Herb & supplement monograph

Kinetin Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Kinetin interacts with medications. The heart of this page is the interaction list — every drug Kinetin is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Kinetin is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Kinetin Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Kinetin drug interaction appears low for most people. None of the listed interactions are rated major, and every one traces back to a single theoretical concern that has not been confirmed in human studies.

Interactions deserving the most attention

The one area worth watching is bleeding risk. Lab research suggests kinetin may make platelets less sticky, and animal studies suggest it could lengthen bleeding time. In theory, that could add to the effect of anticoagulant and antiplatelet drugs, a group that includes aspirin, clopidogrel (Plavix), dalteparin, and enoxaparin. Because these blood thinners are already closely monitored for bleeding, it makes sense to be aware of this possibility even though it remains unproven in people.

What the rest of the list means

Kinetin's long interaction list looks bigger than it really is. All of those medications fall under this one bleeding concern, which comes from lab and animal research rather than human studies. A moderate rating here reflects a cautious, theoretical prediction, not a harmful effect that has actually been documented in patients.

Check your medications against Kinetin

Based on HelloPharmacist’s Kinetin interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Kinetin

122 medications have a known interaction with Kinetin, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AbciximabReoPro› AbrocitinibCibinqo› AcenocoumarolSintrom› Acetaminophen, AspirinGemnisyn› Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine› Acetaminophen, IbuprofenCombogesic› Acetylsalicylic AcidEntrophen› Alteplase, TpaActilyse, Activase› Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2› Aluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin› Anacaulase-bcdbNexoBrid› AnagrelideAgrylin› AnisindioneMiradon› Antithrombin IiiThrombate III› ApixabanEliquis› ArgatrobanArgatroban› AspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more› Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3› Aspirin, ButalbitalAxotal› Aspirin, Butalbital, CaffeineFiorinal› Aspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine› Aspirin, Butalbital, Caffeine, PhenacetinMarnal› Aspirin, CaffeineAnacin› Aspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine› Aspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC› Aspirin, Caffeine, Dover's PwdAcedoval, Dovacet› Aspirin, Caffeine, HydrocodoneDamason-P› Aspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal› Aspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte› Aspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Kinetin combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Kinetin affects

Every type of medication (drug category) Kinetin is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Kinetin interacts with
Anticoagulant/antiplatelet Drugs
Anticoagulant/Antiplatelet Drugs

In vitro research suggests that kinetin inhibits human platelet aggregation and activation. Also, evidence from animal research suggests that kinetin prolongs bleeding time. Theoretically, kinetin might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs. Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Monograph

Kinetin: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Kinetin is a plant growth hormone (a cytokinin) used mainly in topical anti-aging and skincare products, not as an oral dietary supplement. Early laboratory research and small studies suggest it may help skin texture and hydration, but high-quality human evidence is limited. If you want to try it, use it as a cosmetic skin product and check with a pharmacist or dermatologist, especially if you have sensitive skin.

Part used
Plant-derived cytokinin (a type of plant hormone); used as a purified compound
Common forms
Topical creams, serums, lotions, and cosmetic skincare products
People commonly use it for
  • Anti-aging skincare
  • Skin smoothing and texture
  • Reducing skin dryness and roughness
  • Evening skin tone
  • Cosmetic moisturizing

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally used topically in cosmetics; oral supplement use is not well studied and not recommended.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Kinetin is a type of plant hormone called a cytokinin. Plant hormones like this one help control how plant cells grow and divide. Kinetin was first identified many years ago in lab research on plant cells, and it is also produced naturally as cells age.

Unlike most herbs on this site, kinetin is not usually swallowed as a pill or tea. Instead, it is best known as an ingredient in skincare and anti-aging cosmetic products, such as creams, lotions, and serums. Companies add it to these products in hopes of improving the look and feel of the skin.

How it works

In plants, kinetin helps cells divide and slows the breakdown that happens as plant tissue ages. Based on lab research, scientists think it may have antioxidant effects, meaning it might help protect cells from certain kinds of damage.

In skin-cell research, kinetin has been studied for possibly helping cells handle stress and reducing some signs of aging in cultured cells. It is important to know that these are mostly laboratory and test-tube findings. What happens in a dish does not always happen the same way on real human skin.

Effectiveness

Does Kinetin work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 4 uses evaluated
4 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Kinetin, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 4 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Aging skin
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research shows that applying 0.4 mL of a solution containing kinetin 0.03% plus niacinamide 4% twice daily, along with a sunscreen for 12 weeks, does not reduce spots, pores, redness, or wrinkles when compared with niacinamide alone or a vehicle alone in people with aging skin. This study may not have been adequately powered to detect a difference between groups.

Sources Ref 100049
Insufficient Reliable Evidence To Rate Meniere disease
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research shows that filling the small cavity surrounding the middle ear bones with a lidocaine/kinetin solution improves symptoms of Meniere disease, such as vertigo, hearing loss, and tinnitus, in 87.5% of patients when compared to baseline. The validity of these findings is limited by the lack of a comparator group.

Sources Ref 57453
Insufficient Reliable Evidence To Rate Rosacea
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research shows that topical application with kinetin 0.1% lotion (Kinerase, Valeant Pharmaceuticals International) twice daily for 12 weeks, along with sunscreen, improves symptoms of mild to moderate facial rosacea by a moderate to marked amount in approximately 59% of patients when compared with baseline. However, symptoms of inflammation and telangiectasia were not improved. The validity of these findings is limited by the lack of a comparator group.

Sources Ref 100050
Insufficient Reliable Evidence To Rate Wrinkled skin
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research in adults with mild to severe photodamage shows that applying a pea-sized amount of lotion containing kinetin 0.1% (Kinerase, Menarini Inc.) twice daily for 12 weeks modestly improves overall skin condition, skin texture, skin color, and wrinkles, when compared with baseline. Between 31% and 37% of patients showed at least moderate improvement in these symptoms. The validity of these findings is limited by the lack of a comparator group.

Sources Ref 100044

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

When used as directed in cosmetic skin products, kinetin is generally considered well tolerated for most people, and it is often promoted as a gentle option. Still, any skincare ingredient can cause irritation in some people, especially those with sensitive or allergy-prone skin.

If you have sensitive skin, eczema, or known allergies, do a patch test first by applying a small amount to a small area before using it widely. Avoid getting the product in your eyes.

Because there is little safety data for swallowing kinetin, do not take it by mouth unless a healthcare provider tells you to. For pregnancy and breastfeeding, there is not enough reliable safety information, so it is best to avoid it during these times unless your doctor or pharmacist approves.

Side effects

Topical kinetin products are usually well tolerated. When side effects happen, they are typically mild and local, such as:

  • Redness or irritation where applied
  • Itching or a stinging feeling
  • Dryness

Rarely, a person could have an allergic skin reaction. If you develop a rash, swelling, or strong irritation, stop using the product and talk to a healthcare provider. Because oral use is not well studied, its side effects when swallowed are unknown.

Kinetin: Reported Adverse Effects

Documented safety reports on Kinetin from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, the most common adverse effect reported from kinetin is nausea. Headache, diarrhea, tinnitus, flushing, and rash are less common. Topically, kinetin seems to be well tolerated. Erythema, dryness, peeling, burning, stinging, and itching have been reported. However, it is unknown if these symptoms are related to kinetin or other ingredients in the products used.

  1. Gold-von Simson G, Goldberg JD, Rolnitzky LM, et al. Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing. Pediatr Res. 2009;65(3):341-6.
  2. Wanitphakdeedecha R, Meeprathom W, Manuskiatti W. Efficacy and safety of 0.1% kinetin cream in the treatment of photoaging skin. Indian J Dermatol Venereol Leprol. 2015;81(5):547.
  3. Wu JJ, Weinstein GD, Kricorian GJ, Kormeili T, McCullough JL. Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea. Clin Exp Dermatol. 2007;32(6):693-5.
Reports by condition
Cluster headache Neurologic/CNS

Orally, kinetin has been reported to cause headache rarely. Limited research suggests that this reaction is not dose-dependent.

  1. Gold-von Simson G, Goldberg JD, Rolnitzky LM, et al. Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing. Pediatr Res. 2009;65(3):341-6.
Diarrhea Gastrointestinal

Orally, the most common adverse effect reported from kinetin is nausea. Lower doses generally cause mild nausea; however, doses of 16.8 mg/kg to 23.5 mg/kg daily increase the chance of severe nausea. Kinetin has also been reported to cause diarrhea, although at a lower rate.

  1. Gold-von Simson G, Goldberg JD, Rolnitzky LM, et al. Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing. Pediatr Res. 2009;65(3):341-6.
Erythema Dermatologic

Orally, kinetin has been reported to cause flushing and rash rarely. Limited research suggests that these reactions are not dose-dependent. Topically, kinetin has been reported to cause erythema, dryness, peeling, burning, stinging, and itching. However, it is unknown if these symptoms are related to kinetin or other ingredients in the products used.

  1. Gold-von Simson G, Goldberg JD, Rolnitzky LM, et al. Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing. Pediatr Res. 2009;65(3):341-6.
  2. Wanitphakdeedecha R, Meeprathom W, Manuskiatti W. Efficacy and safety of 0.1% kinetin cream in the treatment of photoaging skin. Indian J Dermatol Venereol Leprol. 2015;81(5):547.
Tinnitus Ocular/Otic

Orally, kinetin has been reported to cause tinnitus rarely. Limited research suggests that this reaction is not dose-dependent.

  1. Gold-von Simson G, Goldberg JD, Rolnitzky LM, et al. Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing. Pediatr Res. 2009;65(3):341-6.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established standard dose for kinetin, and it is not meant to be taken as an oral supplement. In cosmetic skincare, it appears as one ingredient among many, usually in low concentrations.

The best approach is to follow the directions on the product label for how often to apply it. If you are unsure whether a product is right for you, ask a pharmacist or dermatologist. Do not assume that using more product more often will give better results.

Pregnancy & Breastfeeding

Kinetin & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Kinetin & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 7 references that drive our Kinetin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hsiao, G., Shen, M. Y., Lin, K. H., Chou, C. Y., Tzu, N. H., Lin, C. H., Chou, D. S., Chen, T. F., and Sheu, J. R. Inhibitory activity of kinetin on free radical formation of activated platelets in vitro and on thrombus formation in vivo. Eur J Pharmacol PubMed
  2. Adunka, O., Moustaklis, E., Weber, A., May, A., von Ilberg, C., Gstoettner, W., and Kierner, A. C. Labyrinth anesthesia--a forgotten but practical treatment option in Meniere's disease. ORL J Otorhinolaryngol.Relat Spec. 2003;65(2):84-90.
  3. Sheu, J. R., Hsiao, G., Shen, M. Y., Chou, C. Y., Lin, C. H., Chen, T. F., and Chou, D. S. Inhibitory mechanisms of kinetin, a plant growth-promoting hormone, in platelet aggregation. Platelets. 2003;14(3):189-196. PubMed
  4. Wanitphakdeedecha R, Meeprathom W, Manuskiatti W. Efficacy and safety of 0.1% kinetin cream in the treatment of photoaging skin. Indian J Dermatol Venereol Leprol. 2015;81(5):547. PubMed
  5. Gold-von Simson G, Goldberg JD, Rolnitzky LM, et al. Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing. Pediatr Res. 2009;65(3):341-6. PubMed
  6. Chiu PC, Chan CC, Lin HM, Chiu HC. The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial. J Cosmet Dermatol. 2007;6(4):243-9. PubMed
  7. Wu JJ, Weinstein GD, Kricorian GJ, Kormeili T, McCullough JL. Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea. Clin Exp Dermatol. 2007;32(6):693-5. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Kinetin: Common Questions

What is Kinetin used for, and does it work?
People use Kinetin for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Kinetin interact with prescription medications?
Yes. We list 122 medications with a known interaction with Kinetin. Use the checker above to see how Kinetin interacts with a specific drug.
How are Kinetin interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Kinetin with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Kinetin interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Kinetin used for?
Kinetin is mainly used as an ingredient in topical anti-aging and skincare products to help with skin smoothness, dryness, and texture. It is not commonly used as an oral supplement.
Does Kinetin really reduce wrinkles?
Some small studies suggest it may modestly improve skin texture and hydration, but the evidence is limited and not strong. It has not been clearly proven to reverse wrinkles or beat a good moisturizer.
Is Kinetin safe to put on my skin?
For most people, topical Kinetin products are well tolerated and are often promoted as gentle. Still, do a patch test first if you have sensitive skin, and stop using it if you get irritation.
Can I use Kinetin while pregnant or breastfeeding?
There isn't enough safety information for Kinetin during pregnancy or breastfeeding, so it's safest to avoid it unless your doctor or pharmacist says it's okay.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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