, meaning a short course at typical doses is very unlikely to cause a real problem for most people. No action is needed for the average patient, but if you have questions about your specific situation, your pharmacist is a great first stop.

References (1)
  1. Jacobson ED, Faloon WW. Malasorptive effects of neomycin in commonly used doses. JAMA 1961;175:187-90.

Full nutrient report for Polymyxin B , Neomycin →

Simvastatin

Insignificant Depletion

Brand names include Zocor

Simvastatin might modestly reduce levels of beta-carotene.

Clinical research shows that simvastatin can reduce serum levels of circulating beta-carotene, but this is probably only in proportion to the lowering of cholesterol (on which beta-carotene is transported). Supplements are not usually needed.
Taking Simvastatin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is a plant pigment your body converts into vitamin A, which supports healthy vision, skin, and immune function. Simvastatin can cause a modest drop in circulating beta-carotene levels, but here is the key detail: beta-carotene travels through the bloodstream attached to cholesterol, so when simvastatin lowers your cholesterol, beta-carotene readings naturally come down a little too. This appears to be a transport effect rather than a true loss, and for most people taking simvastatin it is considered insignificant. No action is usually needed, but if you have questions about your diet or levels, your pharmacist or doctor is a good place to start.

References (2)
  1. Jula, A., Marniemi, J., Huupponen, R., Virtanen, A., Rastas, M., and Ronnemaa, T. Effects of diet and simvastatin on serum lipids, insulin, and antioxidants in hypercholesterolemic men: a randomized controlled trial. JAMA 2-6-2002;287(5):598-605. PubMed
  2. Tonstad S, Silverstein M, Aksnes L, Ose L. Low dose colestipol in adolescents with familial hypercholesterolemia. Arch Dis Child 1996;74:157-60.

Full nutrient report for Simvastatin →

Simvastatin, Sitagliptin

Insignificant Depletion

Brand names include Juvisync

Simvastatin might modestly reduce levels of beta-carotene.

Clinical research shows that simvastatin can reduce serum levels of circulating beta-carotene, but this is probably only in proportion to the lowering of cholesterol (on which beta-carotene is transported). Supplements are not usually needed.
Taking Simvastatin, Sitagliptin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is an antioxidant the body converts into vitamin A, which supports healthy vision, skin, and immune function. Because beta-carotene hitches a ride in the bloodstream on cholesterol particles, simvastatin's job of lowering cholesterol can bring beta-carotene levels down a little along with it. That said, this is rated insignificant, meaning the drop appears to simply reflect lower cholesterol transport rather than a true shortage in your body. For most people on simvastatin, no extra beta-carotene is needed, but feel free to mention it to your pharmacist if you have questions.

References (2)
  1. Jula, A., Marniemi, J., Huupponen, R., Virtanen, A., Rastas, M., and Ronnemaa, T. Effects of diet and simvastatin on serum lipids, insulin, and antioxidants in hypercholesterolemic men: a randomized controlled trial. JAMA 2-6-2002;287(5):598-605. PubMed
  2. Tonstad S, Silverstein M, Aksnes L, Ose L. Low dose colestipol in adolescents with familial hypercholesterolemia. Arch Dis Child 1996;74:157-60.

Full nutrient report for Simvastatin, Sitagliptin →

simvastatin/ezetimibe

Insignificant Depletion

Brand names include Vytorin

Simvastatin might modestly reduce levels of beta-carotene.

Clinical research shows that simvastatin can reduce serum levels of circulating beta-carotene, but this is probably only in proportion to the lowering of cholesterol (on which beta-carotene is transported). Supplements are not usually needed.
Taking simvastatin/ezetimibe? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is an antioxidant your body converts into vitamin A, which supports your vision, immune system, and skin. Because beta-carotene hitches a ride in the bloodstream on cholesterol particles, when simvastatin does its job and brings cholesterol down, beta-carotene levels can dip a little along with it. That said, this is rated as insignificant, meaning the drop appears to be a side effect of cholesterol lowering rather than a true nutritional loss, and supplements are not considered necessary for most people taking this medication.

References (2)
  1. Jula, A., Marniemi, J., Huupponen, R., Virtanen, A., Rastas, M., and Ronnemaa, T. Effects of diet and simvastatin on serum lipids, insulin, and antioxidants in hypercholesterolemic men: a randomized controlled trial. JAMA 2-6-2002;287(5):598-605. PubMed
  2. Tonstad S, Silverstein M, Aksnes L, Ose L. Low dose colestipol in adolescents with familial hypercholesterolemia. Arch Dis Child 1996;74:157-60.

Full nutrient report for simvastatin/ezetimibe →

Sodium Phenylbutyrate, Taurursodiol

Insignificant Depletion

Brand names include Relyvrio

Bile acid sequestrants may modestly reduce absorption of beta-carotene.

Cholestyramine (Questran) and colestipol (Colestid) can reduce absorption of fat-soluble vitamins, including beta-carotene. Serum levels of beta-carotene can be reduced, but this is probably only in proportion to the lowering of cholesterol (on which beta-carotene is transported). Supplements are not usually needed.
Taking Sodium Phenylbutyrate, Taurursodiol? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is a plant pigment your body converts into vitamin A, which supports healthy vision, skin, and immune function. Taurursodiol is a bile acid, and some bile acid compounds have been linked to modest reductions in how well the gut absorbs beta-carotene, since fat-soluble nutrients like this one depend on bile to get into the bloodstream. That said, any dip in beta-carotene levels seen with this type of medication appears to track with normal changes in cholesterol levels rather than representing a true depletion. This is rated insignificant, meaning most people on this medication do not need to take any action, but feel free to mention it to your pharmacist if you have questions.

References (5)
  1. Hathcock JN. Metabolic mechanisms of drug-nutrient interactions. Fed Proc 1985;44:124-9.
  2. Elinder LS, Hadell K, Johansson J, et al. Probucol treatment decreases serum concentrations of diet-derived antioxidants. Arterioscler Thromb Vasc Biol 1995;15:1057-63. PubMed
  3. Knodel LC, Talbert RL. Adverse effects of hypolipidaemic drugs. Med Toxicol 1987;2:10-32. PubMed
  4. Tonstad S, Silverstein M, Aksnes L, Ose L. Low dose colestipol in adolescents with familial hypercholesterolemia. Arch Dis Child 1996;74:157-60.
  5. Matsui MS, Rozovski SJ. Drug-nutrient interaction. Clin Ther 1982;4:423-40.

Full nutrient report for Sodium Phenylbutyrate, Taurursodiol →

Brand names include Talicia

Proton pump inhibitors might reduce absorption of beta-carotene.

Proton pump inhibitors reduce stomach acid, which might in turn reduce absorption of supplemental beta-carotene, but it is not known if this is clinically significant, or if it affects absorption of dietary beta-carotene.
Taking Amoxicillin, Omeprazole Magnesium, Rifabutin? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is something your body converts into vitamin A, which helps support your vision, immune system, and skin. The omeprazole magnesium in this combination lowers stomach acid, and there is some early thinking that less acid in the stomach could make it harder to absorb beta-carotene from supplements. That said, the evidence here is really limited, and whether this actually matters in practice, or even affects the beta-carotene you get from food, simply is not known yet. For now, most people do not need to act on this, but if you take beta-carotene supplements regularly, it is worth mentioning to your pharmacist or doctor.

References (1)
  1. Tang G, Serfaty-Lacrosniere C, Camilo ME, et al. Gastric acidity influences the blood response to a beta-carotene dose in humans. Am J Clin Nutr 1996;64:622-6. PubMed

Full nutrient report for Amoxicillin, Omeprazole Magnesium, Rifabutin →

Dexlansoprazole

Insufficient Evidence

Brand names include Dexilant Solutab

Proton pump inhibitors might reduce absorption of beta-carotene.

Proton pump inhibitors reduce stomach acid, which might in turn reduce absorption of supplemental beta-carotene, but it is not known if this is clinically significant, or if it affects absorption of dietary beta-carotene.
Taking Dexlansoprazole? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is a plant pigment your body converts into vitamin A, which supports healthy vision, skin, and immune function. Dexlansoprazole belongs to a class of drugs that dials down stomach acid, and there is some early thinking that lower acid levels could interfere with how well beta-carotene from supplements gets absorbed in the gut. That said, the evidence here is genuinely thin, and whether this matters for food sources of beta-carotene is still unknown. If you take beta-carotene supplements regularly, it is worth a quick chat with your pharmacist just to keep it on their radar.

References (1)
  1. Tang G, Serfaty-Lacrosniere C, Camilo ME, et al. Gastric acidity influences the blood response to a beta-carotene dose in humans. Am J Clin Nutr 1996;64:622-6. PubMed

Full nutrient report for Dexlansoprazole →

Esomeprazole

Insufficient Evidence

Brand names include Nexium

Proton pump inhibitors might reduce absorption of beta-carotene.

Proton pump inhibitors reduce stomach acid, which might in turn reduce absorption of supplemental beta-carotene, but it is not known if this is clinically significant, or if it affects absorption of dietary beta-carotene.
Taking Esomeprazole? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is something your body converts into vitamin A, which helps keep your eyes, skin, and immune system working well. Because esomeprazole dials down stomach acid, there is some thought that this might make it harder for the gut to absorb beta-carotene from supplements, since stomach acid may play a role in that process. Even so, the research on this is very thin, nobody knows yet whether it matters in real life, and it is unclear whether food sources of beta-carotene are affected at all. For now, most people taking esomeprazole do not need to act on this, but if you are curious or take beta-carotene supplements, it is worth a quick chat with your pharmacist.

References (1)
  1. Tang G, Serfaty-Lacrosniere C, Camilo ME, et al. Gastric acidity influences the blood response to a beta-carotene dose in humans. Am J Clin Nutr 1996;64:622-6. PubMed

Full nutrient report for Esomeprazole →

Esomeprazole Magnesium

Insufficient Evidence

Brand names include Nexium 24hr

Proton pump inhibitors might reduce absorption of beta-carotene.

Proton pump inhibitors reduce stomach acid, which might in turn reduce absorption of supplemental beta-carotene, but it is not known if this is clinically significant, or if it affects absorption of dietary beta-carotene.
Taking Esomeprazole Magnesium? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is something your body converts into vitamin A, which supports healthy vision, skin, and immune function. Esomeprazole works by reducing stomach acid, and there is some thought that acid may play a small role in how the gut absorbs beta-carotene from supplements. That said, the research here is genuinely thin, and it is not clear this matters at all in real life, especially for beta-carotene you get from food. This one is firmly in the 'we just don't know yet' category, so no need to worry, but mention it to your pharmacist if you have questions.

References (1)
  1. Tang G, Serfaty-Lacrosniere C, Camilo ME, et al. Gastric acidity influences the blood response to a beta-carotene dose in humans. Am J Clin Nutr 1996;64:622-6. PubMed

Full nutrient report for Esomeprazole Magnesium →

Esomeprazole Strontium

Insufficient Evidence
Proton pump inhibitors might reduce absorption of beta-carotene.

Proton pump inhibitors reduce stomach acid, which might in turn reduce absorption of supplemental beta-carotene, but it is not known if this is clinically significant, or if it affects absorption of dietary beta-carotene.
Taking Esomeprazole Strontium? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is a plant pigment your body converts into vitamin A, which supports your vision, immune system, and skin. Because esomeprazole strontium works by dialing down stomach acid, there is some concern that this lower-acid environment could make it harder to absorb beta-carotene from supplements. That said, the research here is thin, and it is not yet clear whether this matters for beta-carotene you get from food, or whether the effect is meaningful at all. For now, most people do not need to act on this, but if you take beta-carotene supplements regularly, it is worth mentioning to your pharmacist or doctor.

References (1)
  1. Tang G, Serfaty-Lacrosniere C, Camilo ME, et al. Gastric acidity influences the blood response to a beta-carotene dose in humans. Am J Clin Nutr 1996;64:622-6. PubMed

Full nutrient report for Esomeprazole Strontium →

Esomeprazole, Naproxen

Insufficient Evidence

Brand names include Vimovo

Proton pump inhibitors might reduce absorption of beta-carotene.

Proton pump inhibitors reduce stomach acid, which might in turn reduce absorption of supplemental beta-carotene, but it is not known if this is clinically significant, or if it affects absorption of dietary beta-carotene.
Taking Esomeprazole, Naproxen? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is a plant pigment your body converts into vitamin A, which supports your vision, immune system, and skin. Esomeprazole is a proton pump inhibitor, meaning it dials down stomach acid significantly, and some research suggests that lower acid levels in the gut may reduce how well beta-carotene from supplements is absorbed. That said, the evidence here is genuinely limited, researchers are not sure this matters in real life, and it is unclear whether food sources of beta-carotene are affected at all. If you take esomeprazole long-term and have questions about your diet or supplements, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Tang G, Serfaty-Lacrosniere C, Camilo ME, et al. Gastric acidity influences the blood response to a beta-carotene dose in humans. Am J Clin Nutr 1996;64:622-6. PubMed

Full nutrient report for Esomeprazole, Naproxen →

Lansoprazole

Insufficient Evidence

Brand names include Prevacid

Proton pump inhibitors might reduce absorption of beta-carotene.

Proton pump inhibitors reduce stomach acid, which might in turn reduce absorption of supplemental beta-carotene, but it is not known if this is clinically significant, or if it affects absorption of dietary beta-carotene.
Taking Lansoprazole? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is a plant pigment your body converts into vitamin A, which supports healthy vision, skin, and immune function. Because lansoprazole reduces stomach acid, it may interfere with how well beta-carotene from supplements is absorbed in the gut, since acid appears to play a role in that process. That said, researchers are not yet sure whether this translates into any real-world effect, especially for beta-carotene you get from food. For now, the evidence is too thin to worry, but if you take beta-carotene supplements long-term, it is worth mentioning to your pharmacist.

References (1)
  1. Tang G, Serfaty-Lacrosniere C, Camilo ME, et al. Gastric acidity influences the blood response to a beta-carotene dose in humans. Am J Clin Nutr 1996;64:622-6. PubMed

Full nutrient report for Lansoprazole →

Brand names include Prevpac

Proton pump inhibitors might reduce absorption of beta-carotene.

Proton pump inhibitors reduce stomach acid, which might in turn reduce absorption of supplemental beta-carotene, but it is not known if this is clinically significant, or if it affects absorption of dietary beta-carotene.
Taking Lansoprazole, Amoxicillin, Clarithromycin? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is a plant pigment your body converts into vitamin A, which supports healthy vision, skin, and immune function. The lansoprazole in this combination is a proton pump inhibitor, meaning it dials down stomach acid, and some research suggests that lower acid levels could reduce how well your gut absorbs beta-carotene from supplements. That said, the evidence here is rated insufficient, so it is unclear whether this matters in practice or whether beta-carotene from food is affected at all. If you take beta-carotene supplements regularly and have questions, it is worth a quick chat with your pharmacist.

References (1)
  1. Tang G, Serfaty-Lacrosniere C, Camilo ME, et al. Gastric acidity influences the blood response to a beta-carotene dose in humans. Am J Clin Nutr 1996;64:622-6. PubMed

Full nutrient report for Lansoprazole, Amoxicillin, Clarithromycin →

Omeprazole

Insufficient Evidence

Brand names include Prilosec, Zegerid, Losec

Proton pump inhibitors might reduce absorption of beta-carotene.

Proton pump inhibitors reduce stomach acid, which might in turn reduce absorption of supplemental beta-carotene, but it is not known if this is clinically significant, or if it affects absorption of dietary beta-carotene.
Taking Omeprazole? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is something your body converts into vitamin A, which supports your vision, immune system, and skin. Omeprazole works by reducing stomach acid, and there is some thought that having less acid in the stomach could make it harder to absorb beta-carotene from supplements. That said, the evidence here is quite thin, and researchers are not yet sure this matters in real life, especially for beta-carotene you get from food. For now, most people taking omeprazole do not need to worry about this, but if you take beta-carotene supplements regularly, it is worth mentioning to your pharmacist or doctor.

References (1)
  1. Tang G, Serfaty-Lacrosniere C, Camilo ME, et al. Gastric acidity influences the blood response to a beta-carotene dose in humans. Am J Clin Nutr 1996;64:622-6. PubMed

Full nutrient report for Omeprazole →

Omeprazole, Sodium Bicarbonate

Insufficient Evidence

Brand names include Konvomep

Proton pump inhibitors might reduce absorption of beta-carotene.

Proton pump inhibitors reduce stomach acid, which might in turn reduce absorption of supplemental beta-carotene, but it is not known if this is clinically significant, or if it affects absorption of dietary beta-carotene.
Taking Omeprazole, Sodium Bicarbonate? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is a plant pigment your body converts into vitamin A, which supports your eyes, skin, and immune system. Omeprazole works by turning down stomach acid production, and there is some thinking that lower acid levels could make it harder for your gut to absorb beta-carotene from supplements. That said, the evidence here is really thin, and nobody has shown this causes a real problem in people, especially from food sources. If you take beta-carotene supplements regularly alongside this medication, it is worth mentioning to your pharmacist just to keep it on their radar.

References (1)
  1. Tang G, Serfaty-Lacrosniere C, Camilo ME, et al. Gastric acidity influences the blood response to a beta-carotene dose in humans. Am J Clin Nutr 1996;64:622-6. PubMed

Full nutrient report for Omeprazole, Sodium Bicarbonate →

Pantoprazole

Insufficient Evidence

Brand names include Protonix, Pantoloc, Protonix IV

Proton pump inhibitors might reduce absorption of beta-carotene.

Proton pump inhibitors reduce stomach acid, which might in turn reduce absorption of supplemental beta-carotene, but it is not known if this is clinically significant, or if it affects absorption of dietary beta-carotene.
Taking Pantoprazole? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is a plant pigment your body converts into vitamin A, which supports healthy vision, skin, and immune function. Pantoprazole works by turning down acid production in the stomach, and there is some thought that lower stomach acid could reduce how well beta-carotene from supplements gets absorbed. That said, the evidence here is genuinely thin, and researchers are not even sure it matters for beta-carotene from food. For now, this is something to keep in the back of your mind rather than act on, but if you take beta-carotene supplements regularly, it is worth mentioning to your pharmacist or doctor.

References (1)
  1. Tang G, Serfaty-Lacrosniere C, Camilo ME, et al. Gastric acidity influences the blood response to a beta-carotene dose in humans. Am J Clin Nutr 1996;64:622-6. PubMed

Full nutrient report for Pantoprazole →

Rabeprazole

Insufficient Evidence

Brand names include Pariet

Proton pump inhibitors might reduce absorption of beta-carotene.

Proton pump inhibitors reduce stomach acid, which might in turn reduce absorption of supplemental beta-carotene, but it is not known if this is clinically significant, or if it affects absorption of dietary beta-carotene.
Taking Rabeprazole? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is a plant pigment your body converts into vitamin A, which supports healthy vision, skin, and immune function. Rabeprazole works by dialing down stomach acid production, and some early research suggests that lower acid levels in the stomach could reduce how well supplemental beta-carotene gets absorbed. That said, the evidence here is genuinely thin, and it is not even clear whether this applies to beta-carotene from food at all. If you take rabeprazole long-term and rely heavily on beta-carotene supplements, it is worth a quick mention to your pharmacist or doctor.

References (1)
  1. Tang G, Serfaty-Lacrosniere C, Camilo ME, et al. Gastric acidity influences the blood response to a beta-carotene dose in humans. Am J Clin Nutr 1996;64:622-6. PubMed

Full nutrient report for Rabeprazole →

Rabeprazole Sodium

Insufficient Evidence

Brand names include Aciphex, Aciphex Sprinkle

Proton pump inhibitors might reduce absorption of beta-carotene.

Proton pump inhibitors reduce stomach acid, which might in turn reduce absorption of supplemental beta-carotene, but it is not known if this is clinically significant, or if it affects absorption of dietary beta-carotene.
Taking Rabeprazole Sodium? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Beta-carotene is a plant pigment your body converts into vitamin A, which supports healthy vision, skin, and immune function. Rabeprazole belongs to a class of drugs that dials down stomach acid, and there is some thinking that lower acid levels could interfere with how well supplemental beta-carotene is absorbed in the gut. That said, the evidence here is truly thin, and researchers do not yet know whether this matters in real life or whether the beta-carotene you get from food is affected at all. For now, most people taking this medication do not need to act on this, but if you take beta-carotene supplements and have questions, your pharmacist is a good first stop.

References (1)
  1. Tang G, Serfaty-Lacrosniere C, Camilo ME, et al. Gastric acidity influences the blood response to a beta-carotene dose in humans. Am J Clin Nutr 1996;64:622-6. PubMed

Full nutrient report for Rabeprazole Sodium →

Important

This tool is educational and is not a substitute for professional medical advice. An association is not a diagnosis and does not mean a deficiency will occur. Always talk to your pharmacist or healthcare provider before starting, stopping, or changing any medication or supplement.

Disclaimer: This checker finds which nutrients might be depleted by prescription or over-the-counter medications. Each nutrient depletion issue is rated based on clinical significance. Use your own professional judgment prior to making clinical decisions.

© 2026 Therapeutic Research Center Licensed records refresh weekly · last updated July 3, 2026.
Understand the basics

What drug-induced nutrient depletion means

Some medications can, over time, lower the levels of certain vitamins, minerals, or other nutrients — through reduced absorption, increased loss, or changes in how the body uses them.

Association is not deficiency

An entry here means a depletion has been reported or studied — not that it happens to everyone, or that you are deficient. Dose, duration, diet, and your own health all matter.

Evidence varies by pair

Some drug–nutrient links (like metformin and vitamin B12) are well studied; others rest on limited or preliminary research. Each entry shows the evidence rating from our licensed clinical database.

When to ask about labs

If you take an associated medication long-term, ask your healthcare provider whether monitoring is appropriate for you. Not everyone needs testing — your provider can weigh your dose, duration, and symptoms.

Don't self-supplement blindly

Supplements are not risk-free: some can interact with medications, and some (like potassium or magnesium) can be risky with kidney disease. Talk to your pharmacist before adding anything.

Never stop a medication over this

These medications are prescribed for good reasons, and the benefit usually far outweighs a manageable nutrient consideration. Any change belongs in a conversation with your prescriber.

Food first, usually

For many nutrients, a varied diet covers the gap. Each entry lists common food sources; a supplement is a decision to make with your pharmacist or provider, not a default.

Common questions

BETA-CAROTENE & medications: FAQs

Which medications can lower BETA-CAROTENE?
In our licensed clinical database, 26 medications have been associated with BETA-CAROTENE depletion, including Cholestyramine, Colchicine, Colchicine, Probenecid and Colestipol. Each entry above shows the evidence rating and the published details. An association is not a guarantee — dose, duration, diet, and your own health all matter.
I take one of these medications — am I deficient in BETA-CAROTENE?
Not necessarily. These entries describe reported associations, not certainties. Many people take these medications without developing a meaningful BETA-CAROTENE problem. If you take one long-term, the reasonable step is to ask your healthcare provider whether checking your BETA-CAROTENE status is appropriate for you.
Should I start a BETA-CAROTENE supplement?
Not without checking first. Supplements are not risk-free — some interact with medications, and for certain nutrients (like potassium or magnesium) supplementation can be genuinely risky with kidney disease or particular drug combinations. Food-first strategies and clinician-guided testing usually come before a supplement.
Where does this information come from?
The depletion records come from the Natural Medicines (Therapeutic Research Center) database — an evidence-graded clinical reference — and are displayed as published, with their citations. The plain-English education is written and reviewed by licensed HelloPharmacist pharmacists.

Wondering about your BETA-CAROTENE levels?

Ask a licensed pharmacist — free, no appointment needed.

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Sources

Sources & How We Checked

Medication associations with BETA-CAROTENE are evidence-graded and sourced from the Natural Medicines database, and are displayed as published with their citations.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.