Drug & supplement interaction

Kinetin + Trimethoprim

Trimethoprim brand names: Proloprim, Trimpex.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Kinetin and Trimethoprim in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Kinetin and Trimethoprim

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Trimethoprim and Kinetin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Kinetin safety at a glance

Kinetin overall Use caution Generally used topically in cosmetics; oral supplement use is not well studied and not recommended.
Pregnancy Avoid There is not enough safety information, so it is best to avoid during pregnancy unless your doctor approves.
Breastfeeding Avoid Safety during breastfeeding has not been established, so caution or avoidance is advised.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Trimethoprim and Kinetin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Trimethoprim

Interactions in our licensed database are recorded against drug classes, not just single drug names. Trimethoprim is filed under 4 classifications — including qt interval-prolonging drugs, antibiotic drugs, oral drugs. Kinetin has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Trimethoprim’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Kinetin Does Interact With Other Medications

Kinetin has 122 moderate known drug interactions in our database — Trimethoprim isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Trimethoprim)
Taking anything else?

Check Another of Your Medications Against Kinetin

Covers the 2,830 medications we’ve checked against Kinetin. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Kinetin and Trimethoprim May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Itching / A skin rash reported in 5.3% of FDA reports for Trimethoprim Additional detail

    Kinetin

    “Orally, the most common adverse effect reported from kinetin is nausea. Headache, diarrhea, tinnitus, flushing, and rash are less common. Topically, kinetin seems to be well tolerated. Erythema, dryness, peeling, burning, stinging, and itching have been reported. However, it is unknown if these symptoms are related to kinetin or other ingredients in the products used.”

    Kinetin · Natural Medicines adverse-effect record, reported in cluster headache.

    3 sources cited
    1. 100046. Gold-von Simson G, Goldberg JD, Rolnitzky LM, et al. Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing. Pediatr Res. 2009;65(3):341-6. PubMed
    2. 100044. Wanitphakdeedecha R, Meeprathom W, Manuskiatti W. Efficacy and safety of 0.1% kinetin cream in the treatment of photoaging skin. Indian J Dermatol Venereol Leprol. 2015;81(5):547. PubMed
    3. 100050. Wu JJ, Weinstein GD, Kricorian GJ, Kormeili T, McCullough JL. Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea. Clin Exp Dermatol. 2007;32(6):693-5. PubMed

    “Orally, kinetin has been reported to cause flushing and rash rarely. Limited research suggests that these reactions are not dose-dependent. Topically, kinetin has been reported to cause erythema, dryness, peeling, burning, stinging, and itching. However, it is unknown if these symptoms are related to kinetin or other ingredients in the products used.”

    Kinetin · Natural Medicines adverse-effect record, reported in erythema.

    2 sources cited
    1. 100046. Gold-von Simson G, Goldberg JD, Rolnitzky LM, et al. Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing. Pediatr Res. 2009;65(3):341-6. PubMed
    2. 100044. Wanitphakdeedecha R, Meeprathom W, Manuskiatti W. Efficacy and safety of 0.1% kinetin cream in the treatment of photoaging skin. Indian J Dermatol Venereol Leprol. 2015;81(5):547. PubMed

    Trimethoprim

    Listed in the ADVERSE REACTIONS section of the FDA label for Trimethoprim, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Nausea reported in 6.0% of FDA reports for Trimethoprim Additional detail

    Kinetin

    “Orally, the most common adverse effect reported from kinetin is nausea. Lower doses generally cause mild nausea; however, doses of 16.8 mg/kg to 23.5 mg/kg daily increase the chance of severe nausea. Kinetin has also been reported to cause diarrhea, although at a lower rate.”

    Kinetin · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 100046. Gold-von Simson G, Goldberg JD, Rolnitzky LM, et al. Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing. Pediatr Res. 2009;65(3):341-6. PubMed

    Trimethoprim

    Listed in the ADVERSE REACTIONS section of the FDA label for Trimethoprim, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Kinetin but not commonly for Trimethoprim: diarrhea, headache, flushing and ringing in the ears.

Effects for Trimethoprim come from the ADVERSE REACTIONS section of its FDA label; effects for Kinetin come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 93,588 voluntary FDA FAERS reports for Trimethoprim that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Kinetin or Trimethoprim

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Kinetin or Trimethoprim, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Trimethoprim

This page covers Kinetin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Trimethoprim page lists 59 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 7 major · 41 moderate · 11 minor.

From our pharmacist’s overview on the Trimethoprim page

“Most prescriptions for trimethoprim are short courses for bladder infections, which makes it easy to assume nothing swallowed alongside it matters much. Seven of the 59 supplement and herbal ingredients here rate major, though, and nearly all of them involve heart rhythm: grapefruit in large amounts, ephedra, and a few others can prolo…”

Reviewed by 2 · Jul 18, 2026

Open the Trimethoprim interaction page

How much people look this up

Where Kinetin and Trimethoprim Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Kinetin
Steady interest

#870 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Trimethoprim
Steady interest

#2,126 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Kinetin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Kinetin and Trimethoprim records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Kinetin

What is Kinetin?

  • Anti-aging skincare
  • Skin smoothing and texture
  • Reducing skin dryness and roughness
  • Evening skin tone
  • Cosmetic moisturizing

Kinetin is a plant growth hormone (a cytokinin) used mainly in topical anti-aging and skincare products, not as an oral dietary supplement. Early laboratory research and small studies suggest it may help skin texture and hydration, but high-quality human evidence is limited. If you want to try it, use it as a cosmetic skin product and check with a pharmacist or dermatologist, especially if you have sensitive skin.

Plant-derived cytokinin (a type of plant hormone); used as a purified compound · Topical creams, serums, lotions, and cosmetic skincare products

An interaction check asks whether these two react with each other — it does not ask whether Kinetin is a good idea for someone in your situation. Here is what our Kinetin record says about it on its own.

Kinetin: dosing

There is no established standard dose for kinetin, and it is not meant to be taken as an oral supplement. In cosmetic skincare, it appears as one ingredient among many, usually in low concentrations.The best approach is to follow the directions on the product label for how often to apply it. Do not assume that using more product more often will give better results.

From our Kinetin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Kinetin monograph & all interactions
Medication

About Trimethoprim

What Is Trimethoprim Used For?

Brand names: Proloprim, Trimpex

Trimethoprim tablets are used to treat initial episodes of uncomplicated urinary tract infections (UTIs). It works against specific bacteria — including E. coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species, and coagulase-negative Staphylococcus species (including S. saprophyticus).

It should only be used when there is a proven or strongly suspected bacterial infection. Your doctor may order a urine culture to confirm which bacteria are present and whether trimethoprim will work against them.

Most-Reported Side Effects for Trimethoprim

From FAERS, the FDA’s public side-effect reporting system (95,001 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 6,904 reports
Fatigue 5,992 reports
Diarrhea 5,716 reports
Nausea 5,685 reports
Dyspnea 5,098 reports
See full Trimethoprim drug information
Keep checking

Other Drugs & Kinetin

Browse every other medication we’ve checked against Kinetin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Kinetin page.

No interaction 2,707 drugs checked — show the list

We also checked Kinetin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Kinetin list.

See the full Kinetin interactions page
See every supplement checked against Trimethoprim, ranked by severity
Evidence & sources

Kinetin References

The 7 references that drive our Kinetin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hsiao, G., Shen, M. Y., Lin, K. H., Chou, C. Y., Tzu, N. H., Lin, C. H., Chou, D. S., Chen, T. F., and Sheu, J. R. Inhibitory activity of kinetin on free radical formation of activated platelets in vitro and on thrombus formation in vivo. Eur J Pharmacol PubMed
  2. Adunka, O., Moustaklis, E., Weber, A., May, A., von Ilberg, C., Gstoettner, W., and Kierner, A. C. Labyrinth anesthesia--a forgotten but practical treatment option in Meniere's disease. ORL J Otorhinolaryngol.Relat Spec. 2003;65(2):84-90.
  3. Sheu, J. R., Hsiao, G., Shen, M. Y., Chou, C. Y., Lin, C. H., Chen, T. F., and Chou, D. S. Inhibitory mechanisms of kinetin, a plant growth-promoting hormone, in platelet aggregation. Platelets. 2003;14(3):189-196. PubMed
  4. Wanitphakdeedecha R, Meeprathom W, Manuskiatti W. Efficacy and safety of 0.1% kinetin cream in the treatment of photoaging skin. Indian J Dermatol Venereol Leprol. 2015;81(5):547. PubMed
  5. Gold-von Simson G, Goldberg JD, Rolnitzky LM, et al. Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing. Pediatr Res. 2009;65(3):341-6. PubMed
  6. Chiu PC, Chan CC, Lin HM, Chiu HC. The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial. J Cosmet Dermatol. 2007;6(4):243-9. PubMed
  7. Wu JJ, Weinstein GD, Kricorian GJ, Kormeili T, McCullough JL. Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea. Clin Exp Dermatol. 2007;32(6):693-5. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Kinetin and Trimethoprim Together: Common Questions

Is it safe to take Kinetin with Trimethoprim?
We do not list a known interaction between Kinetin and Trimethoprim. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Kinetin and Trimethoprim have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Kinetin and Trimethoprim combination checked?
Interactions in our licensed database are recorded against drug classes. Trimethoprim is filed under 4 classifications, and Kinetin has documented interactions with 1 drug class — none of Trimethoprim's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Kinetin interact with any other medications?
Yes. Kinetin has 122 documented drug interactions in our database — Trimethoprim is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Trimethoprim interact with any supplements?
Yes. Trimethoprim has documented interactions with 59 supplements in our database — Kinetin is not one of them. The Trimethoprim interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Kinetin monograph Uses, safety profile, and every drug interaction in one place Trimethoprim drug information The full plain-English guide to this medication Trimethoprim supplement interactions Every supplement checked against Trimethoprim, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Trimethoprim and Kinetin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.